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Items: 43

1.

Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.

Xiao J, Gill C, Liang L, Liu J, Wu J, Feng HP, Flanagan S, Tan C, Flattery A.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e00822-18. doi: 10.1128/AAC.00822-18. Print 2019 Jan.

2.

Dual-Targeting Small-Molecule Inhibitors of the Staphylococcus aureus FMN Riboswitch Disrupt Riboflavin Homeostasis in an Infectious Setting.

Wang H, Mann PA, Xiao L, Gill C, Galgoci AM, Howe JA, Villafania A, Barbieri CM, Malinverni JC, Sher X, Mayhood T, McCurry MD, Murgolo N, Flattery A, Mack M, Roemer T.

Cell Chem Biol. 2017 May 18;24(5):576-588.e6. doi: 10.1016/j.chembiol.2017.03.014. Epub 2017 Apr 20.

3.

Can We Make Small Molecules Lean? Optimization of a Highly Lipophilic TarO Inhibitor.

Mandal M, Tan Z, Madsen-Duggan C, Buevich AV, Caldwell JP, Dejesus R, Flattery A, Garlisi CG, Gill C, Ha SN, Ho G, Koseoglu S, Labroli M, Basu K, Lee SH, Liang L, Liu J, Mayhood T, McGuinness D, McLaren DG, Wen X, Parmee E, Rindgen D, Roemer T, Sheth P, Tawa P, Tata J, Yang C, Yang SW, Xiao L, Wang H, Tan C, Tang H, Walsh P, Walsh E, Wu J, Su J.

J Med Chem. 2017 May 11;60(9):3851-3865. doi: 10.1021/acs.jmedchem.7b00113. Epub 2017 Mar 29.

PMID:
28322556
4.

Preclinical Pharmacokinetics and Pharmacodynamic Target of SCY-078, a First-in-Class Orally Active Antifungal Glucan Synthesis Inhibitor, in Murine Models of Disseminated Candidiasis.

Wring SA, Randolph R, Park S, Abruzzo G, Chen Q, Flattery A, Garrett G, Peel M, Outcalt R, Powell K, Trucksis M, Angulo D, Borroto-Esoda K.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02068-16. doi: 10.1128/AAC.02068-16. Print 2017 Apr.

5.

Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin.

Warn P, Thommes P, Sattar A, Corbett D, Flattery A, Zhang Z, Black T, Hernandez LD, Therien AG.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6471-6482. doi: 10.1128/AAC.00974-16. Print 2016 Nov.

6.

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Lee SH, Wang H, Labroli M, Koseoglu S, Zuck P, Mayhood T, Gill C, Mann P, Sher X, Ha S, Yang SW, Mandal M, Yang C, Liang L, Tan Z, Tawa P, Hou Y, Kuvelkar R, DeVito K, Wen X, Xiao J, Batchlett M, Balibar CJ, Liu J, Xiao J, Murgolo N, Garlisi CG, Sheth PR, Flattery A, Su J, Tan C, Roemer T.

Sci Transl Med. 2016 Mar 9;8(329):329ra32. doi: 10.1126/scitranslmed.aad7364.

PMID:
26962156
7.

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis.

Mann PA, McLellan CA, Koseoglu S, Si Q, Kuzmin E, Flattery A, Harris G, Sher X, Murgolo N, Wang H, Devito K, de Pedro N, Genilloud O, Kahn JN, Jiang B, Costanzo M, Boone C, Garlisi CG, Lindquist S, Roemer T.

ACS Infect Dis. 2015 Jan 9;1(1):59-72. doi: 10.1021/id5000212. Epub 2014 Dec 12.

8.

Correction for Zhang et al., Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection.

Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG.

Infect Immun. 2015 Dec;83(12):4899. doi: 10.1128/IAI.01214-15. No abstract available.

9.

Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin.

Apgar JM, Wilkening RR, Greenlee ML, Balkovec JM, Flattery AM, Abruzzo GK, Galgoci AM, Giacobbe RA, Gill CJ, Hsu MJ, Liberator P, Misura AS, Motyl M, Nielsen Kahn J, Powles M, Racine F, Dragovic J, Habulihaz B, Fan W, Kirwan R, Lee S, Liu H, Mamai A, Nelson K, Peel M.

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5813-8. doi: 10.1016/j.bmcl.2015.10.011. Epub 2015 Oct 9.

PMID:
26542966
10.

Toxin-mediated paracellular transport of antitoxin antibodies facilitates protection against Clostridium difficile infection.

Zhang Z, Chen X, Hernandez LD, Lipari P, Flattery A, Chen SC, Kramer S, Polishook JD, Racine F, Cape H, Kelly CP, Therien AG.

