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Chromatin Profiles of Chromosomally Integrated Human Herpesvirus-6A.

Saviola AJ, Zimmermann C, Mariani MP, Signorelli SA, Gerrard DL, Boyd JR, Wight DJ, Morissette G, Gravel A, Dubuc I, Flamand L, Kaufer BB, Frietze S.

Front Microbiol. 2019 Jun 26;10:1408. doi: 10.3389/fmicb.2019.01408. eCollection 2019.


The role of the megakaryocyte in immunity has gone viral.

Boilard E, Flamand L.

Blood. 2019 May 9;133(19):2001-2002. doi: 10.1182/blood-2019-02-900787. No abstract available.


Viral Proteins U41 and U70 of Human Herpesvirus 6A Are Dispensable for Telomere Integration.

Wight DJ, Wallaschek N, Sanyal A, Weller SK, Flamand L, Kaufer BB.

Viruses. 2018 Nov 21;10(11). pii: E656. doi: 10.3390/v10110656.


The ND10 Complex Represses Lytic Human Herpesvirus 6A Replication and Promotes Silencing of the Viral Genome.

Sanyal A, Wallaschek N, Glass M, Flamand L, Wight DJ, Kaufer BB.

Viruses. 2018 Jul 29;10(8). pii: E401. doi: 10.3390/v10080401.


Chromosomal Integration by Human Herpesviruses 6A and 6B.

Flamand L.

Adv Exp Med Biol. 2018;1045:209-226. doi: 10.1007/978-981-10-7230-7_10. Review.


Platelets release pathogenic serotonin and return to circulation after immune complex-mediated sequestration.

Cloutier N, Allaeys I, Marcoux G, Machlus KR, Mailhot B, Zufferey A, Levesque T, Becker Y, Tessandier N, Melki I, Zhi H, Poirier G, Rondina MT, Italiano JE, Flamand L, McKenzie SE, Cote F, Nieswandt B, Khan WI, Flick MJ, Newman PJ, Lacroix S, Fortin PR, Boilard E.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1550-E1559. doi: 10.1073/pnas.1720553115. Epub 2018 Jan 31.


HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B.

Collin V, Flamand L.

Viruses. 2017 Jun 26;9(7). pii: E160. doi: 10.3390/v9070160. Review.


Stabilization of Telomere G-Quadruplexes Interferes with Human Herpesvirus 6A Chromosomal Integration.

Gilbert-Girard S, Gravel A, Artusi S, Richter SN, Wallaschek N, Kaufer BB, Flamand L.

J Virol. 2017 Jun 26;91(14). pii: e00402-17. doi: 10.1128/JVI.00402-17. Print 2017 Jul 15.


Cell Culture Systems To Study Human Herpesvirus 6A/B Chromosomal Integration.

Gravel A, Dubuc I, Wallaschek N, Gilbert-Girard S, Collin V, Hall-Sedlak R, Jerome KR, Mori Y, Carbonneau J, Boivin G, Kaufer BB, Flamand L.

J Virol. 2017 Jun 26;91(14). pii: e00437-17. doi: 10.1128/JVI.00437-17. Print 2017 Jul 15.


Inherited Chromosomally Integrated Human Herpesvirus 6 and Breast Cancer.

Gravel A, Dubuc I, Brooks-Wilson A, Aronson KJ, Simard J, Velásquez-García HA, Spinelli JJ, Flamand L.

Cancer Epidemiol Biomarkers Prev. 2017 Mar;26(3):425-427. doi: 10.1158/1055-9965.EPI-16-0735. Epub 2016 Oct 24.


The Telomeric Repeats of Human Herpesvirus 6A (HHV-6A) Are Required for Efficient Virus Integration.

Wallaschek N, Sanyal A, Pirzer F, Gravel A, Mori Y, Flamand L, Kaufer BB.

PLoS Pathog. 2016 May 31;12(5):e1005666. doi: 10.1371/journal.ppat.1005666. eCollection 2016 May.


The putative U94 integrase is dispensable for human herpesvirus 6 (HHV-6) chromosomal integration.

Wallaschek N, Gravel A, Flamand L, Kaufer BB.

