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Items: 7


Activation of α1A -adrenoceptors desensitizes the rat aorta response to phenylephrine through a neuronal NOS pathway, a mechanism lost with ageing.

Arce C, Vicente D, Segura V, Flacco N, Montó F, Almenar L, Agüero J, Rueda J, Jiménez-Altayó F, Vila E, Noguera MA, D'Ocon P, Ivorra MD.

Br J Pharmacol. 2017 Jul;174(13):2015-2030. doi: 10.1111/bph.13800. Epub 2017 May 10.


Changes in adrenoceptors and G-protein-coupled receptor kinase 2 in L-NAME-induced hypertension compared to spontaneous hypertension in rats.

Oliver E, Flacco N, Arce C, Ivorra MD, D'Ocon MP, Noguera MA.

J Vasc Res. 2014;51(3):209-20. doi: 10.1159/000360400. Epub 2014 Jun 14.


β-Adrenoceptors differentially regulate vascular tone and angiogenesis of rat aorta via ERK1/2 and p38.

Perez-Aso M, Flacco N, Carpena N, Montesinos MC, D'Ocon P, Ivorra MD.

Vascul Pharmacol. 2014 May-Jun;61(2-3):80-9. doi: 10.1016/j.vph.2014.04.003. Epub 2014 Apr 24.


α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries.

Flacco N, Parés J, Serna E, Segura V, Vicente D, Pérez-Aso M, Noguera MA, Ivorra MD, McGrath JC, D'Ocon P.

Pharmacol Res Perspect. 2013 Oct;1(1):e00001. doi: 10.1002/prp2.1. Epub 2013 Aug 28.


Different β-adrenoceptor subtypes coupling to cAMP or NO/cGMP pathways: implications in the relaxant response of rat conductance and resistance vessels.

Flacco N, Segura V, Perez-Aso M, Estrada S, Seller JF, Jiménez-Altayó F, Noguera MA, D'Ocon P, Vila E, Ivorra MD.

Br J Pharmacol. 2013 May;169(2):413-25. doi: 10.1111/bph.12121.


Alpha1-adrenoceptors in the rat cerebral cortex: new insights into the characterization of alpha1L- and alpha1D-adrenoceptors.

Segura V, Flacco N, Oliver E, Barettino D, D'Ocon P, Ivorra MD.

Eur J Pharmacol. 2010 Sep 1;641(1):41-8. doi: 10.1016/j.ejphar.2010.05.016. Epub 2010 May 23.


The impact of alpha1-adrenoceptors up-regulation accompanied by the impairment of beta-adrenergic vasodilatation in hypertension.

Oliver E, Martí D, Montó F, Flacco N, Moreno L, Barettino D, Ivorra MD, D'Ocon P.

J Pharmacol Exp Ther. 2009 Mar;328(3):982-90. doi: 10.1124/jpet.108.146043. Epub 2008 Dec 5. Erratum in: J Pharmacol Exp Ther. 2010 Aug;334(2):679.


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