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Items: 25


Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.

Hudson G, Flannigan KL, Venu VKP, Alston L, Sandall CF, MacDonald JA, Muruve DA, Chang TKH, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2019 Jul;370(1):44-53. doi: 10.1124/jpet.118.255679. Epub 2019 Apr 19.


Combined IL-2 Immunocomplex and Anti-IL-5 mAb Treatment Expands Foxp3+ Treg Cells in the Absence of Eosinophilia and Ameliorates Experimental Colitis.

Abo H, Flannigan KL, Geem D, Ngo VL, Harusato A, Denning TL.

Front Immunol. 2019 Mar 14;10:459. doi: 10.3389/fimmu.2019.00459. eCollection 2019.


An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.

Flannigan KL, Taylor MR, Pereira SK, Rodriguez-Arguello J, Moffat AW, Alston L, Wang X, Poon KK, Beck PL, Rioux KP, Jonnalagadda M, Chelikani PK, Galipeau HJ, Lewis IA, Workentine ML, Greenway SC, Hirota SA.

J Heart Lung Transplant. 2018 Sep;37(9):1047-1059. doi: 10.1016/j.healun.2018.05.002. Epub 2018 May 23.


Segmented filamentous bacteria-induced immune responses: a balancing act between host protection and autoimmunity.

Flannigan KL, Denning TL.

Immunology. 2018 May 17. doi: 10.1111/imm.12950. [Epub ahead of print] Review.


Changes in Composition of the Gut Bacterial Microbiome after Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection in a Pediatric Heart Transplant Patient.

Flannigan KL, Rajbar T, Moffat A, McKenzie LS, Dicke F, Rioux K, Workentine ML, Louie TJ, Hirota SA, Greenway SC.

Front Cardiovasc Med. 2017 Apr 4;4:17. doi: 10.3389/fcvm.2017.00017. eCollection 2017.


Constitutive androstane receptor regulates the intestinal mucosal response to injury.

Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA.

Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19.


Xenobiotic Receptor-Mediated Regulation of Intestinal Barrier Function and Innate Immunity.

Ranhotra HS, Flannigan KL, Brave M, Mukherjee S, Lukin DJ, Hirota SA, Mani S.

Nucl Receptor Res. 2016;3. pii: 101199.


IL-17A-mediated neutrophil recruitment limits expansion of segmented filamentous bacteria.

Flannigan KL, Ngo VL, Geem D, Harusato A, Hirota SA, Parkos CA, Lukacs NW, Nusrat A, Gaboriau-Routhiau V, Cerf-Bensussan N, Gewirtz AT, Denning TL.

Mucosal Immunol. 2017 May;10(3):673-684. doi: 10.1038/mi.2016.80. Epub 2016 Sep 14.


Profound Chemopreventative Effects of a Hydrogen Sulfide-Releasing NSAID in the APCMin/+ Mouse Model of Intestinal Tumorigenesis.

Paul-Clark M, Elsheikh W, Kirkby N, Chan M, Devchand P, Agbor TA, Flannigan KL, Cheadle C, Freydin M, Ianaro A, Mitchell JA, Wallace JL.

PLoS One. 2016 Feb 24;11(2):e0147289. doi: 10.1371/journal.pone.0147289. eCollection 2016.


Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage.

Medina-Contreras O, Harusato A, Nishio H, Flannigan KL, Ngo V, Leoni G, Neumann PA, Geem D, Lili LN, Ramadas RA, Chassaing B, Gewirtz AT, Kohlmeier JE, Parkos CA, Towne JE, Nusrat A, Denning TL.

J Immunol. 2016 Jan 1;196(1):34-8. doi: 10.4049/jimmunol.1501312. Epub 2015 Nov 20.


Gaseous mediators in resolution of inflammation.

Wallace JL, Ianaro A, Flannigan KL, Cirino G.

Semin Immunol. 2015 May;27(3):227-33. doi: 10.1016/j.smim.2015.05.004. Epub 2015 Jun 18. Review.


Hydrogen sulfide-based anti-inflammatory and chemopreventive therapies: an experimental approach.

Flannigan KL, Wallace JL.