J Gen Virol. 2016 Aug;97(8):1899-903. doi: 10.1099/jgv.0.000502. Epub 2016 May 11.


Summary of the 9th international conference on human herpesviruses 6 and 7 (HHV-6A, HHV-6B, and HHV-7).

Komaroff AL, Phan T, Flamand L, Pellett PE.

J Med Virol. 2016 Dec;88(12):2038-2043. doi: 10.1002/jmv.24561. Epub 2016 May 30.


Detection of Human Herpesvirus 6B (HHV-6B) Reactivation in Hematopoietic Cell Transplant Recipients with Inherited Chromosomally Integrated HHV-6A by Droplet Digital PCR.

Sedlak RH, Hill JA, Nguyen T, Cho M, Levin G, Cook L, Huang ML, Flamand L, Zerr DM, Boeckh M, Jerome KR.

J Clin Microbiol. 2016 May;54(5):1223-7. doi: 10.1128/JCM.03275-15. Epub 2016 Feb 17.


Inherited chromosomally integrated human herpesvirus 6 as a predisposing risk factor for the development of angina pectoris.

Gravel A, Dubuc I, Morissette G, Sedlak RH, Jerome KR, Flamand L.

Proc Natl Acad Sci U S A. 2015 Jun 30;112(26):8058-63. doi: 10.1073/pnas.1502741112. Epub 2015 Jun 15.


Characterization of human herpesvirus 6A/B U94 as ATPase, helicase, exonuclease and DNA-binding proteins.

Trempe F, Gravel A, Dubuc I, Wallaschek N, Collin V, Gilbert-Girard S, Morissette G, Kaufer BB, Flamand L.

Nucleic Acids Res. 2015 Jul 13;43(12):6084-98. doi: 10.1093/nar/gkv503. Epub 2015 May 20.


The Herpes Simplex Virus-1 genome contains multiple clusters of repeated G-quadruplex: Implications for the antiviral activity of a G-quadruplex ligand.

Artusi S, Nadai M, Perrone R, Biasolo MA, Palù G, Flamand L, Calistri A, Richter SN.

Antiviral Res. 2015 Jun;118:123-31. doi: 10.1016/j.antiviral.2015.03.016. Epub 2015 Apr 3.


Chromosomally integrated HHV-6: impact on virus, cell and organismal biology.

Kaufer BB, Flamand L.

Curr Opin Virol. 2014 Dec;9:111-8. doi: 10.1016/j.coviro.2014.09.010. Epub 2014 Oct 29. Review.


Human herpesvirus 6B immediate-early I protein contains functional HLA-A*02, HLA-A*03, and HLA-B*07 class I restricted CD8(+) T-cell epitopes.

Iampietro M, Morissette G, Gravel A, Dubuc I, Rousseau M, Hasan A, O'Reilly RJ, Flamand L.

Eur J Immunol. 2014 Dec;44(12):3573-84. doi: 10.1002/eji.201444931. Epub 2014 Oct 29.


Inhibition of interleukin-2 gene expression by human herpesvirus 6B U54 tegument protein.

Iampietro M, Morissette G, Gravel A, Flamand L.

J Virol. 2014 Nov;88(21):12452-63. doi: 10.1128/JVI.02030-14. Epub 2014 Aug 13.


Inhibition of breast cancer cell proliferation through disturbance of the calcineurin/NFAT pathway by human herpesvirus 6B U54 tegument protein.

Iampietro M, Gravel A, Flamand L.

J Virol. 2014 Nov;88(21):12910-4. doi: 10.1128/JVI.02107-14. Epub 2014 Aug 13.


Pathogenesis from the reactivation of chromosomally integrated human herpesvirus type 6: facts rather than fiction.

Flamand L.

Clin Infect Dis. 2014 Aug 15;59(4):549-51. doi: 10.1093/cid/ciu326. Epub 2014 May 6. No abstract available.


Influenza virus H1N1 activates platelets through FcγRIIA signaling and thrombin generation.

Boilard E, Paré G, Rousseau M, Cloutier N, Dubuc I, Lévesque T, Borgeat P, Flamand L.

Blood. 2014 May 1;123(18):2854-63. doi: 10.1182/blood-2013-07-515536. Epub 2014 Mar 24.


