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Items: 1 to 50 of 52

1.

Using LC Retention Times in Organic Structure Determination: Drug Metabolite Identification.

Fitch WL, Khojasteh C, Aliagas I, Johnson K.

Drug Metab Lett. 2018;12(2):93-100. doi: 10.2174/1872312812666180802093347.

PMID:
30070179
2.

In vitro and in vivo metabolite identification of a novel benzimidazole compound ZLN005 by LC-MS/MS.

Sun W, Nguyen KD, Fitch WL, Banister SD, Tang H, Zhang X, Yu L, Engleman EG, Rajadas J.

Rapid Commun Mass Spectrom. 2018 Jan 15. doi: 10.1002/rcm.8060. [Epub ahead of print]

PMID:
29334584
3.

Small-Volume Injections: Evaluation of Volume Administration Deviation From Intended Injection Volumes.

Muffly MK, Chen MI, Claure RE, Drover DR, Efron B, Fitch WL, Hammer GB.

Anesth Analg. 2017 Oct;125(4):1192-1199. doi: 10.1213/ANE.0000000000001976.

PMID:
28338490
4.

Enhancing the Value of Expert Assistance in Pro Se Competence Determinations.

Fitch WL.

J Am Acad Psychiatry Law. 2016 Dec;44(4):437-441.

PMID:
28003387
5.

RRx-001: a systemically non-toxic M2-to-M1 macrophage stimulating and prosensitizing agent in Phase II clinical trials.

Oronsky B, Paulmurugan R, Foygel K, Scicinski J, Knox SJ, Peehl D, Zhao H, Ning S, Cabrales P, Summers TA Jr, Reid TR, Fitch WL, Kim MM, Trepel JB, Lee MJ, Kesari S, Abrouk ND, Day RM, Oronsky A, Ray CM, Carter CA.

Expert Opin Investig Drugs. 2017 Jan;26(1):109-119. doi: 10.1080/13543784.2017.1268600. Review. Erratum in: Expert Opin Investig Drugs. 2017 Feb;26(2):261. Carterg, Corey A [corrected to Carter, Corey A].

6.

Novel Series of Dihydropyridinone P2X7 Receptor Antagonists.

Lopez-Tapia F, Walker KA, Brotherton-Pleiss C, Caroon J, Nitzan D, Lowrie L, Gleason S, Zhao SH, Berger J, Cockayne D, Phippard D, Suttmann R, Fitch WL, Bourdet D, Rege P, Huang X, Broadbent S, Dvorak C, Zhu J, Wagner P, Padilla F, Loe B, Jahangir A, Alker A.

J Med Chem. 2015 Nov 12;58(21):8413-26. doi: 10.1021/acs.jmedchem.5b00365. Epub 2015 Nov 2.

PMID:
26460788
7.

Safety and activity of RRx-001 in patients with advanced cancer: a first-in-human, open-label, dose-escalation phase 1 study.

Reid T, Oronsky B, Scicinski J, Scribner CL, Knox SJ, Ning S, Peehl DM, Korn R, Stirn M, Carter CA, Oronsky A, Taylor MJ, Fitch WL, Cabrales P, Kim MM, Burris HA Rd, Lao CD, Abrouk NED, Fanger GR, Infante JR.

Lancet Oncol. 2015 Sep;16(9):1133-1142. doi: 10.1016/S1470-2045(15)00089-3. Epub 2015 Aug 19.

PMID:
26296952
8.

Reply: To PMID 25492070.

Norko MA, Fitch WL.

J Am Acad Psychiatry Law. 2015 Jun;43(2):263-4. No abstract available.

PMID:
26263569
9.

DSM-5 and substance use disorders: clinicolegal implications.

Norko MA, Fitch WL.

J Am Acad Psychiatry Law. 2014;42(4):443-52. Review.

PMID:
25492070
10.

Development of methods for the bioanalysis of RRx-001 and metabolites.

Scicinski J, Oronsky B, Cooper V, Taylor M, Alexander M, Hadar R, Cosford R, Fleischmann T, Fitch WL.

Bioanalysis. 2014 Apr;6(7):947-56. doi: 10.4155/bio.13.331.

PMID:
24806903
11.

Liquid chromatography/mass spectrometry methods for measuring dipeptide abundance in non-small-cell lung cancer.

Wu M, Xu Y, Fitch WL, Zheng M, Merritt RE, Shrager JB, Zhang W, Dill DL, Peltz G, Hoang CD.

Rapid Commun Mass Spectrom. 2013 Sep 30;27(18):2091-2098. doi: 10.1002/rcm.6656.

12.

Metabolomic-derived novel cyst fluid biomarkers for pancreatic cysts: glucose and kynurenine.

Park WG, Wu M, Bowen R, Zheng M, Fitch WL, Pai RK, Wodziak D, Visser BC, Poultsides GA, Norton JA, Banerjee S, Chen AM, Friedland S, Scott BA, Pasricha PJ, Lowe AW, Peltz G.

