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Items: 39

1.

Bacillus anthracis lethal toxin, but not edema toxin, increases pulmonary artery pressure and permeability in isolated perfused rat lungs.

Cui X, Xu W, Neupane P, Weiser-Schlesinger A, Weng R, Pockros B, Li Y, Moayeri M, Leppla SH, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2019 May 1;316(5):H1076-H1090. doi: 10.1152/ajpheart.00685.2018. Epub 2019 Feb 15.

PMID:
30767685
2.

Anthrax immune globulin improves hemodynamics and survival during B. anthracis toxin-induced shock in canines receiving titrated fluid and vasopressor support.

Suffredini DA, Cui X, Jaswal D, Remy KE, Li Y, Sun J, Solomon SB, Fitz Y, Moayeri M, Leppla S, Eichacker PQ.

Intensive Care Med Exp. 2017 Oct 23;5(1):48. doi: 10.1186/s40635-017-0159-9.

3.

Shock and lethality with anthrax edema toxin in rats are associated with reduced arterial responsiveness to phenylephrine and are reversed with adefovir.

Suffredini DA, Li Y, Xu W, Moayeri M, Leppla S, Fitz Y, Cui X, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H946-H958. doi: 10.1152/ajpheart.00285.2017. Epub 2017 Sep 8.

4.

Bacillus anthracis Edema Toxin Increases Fractional Free Water and Sodium Reabsorption in an Isolated Perfused Rat Kidney Model.

Jaswal DS, Cui X, Torabi-Parizi P, Ohanjanian L, Sampath-Kumar H, Fitz Y, Li Y, Xu W, Eichacker PQ.

Infect Immun. 2017 Jun 20;85(7). pii: e00264-17. doi: 10.1128/IAI.00264-17. Print 2017 Jul.

5.

Nitric oxide production contributes to Bacillus anthracis edema toxin-associated arterial hypotension and lethality: ex vivo and in vivo studies in the rat.

Li Y, Cui X, Xu W, Ohanjanian L, Sampath-Kumar H, Suffredini D, Moayeri M, Leppla S, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2016 Sep 1;311(3):H781-93. doi: 10.1152/ajpheart.00163.2016. Epub 2016 Jul 22.

6.

Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines.

Remy KE, Cui X, Li Y, Sun J, Solomon SB, Fitz Y, Barochia AV, Al-Hamad M, Moayeri M, Leppla SH, Eichacker PQ.

Intensive Care Med Exp. 2015 Dec;3(1):9. doi: 10.1186/s40635-015-0043-4. Epub 2015 Feb 28.

7.

Bacillus anthracis edema but not lethal toxin challenge in rats is associated with depressed myocardial function in hearts isolated and tested in a Langendorff system.

Li Y, Abu-Asab M, Su J, Qiu P, Feng J, Ohanjanian L, Kumar HS, Fitz Y, Eichacker PQ, Cui X.

Am J Physiol Heart Circ Physiol. 2015 Jun 15;308(12):H1592-602. doi: 10.1152/ajpheart.00851.2014. Epub 2015 Apr 10.

8.

Catheterization of the carotid artery and jugular vein to perform hemodynamic measures, infusions and blood sampling in a conscious rat model.

Feng J, Fitz Y, Li Y, Fernandez M, Cortes Puch I, Wang D, Pazniokas S, Bucher B, Cui X, Solomon SB.

J Vis Exp. 2015 Jan 30;(95). doi: 10.3791/51881.

9.

Purified cell wall from the probiotic bacterium Lactobacillus gasseri activates systemic inflammation and, at higher doses, produces lethality in a rat model.

Xu X, Hicks C, Li Y, Su J, Shiloach J, Kaufman JB, Fitz Y, Eichacker PQ, Cui X.

Crit Care. 2014 Jul 2;18(4):R140. doi: 10.1186/cc13966.

10.

