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Metabolomic Profiling of Body Fluids in Mouse Models Demonstrates that Nuclear Magnetic Resonance Is a Putative Diagnostic Tool for the Presence of Thyroid Hormone Receptor α1 Mutations.

Boumaza H, Markossian S, Busi B, Rautureau GJP, Gauthier K, Elena-Herrmann B, Flamant F.

Thyroid. 2019 Sep;29(9):1327-1335. doi: 10.1089/thy.2018.0730. Epub 2019 Aug 28.


Evidence for hormonal control of heart regenerative capacity during endothermy acquisition.

Hirose K, Payumo AY, Cutie S, Hoang A, Zhang H, Guyot R, Lunn D, Bigley RB, Yu H, Wang J, Smith M, Gillett E, Muroy SE, Schmid T, Wilson E, Field KA, Reeder DM, Maden M, Yartsev MM, Wolfgang MJ, Grützner F, Scanlan TS, Szweda LI, Buffenstein R, Hu G, Flamant F, Olgin JE, Huang GN.

Science. 2019 Apr 12;364(6436):184-188. doi: 10.1126/science.aar2038. Epub 2019 Mar 7.


New Case of Thyroid Hormone Resistance α Caused by a Mutation of THRA /TRα1.

Sun H, Wu H, Xie R, Wang F, Chen T, Chen X, Wang X, Flamant F, Chen L.

J Endocr Soc. 2019 Feb 4;3(3):665-669. doi: 10.1210/js.2019-00011. eCollection 2019 Mar 1.


Two Protocols to Study the Interactions of Thyroid Hormone Receptors with Other Proteins and Chromatin.

Guan W, Guyot R, Flamant F.

Methods Mol Biol. 2018;1801:9-16. doi: 10.1007/978-1-4939-7902-8_2. Review.


Regulation of T3 Availability in the Developing Brain: The Mouse Genetics Contribution.

Richard S, Flamant F.

Front Endocrinol (Lausanne). 2018 May 28;9:265. doi: 10.3389/fendo.2018.00265. eCollection 2018. Review.


Author Correction: Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing.

Teixeira M, Py BF, Bosc C, Laubreton D, Moutin MJ, Marvel J, Flamant F, Markossian S.

Sci Rep. 2018 Mar 13;8(1):4679. doi: 10.1038/s41598-018-22724-9.


Electroporation of mice zygotes with dual guide RNA/Cas9 complexes for simple and efficient cloning-free genome editing.

Teixeira M, Py BF, Bosc C, Laubreton D, Moutin MJ, Marvel J, Flamant F, Markossian S.

Sci Rep. 2018 Jan 11;8(1):474. doi: 10.1038/s41598-017-18826-5. Erratum in: Sci Rep. 2018 Mar 13;8(1):4679.


CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone.

Markossian S, Guyot R, Richard S, Teixeira M, Aguilera N, Bouchet M, Plateroti M, Guan W, Gauthier K, Aubert D, Flamant F.

Thyroid. 2018 Jan;28(1):139-150. doi: 10.1089/thy.2017.0389. Epub 2018 Jan 2.


Methylcytosine dioxygenase TET3 interacts with thyroid hormone nuclear receptors and stabilizes their association to chromatin.

Guan W, Guyot R, Samarut J, Flamant F, Wong J, Gauthier KC.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8229-8234. doi: 10.1073/pnas.1702192114. Epub 2017 Jul 17.


Genetic Investigation of Thyroid Hormone Receptor Function in the Developing and Adult Brain.

Flamant F, Gauthier K, Richard S.

Curr Top Dev Biol. 2017;125:303-335. doi: 10.1016/bs.ctdb.2017.01.001. Epub 2017 Feb 13. Review.


Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Flamant F, Cheng SY, Hollenberg AN, Moeller LC, Samarut J, Wondisford FE, Yen PM, Refetoff S.

Endocrinology. 2017 Jul 1;158(7):2052-2057. doi: 10.1210/en.2017-00250.


Neuronal expression of a thyroid hormone receptor α mutation alters mouse behaviour.

Richard S, Aguilera N, Thévenet M, Dkhissi-Benyahya O, Flamant F.

Behav Brain Res. 2017 Mar 15;321:18-27. doi: 10.1016/j.bbr.2016.12.025. Epub 2016 Dec 21.


