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Items: 1 to 50 of 525

1.

L-Pgds but not H-Pgds deletion causes hypertension and accelerates thrombogenesis in mice.

Song WL, Ricciotti E, Liang X, Grosser T, Grant GR, FitzGerald GA.

J Pharmacol Exp Ther. 2018 Oct 10. pii: jpet.118.250936. doi: 10.1124/jpet.118.250936. [Epub ahead of print]

2.

Erratum: Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Oct;59(10):2035. doi: 10.1194/jlr.M079996ERR. No abstract available.

3.

Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy.

Li X, Ballantyne LL, Crawford MC, FitzGerald GA, Funk CD.

Sci Rep. 2018 Aug 14;8(1):12097. doi: 10.1038/s41598-018-30636-x.

4.

Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2.

Paschos GK, Tang SY, Theken KN, Li X, Verginadis I, Lekkas D, Herman L, Yan W, Lawson J, FitzGerald GA.

Cell Rep. 2018 Jul 24;24(4):809-814. doi: 10.1016/j.celrep.2018.06.082.

5.

Cyclooxygenase-2, Asymmetric Dimethylarginine and the Cardiovascular Hazard from NSAIDs.

Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA.

Circulation. 2018 Jun 21. pii: CIRCULATIONAHA.118.033540. doi: 10.1161/CIRCULATIONAHA.118.033540. [Epub ahead of print]

PMID:
29930022
6.

Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms.

Ocana JA, Romer E, Sahu R, Pawelzik SC, FitzGerald GA, Kaplan MH, Travers JB.

J Immunol. 2018 Jun 15;200(12):4004-4011. doi: 10.4049/jimmunol.1701145. Epub 2018 Apr 25.

PMID:
29695417
7.

Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions.

Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD.

FASEB J. 2018 Oct;32(10):5326-5337. doi: 10.1096/fj.201800252R. Epub 2018 Apr 20.

PMID:
29676940
8.

Microbes vs. chemistry in the origin of the anaerobic gut lumen.

Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, Wu GD.

Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4170-4175. doi: 10.1073/pnas.1718635115. Epub 2018 Apr 2.

9.

Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE2 (Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury.

Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):1115-1124. doi: 10.1161/ATVBAHA.118.310713. Epub 2018 Mar 29.

PMID:
29599139
10.

Association between cumulative radiation dose, adverse skin reactions, and changes in surface hemoglobin among women undergoing breast conserving therapy.

Chin MS, Siegel-Reamer L, FitzGerald GA, Wyman A, Connor NM, Lo YC, Sioshansi S, Moni J, Giulia Cicchetti M, Lalikos JF, FitzGerald TJ.

Clin Transl Radiat Oncol. 2017 May 18;4:15-23. doi: 10.1016/j.ctro.2017.03.003. eCollection 2017 Jun.

11.

Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment.

Grosser T, Naji A, FitzGerald GA.

Circ Res. 2018 Feb 16;122(4):537-539. doi: 10.1161/CIRCRESAHA.118.312616. No abstract available.

PMID:
29449357
12.

Regulation of amyloid-β dynamics and pathology by the circadian clock.

Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES.

J Exp Med. 2018 Apr 2;215(4):1059-1068. doi: 10.1084/jem.20172347. Epub 2018 Jan 30.

13.

Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS.

Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C.

J Lipid Res. 2018 Mar;59(3):564-575. doi: 10.1194/jlr.D081414. Epub 2018 Jan 4.

14.

CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis.

Prentice KJ, Wendell SG, Liu Y, Eversley JA, Salvatore SR, Mohan H, Brandt SL, Adams AC, Serena Wang X, Wei D, FitzGerald GA, Durham TB, Hammond CD, Sloop KW, Skarke C, Schopfer FJ, Wheeler MB.

EBioMedicine. 2018 Jan;27:200-213. doi: 10.1016/j.ebiom.2017.12.019. Epub 2017 Dec 19.

15.

A Pilot Characterization of the Human Chronobiome.

Skarke C, Lahens NF, Rhoades SD, Campbell A, Bittinger K, Bailey A, Hoffmann C, Olson RS, Chen L, Yang G, Price TS, Moore JH, Bushman FD, Greene CS, Grant GR, Weljie AM, FitzGerald GA.

Sci Rep. 2017 Dec 7;7(1):17141. doi: 10.1038/s41598-017-17362-6.

16.

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions.

Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Jan;59(1):89-101. doi: 10.1194/jlr.M079996. Epub 2017 Nov 27. Erratum in: J Lipid Res. 2018 Oct;59(10):2035.

PMID:
29180445
17.

Genomic and lipidomic analyses differentiate the compensatory roles of two COX isoforms during systemic inflammation in mice.

Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD.

J Lipid Res. 2018 Jan;59(1):102-112. doi: 10.1194/jlr.M080028. Epub 2017 Nov 27.

