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Crystal structure of the pseudoenzyme PDX1.2 in complex with its cognate enzyme PDX1.3: a total eclipse.

Robinson GC, Kaufmann M, Roux C, Martinez-Font J, Hothorn M, Thore S, Fitzpatrick TB.

Acta Crystallogr D Struct Biol. 2019 Apr 1;75(Pt 4):400-415. doi: 10.1107/S2059798319002912. Epub 2019 Apr 4.


Appropriate thiamin pyrophosphate levels are required for acclimation to changes in photoperiod.

Rosado-Souza L, Proost S, Moulin M, Bergmann S, Bocobza S, Aharoni A, Fitzpatrick TB, Mutwil M, Fernie AR, Obata T.

Plant Physiol. 2019 Mar 5. pii: pp.01346.2018. doi: 10.1104/pp.18.01346. [Epub ahead of print]


Vitamin B1 diversity and characterization of biosynthesis genes in cassava.

Mangel N, Fudge JB, Fitzpatrick TB, Gruissem W, Vanderschuren H.

J Exp Bot. 2017 Jun 15;68(13):3351-3363. doi: 10.1093/jxb/erx196.


The Pseudoenzyme PDX1.2 Sustains Vitamin B6 Biosynthesis as a Function of Heat Stress.

Dell'Aglio E, Boycheva S, Fitzpatrick TB.

Plant Physiol. 2017 Aug;174(4):2098-2112. doi: 10.1104/pp.17.00531. Epub 2017 May 26.


Editorial overview: Biofortification of crops: achievements, future challenges, socio-economic, health and ethical aspects.

Van Der Straeten D, Fitzpatrick TB, De Steur H.

Curr Opin Biotechnol. 2017 Apr;44:vii-x. doi: 10.1016/j.copbio.2017.03.007. Epub 2017 Mar 22. No abstract available.


Rationalising vitamin B6 biofortification in crop plants.

Fudge J, Mangel N, Gruissem W, Vanderschuren H, Fitzpatrick TB.

Curr Opin Biotechnol. 2017 Apr;44:130-137. doi: 10.1016/j.copbio.2016.12.004. Epub 2017 Jan 10. Review.


Structural definition of the lysine swing in Arabidopsis thaliana PDX1: Intermediate channeling facilitating vitamin B6 biosynthesis.

Robinson GC, Kaufmann M, Roux C, Fitzpatrick TB.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):E5821-E5829. Epub 2016 Sep 19.


Chemoselective Dimerization of Phosphates.

Hofer A, Marques E, Kieliger N, Gatter SK, Jordi S, Ferrari E, Hofmann M, Fitzpatrick TB, Hottiger MO, Jessen HJ.

Org Lett. 2016 Jul 1;18(13):3222-5. doi: 10.1021/acs.orglett.6b01466. Epub 2016 Jun 16.


Interaction between vitamin B6 metabolism, nitrogen metabolism and autoimmunity.

Colinas M, Fitzpatrick TB.

Plant Signal Behav. 2016;11(4):e1161876. doi: 10.1080/15592324.2016.1161876.


Long-Distance Transport of Thiamine (Vitamin B1) Is Concomitant with That of Polyamines.

Martinis J, Gas-Pascual E, Szydlowski N, Crèvecoeur M, Gisler A, Bürkle L, Fitzpatrick TB.

Plant Physiol. 2016 May;171(1):542-53. doi: 10.1104/pp.16.00009. Epub 2016 Mar 22.


Balancing of B6 Vitamers Is Essential for Plant Development and Metabolism in Arabidopsis.

Colinas M, Eisenhut M, Tohge T, Pesquera M, Fernie AR, Weber AP, Fitzpatrick TB.

Plant Cell. 2016 Feb;28(2):439-53. doi: 10.1105/tpc.15.01033. Epub 2016 Feb 8.


Increased bioavailable vitamin B6 in field-grown transgenic cassava for dietary sufficiency.

Li KT, Moulin M, Mangel N, Albersen M, Verhoeven-Duif NM, Ma Q, Zhang P, Fitzpatrick TB, Gruissem W, Vanderschuren H.