Thyroid Hormone Signaling in the Mouse Retina.

Arbogast P, Flamant F, Godement P, Glösmann M, Peichl L.

PLoS One. 2016 Dec 12;11(12):e0168003. doi: 10.1371/journal.pone.0168003. eCollection 2016.


Chemical Hybridization of Glucagon and Thyroid Hormone Optimizes Therapeutic Impact for Metabolic Disease.

Finan B, Clemmensen C, Zhu Z, Stemmer K, Gauthier K, Müller L, De Angelis M, Moreth K, Neff F, Perez-Tilve D, Fischer K, Lutter D, Sánchez-Garrido MA, Liu P, Tuckermann J, Malehmir M, Healy ME, Weber A, Heikenwalder M, Jastroch M, Kleinert M, Jall S, Brandt S, Flamant F, Schramm KW, Biebermann H, Döring Y, Weber C, Habegger KM, Keuper M, Gelfanov V, Liu F, Köhrle J, Rozman J, Fuchs H, Gailus-Durner V, Hrabě de Angelis M, Hofmann SM, Yang B, Tschöp MH, DiMarchi R, Müller TD.

Cell. 2016 Oct 20;167(3):843-857.e14. doi: 10.1016/j.cell.2016.09.014. Epub 2016 Oct 6.


Futures Challenges in Thyroid Hormone Signaling Research.

Flamant F.

Front Endocrinol (Lausanne). 2016 Jun 22;7:58. doi: 10.3389/fendo.2016.00058. eCollection 2016. Review.


CRISPR/Cas9: a breakthrough in generating mouse models for endocrinologists.

Markossian S, Flamant F.

J Mol Endocrinol. 2016 Aug;57(2):R81-92. doi: 10.1530/JME-15-0305. Epub 2016 Jun 7. Review.


TRα receptor mutations extend the spectrum of syndromes of reduced sensitivity to thyroid hormone.

Vlaeminck-Guillem V, Espiard S, Flamant F, Wémeau JL.

Presse Med. 2015 Nov;44(11):1103-12. doi: 10.1016/j.lpm.2015.07.022. Epub 2015 Nov 12. Review.


Editorial: "Thyroid Hormone in Brain and Brain Cells".

Flamant F, Koibuchi N, Bernal J.

Front Endocrinol (Lausanne). 2015 Jun 22;6:99. doi: 10.3389/fendo.2015.00099. eCollection 2015. No abstract available.


A Novel Mutation in THRA Gene Associated With an Atypical Phenotype of Resistance to Thyroid Hormone.

Espiard S, Savagner F, Flamant F, Vlaeminck-Guillem V, Guyot R, Munier M, d'Herbomez M, Bourguet W, Pinto G, Rose C, Rodien P, Wémeau JL.

J Clin Endocrinol Metab. 2015 Aug;100(8):2841-8. doi: 10.1210/jc.2015-1120. Epub 2015 Jun 2.


Direct and indirect consequences on gene expression of a thyroid hormone receptor alpha 1 mutation restricted to Sertoli cells.

Chatonnet F, Livera G, Fumel B, FouchÉCourt S, Flamant F.

Mol Reprod Dev. 2014 Dec;81(12):1159-66. doi: 10.1002/mrd.22437. Epub 2014 Dec 8.


Toxicogenomic analysis of the ability of brominated flame retardants TBBPA and BDE-209 to disrupt thyroid hormone signaling in neural cells.

Guyot R, Chatonnet F, Gillet B, Hughes S, Flamant F.

Toxicology. 2014 Nov 5;325:125-32. doi: 10.1016/j.tox.2014.08.007. Epub 2014 Aug 27.


Nongenomic, TRβ-dependent, thyroid hormone response gets genetic support.

Gauthier K, Flamant F.

Endocrinology. 2014 Sep;155(9):3206-9. doi: 10.1210/en.2014-1597. No abstract available.


Chondrocytes play a major role in the stimulation of bone growth by thyroid hormone.

Desjardin C, Charles C, Benoist-Lasselin C, Riviere J, Gilles M, Chassande O, Morgenthaler C, Laloé D, Lecardonnel J, Flamant F, Legeai-Mallet L, Schibler L.

Endocrinology. 2014 Aug;155(8):3123-35. doi: 10.1210/en.2014-1109. Epub 2014 Jun 10.


