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Ambulatory Hemodialysis-Technology Landscape and Potential for Patient-Centered Treatment.

Hojs N, Fissell WH, Roy S.

Clin J Am Soc Nephrol. 2019 Nov 14. pii: CJN.01970219. doi: 10.2215/CJN.01970219. [Epub ahead of print] Review.


Treating the kidneys - a new era in the United States (and beyond).

Fissell WH, Roy S.

Nat Rev Nephrol. 2019 Dec;15(12):727-728. doi: 10.1038/s41581-019-0209-5. No abstract available.


Application of physiological shear stress to renal tubular epithelial cells.

Ferrell N, Sandoval RM, Molitoris BA, Brakeman P, Roy S, Fissell WH.

Methods Cell Biol. 2019;153:43-67. doi: 10.1016/bs.mcb.2019.04.010. Epub 2019 May 24.


Reassessment of Exosome Composition.

Jeppesen DK, Fenix AM, Franklin JL, Higginbotham JN, Zhang Q, Zimmerman LJ, Liebler DC, Ping J, Liu Q, Evans R, Fissell WH, Patton JG, Rome LH, Burnette DT, Coffey RJ.

Cell. 2019 Apr 4;177(2):428-445.e18. doi: 10.1016/j.cell.2019.02.029.


In vitro and in vivo hemocompatibility assessment of ultrathin sulfobetaine polymer coatings for silicon-based implants.

Iqbal Z, Kim S, Moyer J, Moses W, Abada E, Wright N, Kim EJ, Park J, Fissell WH, Vartanian S, Roy S.

J Biomater Appl. 2019 Aug;34(2):297-312. doi: 10.1177/0885328219831044. Epub 2019 Mar 12. No abstract available. Erratum in: J Biomater Appl. 2019 Jun 11;:885328219858450.


Substrate Elasticity Governs Differentiation of Renal Tubule Cells in Prolonged Culture.

Love HD, Ao M, Jorgensen S, Swearingen L, Ferrell N, Evans R, Gewin L, Harris RC, Zent R, Roy S, Fissell WH.

Tissue Eng Part A. 2019 Jul;25(13-14):1013-1022. doi: 10.1089/ten.TEA.2018.0182. Epub 2019 Jun 14.


Innovations in Wearable and Implantable Artificial Kidneys.

Salani M, Roy S, Fissell WH 4th.

Am J Kidney Dis. 2018 Nov;72(5):745-751. doi: 10.1053/j.ajkd.2018.06.005. Epub 2018 Aug 23. Review.


Beta-lactam carryover in arterial and central venous catheters is negligible.

Marsh E, Verhoven SM, Groszek JJ, Fissell WH, An G, Patel P, Creech B, Shotwell M.

Clin Chim Acta. 2018 Nov;486:265-268. doi: 10.1016/j.cca.2018.08.008. Epub 2018 Aug 15.


What Is the Glomerular Ultrafiltration Barrier?

Fissell WH, Miner JH.

J Am Soc Nephrol. 2018 Sep;29(9):2262-2264. doi: 10.1681/ASN.2018050490. Epub 2018 Jul 20. Review. No abstract available.


A Monte Carlo Simulation Approach for Beta-Lactam Dosing in Critically Ill Patients Receiving Prolonged Intermittent Renal Replacement Therapy.

Jang SM, Gharibian KN, Lewis SJ, Fissell WH, Tolwani AJ, Mueller BA.

J Clin Pharmacol. 2018 Oct;58(10):1254-1265. doi: 10.1002/jcph.1137. Epub 2018 May 10.


Therapeutic drug monitoring of piperacillin and tazobactam by RP-HPLC of residual blood specimens.

Verhoven SM, Groszek JJ, Fissell WH, Seegmiller A, Colby J, Patel P, Verstraete A, Shotwell M.

Clin Chim Acta. 2018 Jul;482:60-64. doi: 10.1016/j.cca.2018.03.021. Epub 2018 Mar 26.


Slit pores preferred over cylindrical pores for high selectivity in biomolecular filtration.

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S.

J Colloid Interface Sci. 2018 May 1;517:176-181. doi: 10.1016/j.jcis.2017.12.056. Epub 2017 Dec 20.


Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.