Gastrointest Endosc. 2013 Aug;78(2):295-302.e2. doi: 10.1016/j.gie.2013.02.037. Epub 2013 Apr 6.

13.

Using chimeric mice with humanized livers to predict human drug metabolism and a drug-drug interaction.

Nishimura T, Hu Y, Wu M, Pham E, Suemizu H, Elazar M, Liu M, Idilman R, Yurdaydin C, Angus P, Stedman C, Murphy B, Glenn J, Nakamura M, Nomura T, Chen Y, Zheng M, Fitch WL, Peltz G.

J Pharmacol Exp Ther. 2013 Feb;344(2):388-96. doi: 10.1124/jpet.112.198697. Epub 2012 Nov 8. Erratum in: J Pharmacol Exp Ther. 2013 May;345(2):327. Nishimura, Toshiko [corrected to Nishimura, Toshihiko].

14.

Identification of drug targets by chemogenomic and metabolomic profiling in yeast.

Wu M, Zheng M, Zhang W, Suresh S, Schlecht U, Fitch WL, Aronova S, Baumann S, Davis R, St Onge R, Dill DL, Peltz G.

Pharmacogenet Genomics. 2012 Dec;22(12):877-86. doi: 10.1097/FPC.0b013e32835aa888.

PMID:
23076370
15.

Preclinical evaluation of the metabolism and disposition of RRx-001, a novel investigative anticancer agent.

Scicinski J, Oronsky B, Taylor M, Luo G, Musick T, Marini J, Adams CM, Fitch WL.

Drug Metab Dispos. 2012 Sep;40(9):1810-6. doi: 10.1124/dmd.112.046755. Epub 2012 Jun 14.

PMID:
22699395
16.

Exploration of piperidine-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-Phenyl derivatives with broad potency against resistant mutant viruses.

Tang G, Kertesz DJ, Yang M, Lin X, Wang Z, Li W, Qiu Z, Chen J, Mei J, Chen L, Mirzadegan T, Harris SF, VillaseƱor AG, Fretland J, Fitch WL, Hang JQ, Heilek G, Klumpp K.

Bioorg Med Chem Lett. 2010 Oct 15;20(20):6020-3. doi: 10.1016/j.bmcl.2010.08.068. Epub 2010 Aug 19.

PMID:
20829038
17.

Application of modern drug metabolism structure determination tools and assays to the in vitro metabolism of imiloxan.

Fitch WL, Chen Y, Liu L, Paehler A, Young M.

Drug Metab Lett. 2010 Apr;4(2):77-87.

PMID:
20446913
18.

Revisiting the metabolism of ketoconazole using accurate mass.

Fitch WL, Tran T, Young M, Liu L, Chen Y.

Drug Metab Lett. 2009 Aug;3(3):191-8.

PMID:
19799546
19.

Comparison of in vitro bioactivation of flutamide and its cyano analogue: evidence for reductive activation by human NADPH:cytochrome P450 reductase.

Wen B, Coe KJ, Rademacher P, Fitch WL, Monshouwer M, Nelson SD.

Chem Res Toxicol. 2008 Dec;21(12):2393-406. doi: 10.1021/tx800281h.

20.

Metabolic activation of nevirapine in human liver microsomes: dehydrogenation and inactivation of cytochrome P450 3A4.

Wen B, Chen Y, Fitch WL.

Drug Metab Dispos. 2009 Jul;37(7):1557-62. doi: 10.1124/dmd.108.024851. Epub 2009 Apr 13.

PMID:
19364830
21.

Analytical strategies for the screening and evaluation of chemically reactive drug metabolites.

Wen B, Fitch WL.

Expert Opin Drug Metab Toxicol. 2009 Jan;5(1):39-55. doi: 10.1517/17425250802665706 . Review.

PMID:
19236228
22.
24.

Application of polarity switching in the identification of the metabolites of RO9237.

Fitch WL, He L, Tu YP, Alexandrova L.

Rapid Commun Mass Spectrom. 2007;21(10):1661-8.

PMID:
17465015
25.

Analytical tools and approaches for metabolite identification in early drug discovery.

Chen Y, Monshouwer M, Fitch WL.

Pharm Res. 2007 Feb;24(2):248-57. Epub 2006 Oct 18. Review.

PMID:
17048114
26.

Commentary: Atkins on a diet--a fit but lean guide for policy-makers.

Fitch WL.

J Am Acad Psychiatry Law. 2004;32(3):314-6. No abstract available.

PMID:
15515921
27.

Identification of glutathione-derived metabolites from an IP receptor antagonist.

Fitch WL, Berry PW, Tu Y, Tabatabaei A, Lowrie L, Lopez-Tapia F, Liu Y, Nitzan D, Masjedizadeh MR, Varadarajan A.

Drug Metab Dispos. 2004 Dec;32(12):1482-90. Epub 2004 Sep 15.

