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RGS proteins as critical regulators of motor function and their implications in Parkinson's disease.

Ahlers-Dannen KE, Spicer MM, Fisher RA.

Mol Pharmacol. 2020 Feb 3. pii: mol.119.118836. doi: 10.1124/mol.119.118836. [Epub ahead of print]


Beyond Static Benchmarking: Using Experimental Manipulations to Evaluate Land Model Assumptions.

Wieder WR, Lawrence DM, Fisher RA, Bonan GB, Cheng SJ, Goodale CL, Grandy AS, Koven CD, Lombardozzi DL, Oleson KW, Thomas RQ.

Global Biogeochem Cycles. 2019 Oct;33(10):1289-1309. doi: 10.1029/2018GB006141. Epub 2019 Oct 28.


Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.

Perschbacher KJ, Deng G, Sandgren JA, Walsh JW, Witcher PC, Sapouckey SA, Owens CE, Zhang SY, Scroggins SM, Pearson NA, Devor EJ, Sebag JA, Pierce GL, Fisher RA, Kwitek AE, Santillan DA, Gibson-Corley KN, Sigmund CD, Santillan MK, Grobe JL.

Hypertension. 2020 Feb;75(2):569-579. doi: 10.1161/HYPERTENSIONAHA.119.14056. Epub 2019 Dec 23.


Lung metastases in low-risk gestational trophoblastic neoplasia: a retrospective cohort study.

Frijstein MM, Lok C, van Trommel NE, Ten Kate-Booij MJ, Massuger L, van Werkhoven E, Short D, Aguiar X, Fisher RA, Kaur B, Sarwar N, Sebire NJ, Seckl MJ.

BJOG. 2020 Feb;127(3):389-395. doi: 10.1111/1471-0528.16036. Epub 2019 Dec 20.


Food insecurity and obesity: research gaps, opportunities, and challenges.

Brown AGM, Esposito LE, Fisher RA, Nicastro HL, Tabor DC, Walker JR.

Transl Behav Med. 2019 Oct 1;9(5):980-987. doi: 10.1093/tbm/ibz117.


ABC-transporter upregulation mediates resistance to the CDK7 inhibitors THZ1 and ICEC0942.

Sava GP, Fan H, Fisher RA, Lusvarghi S, Pancholi S, Ambudkar SV, Martin LA, Charles Coombes R, Buluwela L, Ali S.

Oncogene. 2020 Jan;39(3):651-663. doi: 10.1038/s41388-019-1008-y. Epub 2019 Sep 17.


Anonymous live liver donor: the Good Samaritan Stranger.

Fisher RA.

Nat Rev Gastroenterol Hepatol. 2019 Nov;16(11):650-651. doi: 10.1038/s41575-019-0207-x. No abstract available.


A case of intraplacental gestational choriocarcinoma; characterised by the methylation pattern of the early placenta and an absence of driver mutations.

Savage P, Monk D, Hernandez Mora JR, van der Westhuizen N, Rauw J, Tinker A, Robinson W, Song Q, Seckl MJ, Fisher RA.

BMC Cancer. 2019 Jul 29;19(1):744. doi: 10.1186/s12885-019-5906-8.


Extramedullary leukemia behaving as solid cancer: clinical, histologic, and genetic clues to chemoresistance in organ sites.

Cunningham I, Hamele-Bena D, Guo Y, Shiomi T, Papp AC, Chakravarti B, Yang J, Shyr Y, Fisher RA.

Am J Hematol. 2019 Nov;94(11):1200-1207. doi: 10.1002/ajh.25594. Epub 2019 Aug 27.


Generation of fully functional hepatocyte-like organoids from human induced pluripotent stem cells mixed with Endothelial Cells.

Pettinato G, Lehoux S, Ramanathan R, Salem MM, He LX, Muse O, Flaumenhaft R, Thompson MT, Rouse EA, Cummings RD, Wen X, Fisher RA.

Sci Rep. 2019 Jun 20;9(1):8920. doi: 10.1038/s41598-019-45514-3.


Age-dependent nigral dopaminergic neurodegeneration and α-synuclein accumulation in RGS6-deficient mice.

Luo Z, Ahlers-Dannen KE, Spicer MM, Yang J, Alberico S, Stevens HE, Narayanan NS, Fisher RA.

JCI Insight. 2019 May 23;5. pii: 126769. doi: 10.1172/jci.insight.126769.


Intensified therapies improve survival and identification of novel prognostic factors for placental-site and epithelioid trophoblastic tumours.

Froeling FEM, Ramaswami R, Papanastasopoulos P, Kaur B, Sebire NJ, Short D, Fisher RA, Sarwar N, Wells M, Singh K, Ellis L, Horsman JM, Winter MC, Tidy J, Hancock BW, Seckl MJ.

Br J Cancer. 2019 Mar;120(6):587-594. doi: 10.1038/s41416-019-0402-0. Epub 2019 Feb 22.


