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Misguided drug advice for COVID-19.

FitzGerald GA.

Science. 2020 Mar 27;367(6485):1434. doi: 10.1126/science.abb8034. Epub 2020 Mar 20. No abstract available.


Author Correction: Quantifying secondary transport at single-molecule resolution.

Fitzgerald GA, Terry DS, Warren AL, Quick M, Javitch JA, Blanchard SC.

Nature. 2020 Mar;579(7797):E6. doi: 10.1038/s41586-020-2029-y.


The promise and reality of therapeutic discovery from large cohorts.

Melamud E, Taylor DL, Sethi A, Cule M, Baryshnikova A, Saleheen D, van Bruggen N, FitzGerald GA.

J Clin Invest. 2020 Feb 3;130(2):575-581. doi: 10.1172/JCI129196. Review.


Quantifying secondary transport at single-molecule resolution.

Fitzgerald GA, Terry DS, Warren AL, Quick M, Javitch JA, Blanchard SC.

Nature. 2019 Nov;575(7783):528-534. doi: 10.1038/s41586-019-1747-5. Epub 2019 Nov 13. Erratum in: Nature. 2020 Mar;579(7797):E6.


Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input.

Sarantopoulou D, Tang SY, Ricciotti E, Lahens NF, Lekkas D, Schug J, Guo XS, Paschos GK, FitzGerald GA, Pack AI, Grant GR.

Sci Rep. 2019 Sep 17;9(1):13477. doi: 10.1038/s41598-019-49889-1.


Circadian control of lung inflammation in influenza infection.

Sengupta S, Tang SY, Devine JC, Anderson ST, Nayak S, Zhang SL, Valenzuela A, Fisher DG, Grant GR, López CB, FitzGerald GA.

Nat Commun. 2019 Sep 11;10(1):4107. doi: 10.1038/s41467-019-11400-9.


Dosing time matters.

Ruben MD, Smith DF, FitzGerald GA, Hogenesch JB.

Science. 2019 Aug 9;365(6453):547-549. doi: 10.1126/science.aax7621. No abstract available.


Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.

Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P.

J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27.


Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2).

Markosyan N, Li J, Sun YH, Richman LP, Lin JH, Yan F, Quinones L, Sela Y, Yamazoe T, Gordon N, Tobias JW, Byrne KT, Rech AJ, FitzGerald GA, Stanger BZ, Vonderheide RH.

J Clin Invest. 2019 Jun 4;130:3594-3609. doi: 10.1172/JCI127755.


A decade of Science Translational Medicine.

Edelman ER, FitzGerald GA.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaax4327. doi: 10.1126/scitranslmed.aax4327.


The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury.

Zhu L, Xu C, Huo X, Hao H, Wan Q, Chen H, Zhang X, Breyer RM, Huang Y, Cao X, Liu DP, FitzGerald GA, Wang M.

Nat Commun. 2019 Apr 23;10(1):1888. doi: 10.1038/s41467-019-09492-4.


Myeloid Cell mPges-1 Deletion Attenuates Mortality Without Affecting Remodeling After Acute Myocardial Infarction in Mice.

Chen L, Yang G, Jiang T, Tang SY, Wang T, Wan Q, Wang M, FitzGerald GA.

J Pharmacol Exp Ther. 2019 Jul;370(1):18-24. doi: 10.1124/jpet.118.256057. Epub 2019 Apr 16.


Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions.

Yang G, Chen L, Zhang J, Ren B, FitzGerald GA.

JCI Insight. 2019 Apr 11;5. pii: 125133. doi: 10.1172/jci.insight.125133.


Variability in the Analgesic Response to Ibuprofen Is Associated With Cyclooxygenase Activation in Inflammatory Pain.

Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist EJ, Giannakopoulos HE, Levin LM, Secreto SA, Grant GR, Detre JA, FitzGerald GA, Grosser T, Farrar JT.

Clin Pharmacol Ther. 2019 Sep;106(3):632-641. doi: 10.1002/cpt.1446. Epub 2019 Apr 29.


Time-Dependent Hypotensive Effect of Aspirin in Mice.

Chen L, Yang G, Zhang J, Ren B, Tang S, Li X, FitzGerald GA.

Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2819-2826. doi: 10.1161/ATVBAHA.118.311296.


Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis.

Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, FitzGerald GA, Simon MC.

Front Immunol. 2018 Nov 5;9:2565. doi: 10.3389/fimmu.2018.02565. eCollection 2018.


Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2.

Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, Rinn JL, Fitzgerald KA, Carpenter S.

Cell Rep. 2018 Nov 6;25(6):1511-1524.e6. doi: 10.1016/j.celrep.2018.10.027.


The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond.

Devchand PR, Liu T, Altman RB, FitzGerald GA, Schadt EE.

Front Pharmacol. 2018 Oct 4;9:1093. doi: 10.3389/fphar.2018.01093. eCollection 2018. Review.


Lipocalin-Like Prostaglandin D Synthase but Not Hemopoietic Prostaglandin D Synthase Deletion Causes Hypertension and Accelerates Thrombogenesis in Mice.

Song WL, Ricciotti E, Liang X, Grosser T, Grant GR, FitzGerald GA.

J Pharmacol Exp Ther. 2018 Dec;367(3):425-432. doi: 10.1124/jpet.118.250936. Epub 2018 Oct 10.


Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Oct;59(10):2035. doi: 10.1194/jlr.M079996ERR. No abstract available.


Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.

Li X, Ballantyne LL, Crawford MC, FitzGerald GA, Funk CD.

Sci Rep. 2018 Aug 14;8(1):12097. doi: 10.1038/s41598-018-30636-x.


Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2.

Paschos GK, Tang SY, Theken KN, Li X, Verginadis I, Lekkas D, Herman L, Yan W, Lawson J, FitzGerald GA.

Cell Rep. 2018 Jul 24;24(4):809-814. doi: 10.1016/j.celrep.2018.06.082.


Cyclooxygenase-2, Asymmetric Dimethylarginine, and the Cardiovascular Hazard From Nonsteroidal Anti-Inflammatory Drugs.

Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA.

Circulation. 2018 Nov 20;138(21):2367-2378. doi: 10.1161/CIRCULATIONAHA.118.033540.


Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.

Ocana JA, Romer E, Sahu R, Pawelzik SC, FitzGerald GA, Kaplan MH, Travers JB.

J Immunol. 2018 Jun 15;200(12):4004-4011. doi: 10.4049/jimmunol.1701145. Epub 2018 Apr 25.


Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.

Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD.

FASEB J. 2018 Oct;32(10):5326-5337. doi: 10.1096/fj.201800252R. Epub 2018 Apr 20.


Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175. doi: 10.1073/pnas.1718635115. Epub 2018 Apr 2.


Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.

Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1115-1124. doi: 10.1161/ATVBAHA.118.310713. Epub 2018 Mar 29.


Association between cumulative radiation dose, adverse skin reactions, and changes in surface hemoglobin among women undergoing breast conserving therapy.

Chin MS, Siegel-Reamer L, FitzGerald GA, Wyman A, Connor NM, Lo YC, Sioshansi S, Moni J, Giulia Cicchetti M, Lalikos JF, FitzGerald TJ.

Clin Transl Radiat Oncol. 2017 May 18;4:15-23. doi: 10.1016/j.ctro.2017.03.003. eCollection 2017 Jun.


Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.

Grosser T, Naji A, FitzGerald GA.

Circ Res. 2018 Feb 16;122(4):537-539. doi: 10.1161/CIRCRESAHA.118.312616. No abstract available.


Regulation of amyloid-β dynamics and pathology by the circadian clock.

Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES.

J Exp Med. 2018 Apr 2;215(4):1059-1068. doi: 10.1084/jem.20172347. Epub 2018 Jan 30.


Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.

Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C.

J Lipid Res. 2018 Mar;59(3):564-575. doi: 10.1194/jlr.D081414. Epub 2018 Jan 4.


CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.

Prentice KJ, Wendell SG, Liu Y, Eversley JA, Salvatore SR, Mohan H, Brandt SL, Adams AC, Serena Wang X, Wei D, FitzGerald GA, Durham TB, Hammond CD, Sloop KW, Skarke C, Schopfer FJ, Wheeler MB.

EBioMedicine. 2018 Jan;27:200-213. doi: 10.1016/j.ebiom.2017.12.019. Epub 2017 Dec 19.


