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Items: 20


Wnt Signaling in Cancer: Not a Binary ON:OFF Switch.

Flanagan DJ, Vincan E, Phesse TJ.

Cancer Res. 2019 Dec 1;79(23):5901-5906. doi: 10.1158/0008-5472.CAN-19-1362. Epub 2019 Aug 20. Review.


Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations.

Flanagan DJ, Barker N, Costanzo NSD, Mason EA, Gurney A, Meniel VS, Koushyar S, Austin CR, Ernst M, Pearson HB, Boussioutas A, Clevers H, Phesse TJ, Vincan E.

Cancer Res. 2019 Mar 1;79(5):970-981. doi: 10.1158/0008-5472.CAN-18-2095. Epub 2019 Jan 8.


Microenvironmental cues in cancer stemness.

Flanagan DJ, Hodder MC, Sansom OJ.

Nat Cell Biol. 2018 Oct;20(10):1102-1104. doi: 10.1038/s41556-018-0210-4. No abstract available.


Intestinal Stem Cell Dynamics: A Story of Mice and Humans.

Hodder MC, Flanagan DJ, Sansom OJ.

Cell Stem Cell. 2018 Jun 1;22(6):785-787. doi: 10.1016/j.stem.2018.05.005.


Wnt Signalling in Gastrointestinal Epithelial Stem Cells.

Flanagan DJ, Austin CR, Vincan E, Phesse TJ.

Genes (Basel). 2018 Mar 23;9(4). pii: E178. doi: 10.3390/genes9040178. Review.


The Central Role of Wnt Signaling and Organoid Technology in Personalizing Anticancer Therapy.

Vincan E, Schwab RHM, Flanagan DJ, Moselen JM, Tran BM, Barker N, Phesse TJ.

Prog Mol Biol Transl Sci. 2018 Jan;153:299-319. doi: 10.1016/bs.pmbts.2017.11.009. Epub 2017 Dec 21. Review.


Loss of the Wnt receptor frizzled 7 in the mouse gastric epithelium is deleterious and triggers rapid repopulation in vivo.

Flanagan DJ, Barker N, Nowell C, Clevers H, Ernst M, Phesse TJ, Vincan E.

Dis Model Mech. 2017 Aug 1;10(8):971-980. doi: 10.1242/dmm.029876. Epub 2017 Jun 9.


Winding back Wnt signalling: potential therapeutic targets for treating gastric cancers.

Flanagan DJ, Vincan E, Phesse TJ.

Br J Pharmacol. 2017 Dec;174(24):4666-4683. doi: 10.1111/bph.13890. Epub 2017 Jul 5. Review.


Wnt is necessary for mesenchymal to epithelial transition in colorectal cancer cells.

Schwab RHM, Amin N, Flanagan DJ, Johanson TM, Phesse TJ, Vincan E.

Dev Dyn. 2018 Mar;247(3):521-530. doi: 10.1002/dvdy.24527. Epub 2017 Jun 22.


Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.

Flanagan DJ, Schwab RHM, Tran BM, Phesse TJ, Vincan E.

Methods Mol Biol. 2019;1576:123-133. doi: 10.1007/7651_2016_14.


Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells.

Flanagan DJ, Phesse TJ, Barker N, Schwab RH, Amin N, Malaterre J, Stange DE, Nowell CJ, Currie SA, Saw JT, Beuchert E, Ramsay RG, Sansom OJ, Ernst M, Clevers H, Vincan E.

Stem Cell Reports. 2015 May 12;4(5):759-67. doi: 10.1016/j.stemcr.2015.03.003. Epub 2015 Apr 16.


Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration.

Phesse TJ, Buchert M, Stuart E, Flanagan DJ, Faux M, Afshar-Sterle S, Walker F, Zhang HH, Nowell CJ, Jorissen R, Tan CW, Hirokawa Y, Eissmann MF, Poh AR, Malaterre J, Pearson HB, Kirsch DG, Provero P, Poli V, Ramsay RG, Sieber O, Burgess AW, Huszar D, Vincan E, Ernst M.

Sci Signal. 2014 Sep 30;7(345):ra92. doi: 10.1126/scisignal.2005411.


Intestinal epithelial-specific PTEN inactivation results in tumor formation.

Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11.


The core planar cell polarity gene prickle interacts with flamingo to promote sensory axon advance in the Drosophila embryo.

Mrkusich EM, Flanagan DJ, Whitington PM.

Dev Biol. 2011 Oct 1;358(1):224-30. doi: 10.1016/j.ydbio.2011.07.032. Epub 2011 Jul 31.


PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM.

Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10.


Variable FZD7 expression in colorectal cancers indicates regulation by the tumour microenvironment.

Vincan E, Flanagan DJ, Pouliot N, Brabletz T, Spaderna S.

Dev Dyn. 2010 Jan;239(1):311-7. doi: 10.1002/dvdy.22045.


Determinants of union victory in the health care sector.

Deshpande SP, Flanagan DJ.

Health Care Manage Rev. 1994 Summer;19(3):64-9.


Inheritance of chloroplast and mitochondrial DNA in Picea and composition of hybrids from introgression zones.

Sutton BC, Flanagan DJ, Gawley JR, Newton CH, Lester DT, El-Kassaby YA.

Theor Appl Genet. 1991 Aug;82(2):242-8. doi: 10.1007/BF00226220.


Mutants of Chinese hamster ovary cells with altered sensitivity to taxol and benzimidazole carbamates.

Warr JR, Flanagan DJ, Anderson M.

Cell Biol Int Rep. 1982 May;6(5):455-60. No abstract available.


Colchicine binding of cell extracts from colchicine-resistant mutants of Chlamydomonas reinhardi.

Flanagan DJ, Warr JR.

Exp Cell Res. 1978 Oct 15;116(2):474-8. No abstract available.


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