Infect Immun. 2015 Jan;83(1):405-16. doi: 10.1128/IAI.02550-14. Epub 2014 Nov 10. Erratum in: Infect Immun. 2015 Dec;83(12):4899.

11.

Kibdelomycin is a potent and selective agent against toxigenic Clostridium difficile.

Miesel L, Hecht DW, Osmolski JR, Gerding D, Flattery A, Li F, Lan J, Lipari P, Polishook JD, Liang L, Liu J, Olsen DB, Singh SB.

Antimicrob Agents Chemother. 2014;58(4):2387-92. doi: 10.1128/AAC.00021-14. Epub 2014 Feb 10.

12.

Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.

Mann PA, Müller A, Xiao L, Pereira PM, Yang C, Ho Lee S, Wang H, Trzeciak J, Schneeweis J, Dos Santos MM, Murgolo N, She X, Gill C, Balibar CJ, Labroli M, Su J, Flattery A, Sherborne B, Maier R, Tan CM, Black T, Onder K, Kargman S, Monsma FJ Jr, Pinho MG, Schneider T, Roemer T.

ACS Chem Biol. 2013 Nov 15;8(11):2442-51. doi: 10.1021/cb400487f. Epub 2013 Sep 5.

PMID:
23957438
13.

Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.

Wang H, Gill CJ, Lee SH, Mann P, Zuck P, Meredith TC, Murgolo N, She X, Kales S, Liang L, Liu J, Wu J, Santa Maria J, Su J, Pan J, Hailey J, Mcguinness D, Tan CM, Flattery A, Walker S, Black T, Roemer T.

Chem Biol. 2013 Feb 21;20(2):272-84. doi: 10.1016/j.chembiol.2012.11.013.

14.

Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h.

Singh SB, Liu W, Li X, Chen T, Shafiee A, Card D, Abruzzo G, Flattery A, Gill C, Thompson JR, Rosenbach M, Dreikorn S, Hornak V, Meinz M, Kurtz M, Kelly R, Onishi JC.

ACS Med Chem Lett. 2012 Sep 7;3(10):814-7. doi: 10.1021/ml300173e. eCollection 2012 Oct 11.

15.

Comparison of lipoprotein separation and lipid analysis methodologies for human and cynomolgus monkey plasma samples.

Han S, Flattery AM, McLaren D, Raubertas R, Lee SH, Mendoza V, Rosa R, Geoghagen N, Castro-Perez JM, Roddy TP, Forrest G, Johns D, Hubbard BK, Li J.

J Cardiovasc Transl Res. 2012 Feb;5(1):75-83. doi: 10.1007/s12265-011-9340-9. Epub 2011 Dec 23.

PMID:
22194019
16.

A rapid method for cross-species quantitation of apolipoproteins A1, B48 and B100 in plasma by ultra-performance liquid chromatography/tandem mass spectrometry.

Lassman ME, McLaughlin TM, Somers EP, Stefanni AC, Chen Z, Murphy BA, Bierilo KK, Flattery AM, Wong KK, Castro-Perez JM, Hubbard BK, Roddy TP.

Rapid Commun Mass Spectrom. 2012 Jan 30;26(2):101-8. doi: 10.1002/rcm.5296.

PMID:
22173797
17.

Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.

Zhou X, Crook MF, Sharif-Rodriguez W, Zhu Y, Ruben Z, Pan Y, Urosevic-Price O, Wang L, Flattery AM, Forrest G, Szeto D, Zhao H, Roy S, Forrest MJ.

Clin Exp Hypertens. 2011;33(8):538-47. doi: 10.3109/10641963.2011.566956. Epub 2011 Sep 27.

18.

Efficacy of caspofungin in a juvenile mouse model of central nervous system candidiasis.

Flattery AM, Hickey E, Gill CJ, Powles MA, Misura AS, Galgoci AM, Ellis JD, Zhang R, Sandhu P, Ronan J, Abruzzo GK.

Antimicrob Agents Chemother. 2011 Jul;55(7):3491-7. doi: 10.1128/AAC.01328-10. Epub 2011 Apr 25.

19.

Validation of human ApoB and ApoAI immunoturbidity assays for non-human primate dyslipidemia and atherosclerosis research.

Chen Z, Strack AM, Stefanni AC, Chen Y, Wu W, Pan Y, Urosevic-Price O, Wang L, McLaughlin T, Geoghagen N, Lassman ME, Roddy TP, Wong KK, Hubbard BK, Flattery AM.

J Cardiovasc Transl Res. 2011 Jun;4(3):373-83. doi: 10.1007/s12265-011-9264-4. Epub 2011 Mar 11.

