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Items: 31

1.

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs.

Kundert K, Lucas JE, Watters KE, Fellmann C, Ng AH, Heineike BM, Fitzsimmons CM, Oakes BL, Qu J, Prasad N, Rosenberg OS, Savage DF, El-Samad H, Doudna JA, Kortemme T.

Nat Commun. 2019 May 9;10(1):2127. doi: 10.1038/s41467-019-09985-2.

2.

It's complicated… m6A-dependent regulation of gene expression in cancer.

Fitzsimmons CM, Batista PJ.

Biochim Biophys Acta Gene Regul Mech. 2019 Mar;1862(3):382-393. doi: 10.1016/j.bbagrm.2018.09.010. Epub 2018 Oct 5. Review.

PMID:
30296493
3.

Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.

Fitzsimmons CM, Fujimori DG.

PLoS One. 2016 Nov 30;11(11):e0167298. doi: 10.1371/journal.pone.0167298. eCollection 2016.

4.

Comparisons of Allergenic and Metazoan Parasite Proteins: Allergy the Price of Immunity.

Tyagi N, Farnell EJ, Fitzsimmons CM, Ryan S, Tukahebwa E, Maizels RM, Dunne DW, Thornton JM, Furnham N.

PLoS Comput Biol. 2015 Oct 29;11(10):e1004546. doi: 10.1371/journal.pcbi.1004546. eCollection 2015 Oct.

5.

Human IgG1 Responses to Surface Localised Schistosoma mansoni Ly6 Family Members Drop following Praziquantel Treatment.

Chalmers IW, Fitzsimmons CM, Brown M, Pierrot C, Jones FM, Wawrzyniak JM, Fernandez-Fuentes N, Tukahebwa EM, Dunne DW, Khalife J, Hoffmann KF.

PLoS Negl Trop Dis. 2015 Jul 6;9(7):e0003920. doi: 10.1371/journal.pntd.0003920. eCollection 2015.

6.

Known Allergen Structures Predict Schistosoma mansoni IgE-Binding Antigens in Human Infection.

Farnell EJ, Tyagi N, Ryan S, Chalmers IW, Pinot de Moira A, Jones FM, Wawrzyniak J, Fitzsimmons CM, Tukahebwa EM, Furnham N, Maizels RM, Dunne DW.

Front Immunol. 2015 Feb 3;6:26. doi: 10.3389/fimmu.2015.00026. eCollection 2015.

7.

Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties.

Thomas CM, Fitzsimmons CM, Dunne DW, Timson DJ.

Biochimie. 2015 Jan;108:40-7. doi: 10.1016/j.biochi.2014.10.015. Epub 2014 Nov 5.

8.

Use of humanised rat basophilic leukaemia cell line RS-ATL8 for the assessment of allergenicity of Schistosoma mansoni proteins.

Wan D, Ludolf F, Alanine DG, Stretton O, Ali Ali E, Al-Barwary N, Wang X, Doenhoff MJ, Mari A, Fitzsimmons CM, Dunne DW, Nakamura R, Oliveira GC, Alcocer MJ, Falcone FH.

PLoS Negl Trop Dis. 2014 Sep 25;8(9):e3124. doi: 10.1371/journal.pntd.0003124. eCollection 2014 Sep.

9.

Maternal hookworm modifies risk factors for childhood eczema: results from a birth cohort in Uganda.

Mpairwe H, Ndibazza J, Webb EL, Nampijja M, Muhangi L, Apule B, Lule S, Akurut H, Kizito D, Kakande M, Jones FM, Fitzsimmons CM, Muwanga M, Rodrigues LC, Dunne DW, Elliott AM.

Pediatr Allergy Immunol. 2014 Aug;25(5):481-8. doi: 10.1111/pai.12251.

10.

Human Schistosoma haematobium antifecundity immunity is dependent on transmission intensity and associated with immunoglobulin G1 to worm-derived antigens.

Wilson S, Jones FM, van Dam GJ, Corstjens PL, Riveau G, Fitzsimmons CM, Sacko M, Vennervald BJ, Dunne DW.

J Infect Dis. 2014 Dec 15;210(12):2009-16. doi: 10.1093/infdis/jiu374. Epub 2014 Jul 7.

11.

Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni/hookworm coinfection.

Pinot de Moira A, Fitzsimmons CM, Jones FM, Wilson S, Cahen P, Tukahebwa E, Mpairwe H, Mwatha JK, Bethony JM, Skov PS, Kabatereine NB, Dunne DW.

J Infect Dis. 2014 Oct 15;210(8):1198-206. doi: 10.1093/infdis/jiu234. Epub 2014 Apr 29.

12.

Human IgE responses to different splice variants of Schistosoma mansoni tropomyosin: associations with immunity.

Silas S, Fitzsimmons CM, Jones FM, Pinot de Moira A, Wawrzyniak J, Tukahebwa EM, Dunne DW.

Int J Parasitol. 2014 May;44(6):381-90. doi: 10.1016/j.ijpara.2014.02.004. Epub 2014 Mar 19.

13.

Helminth Allergens, Parasite-Specific IgE, and Its Protective Role in Human Immunity.

Fitzsimmons CM, Falcone FH, Dunne DW.

Front Immunol. 2014 Feb 14;5:61. doi: 10.3389/fimmu.2014.00061. eCollection 2014. Review.

14.

Schistosoma mansoni infection in preschool-aged children: development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins.

Pinot de Moira A, Sousa-Figueiredo JC, Jones FM, Fitzsimmons CM, Betson M, Kabatereine NB, Stothard JR, Dunne DW.

J Infect Dis. 2013 Jan 15;207(2):362-6. doi: 10.1093/infdis/jis676. Epub 2012 Nov 2.

15.

Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections.

