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Items: 36


The Specific Organism: Not Bacterial Gram Type: Drives the Inflammatory Response in Septic Shock.

Linder A, Fjell CD, Inghammar M, Hsu J, Walley KR, Boyd JH, Russell JA.

J Innate Immun. 2019 Jun 26:1-9. doi: 10.1159/000500418. [Epub ahead of print]


In Vivo, In Vitro, and In Silico Characterization of Peptoids as Antimicrobial Agents.

Czyzewski AM, Jenssen H, Fjell CD, Waldbrook M, Chongsiriwatana NP, Yuen E, Hancock RE, Barron AE.

PLoS One. 2016 Feb 5;11(2):e0135961. doi: 10.1371/journal.pone.0135961. eCollection 2016.


Increased Plasma PCSK9 Levels Are Associated with Reduced Endotoxin Clearance and the Development of Acute Organ Failures during Sepsis.

Boyd JH, Fjell CD, Russell JA, Sirounis D, Cirstea MS, Walley KR.

J Innate Immun. 2016;8(2):211-20. doi: 10.1159/000442976. Epub 2016 Jan 13. Review.


TNFAIP2 Inhibits Early TNFα-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.

Thair SA, Topchiy E, Boyd JH, Cirstea M, Wang C, Nakada TA, Fjell CD, Wurfel M, Russell JA, Walley KR.

J Innate Immun. 2016;8(1):57-66. doi: 10.1159/000437330. Epub 2015 Sep 9.


VPS13D Gene Variant Is Associated with Altered IL-6 Production and Mortality in Septic Shock.

Nakada TA, Boyd JH, Russell JA, Aguirre-Hernández R, Wilkinson MD, Thair SA, Nakada E, McConechy MK, Fjell CD, Walley KR.

J Innate Immun. 2015;7(5):545-53. doi: 10.1159/000381265. Epub 2015 Apr 17.


An Endotoxin Tolerance Signature Predicts Sepsis and Organ Dysfunction at Initial Clinical Presentation.

Pena OM, Hancock DG, Lyle NH, Linder A, Russell JA, Xia J, Fjell CD, Boyd JH, Hancock RE.

EBioMedicine. 2014 Nov 1;1(1):64-71.


PCSK9 is a critical regulator of the innate immune response and septic shock outcome.

Walley KR, Thain KR, Russell JA, Reilly MP, Meyer NJ, Ferguson JF, Christie JD, Nakada TA, Fjell CD, Thair SA, Cirstea MS, Boyd JH.

Sci Transl Med. 2014 Oct 15;6(258):258ra143. doi: 10.1126/scitranslmed.3008782.


A systems biology approach to the analysis of subset-specific responses to lipopolysaccharide in dendritic cells.

Hancock DG, Shklovskaya E, Guy TV, Falsafi R, Fjell CD, Ritchie W, Hancock RE, Fazekas de St Groth B.

PLoS One. 2014 Jun 20;9(6):e100613. doi: 10.1371/journal.pone.0100613. eCollection 2014.


Knockout of extracytoplasmic function sigma factor ECF-10 affects stress resistance and biofilm formation in Pseudomonas putida KT2440.

Tettmann B, Dötsch A, Armant O, Fjell CD, Overhage J.

Appl Environ Microbiol. 2014 Aug;80(16):4911-9. doi: 10.1128/AEM.01291-14. Epub 2014 Jun 6.


Could altered leukocyte gene expression profile in trauma patients guide immune interventions to prevent gram-negative bacteremia?

Fjell CD, Russell JA.

Crit Care Med. 2014 Jun;42(6):1550-1. doi: 10.1097/CCM.0000000000000270. No abstract available.


The meta-genome of sepsis: host genetics, pathogens and the acute immune response.

Boyd JH, Russell JA, Fjell CD.

J Innate Immun. 2014;6(3):272-83. doi: 10.1159/000358835. Epub 2014 Feb 12. Review.


Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery.

Anantasit N, Boyd JH, Russell JA, Fjell CD, Lichtenstein SV, Walley KR.

J Thorac Cardiovasc Surg. 2014 May;147(5):1627-33. doi: 10.1016/j.jtcvs.2013.11.043. Epub 2013 Dec 31.


