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Items: 20


The ERM protein Moesin is essential for neuronal morphogenesis and long-term memory in Drosophila.

Freymuth PS, Fitzsimons HL.

Mol Brain. 2017 Aug 29;10(1):41. doi: 10.1186/s13041-017-0322-y.


SymB and SymC, two membrane associated proteins, are required for Epichloƫ festucae hyphal cell-cell fusion and maintenance of a mutualistic interaction with Lolium perenne.

Green KA, Becker Y, Tanaka A, Takemoto D, Fitzsimons HL, Seiler S, Lalucque H, Silar P, Scott B.

Mol Microbiol. 2017 Feb;103(4):657-677. doi: 10.1111/mmi.13580. Epub 2016 Dec 14.


An Epichloƫ festucae homologue of MOB3, a component of the STRIPAK complex, is required for the establishment of a mutualistic symbiotic interaction with Lolium perenne.

Green KA, Becker Y, Fitzsimons HL, Scott B.

Mol Plant Pathol. 2016 Dec;17(9):1480-1492. doi: 10.1111/mpp.12443. Epub 2016 Aug 14.


Long-Term Memory in Drosophila Is Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9.

Schwartz S, Truglio M, Scott MJ, Fitzsimons HL.

Genetics. 2016 Jul;203(3):1249-64. doi: 10.1534/genetics.115.183194. Epub 2016 May 6.


Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor.

Linger RJ, Belikoff EJ, Yan Y, Li F, Wantuch HA, Fitzsimons HL, Scott MJ.

BMC Biotechnol. 2016 Mar 22;16:30. doi: 10.1186/s12896-016-0263-z.


The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?

Fitzsimons HL.

Neurobiol Learn Mem. 2015 Sep;123:149-58. doi: 10.1016/j.nlm.2015.06.006. Epub 2015 Jun 11. Review.


The histone deacetylase HDAC4 regulates long-term memory in Drosophila.

Fitzsimons HL, Schwartz S, Given FM, Scott MJ.

PLoS One. 2013 Dec 9;8(12):e83903. doi: 10.1371/journal.pone.0083903. eCollection 2013.


Genetic modulation of Rpd3 expression impairs long-term courtship memory in Drosophila.

Fitzsimons HL, Scott MJ.

PLoS One. 2011;6(12):e29171. doi: 10.1371/journal.pone.0029171. Epub 2011 Dec 15.


Biodistribution and safety assessment of AAV2-GAD following intrasubthalamic injection in the rat.

Fitzsimons HL, Riban V, Bland RJ, Wendelken JL, Sapan CV, During MJ.

J Gene Med. 2010 Apr;12(4):385-98. doi: 10.1002/jgm.1449.


Gene therapy in epilepsy.

Riban V, Fitzsimons HL, During MJ.

Epilepsia. 2009 Jan;50(1):24-32. doi: 10.1111/j.1528-1167.2008.01743.x. Epub 2008 Aug 19. Review.


HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity.

Jung AE, Fitzsimons HL, Bland RJ, During MJ, Young D.

Mol Ther. 2008 Jun;16(6):1048-55. doi: 10.1038/mt.2008.68. Epub 2008 Apr 8.


AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's disease.

Franich NR, Fitzsimons HL, Fong DM, Klugmann M, During MJ, Young D.

Mol Ther. 2008 May;16(5):947-56. doi: 10.1038/mt.2008.50. Epub 2008 Mar 25.


Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial.

Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA, Bland RJ, Young D, Strybing K, Eidelberg D, During MJ.

Lancet. 2007 Jun 23;369(9579):2097-105.


Adeno-associated viral glutamate decarboxylase expression in the lateral nucleus of the rat hypothalamus reduces feeding behavior.

Noordmans AJ, Song DK, Noordmans CJ, Garrity-Moses M, During MJ, Fitzsimons HL, Imperiale MJ, Boulis NM.

Gene Ther. 2004 May;11(9):797-804.


Glucagon-like peptide-1 receptor is involved in learning and neuroprotection.

During MJ, Cao L, Zuzga DS, Francis JS, Fitzsimons HL, Jiao X, Bland RJ, Klugmann M, Banks WA, Drucker DJ, Haile CN.

Nat Med. 2003 Sep;9(9):1173-9. Epub 2003 Aug 17.


Promoters and regulatory elements that improve adeno-associated virus transgene expression in the brain.

Fitzsimons HL, Bland RJ, During MJ.

Methods. 2002 Oct;28(2):227-36. Review.


Subthalamic GAD gene therapy in a Parkinson's disease rat model.

Luo J, Kaplitt MG, Fitzsimons HL, Zuzga DS, Liu Y, Oshinsky ML, During MJ.

Science. 2002 Oct 11;298(5592):425-9.


Development of an insulated reporter system to search for cis-acting DNA sequences required for dosage compensation in Drosophila.

Fitzsimons HL, Henry RA, Scott MJ.

Genetica. 1999;105(3):215-26. Erratum in: Genetica 2000;108(2):203.


An oral vaccine against NMDAR1 with efficacy in experimental stroke and epilepsy.

During MJ, Symes CW, Lawlor PA, Lin J, Dunning J, Fitzsimons HL, Poulsen D, Leone P, Xu R, Dicker BL, Lipski J, Young D.

Science. 2000 Feb 25;287(5457):1453-60.

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