Frequency of chromosomally-integrated human herpesvirus 6 in children with acute lymphoblastic leukemia.

Gravel A, Sinnett D, Flamand L.

PLoS One. 2013 Dec 26;8(12):e84322. doi: 10.1371/journal.pone.0084322. eCollection 2013.


Classification of HHV-6A and HHV-6B as distinct viruses.

Ablashi D, Agut H, Alvarez-Lafuente R, Clark DA, Dewhurst S, DiLuca D, Flamand L, Frenkel N, Gallo R, Gompels UA, Höllsberg P, Jacobson S, Luppi M, Lusso P, Malnati M, Medveczky P, Mori Y, Pellett PE, Pritchett JC, Yamanishi K, Yoshikawa T.

Arch Virol. 2014 May;159(5):863-70. doi: 10.1007/s00705-013-1902-5. Epub 2013 Nov 6. Review.


Randomized clinical trial to evaluate the efficacy and safety of valganciclovir in a subset of patients with chronic fatigue syndrome.

Montoya JG, Kogelnik AM, Bhangoo M, Lunn MR, Flamand L, Merrihew LE, Watt T, Kubo JT, Paik J, Desai M.

J Med Virol. 2013 Dec;85(12):2101-9. doi: 10.1002/jmv.23713. Epub 2013 Aug 19.


Complete Genome Sequence of Early Passaged Human Herpesvirus 6A (GS Strain) Isolated from North America.

Gravel A, Ablashi D, Flamand L.

Genome Announc. 2013 Jun 13;1(3). pii: e00012-13. doi: 10.1128/genomeA.00012-13.


Sequence analysis of transplacentally acquired human herpesvirus 6 DNA is consistent with transmission of a chromosomally integrated reactivated virus.

Gravel A, Hall CB, Flamand L.

J Infect Dis. 2013 May 15;207(10):1585-9. doi: 10.1093/infdis/jit060. Epub 2013 Feb 13.


2-Arachidonoyl-glycerol- and arachidonic acid-stimulated neutrophils release antimicrobial effectors against E. coli, S. aureus, HSV-1, and RSV.

Chouinard F, Turcotte C, Guan X, Larose MC, Poirier S, Bouchard L, Provost V, Flamand L, Grandvaux N, Flamand N.

J Leukoc Biol. 2013 Feb;93(2):267-76. doi: 10.1189/jlb.0412200. Epub 2012 Dec 12.


Chromosomally integrated human herpesvirus 6: questions and answers.

Pellett PE, Ablashi DV, Ambros PF, Agut H, Caserta MT, Descamps V, Flamand L, Gautheret-Dejean A, Hall CB, Kamble RT, Kuehl U, Lassner D, Lautenschlager I, Loomis KS, Luppi M, Lusso P, Medveczky PG, Montoya JG, Mori Y, Ogata M, Pritchett JC, Rogez S, Seto E, Ward KN, Yoshikawa T, Razonable RR.

Rev Med Virol. 2012 May;22(3):144-55. doi: 10.1002/rmv.715. Epub 2011 Nov 4. Review.


Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4.

Lefebvre JS, Lévesque T, Picard S, Paré G, Gravel A, Flamand L, Borgeat P.

Arthritis Rheum. 2011 Jun;63(6):1527-33. doi: 10.1002/art.30308.


LTB4 increases nasal neutrophil activity and conditions neutrophils to exert antiviral effects.

Widegren H, Andersson M, Borgeat P, Flamand L, Johnston S, Greiff L.

Respir Med. 2011 Jul;105(7):997-1006. doi: 10.1016/j.rmed.2010.12.021. Epub 2011 Jan 19.


Repression of interferon-α stimulated genes expression by Kaposi's sarcoma-associated herpesvirus K-bZIP protein.

Lefort S, Gravel A, Flamand L.

Virology. 2010 Dec 5;408(1):14-30. doi: 10.1016/j.virol.2010.07.027. Epub 2010 Sep 26.


Herpesviruses and chromosomal integration.

Morissette G, Flamand L.