Nat Biotechnol. 2015 Oct;33(10):1029-32. doi: 10.1038/nbt.3318. No abstract available.


Natures balancing act: examining biosynthesis de novo, recycling and processing damaged vitamin B metabolites.

Colinas M, Fitzpatrick TB.

Curr Opin Plant Biol. 2015 Jun;25:98-106. doi: 10.1016/j.pbi.2015.05.001. Epub 2015 May 22. Review.


Consequences of a deficit in vitamin B6 biosynthesis de novo for hormone homeostasis and root development in Arabidopsis.

Boycheva S, Dominguez A, Rolcik J, Boller T, Fitzpatrick TB.

Plant Physiol. 2015 Jan;167(1):102-17. doi: 10.1104/pp.114.247767. Epub 2014 Dec 4.


Complex behavior: from cannibalism to suicide in the vitamin B1 biosynthesis world.

Fitzpatrick TB, Thore S.

Curr Opin Struct Biol. 2014 Dec;29:34-43. doi: 10.1016/ Epub 2014 Sep 26. Review.


A pathway for repair of NAD(P)H in plants.

Colinas M, Shaw HV, Loubéry S, Kaufmann M, Moulin M, Fitzpatrick TB.

J Biol Chem. 2014 May 23;289(21):14692-706. doi: 10.1074/jbc.M114.556092. Epub 2014 Apr 4.


The rise of operon-like gene clusters in plants.

Boycheva S, Daviet L, Wolfender JL, Fitzpatrick TB.

Trends Plant Sci. 2014 Jul;19(7):447-59. doi: 10.1016/j.tplants.2014.01.013. Epub 2014 Feb 27. Review.


The pseudoenzyme PDX1.2 boosts vitamin B6 biosynthesis under heat and oxidative stress in Arabidopsis.

Moccand C, Boycheva S, Surriabre P, Tambasco-Studart M, Raschke M, Kaufmann M, Fitzpatrick TB.

J Biol Chem. 2014 Mar 21;289(12):8203-16. doi: 10.1074/jbc.M113.540526. Epub 2014 Feb 6.


High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana.

Coquille S, Roux C, Mehta A, Begley TP, Fitzpatrick TB, Thore S.

J Struct Biol. 2013 Dec;184(3):438-44. doi: 10.1016/j.jsb.2013.10.005. Epub 2013 Oct 23.


Analysis of Chlamydomonas thiamin metabolism in vivo reveals riboswitch plasticity.

Moulin M, Nguyen GT, Scaife MA, Smith AG, Fitzpatrick TB.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14622-7. doi: 10.1073/pnas.1307741110. Epub 2013 Aug 19.


Examining strategies to facilitate vitamin B1 biofortification of plants by genetic engineering.

Pourcel L, Moulin M, Fitzpatrick TB.

Front Plant Sci. 2013 May 29;4:160. doi: 10.3389/fpls.2013.00160. eCollection 2013.


Strategies for vitamin B6 biofortification of plants: a dual role as a micronutrient and a stress protectant.

Vanderschuren H, Boycheva S, Li KT, Szydlowski N, Gruissem W, Fitzpatrick TB.

Front Plant Sci. 2013 May 21;4:143. doi: 10.3389/fpls.2013.00143. eCollection 2013.


Recycling of pyridoxine (vitamin B6) by PUP1 in Arabidopsis.

Szydlowski N, Bürkle L, Pourcel L, Moulin M, Stolz J, Fitzpatrick TB.

Plant J. 2013 Jul;75(1):40-52. doi: 10.1111/tpj.12195. Epub 2013 May 16.


The last piece in the vitamin B1 biosynthesis puzzle: structural and functional insight into yeast 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P) synthase.

Coquille S, Roux C, Fitzpatrick TB, Thore S.

J Biol Chem. 2012 Dec 7;287(50):42333-43. doi: 10.1074/jbc.M112.397240. Epub 2012 Oct 9.