The results of treatment with high-dose chemotherapy and peripheral blood stem cell support for gestational trophoblastic neoplasia.

Frijstein MM, Lok CAR, Short D, Singh K, Fisher RA, Hancock BW, Tidy JA, Sarwar N, Kanfer E, Winter MC, Savage PM, Seckl MJ.

Eur J Cancer. 2019 Mar;109:162-171. doi: 10.1016/j.ejca.2018.12.033. Epub 2019 Feb 4.


Do we need post-pregnancy screening with human chorionic gonadotrophin after previous hydatidiform mole to identify patients with recurrent gestational trophoblastic disease?

Earp KE, Hancock BW, Short D, Harvey RA, Fisher RA, Drew D, Sarwar N, Tidy JA, Winter MC, Chien P, Seckl MJ.

Eur J Obstet Gynecol Reprod Biol. 2019 Mar;234:117-119. doi: 10.1016/j.ejogrb.2018.12.029. Epub 2019 Jan 6.


Salmonella persisters undermine host immune defenses during antibiotic treatment.

Stapels DAC, Hill PWS, Westermann AJ, Fisher RA, Thurston TL, Saliba AE, Blommestein I, Vogel J, Helaine S.

Science. 2018 Dec 7;362(6419):1156-1160. doi: 10.1126/science.aat7148.


Diploid/triploid mixoploidy: A consequence of asymmetric zygotic segregation of parental genomes.

Carson JC, Hoffner L, Conlin L, Parks WT, Fisher RA, Spinner N, Yatsenko SA, Bonadio J, Surti U.

Am J Med Genet A. 2018 Dec;176(12):2720-2732. doi: 10.1002/ajmg.a.40646. Epub 2018 Oct 10.


New insights into the variability of the tropical land carbon cycle from the El Niño of 2015/2016.

Malhi Y, Rowland L, Aragão LEOC, Fisher RA.

Philos Trans R Soc Lond B Biol Sci. 2018 Oct 8;373(1760). pii: 20170298. doi: 10.1098/rstb.2017.0298. No abstract available.


Response to: "Colonic Interposition After Adult Oesophagectomy: Systematic Review and Meta-analysis of Conduit Choice and Outcome".

Fisher RA, Gossage J, Griffiths E.

J Gastrointest Surg. 2018 Nov;22(11):2002. doi: 10.1007/s11605-018-3909-4. Epub 2018 Aug 3. No abstract available.


Variation in hydroclimate sustains tropical forest biomass and promotes functional diversity.

Powell TL, Koven CD, Johnson DJ, Faybishenko B, Fisher RA, Knox RG, McDowell NG, Condit R, Hubbell SP, Wright SJ, Chambers JQ, Kueppers LM.

New Phytol. 2018 Aug;219(3):932-946. doi: 10.1111/nph.15271. Epub 2018 Jun 20.


Regulators of G protein signaling in cardiovascular function during pregnancy.

Perschbacher KJ, Deng G, Fisher RA, Gibson-Corley KN, Santillan MK, Grobe JL.

Physiol Genomics. 2018 Aug 1;50(8):590-604. doi: 10.1152/physiolgenomics.00037.2018. Epub 2018 Apr 27. Review.


Fatigue, Pain, and Other Physical Symptoms of Living Liver Donors in the Adult-to-Adult Living Donor Liver Transplantation Cohort Study.

Butt Z, DiMartini AF, Liu Q, Simpson MA, Smith AR, Zee J, Gillespie BW, Holtzman S, Ladner D, Olthoff K, Fisher RA, Hafliger S, Freise CE, Mandell MS, Sherker AH, Dew MA.

Liver Transpl. 2018 Sep;24(9):1221-1232. doi: 10.1002/lt.25185.


Posttransplant Lymphoproliferative Disorder Isolated to the Adrenal Gland in a Liver Transplant Patient.

Ghaziani TT, Liu JJ, Jiang ZG, Nasser I, Khwaja K, Fisher RA, Nahas M, Curry MP.

ACG Case Rep J. 2018 Jan 31;5:e10. doi: 10.14309/crj.2018.10. eCollection 2018.


Pembrolizumab is effective for drug-resistant gestational trophoblastic neoplasia.

Ghorani E, Kaur B, Fisher RA, Short D, Joneborg U, Carlson JW, Akarca A, Marafioti T, Quezada SA, Sarwar N, Seckl MJ.

Lancet. 2017 Nov 25;390(10110):2343-2345. doi: 10.1016/S0140-6736(17)32894-5. No abstract available.


Essentiality of Regulator of G Protein Signaling 6 and Oxidized Ca2+/Calmodulin-Dependent Protein Kinase II in Notch Signaling and Cardiovascular Development.

Chakravarti B, Yang J, Ahlers-Dannen KE, Luo Z, Flaherty HA, Meyerholz DK, Anderson ME, Fisher RA.