J Virol. 2010 Dec;84(23):12100-9. doi: 10.1128/JVI.01169-10. Epub 2010 Sep 15. Review.


Serological and virological investigation of the role of the herpesviruses EBV, CMV and HHV-6 in post-infective fatigue syndrome.

Cameron B, Flamand L, Juwana H, Middeldorp J, Naing Z, Rawlinson W, Ablashi D, Lloyd A.

J Med Virol. 2010 Oct;82(10):1684-8. doi: 10.1002/jmv.21873.


Review, part 1: Human herpesvirus-6-basic biology, diagnostic testing, and antiviral efficacy.

Flamand L, Komaroff AL, Arbuckle JH, Medveczky PG, Ablashi DV.

J Med Virol. 2010 Sep;82(9):1560-8. doi: 10.1002/jmv.21839. Review. No abstract available.


Human herpesvirus-6 in patients with Crohn's disease.

Sura R, Gavrilov B, Flamand L, Ablashi D, Cartun R, Colombel JF, Van Kruiningen HJ.

APMIS. 2010 May;118(5):394-400. doi: 10.1111/j.1600-0463.2010.02613.x.


Contagious period for pandemic (H1N1) 2009.

De Serres G, Rouleau I, Hamelin ME, Quach C, Skowronski D, Flamand L, Boulianne N, Li Y, Carbonneau J, Bourgault A, Couillard M, Charest H, Boivin G.

Emerg Infect Dis. 2010 May;16(5):783-8. doi: 10.3201/eid1605.091894.


Divergent susceptibilities of human herpesvirus 6 variants to type I interferons.

Jaworska J, Gravel A, Flamand L.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8369-74. doi: 10.1073/pnas.0909951107. Epub 2010 Apr 19.


Amphipathic DNA polymers exhibit antiviral activity against systemic murine Cytomegalovirus infection.

Cardin RD, Bravo FJ, Sewell AP, Cummins J, Flamand L, Juteau JM, Bernstein DI, Vaillant A.

Virol J. 2009 Dec 2;6:214. doi: 10.1186/1743-422X-6-214.


Multicenter comparison of PCR assays for detection of human herpesvirus 6 DNA in serum.

Flamand L, Gravel A, Boutolleau D, Alvarez-Lafuente R, Jacobson S, Malnati MS, Kohn D, Tang YW, Yoshikawa T, Ablashi D.

J Clin Microbiol. 2008 Aug;46(8):2700-6. doi: 10.1128/JCM.00370-08. Epub 2008 Jun 11. Erratum in: J Clin Microbiol. 2009 Feb;47(2):519.


Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element.

Ouellet DL, Plante I, Landry P, Barat C, Janelle ME, Flamand L, Tremblay MJ, Provost P.

Nucleic Acids Res. 2008 Apr;36(7):2353-65. doi: 10.1093/nar/gkn076. Epub 2008 Feb 24.


Normal human primary CD4+ T lymphocytes synthesize and release functional osteoprotegerin in vitro.

Chakravarti A, Marceau AA, Flamand L, Poubelle PE.

Lab Invest. 2008 Feb;88(2):171-84. Epub 2007 Nov 26.


Increased tumorigenicity of cells carrying recombinant human herpesvirus 8.

Cloutier N, van Eyll O, Janelle ME, Lefort S, Gao SJ, Flamand L.

Arch Virol. 2008;153(1):93-103. Epub 2007 Oct 18.


Binding of Kaposi's sarcoma-associated herpesvirus K-bZIP to interferon-responsive factor 3 elements modulates antiviral gene expression.

Lefort S, Soucy-Faulkner A, Grandvaux N, Flamand L.

J Virol. 2007 Oct;81(20):10950-60. Epub 2007 Jul 25.


Leukotriene B4 triggers the in vitro and in vivo release of potent antimicrobial agents.

Flamand L, Tremblay MJ, Borgeat P.

J Immunol. 2007 Jun 15;178(12):8036-45.


Inhibition of transcription of the beta interferon gene by the human herpesvirus 6 immediate-early 1 protein.

Jaworska J, Gravel A, Fink K, Grandvaux N, Flamand L.

J Virol. 2007 Jun;81(11):5737-48. Epub 2007 Mar 21.

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