A temporary compendium of thyroid hormone target genes in brain.

Chatonnet F, Flamant F, Morte B.

Biochim Biophys Acta. 2015 Feb;1849(2):122-9. doi: 10.1016/j.bbagrm.2014.05.023. Epub 2014 Jun 2. Review.


Deciphering direct and indirect influence of thyroid hormone with mouse genetics.

Picou F, Fauquier T, Chatonnet F, Richard S, Flamant F.

Mol Endocrinol. 2014 Apr;28(4):429-41. doi: 10.1210/me.2013-1414. Epub 2014 Mar 10. Review.


Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development.

Fauquier T, Chatonnet F, Picou F, Richard S, Fossat N, Aguilera N, Lamonerie T, Flamant F.

Development. 2014 Jan;141(1):166-75. doi: 10.1242/dev.103226.


The targeted inactivation of TRβ gene in thyroid follicular cells suggests a new mechanism of regulation of thyroid hormone production.

Selmi-Ruby S, Bouazza L, Obregon MJ, Conscience A, Flamant F, Samarut J, Borson-Chazot F, Rousset B.

Endocrinology. 2014 Feb;155(2):635-46. doi: 10.1210/en.2013-1435. Epub 2013 Nov 21.


Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells.

Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Rüttiger L, Knipper M.

Mol Cell Endocrinol. 2014 Jan 25;382(1):26-37. doi: 10.1016/j.mce.2013.08.025. Epub 2013 Sep 6.


[Thyroid hormone T3 triggers the developmental loss of axonal regenerative capacity].

Avci HX, Flamant F, Dusart I.

Med Sci (Paris). 2013 Mar;29(3):245-7. doi: 10.1051/medsci/2013293005. Epub 2013 Mar 27. French. No abstract available.


Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells.

Chatonnet F, Guyot R, Benoît G, Flamant F.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E766-75. doi: 10.1073/pnas.1210626110. Epub 2013 Feb 4.


Thyroid hormone triggers the developmental loss of axonal regenerative capacity via thyroid hormone receptor α1 and krüppel-like factor 9 in Purkinje cells.

Avci HX, Lebrun C, Wehrlé R, Doulazmi M, Chatonnet F, Morel MP, Ema M, Vodjdani G, Sotelo C, Flamant F, Dusart I.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14206-11. doi: 10.1073/pnas.1119853109. Epub 2012 Aug 13.


Thyroid hormone receptors: the challenge of elucidating isotype-specific functions and cell-specific response.

Flamant F, Gauthier K.

Biochim Biophys Acta. 2013 Jul;1830(7):3900-7. doi: 10.1016/j.bbagen.2012.06.003. Epub 2012 Jun 13. Review.


Genome-wide search reveals the existence of a limited number of thyroid hormone receptor alpha target genes in cerebellar neurons.

Chatonnet F, Guyot R, Picou F, Bondesson M, Flamant F.

PLoS One. 2012;7(5):e30703. doi: 10.1371/journal.pone.0030703. Epub 2012 May 7.


Thyroid hormone limits postnatal Sertoli cell proliferation in vivo by activation of its alpha1 isoform receptor (TRalpha1) present in these cells and by regulation of Cdk4/JunD/c-myc mRNA levels in mice.

Fumel B, Guerquin MJ, Livera G, Staub C, Magistrini M, Gauthier C, Flamant F, Guillou F, Fouchécourt S.

Biol Reprod. 2012 Jul 19;87(1):16, 1-9. doi: 10.1095/biolreprod.111.098418. Print 2012 Jul.


Profound morphological and functional changes of rodent Purkinje cells between the first and the second postnatal weeks: a metamorphosis?

Dusart I, Flamant F.

Front Neuroanat. 2012 Apr 11;6:11. doi: 10.3389/fnana.2012.00011. eCollection 2012.


A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation.

Picou F, Fauquier T, Chatonnet F, Flamant F.

Mol Endocrinol. 2012 Apr;26(4):608-18. doi: 10.1210/me.2011-1316. Epub 2012 Feb 23.


Thyroid hormone action in cerebellum and cerebral cortex development.

Chatonnet F, Picou F, Fauquier T, Flamant F.