Buck AKW, Goebel SG, Goodin MS, Wright NJ, Groszek JJ, Moyer J, Singh S, Bluestein D, Fissell WH, Roy S.

J Biomech. 2018 Mar 1;69:26-33. doi: 10.1016/j.jbiomech.2018.01.014. Epub 2018 Jan 16.


Orbital Shear Stress Regulates Differentiation and Barrier Function of Primary Renal Tubular Epithelial Cells.

Ferrell N, Cheng J, Miao S, Roy S, Fissell WH.

ASAIO J. 2018 Nov/Dec;64(6):766-772. doi: 10.1097/MAT.0000000000000723.


The bridge between transplantation and regenerative medicine: Beginning a new Banff classification of tissue engineering pathology.

Solez K, Fung KC, Saliba KA, Sheldon VLC, Petrosyan A, Perin L, Burdick JF, Fissell WH, Demetris AJ, Cornell LD.

Am J Transplant. 2018 Feb;18(2):321-327. doi: 10.1111/ajt.14610. Epub 2018 Jan 16.


Sterilization effects on ultrathin film polymer coatings for silicon-based implantable medical devices.

Iqbal Z, Moses W, Kim S, Kim EJ, Fissell WH, Roy S.

J Biomed Mater Res B Appl Biomater. 2018 Aug;106(6):2327-2336. doi: 10.1002/jbm.b.34039. Epub 2017 Nov 6.


Silicon nanoporous membranes as a rigorous platform for validation of biomolecular transport models.

Feinberg BJ, Hsiao JC, Park J, Zydney AL, Fissell WH, Roy S.

J Memb Sci. 2017 Aug 15;536:44-51. doi: 10.1016/j.memsci.2017.04.030. Epub 2017 Apr 17.


Combined In Silico and In Vitro Approach Predicts Low Wall Shear Stress Regions in a Hemofilter that Correlate with Thrombus Formation In Vivo.

Buck AKW, Groszek JJ, Colvin DC, Keller SB, Kensinger C, Forbes R, Karp S, Williams P, Roy S, Fissell WH.

ASAIO J. 2018 Mar/Apr;64(2):211-217. doi: 10.1097/MAT.0000000000000649.


A distributed solute model: an extended two-pore model with application to the glomerular sieving of Ficoll.

Öberg CM, Groszek JJ, Roy S, Fissell WH, Rippe B.

Am J Physiol Renal Physiol. 2018 Jun 1;314(6):F1108-F1116. doi: 10.1152/ajprenal.00066.2017. Epub 2017 Apr 19.


A modular microfluidic bioreactor with improved throughput for evaluation of polarized renal epithelial cells.

Brakeman P, Miao S, Cheng J, Lee CZ, Roy S, Fissell WH, Ferrell N.

Biomicrofluidics. 2016 Nov 16;10(6):064106. eCollection 2016 Nov.


Acute Kidney Injury as a Risk Factor for Delirium and Coma during Critical Illness.

Siew ED, Fissell WH, Tripp CM, Blume JD, Wilson MD, Clark AJ, Vincz AJ, Ely EW, Pandharipande PP, Girard TD.

Am J Respir Crit Care Med. 2017 Jun 15;195(12):1597-1607. doi: 10.1164/rccm.201603-0476OC.


Introduction to Making Dialysis Adequate-Addressing its Limitations.

Fissell WH.

Semin Dial. 2016 Nov;29(6):423-424. doi: 10.1111/sdi.12545. Epub 2016 Sep 27. No abstract available.


Diffusive Silicon Nanopore Membranes for Hemodialysis Applications.

Kim S, Feinberg B, Kant R, Chui B, Goldman K, Park J, Moses W, Blaha C, Iqbal Z, Chow C, Wright N, Fissell WH, Zydney A, Roy S.

PLoS One. 2016 Jul 20;11(7):e0159526. doi: 10.1371/journal.pone.0159526. eCollection 2016.


Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT.

Shotwell MS, Nesbitt R, Madonia PN, Gould ER, Connor MJ, Salem C, Aduroja OA, Amde M, Groszek JJ, Wei P, Taylor ME, Tolwani AJ, Fissell WH.

Clin J Am Soc Nephrol. 2016 Aug 8;11(8):1377-83. doi: 10.2215/CJN.10260915. Epub 2016 May 19.


First Implantation of Silicon Nanopore Membrane Hemofilters.