Bacillus anthracis cell wall peptidoglycan but not lethal or edema toxins produces changes consistent with disseminated intravascular coagulation in a rat model.

Qiu P, Li Y, Shiloach J, Cui X, Sun J, Trinh L, Kubler-Kielb J, Vinogradov E, Mani H, Al-Hamad M, Fitz Y, Eichacker PQ.

J Infect Dis. 2013 Sep;208(6):978-89. doi: 10.1093/infdis/jit247. Epub 2013 Jun 3.

11.

B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model.

Li Y, Cui X, Solomon SB, Remy K, Fitz Y, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2013 Jul 15;305(2):H238-50. doi: 10.1152/ajpheart.00185.2013. Epub 2013 Apr 12.

12.

The individual survival benefits of tumor necrosis factor soluble receptor and fluid administration are not additive in a rat sepsis model.

Qiu P, Li Y, Ding Y, Weng J, Banks SM, Kern S, Fitz Y, Suffredini AF, Eichacker PQ, Cui X.

Intensive Care Med. 2011 Oct;37(10):1688-95. doi: 10.1007/s00134-011-2324-z. Epub 2011 Aug 30.

13.

Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.

Altaweel L, Chen Z, Moayeri M, Cui X, Li Y, Su J, Fitz Y, Johnson S, Leppla SH, Purcell R, Eichacker PQ.

Crit Care Med. 2011 Jun;39(6):1439-47. doi: 10.1097/CCM.0b013e3182120691.

14.

The effect of heparin administration in animal models of sepsis: a prospective study in Escherichia coli-challenged mice and a systematic review and metaregression analysis of published studies.

Li Y, Sun JF, Cui X, Mani H, Danner RL, Li X, Su JW, Fitz Y, Eichacker PQ.

Crit Care Med. 2011 May;39(5):1104-12. doi: 10.1097/CCM.0b013e31820eb718. Review.

15.

Anthrax edema toxin has cAMP-mediated stimulatory effects and high-dose lethal toxin has depressant effects in an isolated perfused rat heart model.

Hicks CW, Li Y, Okugawa S, Solomon SB, Moayeri M, Leppla SH, Mohanty A, Subramanian GM, Mignone TS, Fitz Y, Cui X, Eichacker PQ.

Am J Physiol Heart Circ Physiol. 2011 Mar;300(3):H1108-18. doi: 10.1152/ajpheart.01128.2010. Epub 2011 Jan 7.

16.

SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice.

Su J, Cui X, Li Y, Mani H, Ferreyra GA, Danner RL, Hsu LL, Fitz Y, Eichacker PQ.

J Trauma. 2010 Jun;68(6):1317-27. doi: 10.1097/TA.0b013e3181bb9cd3.

17.

Bacillus anthracis cell wall produces injurious inflammation but paradoxically decreases the lethality of anthrax lethal toxin in a rat model.

Cui X, Su J, Li Y, Shiloach J, Solomon S, Kaufman JB, Mani H, Fitz Y, Weng J, Altaweel L, Besch V, Eichacker PQ.

Intensive Care Med. 2010 Jan;36(1):148-56. doi: 10.1007/s00134-009-1643-9. Epub 2009 Sep 15.

18.

Norepinephrine increases blood pressure but not survival with anthrax lethal toxin in rats.

Li Y, Cui X, Su J, Haley M, Macarthur H, Sherer K, Moayeri M, Leppla SH, Fitz Y, Eichacker PQ.

Crit Care Med. 2009 Apr;37(4):1348-54. doi: 10.1097/CCM.0b013e31819cee38.

19.

Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice.

Su J, Li X, Cui X, Li Y, Fitz Y, Hsu L, Mani H, Quezado M, Eichacker PQ.

Crit Care Med. 2008 Apr;36(4):1059-67. doi: 10.1097/CCM.0B013E318164403B.

PMID:
18176313
20.

Risk of death does not alter the efficacy of hydrocortisone therapy in a mouse E. coli pneumonia model: risk and corticosteroids in sepsis.

