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Items: 1 to 50 of 287

1.

Assembling the Inflammasome, Piece by Piece.

Humphries F, Fitzgerald KA.

J Immunol. 2019 Sep 1;203(5):1093-1094. doi: 10.4049/jimmunol.1900764. No abstract available.

PMID:
31427397
2.

DNA sensing by the cGAS-STING pathway in health and disease.

Motwani M, Pesiridis S, Fitzgerald KA.

Nat Rev Genet. 2019 Jul 29. doi: 10.1038/s41576-019-0151-1. [Epub ahead of print] Review.

PMID:
31358977
3.

Control of antiviral innate immune response by protein geranylgeranylation.

Yang S, Harding AT, Sweeney C, Miao D, Swan G, Zhou C, Jiang Z, Fitzgerald KA, Hammer G, Bergo MO, Kroh HK, Lacy DB, Sun C, Glogauer M, Que LG, Heaton NS, Wang D.

Sci Adv. 2019 May 29;5(5):eaav7999. doi: 10.1126/sciadv.aav7999. eCollection 2019 May.

4.

HiChIRP reveals RNA-associated chromosome conformation.

Mumbach MR, Granja JM, Flynn RA, Roake CM, Satpathy AT, Rubin AJ, Qi Y, Jiang Z, Shams S, Louie BH, Guo JK, Gennert DG, Corces MR, Khavari PA, Atianand MK, Artandi SE, Fitzgerald KA, Greenleaf WJ, Chang HY.

Nat Methods. 2019 Jun;16(6):489-492. doi: 10.1038/s41592-019-0407-x. Epub 2019 May 27.

5.

Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.

Carty M, Kearney J, Shanahan KA, Hams E, Sugisawa R, Connolly D, Doran CG, Muñoz-Wolf N, Gürtler C, Fitzgerald KA, Lavelle EC, Fallon PG, Bowie AG.

Immunity. 2019 Jun 18;50(6):1412-1424.e6. doi: 10.1016/j.immuni.2019.04.005. Epub 2019 May 7.

PMID:
31076360
6.

Hierarchy of clinical manifestations in SAVI N153S and V154M mouse models.

Motwani M, Pawaria S, Bernier J, Moses S, Henry K, Fang T, Burkly L, Marshak-Rothstein A, Fitzgerald KA.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7941-7950. doi: 10.1073/pnas.1818281116. Epub 2019 Apr 3.

PMID:
30944222
7.

Motivational Interviewing: Improving Confidence With Self-care Management in Postoperative Thoracolumbar Spine Patients.

Scheffel K, Amidei C, Fitzgerald KA.

J Neurosci Nurs. 2019 Jun;51(3):113-118. doi: 10.1097/JNN.0000000000000431.

PMID:
30801445
8.

CNBP controls IL-12 gene transcription and Th1 immunity.

Chen Y, Sharma S, Assis PA, Jiang Z, Elling R, Olive AJ, Hang S, Bernier J, Huh JR, Sassetti CM, Knipe DM, Gazzinelli RT, Fitzgerald KA.

J Exp Med. 2018 Dec 3;215(12):3136-3150. doi: 10.1084/jem.20181031. Epub 2018 Nov 15.

9.

Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, Rinn JL, Fitzgerald KA, Carpenter S.

Cell Rep. 2018 Nov 6;25(6):1511-1524.e6. doi: 10.1016/j.celrep.2018.10.027.

10.

Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.

Orning P, Weng D, Starheim K, Ratner D, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E.

Science. 2018 Nov 30;362(6418):1064-1069. doi: 10.1126/science.aau2818. Epub 2018 Oct 25.

11.

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis.

Banerjee I, Behl B, Mendonca M, Shrivastava G, Russo AJ, Menoret A, Ghosh A, Vella AT, Vanaja SK, Sarkar SN, Fitzgerald KA, Rathinam VAK.

Immunity. 2018 Sep 18;49(3):413-426.e5. doi: 10.1016/j.immuni.2018.07.006. Epub 2018 Aug 28.

PMID:
30170814
12.