Vitamin deficiencies in humans: can plant science help?

Fitzpatrick TB, Basset GJ, Borel P, Carrari F, DellaPenna D, Fraser PD, Hellmann H, Osorio S, Rothan C, Valpuesta V, Caris-Veyrat C, Fernie AR.

Plant Cell. 2012 Feb;24(2):395-414. doi: 10.1105/tpc.111.093120. Epub 2012 Feb 28. Review.


It takes two to tango: defining an essential second active site in pyridoxal 5'-phosphate synthase.

Moccand C, Kaufmann M, Fitzpatrick TB.

PLoS One. 2011 Jan 21;6(1):e16042. doi: 10.1371/journal.pone.0016042.


Enhanced levels of vitamin B(6) increase aerial organ size and positively affect stress tolerance in Arabidopsis.

Raschke M, Boycheva S, Crèvecoeur M, Nunes-Nesi A, Witt S, Fernie AR, Amrhein N, Fitzpatrick TB.

Plant J. 2011 May;66(3):414-32. doi: 10.1111/j.1365-313X.2011.04499.x. Epub 2011 Mar 1.


Vitamin B6 biosynthesis: charting the mechanistic landscape.

Fitzpatrick TB, Moccand C, Roux C.

Chembiochem. 2010 Jun 14;11(9):1185-93. doi: 10.1002/cbic.201000084. Review. No abstract available.


GintPDX1 encodes a protein involved in vitamin B6 biosynthesis that is up-regulated by oxidative stress in the arbuscular mycorrhizal fungus Glomus intraradices.

Benabdellah K, Azcón-Aguilar C, Valderas A, Speziga D, Fitzpatrick TB, Ferrol N.

New Phytol. 2009 Nov;184(3):682-93. doi: 10.1111/j.1469-8137.2009.02978.x. Epub 2009 Aug 5.


Intersubunit cross-talk in pyridoxal 5'-phosphate synthase, coordinated by the C terminus of the synthase subunit.

Raschle T, Speziga D, Kress W, Moccand C, Gehrig P, Amrhein N, Weber-Ban E, Fitzpatrick TB.

J Biol Chem. 2009 Mar 20;284(12):7706-18. doi: 10.1074/jbc.M804728200. Epub 2008 Dec 14.


Vitamin B1 biosynthesis in plants requires the essential iron sulfur cluster protein, THIC.

Raschke M, Bürkle L, Müller N, Nunes-Nesi A, Fernie AR, Arigoni D, Amrhein N, Fitzpatrick TB.

Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19637-42. Epub 2007 Nov 28.


Two independent routes of de novo vitamin B6 biosynthesis: not that different after all.

Fitzpatrick TB, Amrhein N, Kappes B, Macheroux P, Tews I, Raschle T.

Biochem J. 2007 Oct 1;407(1):1-13. Review.


Functional analysis of PDX2 from Arabidopsis, a glutaminase involved in vitamin B6 biosynthesis.

Tambasco-Studart M, Tews I, Amrhein N, Fitzpatrick TB.

Plant Physiol. 2007 Jun;144(2):915-25. Epub 2007 Apr 27.


PDX1 is essential for vitamin B6 biosynthesis, development and stress tolerance in Arabidopsis.

Titiz O, Tambasco-Studart M, Warzych E, Apel K, Amrhein N, Laloi C, Fitzpatrick TB.

Plant J. 2006 Dec;48(6):933-46.


Reaction mechanism of pyridoxal 5'-phosphate synthase. Detection of an enzyme-bound chromophoric intermediate.

Raschle T, Arigoni D, Brunisholz R, Rechsteiner H, Amrhein N, Fitzpatrick TB.

J Biol Chem. 2007 Mar 2;282(9):6098-105. Epub 2006 Dec 21.


Structure of a bacterial pyridoxal 5'-phosphate synthase complex.

Strohmeier M, Raschle T, Mazurkiewicz J, Rippe K, Sinning I, Fitzpatrick TB, Tews I.

Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19284-9. Epub 2006 Dec 11.