Curr Pharm Des. 2015;21(21):3012-22. Review.


Intestinal Antigen-Presenting Cells: Key Regulators of Immune Homeostasis and Inflammation.

Flannigan KL, Geem D, Harusato A, Denning TL.

Am J Pathol. 2015 Jul;185(7):1809-19. doi: 10.1016/j.ajpath.2015.02.024. Epub 2015 May 11. Review.


Phenotypic and functional profiling of mouse intestinal antigen presenting cells.

Harusato A, Flannigan KL, Geem D, Denning TL.

J Immunol Methods. 2015 Jun;421:20-26. doi: 10.1016/j.jim.2015.03.023. Epub 2015 Apr 17. Review.


Deciphering the pathogenesis of NSAID enteropathy using proton pump inhibitors and a hydrogen sulfide-releasing NSAID.

Blackler RW, De Palma G, Manko A, Da Silva GJ, Flannigan KL, Bercik P, Surette MG, Buret AG, Wallace JL.

Am J Physiol Gastrointest Liver Physiol. 2015 Jun 15;308(12):G994-1003.


Hydrogen sulfide protects from colitis and restores intestinal microbiota biofilm and mucus production.

Motta JP, Flannigan KL, Agbor TA, Beatty JK, Blackler RW, Workentine ML, Da Silva GJ, Wang R, Buret AG, Wallace JL.

Inflamm Bowel Dis. 2015 May;21(5):1006-17. doi: 10.1097/MIB.0000000000000345.


Proresolution effects of hydrogen sulfide during colitis are mediated through hypoxia-inducible factor-1α.

Flannigan KL, Agbor TA, Motta JP, Ferraz JG, Wang R, Buret AG, Wallace JL.

FASEB J. 2015 Apr;29(4):1591-602. doi: 10.1096/fj.14-266015. Epub 2014 Dec 30.


Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis.

Flannigan KL, Agbor TA, Blackler RW, Kim JJ, Khan WI, Verdu EF, Ferraz JG, Wallace JL.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13559-64. doi: 10.1073/pnas.1413390111. Epub 2014 Sep 3.


Enhanced chemopreventive effects of a hydrogen sulfide-releasing anti-inflammatory drug (ATB-346) in experimental colorectal cancer.

Elsheikh W, Blackler RW, Flannigan KL, Wallace JL.

Nitric Oxide. 2014 Sep 15;41:131-7. doi: 10.1016/j.niox.2014.04.006. Epub 2014 Apr 18.


Anti-inflammatory and cytoprotective actions of hydrogen sulfide: translation to therapeutics.

Wallace JL, Blackler RW, Chan MV, Da Silva GJ, Elsheikh W, Flannigan KL, Gamaniek I, Manko A, Wang L, Motta JP, Buret AG.

Antioxid Redox Signal. 2015 Feb 10;22(5):398-410. doi: 10.1089/ars.2014.5901. Epub 2014 Apr 15. Review.


Enhanced synthesis and diminished degradation of hydrogen sulfide in experimental colitis: a site-specific, pro-resolution mechanism.

Flannigan KL, Ferraz JG, Wang R, Wallace JL.

PLoS One. 2013 Aug 5;8(8):e71962. doi: 10.1371/journal.pone.0071962. Print 2013.


Pro-resolution, protective and anti-nociceptive effects of a cannabis extract in the rat gastrointestinal tract.

Wallace JL, Flannigan KL, McKnight W, Wang L, Ferraz JG, Tuitt D.

J Physiol Pharmacol. 2013 Apr;64(2):167-75.


Dextran sulfate sodium induces pan-gastroenteritis in rodents: implications for studies of colitis.

Elsheikh W, Flannigan KL, McKnight W, Ferraz JG, Wallace JL.

J Physiol Pharmacol. 2012 Oct;63(5):463-9.


Eukaryotic and prokaryotic contributions to colonic hydrogen sulfide synthesis.

Flannigan KL, McCoy KD, Wallace JL.

Am J Physiol Gastrointest Liver Physiol. 2011 Jul;301(1):G188-93. doi: 10.1152/ajpgi.00105.2011. Epub 2011 Apr 7.


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