Nrf2 negatively regulates STING indicating a link between antiviral sensing and metabolic reprogramming.

Olagnier D, Brandtoft AM, Gunderstofte C, Villadsen NL, Krapp C, Thielke AL, Laustsen A, Peri S, Hansen AL, Bonefeld L, Thyrsted J, Bruun V, Iversen MB, Lin L, Artegoitia VM, Su C, Yang L, Lin R, Balachandran S, Luo Y, Nyegaard M, Marrero B, Goldbach-Mansky R, Motwani M, Ryan DG, Fitzgerald KA, O'Neill LA, Hollensen AK, Damgaard CK, de Paoli FV, Bertram HC, Jakobsen MR, Poulsen TB, Holm CK.

Nat Commun. 2018 Aug 29;9(1):3506. doi: 10.1038/s41467-018-05861-7.

13.

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling.

Hansen AL, Buchan GJ, Rühl M, Mukai K, Salvatore SR, Ogawa E, Andersen SD, Iversen MB, Thielke AL, Gunderstofte C, Motwani M, Møller CT, Jakobsen AS, Fitzgerald KA, Roos J, Lin R, Maier TJ, Goldbach-Mansky R, Miner CA, Qian W, Miner JJ, Rigby RE, Rehwinkel J, Jakobsen MR, Arai H, Taguchi T, Schopfer FJ, Olagnier D, Holm CK.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7768-E7775. doi: 10.1073/pnas.1806239115. Epub 2018 Jul 30.

14.

Fas ligand promotes an inducible TLR-dependent model of cutaneous lupus-like inflammation.

Mande P, Zirak B, Ko WC, Taravati K, Bride KL, Brodeur TY, Deng A, Dresser K, Jiang Z, Ettinger R, Fitzgerald KA, Rosenblum MD, Harris JE, Marshak-Rothstein A.

J Clin Invest. 2018 Jul 2;128(7):2966-2978. doi: 10.1172/JCI98219. Epub 2018 Jun 11.

15.

Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.

Sarhan J, Liu BC, Muendlein HI, Weindel CG, Smirnova I, Tang AY, Ilyukha V, Sorokin M, Buzdin A, Fitzgerald KA, Poltorak A.

Cell Death Differ. 2019 Jan;26(2):332-347. doi: 10.1038/s41418-018-0122-7. Epub 2018 May 21.

16.

Correction: Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.

O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA.

J Immunol. 2018 Apr 15;200(8):3020-3021. doi: 10.4049/jimmunol.1800240. Epub 2018 Mar 12. No abstract available.

17.

Activation of Stimulator of Interferon Genes (STING) and Sjögren Syndrome.

Papinska J, Bagavant H, Gmyrek GB, Sroka M, Tummala S, Fitzgerald KA, Deshmukh US.

J Dent Res. 2018 Jul;97(8):893-900. doi: 10.1177/0022034518760855. Epub 2018 Mar 5.

PMID:
29505322
18.

Cutting Edge: Plasmodium falciparum Induces Trained Innate Immunity.

Schrum JE, Crabtree JN, Dobbs KR, Kiritsy MC, Reed GW, Gazzinelli RT, Netea MG, Kazura JW, Dent AE, Fitzgerald KA, Golenbock DT.

J Immunol. 2018 Feb 15;200(4):1243-1248. doi: 10.4049/jimmunol.1701010. Epub 2018 Jan 12.

19.

Cyclic GMP-AMP Synthase Is the Cytosolic Sensor of Plasmodium falciparum Genomic DNA and Activates Type I IFN in Malaria.

Gallego-Marin C, Schrum JE, Andrade WA, Shaffer SA, Giraldo LF, Lasso AM, Kurt-Jones EA, Fitzgerald KA, Golenbock DT.

J Immunol. 2018 Jan 15;200(2):768-774. doi: 10.4049/jimmunol.1701048. Epub 2017 Dec 6.

20.

Dendritic Cell RIPK1 Maintains Immune Homeostasis by Preventing Inflammation and Autoimmunity.