Li Y, Cui X, Li X, Solomon SB, Danner RL, Banks SM, Fitz Y, Annane D, Natanson C, Eichacker PQ.

Intensive Care Med. 2008 Mar;34(3):568-77. Epub 2007 Nov 9.

PMID:
17992512
21.

Fluid support worsens outcome and negates the benefit of protective antigen-directed monoclonal antibody in a lethal toxin-infused rat Bacillus anthracis shock model.

Sherer K, Li Y, Cui X, Li X, Subramanian M, Laird MW, Moayeri M, Leppla SH, Fitz Y, Su J, Eichacker PQ.

Crit Care Med. 2007 Jun;35(6):1560-7.

PMID:
17452924
22.

Bacillus anthracis edema and lethal toxin have different hemodynamic effects but function together to worsen shock and outcome in a rat model.

Cui X, Li Y, Li X, Laird MW, Subramanian M, Moayeri M, Leppla SH, Fitz Y, Su J, Sherer K, Eichacker PQ.

J Infect Dis. 2007 Feb 15;195(4):572-80. Epub 2007 Jan 3.

PMID:
17230417
23.

DTPA Fe(III) decreases cytokines and hypotension but worsens survival with Escherichia coli sepsis in rats.

Li Y, Li X, Haley M, Fitz Y, Gerstenberger E, Banks SM, Eichacker PQ, Cui X.

Intensive Care Med. 2006 Aug;32(8):1263-70. Epub 2006 Jun 15.

PMID:
16775718
24.

Parthenolide has limited effects on nuclear factor-kappa beta increases and worsens survival in lipopolysaccharide-challenged C57BL/6J mice.

Li X, Cui X, Li Y, Fitz Y, Hsu L, Eichacker PQ.

Cytokine. 2006 Mar 21;33(6):299-308. Epub 2006 May 23.

PMID:
16720096
25.

Sublethal doses of Bacillus anthracis lethal toxin inhibit inflammation with lipopolysaccharide and Escherichia coli challenge but have opposite effects on survival.

Cui X, Li Y, Li X, Haley M, Moayeri M, Fitz Y, Leppla SH, Eichacker PQ.

J Infect Dis. 2006 Mar 15;193(6):829-40. Epub 2006 Feb 9.

PMID:
16479518
26.

Effective dosing of lipid A analogue E5564 in rats depends on the timing of treatment and the route of Escherichia coli infection.

Solomon SB, Cui X, Gerstenberger E, Danner RL, Fitz Y, Banks SM, Natanson C, Eichacker PQ.

J Infect Dis. 2006 Mar 1;193(5):634-44. Epub 2006 Jan 31.

PMID:
16453258
27.

Neutrophil inhibition with L-selectin-directed MAb improves or worsens survival dependent on the route but not severity of infection in a rat sepsis model.

Haley M, Parent C, Cui X, Kalil A, Fitz Y, Correa-Araujo R, Natanson C, Danner RL, Banks SM, Eichacker PQ.

J Appl Physiol (1985). 2005 Jun;98(6):2155-62. Epub 2005 Jan 27.

28.

Late treatment with a protective antigen-directed monoclonal antibody improves hemodynamic function and survival in a lethal toxin-infused rat model of anthrax sepsis.

Cui X, Li Y, Moayeri M, Choi GH, Subramanian GM, Li X, Haley M, Fitz Y, Feng J, Banks SM, Leppla SH, Eichacker PQ.

J Infect Dis. 2005 Feb 1;191(3):422-34. Epub 2004 Dec 22.

PMID:
15633102
29.

Granulocyte colony-stimulating factor has differing effects comparing intravascular versus extravascular models of sepsis.

Sevransky JE, Parent C, Cui X, Karzai W, Fitz Y, Banks SM, Gerstenberger E, Danner RL, Natanson C, Eichacker PQ.