Innate defense regulator peptide 1018 protects against perinatal brain injury.

Bolouri H, Sävman K, Wang W, Thomas A, Maurer N, Dullaghan E, Fjell CD, Ek CJ, Hagberg H, Hancock RE, Brown KL, Mallard C.

Ann Neurol. 2014 Mar;75(3):395-410. doi: 10.1002/ana.24087. Epub 2014 Mar 7.


A multibiomarker-based outcome risk stratification model for adult septic shock*.

Wong HR, Lindsell CJ, Pettilä V, Meyer NJ, Thair SA, Karlsson S, Russell JA, Fjell CD, Boyd JH, Ruokonen E, Shashaty MG, Christie JD, Hart KW, Lahni P, Walley KR.

Crit Care Med. 2014 Apr;42(4):781-9. doi: 10.1097/CCM.0000000000000106.


Cytokines and signaling molecules predict clinical outcomes in sepsis.

Fjell CD, Thair S, Hsu JL, Walley KR, Russell JA, Boyd J.

PLoS One. 2013 Nov 14;8(11):e79207. doi: 10.1371/journal.pone.0079207. eCollection 2013.


INMEX--a web-based tool for integrative meta-analysis of expression data.

Xia J, Fjell CD, Mayer ML, Pena OM, Wishart DS, Hancock RE.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W63-70. doi: 10.1093/nar/gkt338. Epub 2013 Jun 12.


Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia.

Ali S, Hirschfeld AF, Mayer ML, Fortuno ES 3rd, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L, Aminuddin F, Marr N, Lacaze-Masmonteil T, Hegele RG, Becker A, Chan-Yeung M, Hancock RE, Kollmann TR, Daley D, Sandford AJ, Lavoie PM, Turvey SE.

J Immunol. 2013 Apr 15;190(8):3949-58. doi: 10.4049/jimmunol.1201015. Epub 2013 Mar 13.


Synthetic cationic peptide IDR-1018 modulates human macrophage differentiation.

Pena OM, Afacan N, Pistolic J, Chen C, Madera L, Falsafi R, Fjell CD, Hancock RE.

PLoS One. 2013;8(1):e52449. doi: 10.1371/journal.pone.0052449. Epub 2013 Jan 7.


Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells.

Mayer ML, Blohmke CJ, Falsafi R, Fjell CD, Madera L, Turvey SE, Hancock RE.

J Immunol. 2013 Feb 1;190(3):1227-38. doi: 10.4049/jimmunol.1201404. Epub 2012 Dec 21.


Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses.

Blohmke CJ, Mayer ML, Tang AC, Hirschfeld AF, Fjell CD, Sze MA, Falsafi R, Wang S, Hsu K, Chilvers MA, Hogg JC, Hancock RE, Turvey SE.

J Immunol. 2012 Dec 1;189(11):5467-75. doi: 10.4049/jimmunol.1103661. Epub 2012 Oct 26.


Designing antimicrobial peptides: form follows function.

Fjell CD, Hiss JA, Hancock RE, Schneider G.

Nat Rev Drug Discov. 2011 Dec 16;11(1):37-51. doi: 10.1038/nrd3591. Review. Erratum in: Nat Rev Drug Discov. 2012 Feb;11(2):168.


A systems biology approach to nutritional immunology - focus on innate immunity.

Afacan NJ, Fjell CD, Hancock RE.

Mol Aspects Med. 2012 Feb;33(1):14-25. doi: 10.1016/j.mam.2011.10.013. Epub 2011 Oct 29. Review.


Endotoxin tolerance represents a distinctive state of alternative polarization (M2) in human mononuclear cells.

Pena OM, Pistolic J, Raj D, Fjell CD, Hancock RE.

J Immunol. 2011 Jun 15;186(12):7243-54. doi: 10.4049/jimmunol.1001952. Epub 2011 May 16.


Optimization of antibacterial peptides by genetic algorithms and cheminformatics.

Fjell CD, Jenssen H, Cheung WA, Hancock RE, Cherkasov A.

Chem Biol Drug Des. 2011 Jan;77(1):48-56. doi: 10.1111/j.1747-0285.2010.01044.x. Epub 2010 Oct 13.