O'Donnell JA, Lehman J, Roderick JE, Martinez-Marin D, Zelic M, Doran C, Hermance N, Lyle S, Pasparakis M, Fitzgerald KA, Marshak-Rothstein A, Kelliher MA.

J Immunol. 2018 Jan 15;200(2):737-748. doi: 10.4049/jimmunol.1701229. Epub 2017 Dec 6. Erratum in: J Immunol. 2018 Mar 12;:.

21.

cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.

Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, Varshney A, Yasuma R, Fowler BJ, Baghdasaryan E, Marion KM, Huang X, Yasuma T, Hirano Y, Serbulea V, Ambati M, Ambati VL, Kajiwara Y, Ambati K, Hirahara S, Bastos-Carvalho A, Ogura Y, Terasaki H, Oshika T, Kim KB, Hinton DR, Leitinger N, Cambier JC, Buxbaum JD, Kenney MC, Jazwinski SM, Nagai H, Hara I, West AP, Fitzgerald KA, Sadda SR, Gelfand BD, Ambati J.

Nat Med. 2018 Jan;24(1):50-61. doi: 10.1038/nm.4450. Epub 2017 Nov 27.

22.

IRF3 and type I interferons fuel a fatal response to myocardial infarction.

King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP Jr, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R.

Nat Med. 2017 Dec;23(12):1481-1487. doi: 10.1038/nm.4428. Epub 2017 Nov 6.

23.

A Dectin-1-Caspase-8 Pathway Licenses Canonical Caspase-1 Inflammasome Activation and Interleukin-1β Release in Response to a Pathogenic Fungus.

Ketelut-Carneiro N, Ghosh S, Levitz SM, Fitzgerald KA, da Silva JS.

J Infect Dis. 2018 Jan 4;217(2):329-339. doi: 10.1093/infdis/jix568.

24.

cGAS Micro-Manages Genotoxic Stress.

Motwani M, Fitzgerald KA.

Immunity. 2017 Oct 17;47(4):616-617. doi: 10.1016/j.immuni.2017.09.020.

25.

The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.

Ghosh S, Wallerath C, Covarrubias S, Hornung V, Carpenter S, Fitzgerald KA.

J Immunol. 2017 Nov 1;199(9):3249-3260. doi: 10.4049/jimmunol.1700823. Epub 2017 Sep 20.

26.

Cytokines and Long Noncoding RNAs.

Carpenter S, Fitzgerald KA.

Cold Spring Harb Perspect Biol. 2018 Jun 1;10(6). pii: a028589. doi: 10.1101/cshperspect.a028589. Review.

PMID:
28716885
27.

Kinase Activities of RIPK1 and RIPK3 Can Direct IFN-β Synthesis Induced by Lipopolysaccharide.

Saleh D, Najjar M, Zelic M, Shah S, Nogusa S, Polykratis A, Paczosa MK, Gough PJ, Bertin J, Whalen M, Fitzgerald KA, Slavov N, Pasparakis M, Balachandran S, Kelliher M, Mecsas J, Degterev A.

J Immunol. 2017 Jun 1;198(11):4435-4447. doi: 10.4049/jimmunol.1601717. Epub 2017 May 1.

28.

miR-718 represses proinflammatory cytokine production through targeting phosphatase and tensin homolog (PTEN).

Kalantari P, Harandi OF, Agarwal S, Rus F, Kurt-Jones EA, Fitzgerald KA, Caffrey DR, Golenbock DT.

J Biol Chem. 2017 Apr 7;292(14):5634-5644. doi: 10.1074/jbc.M116.749325. Epub 2017 Feb 16.

29.

Immunobiology of Long Noncoding RNAs.

Atianand MK, Caffrey DR, Fitzgerald KA.

Annu Rev Immunol. 2017 Apr 26;35:177-198. doi: 10.1146/annurev-immunol-041015-055459. Epub 2017 Jan 11. Review.

30.

Formulation and Evaluation of Anisamide-Targeted Amphiphilic Cyclodextrin Nanoparticles To Promote Therapeutic Gene Silencing in a 3D Prostate Cancer Bone Metastases Model.