J Trauma. 2004 Sep;57(3):618-25.

PMID:
15454812
30.

Severity of sepsis alters the effects of superoxide anion inhibition in a rat sepsis model.

Cui X, Parent C, Macarthur H, Ochs SD, Gerstenberg E, Solomon S, Fitz Y, Danner RL, Banks SM, Natanson C, Salvemini D, Eichacker PQ.

J Appl Physiol (1985). 2004 Oct;97(4):1349-57. Epub 2004 May 28.

31.

Lethality during continuous anthrax lethal toxin infusion is associated with circulatory shock but not inflammatory cytokine or nitric oxide release in rats.

Cui X, Moayeri M, Li Y, Li X, Haley M, Fitz Y, Correa-Araujo R, Banks SM, Leppla SH, Eichacker PQ.

Am J Physiol Regul Integr Comp Physiol. 2004 Apr;286(4):R699-709. Epub 2004 Jan 8.

32.

TGF-beta1 increases microbial clearance but worsens lung injury during Escherichia coli pneumonia in rats.

Cui X, Zeni F, Vodovitz Y, Correa-de-Araujo R, Quezado M, Roberts A, Wahl S, Danner RL, Banks SM, Gerstenberger E, Fitz Y, Natanson C, Eichacker PQ.

Cytokine. 2003 Nov 21;24(4):115-27.

PMID:
14572790
33.

Risk and the efficacy of antiinflammatory agents: retrospective and confirmatory studies of sepsis.

Eichacker PQ, Parent C, Kalil A, Esposito C, Cui X, Banks SM, Gerstenberger EP, Fitz Y, Danner RL, Natanson C.

Am J Respir Crit Care Med. 2002 Nov 1;166(9):1197-205.

PMID:
12403688
34.

Acute G-CSF therapy is not protective during lethal E. coli sepsis.

Quezado Z, Parent C, Karzai W, Depietro M, Natanson C, Hammond W, Danner RL, Cui X, Fitz Y, Banks SM, Gerstenberger E, Eichacker PQ.

Am J Physiol Regul Integr Comp Physiol. 2001 Oct;281(4):R1177-85.

35.

ICAM-1 and CD11b inhibition worsen outcome in rats with E. coli pneumonia.

Zeni F, Parent C, Correa R, Natanson C, Freeman B, Fontana J, Quezado M, Danner RL, Fitz Y, Richmond S, Gerstenberger E, Banks SM, Eichacker PQ.

J Appl Physiol (1985). 1999 Jul;87(1):299-307.

36.

Cardiopulmonary effects of inhaled nitric oxide in normal dogs and during E. coli pneumonia and sepsis.

Quezado ZM, Natanson C, Karzai W, Danner RL, Koev CA, Fitz Y, Dolan DP, Richmond S, Banks SM, Wilson L, Eichacker PQ.

J Appl Physiol (1985). 1998 Jan;84(1):107-15.

37.

rG-CSF reduces endotoxemia and improves survival during E. coli pneumonia.

Freeman BD, Quezado Z, Zeni F, Natanson C, Danner RL, Banks S, Quezado M, Fitz Y, Bacher J, Eichacker PQ.

J Appl Physiol (1985). 1997 Nov;83(5):1467-75.

38.

Serial measures of total body oxygen consumption in an awake canine model of septic shock.

Eichacker PQ, Hoffman WD, Danner RL, Banks SM, Richmond S, Fitz Y, Natanson C.

Am J Respir Crit Care Med. 1996 Jul;154(1):68-75.

PMID:
8680702
39.

Controlled trials of rG-CSF and CD11b-directed MAb during hyperoxia and E. coli pneumonia in rats.

Freeman BD, Correa R, Karzai W, Natanson C, Patterson M, Banks S, Fitz Y, Danner RL, Wilson L, Eichacker PQ.

J Appl Physiol (1985). 1996 Jun;80(6):2066-76.

PMID:
8806915

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