Kensinger C, Karp S, Kant R, Chui BW, Goldman K, Yeager T, Gould ER, Buck A, Laneve DC, Groszek JJ, Roy S, Fissell WH.

ASAIO J. 2016 Jul-Aug;62(4):491-5. doi: 10.1097/MAT.0000000000000367.


Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A; American Society of Nephrology Acute Kidney Injury Advisory Group.

Am J Kidney Dis. 2016 Jul;68(1):19-28. doi: 10.1053/j.ajkd.2015.12.033. Epub 2016 Mar 4.


Preliminary Diffusive Clearance of Silicon Nanopore Membranes in a Parallel Plate Configuration for Renal Replacement Therapy.

Kim S, Heller J, Iqbal Z, Kant R, Kim EJ, Durack J, Saeed M, Do L, Hetts S, Wilson M, Brakeman P, Fissell WH, Roy S.

ASAIO J. 2016 Mar-Apr;62(2):169-75. doi: 10.1097/MAT.0000000000000311.


Bridging Translation by Improving Preclinical Study Design in AKI.

de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE Jr, Pullen N, Okusa MD, Faubel S; ASN AKI Advisory Group.

J Am Soc Nephrol. 2015 Dec;26(12):2905-16. doi: 10.1681/ASN.2015070832. Epub 2015 Nov 4. Review.


Optimal design of perturbations for individual two-compartment pharmacokinetic analysis.

Shotwell MS, Zhou M, Fissell WH.

J Biopharm Stat. 2016;26(5):803-15. doi: 10.1080/10543406.2015.1074918. Epub 2015 Aug 6.


Ciprofloxacin pharmacokinetics in critically ill patients receiving concomitant continuous venovenous hemodialysis.

Shotwell MS, Madonia PN, Connor MJ, Amde M, Salem C, Aduroja OA, Bauer SR, Groszek JJ, Fissell WH.

Am J Kidney Dis. 2015 Jul;66(1):173-5. doi: 10.1053/j.ajkd.2015.03.001. Epub 2015 Apr 23. No abstract available.


Shear stress is normalized in glomerular capillaries following ⅚ nephrectomy.

Ferrell N, Sandoval RM, Bian A, Campos-Bilderback SB, Molitoris BA, Fissell WH.

Am J Physiol Renal Physiol. 2015 Mar 15;308(6):F588-93. doi: 10.1152/ajprenal.00290.2014. Epub 2015 Jan 13.


Current strategies and challenges in engineering a bioartificial kidney.

Kim S, Fissell WH, Humes DH, Roy S.

Front Biosci (Elite Ed). 2015 Jan 1;7:215-28. Review.


Staying on target with continuous dialysis.

Demirjian S, Fissell WH.

Clin J Am Soc Nephrol. 2015 Jan 7;10(1):7-8. doi: 10.2215/CJN.11251114. Epub 2014 Dec 23. No abstract available.


Pharmacokinetic assessment in patients receiving continuous RRT: perspectives from the Kidney Health Initiative.

Nolin TD, Aronoff GR, Fissell WH, Jain L, Madabushi R, Reynolds K, Zhang L, Huang SM, Mehrotra R, Flessner MF, Leypoldt JK, Witcher JW, Zineh I, Archdeacon P, Roy-Chaudhury P, Goldstein SL; Kidney Health Initiative.

Clin J Am Soc Nephrol. 2015 Jan 7;10(1):159-64. doi: 10.2215/CJN.05630614. Epub 2014 Sep 4.


Imaging assessment of a portable hemodialysis device: detection of possible failure modes and monitoring of functional performance.

Olorunsola OG, Kim SH, Chang R, Kuo YC, Hetts SW, Heller A, Kant R, Saeed M, Fissell WH, Roy S, Wilson MW.

Med Instrum (Luton). 2014 Mar 27;2(2). doi: 10.7243/2052-6962-2-2.


Laboratory assays in renal failure: therapeutic drug monitoring.

Fissell WH.

Semin Dial. 2014 Nov-Dec;27(6):614-7. doi: 10.1111/sdi.12279. Epub 2014 Jul 3. No abstract available.


Hemodialysis: core curriculum 2014.

Golper TA, Fissell R, Fissell WH, Hartle PM, Sanders ML, Schulman G.