PMID:
15371298
28.

Agonists of the follicle stimulating hormone receptor from an encoded thiazolidinone library.

Maclean D, Holden F, Davis AM, Scheuerman RA, Yanofsky S, Holmes CP, Fitch WL, Tsutsui K, Barrett RW, Gallop MA.

J Comb Chem. 2004 Mar-Apr;6(2):196-206.

PMID:
15002967
29.
30.

Software for automating analysis of encoded combinatorial libraries.

Fitch WL, Zhang JJ, Shah N, Ouchi G, Wilgus RL, Muskal S.

Comb Chem High Throughput Screen. 2002 Nov;5(7):531-43.

PMID:
12470266
31.

Prediction of ultraviolet spectral absorbance using quantitative structure-property relationships.

Fitch WL, McGregor M, Katritzky AR, Lomaka A, Petrukhin R, Karelson M.

J Chem Inf Comput Sci. 2002 Jul-Aug;42(4):830-40.

PMID:
12132883
32.

Capillary electrochromatography-laser-induced fluorescence method for separation and detection of dansylated dialkylamine tags in encoded combinatorial libraries.

Liu X, Takahashi LH, Fitch WL, Rozing G, Bayle C, Couderc F.

J Chromatogr A. 2001 Jul 27;924(1-2):323-9.

PMID:
11521881
33.

On-line sample preparation for high throughput reversed-phase LC/MS analysis of combinatorial chemistry libraries.

Tang L, Fitch WL, Smith P, Tumelty D, Cao K, Ferla SW.

Comb Chem High Throughput Screen. 2001 May;4(3):287-93.

PMID:
11375743
34.

Law and the confinement of psychopaths.

Fitch WL, Ortega RJ.

Behav Sci Law. 2000;18(5):663-78.

PMID:
11113967
36.

A novel approach to high-throughput quality control of parallel synthesis libraries.

Shah N, Gao M, Tsutsui K, Lu A, Davis J, Scheuerman R, Fitch WL, Wilgus RL.

J Comb Chem. 2000 Sep-Oct;2(5):453-60.

PMID:
11029170
37.

Analytical methods for quality control of combinatorial libraries.

Fitch WL.

Mol Divers. 1998-1999;4(1):39-45. Review.

PMID:
10320988
38.

Forensic mental health clinical evaluation: an analysis of interstate and intersystemic differences.

Warren JI, Rosenfeld B, Fitch WL, Hawk G.

Law Hum Behav. 1997 Aug;21(4):377-90.

PMID:
9335195
39.

New methods for analyzing compounds on polymeric supports.

Gallop MA, Fitch WL.

Curr Opin Chem Biol. 1997 Jun;1(1):94-100. Review.

PMID:
9667832
40.

Beyond competence and sanity: the influence of pretrial evaluation on case disposition.

Warren JI, Rosenfeld B, Fitch WL.

Bull Am Acad Psychiatry Law. 1994;22(3):379-88.

PMID:
7841509
41.

Informed decision making in persons acquitted not guilty by reason of insanity.

Elliott RL, Nelson E, Fitch WL, Scott R, Wolber G, Singh R.

Bull Am Acad Psychiatry Law. 1993;21(3):309-20.

PMID:
8148513
42.

Criminal offense, psychiatric diagnosis, and psycholegal opinion: an analysis of 894 pretrial referrals.

Warren JI, Fitch WL, Dietz PE, Rosenfeld BD.

Bull Am Acad Psychiatry Law. 1991;19(1):63-9.

PMID:
2039849
43.

Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia.

Austin MA, Brunzell JD, Fitch WL, Krauss RM.

Arteriosclerosis. 1990 Jul-Aug;10(4):520-30.

PMID:
2369363
44.

Defective catabolism and abnormal composition of low-density lipoproteins from mutant pigs with hypercholesterolemia.

Checovich WJ, Fitch WL, Krauss RM, Smith MP, Rapacz J, Smith CL, Attie AD.

Biochemistry. 1988 Mar 22;27(6):1934-41.

PMID:
3378039
45.

Community-based forensic evaluation.

Fitch WL, Warren JI.

Int J Law Psychiatry. 1988;11(4):359-70. No abstract available.

PMID:
3248915
46.
48.

Nutrient utilization during pregnancy.

King JC, Bronstein MN, Fitch WL, Weininger J.

World Rev Nutr Diet. 1987;52:71-142. Review. No abstract available.

PMID:
3327234
49.

Measurement of urinary 3-methylhistidine with cationic-exchange resin.

Fitch WL, Watson JE, King JC.

Anal Biochem. 1986 May 1;154(2):632-7. Erratum in: Anal Biochem 1986 Oct;158(1):238.

PMID:
3728972
50.

Isolation, identification and quantitation of urinary organic acids.

Fitch WL, Anderson PJ, Smith DH.

J Chromatogr. 1979 Mar 1;162(3):249-59.

PMID:
528593

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