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Items: 16

1.

Structure activity relationships of anthranilic acid-based compounds on cellular and in vivo mitogen activated protein kinase-5 signaling pathways.

Chakrabarty S, Monlish DA, Gupta M, Wright TD, Hoang VT, Fedak M, Chopra I, Flaherty PT, Madura J, Mannepelli S, Burow ME, Cavanaugh JE.

Bioorg Med Chem Lett. 2018 Jul 15;28(13):2294-2301. doi: 10.1016/j.bmcl.2018.05.029. Epub 2018 May 20. No abstract available.

PMID:
29803729
2.

N-Acetyl-l-Cysteine Protects Astrocytes against Proteotoxicity without Recourse to Glutathione.

Gleixner AM, Hutchison DF, Sannino S, Bhatia TN, Leak LC, Flaherty PT, Wipf P, Brodsky JL, Leak RK.

Mol Pharmacol. 2017 Nov;92(5):564-575. doi: 10.1124/mol.117.109926. Epub 2017 Aug 22.

PMID:
28830914
3.

Oncogenic signaling of MEK5-ERK5.

Hoang VT, Yan TJ, Cavanaugh JE, Flaherty PT, Beckman BS, Burow ME.

Cancer Lett. 2017 Apr 28;392:51-59. doi: 10.1016/j.canlet.2017.01.034. Epub 2017 Jan 30. Review.

4.

The effect of the steroid sulfatase inhibitor (p-O-sulfamoyl)-tetradecanoyl tyramine (DU-14) on learning and memory in rats with selective lesion of septal-hippocampal cholinergic tract.

Babalola PA, Fitz NF, Gibbs RB, Flaherty PT, Li PK, Johnson DA.

Neurobiol Learn Mem. 2012 Oct;98(3):303-10. doi: 10.1016/j.nlm.2012.09.003. Epub 2012 Sep 26.

5.

Identification of HIV inhibitors guided by free energy perturbation calculations.

Acevedo O, Ambrose Z, Flaherty PT, Aamer H, Jain P, Sambasivarao SV.

Curr Pharm Des. 2012;18(9):1199-216. Review.

6.

Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.

Yuan J, Simpson RD, Zhao W, Tice CM, Xu Z, Cacatian S, Jia L, Flaherty PT, Guo J, Ishchenko A, Wu Z, McKeever BM, Scott BB, Bukhtiyarov Y, Berbaum J, Panemangalore R, Bentley R, Doe CP, Harrison RK, McGeehan GM, Singh SB, Dillard LW, Baldwin JJ, Claremon DA.

Bioorg Med Chem Lett. 2011 Aug 15;21(16):4836-43. doi: 10.1016/j.bmcl.2011.06.043. Epub 2011 Jun 17.

PMID:
21741239
7.

Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25.

Jain P, Flaherty PT, Yi S, Chopra I, Bleasdell G, Lipay J, Ferandin Y, Meijer L, Madura JD.

Bioorg Med Chem. 2011 Jan 1;19(1):359-73. doi: 10.1016/j.bmc.2010.11.022. Epub 2010 Dec 6.

PMID:
21144757
8.

Structure-activity relationships of benzimidazole-based selective inhibitors of the mitogen activated kinase-5 signaling pathway.

Flaherty PT, Chopra I, Jain P, Monlish D, Cavanaugh J.

Bioorg Med Chem. 2010 Nov 15;18(22):8054-60. doi: 10.1016/j.bmc.2010.09.017. Epub 2010 Oct 19.

PMID:
20965737
9.

Identification of benzimidazole-based inhibitors of the mitogen activated kinase-5 signaling pathway.

Flaherty PT, Chopra I, Jain P, Yi S, Allen E, Cavanaugh J.

Bioorg Med Chem Lett. 2010 May 1;20(9):2892-6. doi: 10.1016/j.bmcl.2010.03.033. Epub 2010 Mar 10.

PMID:
20382528
10.

Optimization of orally bioavailable alkyl amine renin inhibitors.

Xu Z, Cacatian S, Yuan J, Simpson RD, Jia L, Zhao W, Tice CM, Flaherty PT, Guo J, Ishchenko A, Singh SB, Wu Z, McKeever BM, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Bentley R, Doe CP, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA.

Bioorg Med Chem Lett. 2010 Jan 15;20(2):694-9. doi: 10.1016/j.bmcl.2009.11.066. Epub 2009 Dec 1.

PMID:
19959358
11.

Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.

Tice CM, Xu Z, Yuan J, Simpson RD, Cacatian ST, Flaherty PT, Zhao W, Guo J, Ishchenko A, Singh SB, Wu Z, Scott BB, Bukhtiyarov Y, Berbaum J, Mason J, Panemangalore R, Cappiello MG, Müller D, Harrison RK, McGeehan GM, Dillard LW, Baldwin JJ, Claremon DA.

Bioorg Med Chem Lett. 2009 Jul 1;19(13):3541-5. doi: 10.1016/j.bmcl.2009.04.140. Epub 2009 May 5.

PMID:
19457666
12.

1-Isopropyl-4-nitro-6-meth-oxy-1H-benzimidazole.

Moore MD, Jain P, Flaherty PT, Wildfong PL.

Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 25;64(Pt 7):o1336-7. doi: 10.1107/S160053680801859X.

13.

Synthesis and anti-tubulin activity of a 3'-(4-azidophenyl)-3'-dephenylpaclitaxel photoaffinity probe.

Spletstoser JT, Flaherty PT, Himes RH, Georg GI.

J Med Chem. 2004 Dec 16;47(26):6459-65.

PMID:
15588080
14.

Formal total synthesis of (+)-salicylihalamides A and B: a combined chiral pool and RCM strategy.

Yang K, Blackman B, Diederich W, Flaherty PT, Mossman CJ, Roy S, Ahn YM, Georg GI.

J Org Chem. 2003 Dec 26;68(26):10030-9.

PMID:
14682697
15.

Synthesis and evaluation of N-(phenylacetyl)trifluoromethanesulfonamides as anticonvulsant agents.

Flaherty PT, Greenwood TD, Manheim AL, Wolfe JF.

J Med Chem. 1996 Mar 29;39(7):1509-13.

PMID:
8691481
16.

A-ring ortho-disubstituted aporphine derivatives as potential agonists or antagonists at serotonergic 5-HT1A receptors.

Cannon JG, Flaherty PT, Ozkutlu U, Long JP.

J Med Chem. 1995 May 26;38(11):1841-5.

PMID:
7783115

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