PMID:
29180443
18.

Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury.

Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E.

Mol Metab. 2017 Nov;6(11):1395-1406. doi: 10.1016/j.molmet.2017.08.004. Epub 2017 Aug 19.

19.

Guidelines for Genome-Scale Analysis of Biological Rhythms.

Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, Crowell AM, DeBruyne JP, Dijk DJ, DiTacchio L, Doyle FJ, Duffield GE, Dunlap JC, Eckel-Mahan K, Esser KA, FitzGerald GA, Forger DB, Francey LJ, Fu YH, Gachon F, Gatfield D, de Goede P, Golden SS, Green C, Harer J, Harmer S, Haspel J, Hastings MH, Herzel H, Herzog ED, Hoffmann C, Hong C, Hughey JJ, Hurley JM, de la Iglesia HO, Johnson C, Kay SA, Koike N, Kornacker K, Kramer A, Lamia K, Leise T, Lewis SA, Li J, Li X, Liu AC, Loros JJ, Martino TA, Menet JS, Merrow M, Millar AJ, Mockler T, Naef F, Nagoshi E, Nitabach MN, Olmedo M, Nusinow DA, Ptáček LJ, Rand D, Reddy AB, Robles MS, Roenneberg T, Rosbash M, Ruben MD, Rund SSC, Sancar A, Sassone-Corsi P, Sehgal A, Sherrill-Mix S, Skene DJ, Storch KF, Takahashi JS, Ueda HR, Wang H, Weitz C, Westermark PO, Wijnen H, Xu Y, Wu G, Yoo SH, Young M, Zhang EE, Zielinski T, Hogenesch JB.

J Biol Rhythms. 2017 Oct;32(5):380-393. doi: 10.1177/0748730417728663. Epub 2017 Nov 3.

20.

Timing the Microbes: The Circadian Rhythm of the Gut Microbiome.

Liang X, FitzGerald GA.

J Biol Rhythms. 2017 Dec;32(6):505-515. doi: 10.1177/0748730417729066. Epub 2017 Sep 1. Review.

PMID:
28862076
21.

Circadian Clocks and Metabolism: Implications for Microbiome and Aging.

Paschos GK, FitzGerald GA.

Trends Genet. 2017 Oct;33(10):760-769. doi: 10.1016/j.tig.2017.07.010. Epub 2017 Aug 24. Review.

22.

Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System.

Grosser T, Theken KN, FitzGerald GA.

Clin Pharmacol Ther. 2017 Oct;102(4):611-622. doi: 10.1002/cpt.794. Epub 2017 Aug 17.

PMID:
28710775
23.

The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.

Grosser T, Ricciotti E, FitzGerald GA.

Trends Pharmacol Sci. 2017 Aug;38(8):733-748. doi: 10.1016/j.tips.2017.05.008. Epub 2017 Jun 23. Review.

24.

Time for nonaddictive relief of pain.

Grosser T, Woolf CJ, FitzGerald GA.

Science. 2017 Mar 10;355(6329):1026-1027. doi: 10.1126/science.aan0088. Epub 2017 Mar 9. No abstract available.

PMID:
28280170
25.

A general method for determining secondary active transporter substrate stoichiometry.

Fitzgerald GA, Mulligan C, Mindell JA.

Elife. 2017 Jan 25;6. pii: e21016. doi: 10.7554/eLife.21016.

26.

Simulation-based comprehensive benchmarking of RNA-seq aligners.

Baruzzo G, Hayer KE, Kim EJ, Di Camillo B, FitzGerald GA, Grant GR.

Nat Methods. 2017 Feb;14(2):135-139. doi: 10.1038/nmeth.4106. Epub 2016 Dec 12.

27.

Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial.

FitzGerald GA.

Circulation. 2017 Jan 10;135(2):113-115. doi: 10.1161/CIRCULATIONAHA.116.026324. Epub 2016 Nov 13. No abstract available.

28.

A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood.

Mazaleuskaya LL, Lawson JA, Li X, Grant G, Mesaros C, Grosser T, Blair IA, Ricciotti E, FitzGerald GA.

JCI Insight. 2016 Aug 4;1(12). pii: e87031.

29.

Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1-Deficient Hyperlipidemic Mice.

Tang SY, Monslow J, R Grant G, Todd L, Pawelzik SC, Chen L, Lawson J, Puré E, FitzGerald GA.

Circulation. 2016 Jul 26;134(4):328-38. doi: 10.1161/CIRCULATIONAHA.116.022308.

30.

Measure for Measure: Biomarker standards and transparency.

FitzGerald GA.

Sci Transl Med. 2016 Jun 15;8(343):343fs10. doi: 10.1126/scitranslmed.aaf8590. Review.