PMID:
21394531
20.

PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products.

Jiang B, Xu D, Allocco J, Parish C, Davison J, Veillette K, Sillaots S, Hu W, Rodriguez-Suarez R, Trosok S, Zhang L, Li Y, Rahkhoodaee F, Ransom T, Martel N, Wang H, Gauvin D, Wiltsie J, Wisniewski D, Salowe S, Kahn JN, Hsu MJ, Giacobbe R, Abruzzo G, Flattery A, Gill C, Youngman P, Wilson K, Bills G, Platas G, Pelaez F, Diez MT, Kauffman S, Becker J, Harris G, Liberator P, Roemer T.

Chem Biol. 2008 Apr;15(4):363-74. doi: 10.1016/j.chembiol.2008.02.016.

21.

In vivo efficacy of a novel oxazolidinone compound in two mouse models of infection.

Gill CJ, Abruzzo GK, Flattery AM, Misura AS, Bartizal K, Hickey EJ.

Antimicrob Agents Chemother. 2007 Sep;51(9):3434-6. Epub 2007 Jul 2.

22.

Efficacy of caspofungin against Aspergillus flavus, Aspergillus terreus, and Aspergillus nidulans.

Bowman JC, Abruzzo GK, Flattery AM, Gill CJ, Hickey EJ, Hsu MJ, Kahn JN, Liberator PA, Misura AS, Pelak BA, Wang TC, Douglas CM.

Antimicrob Agents Chemother. 2006 Dec;50(12):4202-5. Epub 2006 Oct 2.

23.

Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates.

Park S, Kelly R, Kahn JN, Robles J, Hsu MJ, Register E, Li W, Vyas V, Fan H, Abruzzo G, Flattery A, Gill C, Chrebet G, Parent SA, Kurtz M, Teppler H, Douglas CM, Perlin DS.

Antimicrob Agents Chemother. 2005 Aug;49(8):3264-73.

24.

Inactivation of Kex2p diminishes the virulence of Candida albicans.

Newport G, Kuo A, Flattery A, Gill C, Blake JJ, Kurtz MB, Abruzzo GK, Agabian N.

J Biol Chem. 2003 Jan 17;278(3):1713-20. Epub 2002 Nov 4.

25.

Arundifungin, a novel antifungal compound produced by fungi: biological activity and taxonomy of the producing organisms.

Cabello MA, Platas G, Collado J, Díez MT, Martín I, Vicente F, Meinz M, Onishi JC, Douglas C, Thompson J, Kurtz MB, Schwartz RE, Bills GF, Giacobbe RA, Abruzzo GK, Flattery AM, Kong L, Peláez F.

Int Microbiol. 2001 Jun;4(2):93-102.

PMID:
11770831
26.

Antimicrobial activity of ergokonin A from Trichoderma longibrachiatum.

Vicente MF, Cabello A, Platas G, Basilio A, Díez MT, Dreikorn S, Giacobbe RA, Onishi JC, Meinz M, Kurtz MB, Rosenbach M, Thompson J, Abruzzo G, Flattery A, Kong L, Tsipouras A, Wilson KE, Peláez F.

J Appl Microbiol. 2001 Nov;91(5):806-13.

27.

Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: demonstration of efficacy of caspofungin acetate.

Bowman JC, Abruzzo GK, Anderson JW, Flattery AM, Gill CJ, Pikounis VB, Schmatz DM, Liberator PA, Douglas CM.

Antimicrob Agents Chemother. 2001 Dec;45(12):3474-81.

28.

The discovery of enfumafungin, a novel antifungal compound produced by an endophytic Hormonema species biological activity and taxonomy of the producing organisms.

Peláez F, Cabello A, Platas G, Díez MT, González del Val A, Basilio A, Martán I, Vicente F, Bills GE, Giacobbe RA, Schwartz RE, Onish JC, Meinz MS, Abruzzo GK, Flattery AM, Kong L, Kurtz MB.

Syst Appl Microbiol. 2000 Oct;23(3):333-43.

PMID:
11108011
29.

Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice.

Abruzzo GK, Gill CJ, Flattery AM, Kong L, Leighton C, Smith JG, Pikounis VB, Bartizal K, Rosen H.

Antimicrob Agents Chemother. 2000 Sep;44(9):2310-8.

30.

Discovery of novel antifungal (1,3)-beta-D-glucan synthase inhibitors.