Evans JC, Malhotra M, Fitzgerald KA, Guo J, Cronin MF, Curtin CM, O'Brien FJ, Darcy R, O'Driscoll CM.

Mol Pharm. 2017 Jan 3;14(1):42-52. doi: 10.1021/acs.molpharmaceut.6b00646. Epub 2016 Nov 23.

PMID:
28043128
31.

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury.

Hu B, Jin C, Li HB, Tong J, Ouyang X, Cetinbas NM, Zhu S, Strowig T, Lam FC, Zhao C, Henao-Mejia J, Yilmaz O, Fitzgerald KA, Eisenbarth SC, Elinav E, Flavell RA.

Science. 2016 Nov 11;354(6313):765-768.

32.

Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS.

Reinert LS, Lopušná K, Winther H, Sun C, Thomsen MK, Nandakumar R, Mogensen TH, Meyer M, Vægter C, Nyengaard JR, Fitzgerald KA, Paludan SR.

Nat Commun. 2016 Nov 10;7:13348. doi: 10.1038/ncomms13348.

33.

Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.

Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G.

J Biol Chem. 2016 Dec 23;291(52):26794-26805. doi: 10.1074/jbc.M116.736991. Epub 2016 Nov 3.

34.

"Could We Hold Hands?" Older Lesbian and Gay Couples' Perceptions of Long-Term Care Homes and Home Care.

Furlotte C, Gladstone JW, Cosby RF, Fitzgerald KA.

Can J Aging. 2016 Dec;35(4):432-446. Epub 2016 Oct 17.

PMID:
27745565
35.

STING Contributes to Abnormal Bone Formation Induced by Deficiency of DNase II in Mice.

Baum R, Sharma S, Organ JM, Jakobs C, Hornung V, Burr DB, Marshak-Rothstein A, Fitzgerald KA, Gravallese EM.

Arthritis Rheumatol. 2017 Feb;69(2):460-471. doi: 10.1002/art.39863.

36.

Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?

Pawaria S, Sharma S, Baum R, Nündel K, Busto P, Gravallese EM, Fitzgerald KA, Marshak-Rothstein A.

J Leukoc Biol. 2017 Jan;101(1):121-126. doi: 10.1189/jlb.3MR0316-115R. Epub 2016 Aug 16. Review.

37.

Nanoparticle-mediated siRNA delivery assessed in a 3D co-culture model simulating prostate cancer bone metastasis.

Fitzgerald KA, Guo J, Raftery RM, Castaño IM, Curtin CM, Gooding M, Darcy R, O' Brien FJ, O' Driscoll CM.

Int J Pharm. 2016 Sep 25;511(2):1058-69. doi: 10.1016/j.ijpharm.2016.07.079. Epub 2016 Aug 1.

PMID:
27492023
38.

Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production.

Andrade WA, Firon A, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Trieu-Cuot P, Golenbock DT, Kaminski PA.

Cell Host Microbe. 2016 Jul 13;20(1):49-59. doi: 10.1016/j.chom.2016.06.003.

39.

A Long Noncoding RNA lincRNA-EPS Acts as a Transcriptional Brake to Restrain Inflammation.

Atianand MK, Hu W, Satpathy AT, Shen Y, Ricci EP, Alvarez-Dominguez JR, Bhatta A, Schattgen SA, McGowan JD, Blin J, Braun JE, Gandhi P, Moore MJ, Chang HY, Lodish HF, Caffrey DR, Fitzgerald KA.

Cell. 2016 Jun 16;165(7):1672-1685. doi: 10.1016/j.cell.2016.05.075.

40.

Control of the innate immune response by the mevalonate pathway.

Akula MK, Shi M, Jiang Z, Foster CE, Miao D, Li AS, Zhang X, Gavin RM, Forde SD, Germain G, Carpenter S, Rosadini CV, Gritsman K, Chae JJ, Hampton R, Silverman N, Gravallese EM, Kagan JC, Fitzgerald KA, Kastner DL, Golenbock DT, Bergo MO, Wang D.

Nat Immunol. 2016 Aug;17(8):922-9. doi: 10.1038/ni.3487. Epub 2016 Jun 6.

41.