PMID:
27306662
31.

Human Platelet Lipidomics: Variance, Visualization, Flux, and Fuel.

FitzGerald GA.

Cell Metab. 2016 May 10;23(5):757-9. doi: 10.1016/j.cmet.2016.04.025.

32.

Conflict or Confluence of Interest?--Reply.

Cappola AR, FitzGerald GA.

JAMA. 2016 Apr 26;315(16):1793-4. doi: 10.1001/jama.2016.0327. No abstract available.

PMID:
27115391
33.

Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.

Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P.

Oncotarget. 2016 May 31;7(22):32462-77. doi: 10.18632/oncotarget.8655.

34.

Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival.

Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA.

Sci Transl Med. 2016 Feb 3;8(324):324ra16. doi: 10.1126/scitranslmed.aad3305. Epub 2016 Feb 3.

35.

The bacterial dicarboxylate transporter VcINDY uses a two-domain elevator-type mechanism.

Mulligan C, Fenollar-Ferrer C, Fitzgerald GA, Vergara-Jaque A, Kaufmann D, Li Y, Forrest LR, Mindell JA.

Nat Struct Mol Biol. 2016 Mar;23(3):256-63. doi: 10.1038/nsmb.3166. Epub 2016 Feb 1.

36.

Bidirectional interactions between indomethacin and the murine intestinal microbiota.

Liang X, Bittinger K, Li X, Abernethy DR, Bushman FD, FitzGerald GA.

Elife. 2015 Dec 23;4:e08973. doi: 10.7554/eLife.08973.

37.

MEDICINE. Personalization in practice.

Iyengar R, Altman RB, Troyanskya O, FitzGerald GA.

Science. 2015 Oct 16;350(6258):282-3. doi: 10.1126/science.aad5204. No abstract available.

PMID:
26472898
38.

Confluence, Not Conflict of Interest: Name Change Necessary.

Cappola AR, FitzGerald GA.

JAMA. 2015 Nov 3;314(17):1791-2. doi: 10.1001/jama.2015.12020. No abstract available.

PMID:
26402846
39.

Molecular clocks and the human condition: approaching their characterization in human physiology and disease.

Fitzgerald GA, Yang G, Paschos GK, Liang X, Skarke C.

Diabetes Obes Metab. 2015 Sep;17 Suppl 1:139-42. doi: 10.1111/dom.12526. Review.

40.

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock.

Liang X, Bushman FD, FitzGerald GA.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10479-84. doi: 10.1073/pnas.1501305112. Epub 2015 Aug 3.

41.

Bioactive products formed in humans from fish oils.

Skarke C, Alamuddin N, Lawson JA, Li X, Ferguson JF, Reilly MP, FitzGerald GA.

J Lipid Res. 2015 Sep;56(9):1808-20. doi: 10.1194/jlr.M060392. Epub 2015 Jul 15.

42.

BIOMEDICINE. Bringing PGE₂ in from the cold.

FitzGerald GA.

Science. 2015 Jun 12;348(6240):1208-9. doi: 10.1126/science.aac5515. No abstract available.

PMID:
26068834
43.

PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses.

Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE.

Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150. No abstract available.

44.

Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1.

Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, Vigorito E, FitzGerald GA, O'Neill LA.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):7231-6. doi: 10.1073/pnas.1501327112. Epub 2015 May 20.

45.

Understanding multicellular function and disease with human tissue-specific networks.

Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG.

Nat Genet. 2015 Jun;47(6):569-76. doi: 10.1038/ng.3259. Epub 2015 Apr 27.

46.

A metabolomic study of adipose tissue in mice with a disruption of the circadian system.

Castro C, Briggs W, Paschos GK, FitzGerald GA, Griffin JL.

Mol Biosyst. 2015 Jul;11(7):1897-906. doi: 10.1039/c5mb00032g.

47.

Evolution in translational science: Whither the CTSAs?

FitzGerald GA.

Sci Transl Med. 2015 Apr 22;7(284):284fs15. doi: 10.1126/scitranslmed.aab1596.

48.

Clocks and cardiovascular function.

McLoughlin SC, Haines P, FitzGerald GA.

Methods Enzymol. 2015;552:211-28. doi: 10.1016/bs.mie.2014.11.029. Epub 2014 Dec 26. Review.

49.

PharmGKB summary: ibuprofen pathways.

Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE.

Pharmacogenet Genomics. 2015 Feb;25(2):96-106. doi: 10.1097/FPC.0000000000000113. No abstract available.

50.

Selective COX-2 inhibitors suppress prostacyclin.

Skarke C, FitzGerald GA.

Clin Ther. 2014 Dec 1;36(12):2120-2121. doi: 10.1016/j.clinthera.2014.09.024. Epub 2014 Oct 23. No abstract available.

PMID:
25450471

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