Onishi J, Meinz M, Thompson J, Curotto J, Dreikorn S, Rosenbach M, Douglas C, Abruzzo G, Flattery A, Kong L, Cabello A, Vicente F, Pelaez F, Diez MT, Martin I, Bills G, Giacobbe R, Dombrowski A, Schwartz R, Morris S, Harris G, Tsipouras A, Wilson K, Kurtz MB.

Antimicrob Agents Chemother. 2000 Feb;44(2):368-77.

31.

Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase.

Mandala SM, Thornton RA, Milligan J, Rosenbach M, Garcia-Calvo M, Bull HG, Harris G, Abruzzo GK, Flattery AM, Gill CJ, Bartizal K, Dreikorn S, Kurtz MB.

J Biol Chem. 1998 Jun 12;273(24):14942-9.

32.

Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-beta-D-glucan synthase inhibitors.

Douglas CM, D'Ippolito JA, Shei GJ, Meinz M, Onishi J, Marrinan JA, Li W, Abruzzo GK, Flattery A, Bartizal K, Mitchell A, Kurtz MB.

Antimicrob Agents Chemother. 1997 Nov;41(11):2471-9.

33.

Evaluation of the echinocandin antifungal MK-0991 (L-743,872): efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.

Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Pikounis VB, Balkovec JM, Bouffard AF, Dropinski JF, Rosen H, Kropp H, Bartizal K.

Antimicrob Agents Chemother. 1997 Nov;41(11):2333-8.

34.

In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872).

Bartizal K, Gill CJ, Abruzzo GK, Flattery AM, Kong L, Scott PM, Smith JG, Leighton CE, Bouffard A, Dropinski JF, Balkovec J.

Antimicrob Agents Chemother. 1997 Nov;41(11):2326-32.

35.

Evaluation of experimental therapeutics in a new mouse model of Helicobacter felis utilizing 16S rRNA polymerase chain reaction for detection.

Smith JG, Kong L, Abruzzo GK, Gill CJ, Flattery AM, Scott PM, Silver L, Kropp H, Bartizal K.

Scand J Gastroenterol. 1997 Apr;32(4):297-302.

PMID:
9140149
36.

Characterization of echinocandin-resistant mutants of Candida albicans: genetic, biochemical, and virulence studies.

Kurtz MB, Abruzzo G, Flattery A, Bartizal K, Marrinan JA, Li W, Milligan J, Nollstadt K, Douglas CM.

Infect Immun. 1996 Aug;64(8):3244-51.

37.

New model of oropharyngeal and gastrointestinal colonization by Candida albicans in CD4+ T-cell-deficient mice for evaluation of antifungal agents.

Flattery AM, Abruzzo GK, Gill CJ, Smith JG, Bartizal K.

Antimicrob Agents Chemother. 1996 Jul;40(7):1604-9.

38.

A sensitive and specific PCR method to detect Helicobacter felis in a conventional mouse model.

Kong L, Smith JG, Bramhill D, Abruzzo GK, Bonfiglio C, Cioffe C, Flattery AM, Gill CJ, Lynch L, Scott PM, Silver L, Thompson C, Kropp H, Bartizal K.

Clin Diagn Lab Immunol. 1996 Jan;3(1):73-8.

39.

PCR detection of colonization by Helicobacter pylori in conventional, euthymic mice based on the 16S ribosomal gene sequence.

Smith JG, Kong L, Abruzzo GK, Gill CJ, Flattery AM, Scott PM, Bramhill D, Cioffe C, Thompson CM, Bartizal K.

Clin Diagn Lab Immunol. 1996 Jan;3(1):66-72.

40.

In vivo evaluation of three acid-stable azalide compounds, L-701,677, L-708,299 and L-708,365 compared to erythromycin, azithromycin and clarithromycin.

Gill CJ, Abruzzo GK, Flattery AM, Smith JG, Jackson J, Kong L, Wilkening R, Shankaran K, Kropp H, Bartizal K.

J Antibiot (Tokyo). 1995 Oct;48(10):1141-7.

41.

Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis.

Abruzzo GK, Flattery AM, Gill CJ, Kong L, Smith JG, Krupa D, Pikounis VB, Kropp H, Bartizal K.

Antimicrob Agents Chemother. 1995 May;39(5):1077-81.

42.

Use of anti-CD4+ hybridoma cells to induce Pneumocystis carinii in mice.

McFadden DC, Powles MA, Smith JG, Flattery AM, Bartizal K, Schmatz DM.

Infect Immun. 1994 Nov;62(11):4887-92.

43.

Up-regulation of gene expression by FK 506.

Dumont FJ, Staruch MJ, Flattery A, Altmeyer A, Sigal NH.

Transplant Proc. 1991 Dec;23(6):2870-2. No abstract available.

PMID:
1721300

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