Pinot de Moira A, Jones FM, Wilson S, Tukahebwa E, Fitzsimmons CM, Mwatha JK, Bethony JM, Kabatereine NB, Dunne DW.

Infect Immun. 2013 Jan;81(1):23-32. doi: 10.1128/IAI.00748-12. Epub 2012 Oct 15.

16.

Progressive cross-reactivity in IgE responses: an explanation for the slow development of human immunity to schistosomiasis?

Fitzsimmons CM, Jones FM, Pinot de Moira A, Protasio AV, Khalife J, Dickinson HA, Tukahebwa EM, Dunne DW.

Infect Immun. 2012 Dec;80(12):4264-70. doi: 10.1128/IAI.00641-12. Epub 2012 Sep 24.

17.

The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: influence of developmental expression on human IgE responses.

Fitzsimmons CM, Jones FM, Stearn A, Chalmers IW, Hoffmann KF, Wawrzyniak J, Wilson S, Kabatereine NB, Dunne DW.

PLoS Negl Trop Dis. 2012;6(4):e1593. doi: 10.1371/journal.pntd.0001593. Epub 2012 Apr 3.

18.

Influence of exposure history on the immunology and development of resistance to human Schistosomiasis mansoni.

Black CL, Mwinzi PN, Muok EM, Abudho B, Fitzsimmons CM, Dunne DW, Karanja DM, Secor WE, Colley DG.

PLoS Negl Trop Dis. 2010 Mar 23;4(3):e637. doi: 10.1371/journal.pntd.0000637.

19.

Survival of the fittest: allergology or parasitology?

Fitzsimmons CM, Dunne DW.

Trends Parasitol. 2009 Oct;25(10):447-51. doi: 10.1016/j.pt.2009.07.004. Epub 2009 Sep 9.

PMID:
19744885
20.

Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses.

Everts B, Perona-Wright G, Smits HH, Hokke CH, van der Ham AJ, Fitzsimmons CM, Doenhoff MJ, van der Bosch J, Mohrs K, Haas H, Mohrs M, Yazdanbakhsh M, Schramm G.

J Exp Med. 2009 Aug 3;206(8):1673-80. doi: 10.1084/jem.20082460. Epub 2009 Jul 27.

21.

Factors affecting human IgE and IgG responses to allergen-like Schistosoma mansoni antigens: Molecular structure and patterns of in vivo exposure.

Fitzsimmons CM, McBeath R, Joseph S, Jones FM, Walter K, Hoffmann KF, Kariuki HC, Mwatha JK, Kimani G, Kabatereine NB, Vennervald BJ, Ouma JH, Dunne DW.

Int Arch Allergy Immunol. 2007;142(1):40-50. Epub 2006 Oct 2.

PMID:
17019080
22.

Eosinophil activity in Schistosoma mansoni infections in vivo and in vitro in relation to plasma cytokine profile pre- and posttreatment with praziquantel.

Reimert CM, Fitzsimmons CM, Joseph S, Mwatha JK, Jones FM, Kimani G, Hoffmann KF, Booth M, Kabatereine NB, Dunne DW, Vennervald BJ.

Clin Vaccine Immunol. 2006 May;13(5):584-93.

23.

Applied and basic research on the epidemiology, morbidity, and immunology of schistosomiasis in fishing communities on Lake Albert, Uganda.

Dunne DW, Vennervald BJ, Booth M, Joseph S, Fitzsimmons CM, Cahen P, Sturrock RF, Ouma JH, Mwatha JK, Kimani G, Kariuki HC, Kazibwe F, Tukahebwa E, Kabatereine NB.

Trans R Soc Trop Med Hyg. 2006 Mar;100(3):216-23. Epub 2005 Dec 15.

PMID:
16359714
24.

Molecular characterization of omega-1: a hepatotoxic ribonuclease from Schistosoma mansoni eggs.

Fitzsimmons CM, Schramm G, Jones FM, Chalmers IW, Hoffmann KF, Grevelding CG, Wuhrer M, Hokke CH, Haas H, Doenhoff MJ, Dunne DW.

Mol Biochem Parasitol. 2005 Nov;144(1):123-7. No abstract available.

PMID:
16143411
25.

Human IgE response to the Schistosoma haematobium 22.6 kDa antigen.

Fitzsimmons CM, Stewart TJ, Hoffmann KF, Grogan JL, Yazdanbakhsh M, Dunne DW.

Parasite Immunol. 2004 Aug-Sep;26(8-9):371-6.

26.

Chemotherapy for schistosomiasis in Ugandan fishermen: treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E.

Fitzsimmons CM, Joseph S, Jones FM, Reimert CM, Hoffmann KF, Kazibwe F, Kimani G, Mwatha JK, Ouma JH, Tukahebwa EM, Kariuki HC, Vennervald BJ, Kabatereine NB, Dunne DW.

Infect Immun. 2004 Jul;72(7):4023-30.

27.
28.

The interaction of von Willebrand factor (vWf) with collagen: investigation of vWf-binding sites in the collagen molecule.

Fitzsimmons CM, Cockburn CG, Hornsey V, Prowse CV, Barnes MJ.

Thromb Haemost. 1988 Apr 8;59(2):186-92.

PMID:
3260414
29.

Platelet-reactive sites in collagen. Collagens I and III possess different aggregatory sites.

Morton LF, Fitzsimmons CM, Rauterberg J, Barnes MJ.

Biochem J. 1987 Dec 1;248(2):483-7.

30.

The platelet reactivity of collagen type I: evidence for multiple platelet-reactive sites in the type I collagen molecule.

Fitzsimmons CM, Cawston TE, Barnes MJ.

Thromb Haemost. 1986 Aug 20;56(1):95-9.

PMID:
3022415

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