The "missing link" in the chain of discovery of early melanoma of the skin.

Fitzpatrick TB, Howell JB.

Proc (Bayl Univ Med Cent). 2001 Oct;14(4):377. No abstract available.


Vitamin B6 biosynthesis by the malaria parasite Plasmodium falciparum: biochemical and structural insights.

Gengenbacher M, Fitzpatrick TB, Raschle T, Flicker K, Sinning I, Müller S, Macheroux P, Tews I, Kappes B.

J Biol Chem. 2006 Feb 10;281(6):3633-41. Epub 2005 Dec 8.


Structure and function of YcnD from Bacillus subtilis, a flavin-containing oxidoreductase.

Morokutti A, Lyskowski A, Sollner S, Pointner E, Fitzpatrick TB, Kratky C, Gruber K, Macheroux P.

Biochemistry. 2005 Oct 25;44(42):13724-33.


Vitamin B6 biosynthesis in higher plants.

Tambasco-Studart M, Titiz O, Raschle T, Forster G, Amrhein N, Fitzpatrick TB.

Proc Natl Acad Sci U S A. 2005 Sep 20;102(38):13687-92. Epub 2005 Sep 12.


On the two components of pyridoxal 5'-phosphate synthase from Bacillus subtilis.

Raschle T, Amrhein N, Fitzpatrick TB.

J Biol Chem. 2005 Sep 16;280(37):32291-300. Epub 2005 Jul 19.


The 1.3 A crystal structure of the flavoprotein YqjM reveals a novel class of Old Yellow Enzymes.

Kitzing K, Fitzpatrick TB, Wilken C, Sawa J, Bourenkov GP, Macheroux P, Clausen T.

J Biol Chem. 2005 Jul 29;280(30):27904-13. Epub 2005 May 12.


Oral Polypodium leucotomos extract decreases ultraviolet-induced damage of human skin.

Middelkamp-Hup MA, Pathak MA, Parrado C, Goukassian D, Rius-Díaz F, Mihm MC, Fitzpatrick TB, González S.

J Am Acad Dermatol. 2004 Dec;51(6):910-8.


Structural and functional impairment of an Old Yellow Enzyme homologue upon affinity tag incorporation.

Fitzpatrick TB, Auweter S, Kitzing K, Clausen T, Amrhein N, Macheroux P.

Protein Expr Purif. 2004 Aug;36(2):280-91.


Annotating the Plasmodium genome and the enigma of the shikimate pathway.

McConkey GA, Pinney JW, Westhead DR, Plueckhahn K, Fitzpatrick TB, Macheroux P, Kappes B.

Trends Parasitol. 2004 Feb;20(2):60-5. Review.


Orally administered Polypodium leucotomos extract decreases psoralen-UVA-induced phototoxicity, pigmentation, and damage of human skin.

Middelkamp-Hup MA, Pathak MA, Parrado C, Garcia-Caballero T, Rius-Díaz F, Fitzpatrick TB, González S.

J Am Acad Dermatol. 2004 Jan;50(1):41-9.


Characterization of YqjM, an Old Yellow Enzyme homolog from Bacillus subtilis involved in the oxidative stress response.

Fitzpatrick TB, Amrhein N, Macheroux P.

J Biol Chem. 2003 May 30;278(22):19891-7. Epub 2003 Mar 26.


Structure and characterization of the glycan moiety of L-amino-acid oxidase from the Malayan pit viper Calloselasma rhodostoma.

Geyer A, Fitzpatrick TB, Pawelek PD, Kitzing K, Vrielink A, Ghisla S, Macheroux P.

Eur J Biochem. 2001 Jul;268(14):4044-53.


Chorismate synthase from the hyperthermophile Thermotoga maritima combines thermostability and increased rigidity with catalytic and spectral properties similar to mesophilic counterparts.

Fitzpatrick TB, Killer P, Thomas RM, Jelesarov I, Amrhein N, Macheroux P.

J Biol Chem. 2001 May 25;276(21):18052-9. Epub 2001 Mar 9.


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