A Pilot Characterization of the Human Chronobiome.

Skarke C, Lahens NF, Rhoades SD, Campbell A, Bittinger K, Bailey A, Hoffmann C, Olson RS, Chen L, Yang G, Price TS, Moore JH, Bushman FD, Greene CS, Grant GR, Weljie AM, FitzGerald GA.

Sci Rep. 2017 Dec 7;7(1):17141. doi: 10.1038/s41598-017-17362-6.


Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Jan;59(1):89-101. doi: 10.1194/jlr.M079996. Epub 2017 Nov 27. Erratum in: J Lipid Res. 2018 Oct;59(10):2035.


Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.

Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Jan;59(1):102-112. doi: 10.1194/jlr.M080028. Epub 2017 Nov 27.


Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.

Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E.

Mol Metab. 2017 Nov;6(11):1395-1406. doi: 10.1016/j.molmet.2017.08.004. Epub 2017 Aug 19.


Guidelines for Genome-Scale Analysis of Biological Rhythms.

Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB.

J Biol Rhythms. 2017 Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3.


Timing the Microbes: The Circadian Rhythm of the Gut Microbiome.

Liang X, FitzGerald GA.

J Biol Rhythms. 2017 Dec;32(6):505-515. doi: 10.1177/0748730417729066. Epub 2017 Sep 1. Review.


Circadian Clocks and Metabolism: Implications for Microbiome and Aging.

Paschos GK, FitzGerald GA.

Trends Genet. 2017 Oct;33(10):760-769. doi: 10.1016/j.tig.2017.07.010. Epub 2017 Aug 24. Review.


Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System.

Grosser T, Theken KN, FitzGerald GA.

Clin Pharmacol Ther. 2017 Oct;102(4):611-622. doi: 10.1002/cpt.794. Epub 2017 Aug 17.


The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.

Grosser T, Ricciotti E, FitzGerald GA.

Trends Pharmacol Sci. 2017 Aug;38(8):733-748. doi: 10.1016/ Epub 2017 Jun 23. Review.


Time for nonaddictive relief of pain.

Grosser T, Woolf CJ, FitzGerald GA.

Science. 2017 Mar 10;355(6329):1026-1027. doi: 10.1126/science.aan0088. Epub 2017 Mar 9. No abstract available.


A general method for determining secondary active transporter substrate stoichiometry.

Fitzgerald GA, Mulligan C, Mindell JA.

Elife. 2017 Jan 25;6. pii: e21016. doi: 10.7554/eLife.21016.


Simulation-based comprehensive benchmarking of RNA-seq aligners.

Baruzzo G, Hayer KE, Kim EJ, Di Camillo B, FitzGerald GA, Grant GR.

Nat Methods. 2017 Feb;14(2):135-139. doi: 10.1038/nmeth.4106. Epub 2016 Dec 12.


Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial.

FitzGerald GA.

Circulation. 2017 Jan 10;135(2):113-115. doi: 10.1161/CIRCULATIONAHA.116.026324. Epub 2016 Nov 13. No abstract available.


A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood.

Mazaleuskaya LL, Lawson JA, Li X, Grant G, Mesaros C, Grosser T, Blair IA, Ricciotti E, FitzGerald GA.

JCI Insight. 2016 Aug 4;1(12). pii: e87031.


Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.

Tang SY, Monslow J, R Grant G, Todd L, Pawelzik SC, Chen L, Lawson J, Puré E, FitzGerald GA.

Circulation. 2016 Jul 26;134(4):328-38. doi: 10.1161/CIRCULATIONAHA.116.022308.


Measure for Measure: Biomarker standards and transparency.

FitzGerald GA.

Sci Transl Med. 2016 Jun 15;8(343):343fs10. doi: 10.1126/scitranslmed.aaf8590. Review.


Human Platelet Lipidomics: Variance, Visualization, Flux, and Fuel.

FitzGerald GA.

Cell Metab. 2016 May 10;23(5):757-9. doi: 10.1016/j.cmet.2016.04.025.


Conflict or Confluence of Interest?--Reply.

Cappola AR, FitzGerald GA.

JAMA. 2016 Apr 26;315(16):1793-4. doi: 10.1001/jama.2016.0327. No abstract available.


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