Am J Kidney Dis. 2014 Jan;63(1):153-63. doi: 10.1053/j.ajkd.2013.07.028. Epub 2013 Nov 19. No abstract available.


What is nanotechnology?

Fissell WH.

Adv Chronic Kidney Dis. 2013 Nov;20(6):452-3. doi: 10.1053/j.ackd.2013.08.008. No abstract available.


Pharmacokinetics and pharmacodynamics of imipenem and meropenem in critically ill patients treated with continuous venovenous hemodialysis.

Afshartous D, Bauer SR, Connor MJ, Aduroja OA, Amde M, Salem C, Groszek JJ, Fissell WH.

Am J Kidney Dis. 2014 Jan;63(1):170-1. doi: 10.1053/j.ajkd.2013.08.015. Epub 2013 Oct 19. No abstract available.


The bioartificial kidney: current status and future promise.

Humes HD, Buffington D, Westover AJ, Roy S, Fissell WH.

Pediatr Nephrol. 2014 Mar;29(3):343-51. doi: 10.1007/s00467-013-2467-y. Epub 2013 Apr 26. Review.


Effects of pressure and electrical charge on macromolecular transport across bovine lens basement membrane.

Ferrell N, Cameron KO, Groszek JJ, Hofmann CL, Li L, Smith RA, Bian A, Shintani A, Zydney AL, Fissell WH.

Biophys J. 2013 Apr 2;104(7):1476-84. doi: 10.1016/j.bpj.2013.01.062.


Achieving more frequent and longer dialysis for the majority: wearable dialysis and implantable artificial kidney devices.

Fissell WH, Roy S, Davenport A.

Kidney Int. 2013 Aug;84(2):256-64. doi: 10.1038/ki.2012.466. Epub 2013 Feb 13. Review.


Antimicrobial dosing in acute renal replacement.

Fissell WH.

Adv Chronic Kidney Dis. 2013 Jan;20(1):85-93. doi: 10.1053/j.ackd.2012.10.004. Review.


Intradialytic hypotension: a case for going slow and looking carefully.

Garg N, Fissell WH.

Nephrol Dial Transplant. 2013 Feb;28(2):247-9. doi: 10.1093/ndt/gfs316. Epub 2012 Jul 29. No abstract available.


Use of therapeutic drug monitoring to treat Elizabethkingia meningoseptica meningitis and bacteraemia in an adult.

Neuner EA, Ahrens CL, Groszek JJ, Isada C, Vogelbaum MA, Fissell WH, Bhimraj A.

J Antimicrob Chemother. 2012 Jun;67(6):1558-60. doi: 10.1093/jac/dks053. Epub 2012 Feb 22. No abstract available.


A low-cost automated streaming potential measurement system.

Smith RA, Fissell WH, Fleischman AJ, Zorman CA.

J Lab Autom. 2012 Apr;17(2):125-33. doi: 10.1177/2211068211425663. Epub 2012 Jan 24.


Illuminating the glomerular filtration barrier, two photons at a time.

Fissell WH.

J Am Soc Nephrol. 2012 Mar;23(3):373-5. doi: 10.1681/ASN.2012010067. Epub 2012 Feb 9. No abstract available.


Pharmacokinetics and pharmacodynamics of piperacillin-tazobactam in 42 patients treated with concomitant CRRT.

Bauer SR, Salem C, Connor MJ Jr, Groszek J, Taylor ME, Wei P, Tolwani AJ, Fissell WH.

Clin J Am Soc Nephrol. 2012 Mar;7(3):452-7. doi: 10.2215/CJN.10741011. Epub 2012 Jan 26.


Albumin handling by renal tubular epithelial cells in a microfluidic bioreactor.

Ferrell N, Ricci KB, Groszek J, Marmerstein JT, Fissell WH.

Biotechnol Bioeng. 2012 Mar;109(3):797-803. doi: 10.1002/bit.24339. Epub 2011 Nov 10.


Detectability of vasopressin in continuous venovenous hemodialysis effluent of patients with vasodilatory shock treated with exogenous arginine vasopressin.

Bauer SR, Culver DA, Abraham S, Lam SW, Fissell WH, Wiedemann HP, Reddy AJ.

Pharmacotherapy. 2011 Sep;31(9):857-62. doi: 10.1592/phco.31.9.857.


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