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

Andrade WA, Agarwal S, Mo S, Shaffer SA, Dillard JP, Schmidt T, Hornung V, Fitzgerald KA, Kurt-Jones EA, Golenbock DT.

Cell Rep. 2016 Jun 14;15(11):2438-48. doi: 10.1016/j.celrep.2016.05.030. Epub 2016 Jun 2.

42.

Inflammasome Complexes: Emerging Mechanisms and Effector Functions.

Rathinam VA, Fitzgerald KA.

Cell. 2016 May 5;165(4):792-800. doi: 10.1016/j.cell.2016.03.046. Review.

43.

S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3.

Wang F, Alain T, Szretter KJ, Stephenson K, Pol JG, Atherton MJ, Hoang HD, Fonseca BD, Zakaria C, Chen L, Rangwala Z, Hesch A, Chan ESY, Tuinman C, Suthar MS, Jiang Z, Ashkar AA, Thomas G, Kozma SC, Gale M Jr, Fitzgerald KA, Diamond MS, Mossman K, Sonenberg N, Wan Y, Lichty BD.

Nat Immunol. 2016 May;17(5):514-522. doi: 10.1038/ni.3433. Epub 2016 Apr 4.

44.

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons.

Carroll EC, Jin L, Mori A, Muñoz-Wolf N, Oleszycka E, Moran HBT, Mansouri S, McEntee CP, Lambe E, Agger EM, Andersen P, Cunningham C, Hertzog P, Fitzgerald KA, Bowie AG, Lavelle EC.

Immunity. 2016 Mar 15;44(3):597-608. doi: 10.1016/j.immuni.2016.02.004. Epub 2016 Mar 2.

45.

IMMUNOLOGY. An RNA twist to T(H)17 cells.

Atianand MK, Fitzgerald KA.

Science. 2016 Mar 4;351(6277):1032. doi: 10.1126/science.aaf4691. No abstract available.

PMID:
26941307
46.

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

Holm CK, Rahbek SH, Gad HH, Bak RO, Jakobsen MR, Jiang Z, Hansen AL, Jensen SK, Sun C, Thomsen MK, Laustsen A, Nielsen CG, Severinsen K, Xiong Y, Burdette DL, Hornung V, Lebbink RJ, Duch M, Fitzgerald KA, Bahrami S, Mikkelsen JG, Hartmann R, Paludan SR.

Nat Commun. 2016 Feb 19;7:10680. doi: 10.1038/ncomms10680.

47.

Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression.

Elling R, Chan J, Fitzgerald KA.

Eur J Immunol. 2016 Mar;46(3):504-12. doi: 10.1002/eji.201444558. Epub 2016 Feb 24. Review.

48.

Synergy between Hematopoietic and Radioresistant Stromal Cells Is Required for Autoimmune Manifestations of DNase II-/-IFNaR-/- Mice.

Baum R, Nündel K, Pawaria S, Sharma S, Busto P, Fitzgerald KA, Gravallese EM, Marshak-Rothstein A.

J Immunol. 2016 Feb 1;196(3):1348-54. doi: 10.4049/jimmunol.1502130. Epub 2016 Jan 4.

49.

A novel, anisamide-targeted cyclodextrin nanoformulation for siRNA delivery to prostate cancer cells expressing the sigma-1 receptor.

Fitzgerald KA, Malhotra M, Gooding M, Sallas F, Evans JC, Darcy R, O'Driscoll CM.

Int J Pharm. 2016 Feb 29;499(1-2):131-145. doi: 10.1016/j.ijpharm.2015.12.055. Epub 2015 Dec 22.

PMID:
26721726
50.

Cutting Edge: Novel Tmem173 Allele Reveals Importance of STING N Terminus in Trafficking and Type I IFN Production.

Surpris G, Chan J, Thompson M, Ilyukha V, Liu BC, Atianand M, Sharma S, Volkova T, Smirnova I, Fitzgerald KA, Poltorak A.

J Immunol. 2016 Jan 15;196(2):547-52. doi: 10.4049/jimmunol.1501415. Epub 2015 Dec 18.

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