J Thyroid Res. 2011;2011:145762. doi: 10.4061/2011/145762. Epub 2011 Jun 16.


Association between a thyroid hormone receptor-α gene polymorphism and blood pressure but not with coronary heart disease risk.

Goumidi L, Gauthier K, Legry V, Mayi TH, Houzet A, Cottel D, Montaye M, Proust C, Kee F, Ferrières J, Arveiler D, Ducimetière P, Staels B, Dallongeville J, Chinetti G, Flamant F, Amouyel P, Meirhaeghe A.

Am J Hypertens. 2011 Sep;24(9):1027-34. doi: 10.1038/ajh.2011.94. Epub 2011 Jun 9.


Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoform.

Fauquier T, Romero E, Picou F, Chatonnet F, Nguyen XN, Quignodon L, Flamant F.

Dev Biol. 2011 Aug 15;356(2):350-8. doi: 10.1016/j.ydbio.2011.05.657. Epub 2011 May 20.


[Thyroid hormone and cerebellum development: direct and indirect effects?].

Chatonnet F, Fauquier T, Picou F, Guyot R, Flamant F.

Ann Endocrinol (Paris). 2011 Apr;72(2):99-102. doi: 10.1016/j.ando.2011.03.012. Epub 2011 Apr 20. Review. French.


Type 3 deiodinase deficiency causes spatial and temporal alterations in brain T3 signaling that are dissociated from serum thyroid hormone levels.

Hernandez A, Quignodon L, Martinez ME, Flamant F, St Germain DL.

Endocrinology. 2010 Nov;151(11):5550-8. doi: 10.1210/en.2010-0450. Epub 2010 Aug 18.


Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration.

Béby F, Housset M, Fossat N, Le Greneur C, Flamant F, Godement P, Lamonerie T.

PLoS One. 2010 Jul 21;5(7):e11673. doi: 10.1371/journal.pone.0011673.


Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease.

Goumidi L, Flamant F, Lendon C, Galimberti D, Pasquier F, Scarpini E, Hannequin D, Campion D, Amouyel P, Lambert JC, Meirhaeghe A.

Neurobiol Aging. 2011 Apr;32(4):624-30. doi: 10.1016/j.neurobiolaging.2009.04.007. Epub 2009 May 7.


Interference of a mutant thyroid hormone receptor alpha1 with hepatic glucose metabolism.

Vujovic M, Nordström K, Gauthier K, Flamant F, Visser TJ, Vennström B, Mittag J.

Endocrinology. 2009 Jun;150(6):2940-7. doi: 10.1210/en.2008-1085. Epub 2009 Mar 12.


Deafness in TRbeta mutants is caused by malformation of the tectorial membrane.

Winter H, Rüttiger L, Müller M, Kuhn S, Brandt N, Zimmermann U, Hirt B, Bress A, Sausbier M, Conscience A, Flamant F, Tian Y, Zuo J, Pfister M, Ruth P, Löwenheim H, Samarut J, Engel J, Knipper M.

J Neurosci. 2009 Feb 25;29(8):2581-7. doi: 10.1523/JNEUROSCI.3557-08.2009.


Use of a new model of transgenic mice to clarify the respective functions of thyroid hormone receptors in vivo.

Flamant F, Quignodon L.

Heart Fail Rev. 2010 Mar;15(2):117-20. doi: 10.1007/s10741-008-9121-y. Epub 2009 Jan 10. Review.


[Thyroid hormone and its receptors: have mouse genetics clarified the situation?].

Flamant F, Quignodon L.

J Soc Biol. 2008;202(2):67-71. doi: 10.1051/jbio:2008008. Epub 2008 Jun 13. French.


A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.

Bassett JH, Williams AJ, Murphy E, Boyde A, Howell PG, Swinhoe R, Archanco M, Flamant F, Samarut J, Costagliola S, Vassart G, Weiss RE, Refetoff S, Williams GR.

Mol Endocrinol. 2008 Feb;22(2):501-12. Epub 2007 Oct 11.


A point mutation in the activation function 2 domain of thyroid hormone receptor alpha1 expressed after CRE-mediated recombination partially recapitulates hypothyroidism.

Quignodon L, Vincent S, Winter H, Samarut J, Flamant F.

Mol Endocrinol. 2007 Oct;21(10):2350-60. Epub 2007 Jul 10.


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