Identification of novel antibacterial peptides by chemoinformatics and machine learning.

Fjell CD, Jenssen H, Hilpert K, Cheung WA, Panté N, Hancock RE, Cherkasov A.

J Med Chem. 2009 Apr 9;52(7):2006-15. doi: 10.1021/jm8015365.


Screening and characterization of surface-tethered cationic peptides for antimicrobial activity.

Hilpert K, Elliott M, Jenssen H, Kindrachuk J, Fjell CD, Körner J, Winkler DF, Weaver LL, Henklein P, Ulrich AS, Chiang SH, Farmer SW, Pante N, Volkmer R, Hancock RE.

Chem Biol. 2009 Jan 30;16(1):58-69. doi: 10.1016/j.chembiol.2008.11.006.


Use of artificial intelligence in the design of small peptide antibiotics effective against a broad spectrum of highly antibiotic-resistant superbugs.

Cherkasov A, Hilpert K, Jenssen H, Fjell CD, Waldbrook M, Mullaly SC, Volkmer R, Hancock RE.

ACS Chem Biol. 2009 Jan 16;4(1):65-74. doi: 10.1021/cb800240j.


Short linear cationic antimicrobial peptides: screening, optimizing, and prediction.

Hilpert K, Fjell CD, Cherkasov A.

Methods Mol Biol. 2008;494:127-59. doi: 10.1007/978-1-59745-419-3_8.


Identification of novel host defense peptides and the absence of alpha-defensins in the bovine genome.

Fjell CD, Jenssen H, Fries P, Aich P, Griebel P, Hilpert K, Hancock RE, Cherkasov A.

Proteins. 2008 Nov 1;73(2):420-30. doi: 10.1002/prot.22059.


QSAR modeling and computer-aided design of antimicrobial peptides.

Jenssen H, Fjell CD, Cherkasov A, Hancock RE.

J Pept Sci. 2008 Jan;14(1):110-4.


Evaluating different descriptors for model design of antimicrobial peptides with enhanced activity toward P. aeruginosa.

Jenssen H, Lejon T, Hilpert K, Fjell CD, Cherkasov A, Hancock RE.

Chem Biol Drug Des. 2007 Aug;70(2):134-42.


A physical map of the highly heterozygous Populus genome: integration with the genome sequence and genetic map and analysis of haplotype variation.

Kelleher CT, Chiu R, Shin H, Bosdet IE, Krzywinski MI, Fjell CD, Wilkin J, Yin T, DiFazio SP, Ali J, Asano JK, Chan S, Cloutier A, Girn N, Leach S, Lee D, Mathewson CA, Olson T, O'connor K, Prabhu AL, Smailus DE, Stott JM, Tsai M, Wye NH, Yang GS, Zhuang J, Holt RA, Putnam NH, Vrebalov J, Giovannoni JJ, Grimwood J, Schmutz J, Rokhsar D, Jones SJ, Marra MA, Tuskan GA, Bohlmann J, Ellis BE, Ritland K, Douglas CJ, Schein JE.

Plant J. 2007 Jun;50(6):1063-78. Epub 2007 May 3.


AMPer: a database and an automated discovery tool for antimicrobial peptides.

Fjell CD, Hancock RE, Cherkasov A.

Bioinformatics. 2007 May 1;23(9):1148-55. Epub 2007 Mar 6.


A physical map of the genome of Atlantic salmon, Salmo salar.

Ng SH, Artieri CG, Bosdet IE, Chiu R, Danzmann RG, Davidson WS, Ferguson MM, Fjell CD, Hoyheim B, Jones SJ, de Jong PJ, Koop BF, Krzywinski MI, Lubieniecki K, Marra MA, Mitchell LA, Mathewson C, Osoegawa K, Parisotto SE, Phillips RB, Rise ML, von Schalburg KR, Schein JE, Shin H, Siddiqui A, Thorsen J, Wye N, Yang G, Zhu B.

Genomics. 2005 Oct;86(4):396-404.


Internet Contig Explorer (iCE)--a tool for visualizing clone fingerprint maps.

Fjell CD, Bosdet I, Schein JE, Jones SJ, Marra MA.

Genome Res. 2003 Jun;13(6A):1244-9.


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