J Am Heart Assoc. 2017 Oct 27;6(11). pii: e007038. doi: 10.1161/JAHA.117.007038.


Vegetation demographics in Earth System Models: A review of progress and priorities.

Fisher RA, Koven CD, Anderegg WRL, Christoffersen BO, Dietze MC, Farrior CE, Holm JA, Hurtt GC, Knox RG, Lawrence PJ, Lichstein JW, Longo M, Matheny AM, Medvigy D, Muller-Landau HC, Powell TL, Serbin SP, Sato H, Shuman JK, Smith B, Trugman AT, Viskari T, Verbeeck H, Weng E, Xu C, Xu X, Zhang T, Moorcroft PR.

Glob Chang Biol. 2018 Jan;24(1):35-54. doi: 10.1111/gcb.13910. Epub 2017 Oct 24. Review.


Prevalence and Predictors of Patient-Reported Long-term Mental and Physical Health After Donation in the Adult-to-Adult Living-Donor Liver Transplantation Cohort Study.

Dew MA, Butt Z, Liu Q, Simpson MA, Zee J, Ladner DP, Holtzman S, Smith AR, Pomfret EA, Merion RM, Gillespie BW, Sherker AH, Fisher RA, Olthoff KM, Burton JR Jr, Terrault NA, Fox AN, DiMartini AF.

Transplantation. 2018 Jan;102(1):105-118. doi: 10.1097/TP.0000000000001942.


Surgical Management of Gallbladder Cancer: Simple Versus Extended Cholecystectomy and the Role of Adjuvant Therapy.

Kasumova GG, Tabatabaie O, Najarian RM, Callery MP, Ng SC, Bullock AJ, Fisher RA, Tseng JF.

Ann Surg. 2017 Oct;266(4):625-631. doi: 10.1097/SLA.0000000000002385.


Persistent bacterial infections and persister cells.

Fisher RA, Gollan B, Helaine S.

Nat Rev Microbiol. 2017 Aug;15(8):453-464. doi: 10.1038/nrmicro.2017.42. Epub 2017 May 22. Review.


Hepatic Hemodynamics and Portal Flow Modulation: The A2ALL Experience.

Emond JC, Goodrich NP, Pomposelli JJ, Baker TB, Humar A, Grant DR, Abt P, Friese CE, Fisher RA, Kam I, Sherker AH, Gillespie BW, Merion RM.

Transplantation. 2017 Oct;101(10):2375-2384. doi: 10.1097/TP.0000000000001823.


A national audit of colonic interposition for esophageal replacement.

Fisher RA, Griffiths EA, Evison F, Mason RC, Zylstra J, Davies AR, Alderson D, Gossage JA.

Dis Esophagus. 2017 May 1;30(5):1-10. doi: 10.1093/dote/dow003.


Living donor liver transplantation: eliminating the wait for death in end-stage liver disease?

Fisher RA.

Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):373-382. doi: 10.1038/nrgastro.2017.2. Epub 2017 Feb 15. Review.


Regulator of G Protein Signaling 6 Protects the Heart from Ischemic Injury.

Rorabaugh BR, Chakravarti B, Mabe NW, Seeley SL, Bui AD, Yang J, Watts SW, Neubig RR, Fisher RA.

J Pharmacol Exp Ther. 2017 Mar;360(3):409-416. doi: 10.1124/jpet.116.238345. Epub 2016 Dec 29.


The causes of human variability.

Fisher RA.

Int J Epidemiol. 2019 Feb;48(1):7-10. doi: 10.1093/ije/dyw315. Epub 2016 Dec 26. No abstract available.


Psychological Outcomes of Living Liver Donors From a Multicenter Prospective Study: Results From the Adult-to-Adult Living Donor Liver Transplantation Cohort Study2 (A2ALL-2).

Butt Z, Dew MA, Liu Q, Simpson MA, Smith AR, Zee J, Gillespie BW, Abbey SE, Ladner DP, Weinrieb R, Fisher RA, Hafliger S, Terrault N, Burton J, Sherker AH, DiMartini A.

Am J Transplant. 2017 May;17(5):1267-1277. doi: 10.1111/ajt.14134. Epub 2017 Jan 3.


Early Postoperative Pain and its Predictors in the Adult to Adult Living Donor Liver Transplantation Cohort Study.

Mandell MS, Smith AR, Dew MA, Gordon DB, Holtzman S, Howell T, DiMartini AF, Butt Z, Simpson MA, Ladner DP, Freise CE, McCluskey SA, Fisher RA, Guarrera JV, Olthoff KM, Pomfret EA.

Transplantation. 2016 Nov;100(11):2362-2371.


RGS6 is an essential tumor suppressor that prevents bladder carcinogenesis by promoting p53 activation and DNMT1 downregulation.

Yang J, Platt LT, Maity B, Ahlers KE, Luo Z, Lin Z, Chakravarti B, Ibeawuchi SR, Askeland RW, Bondaruk J, Czerniak BA, Fisher RA.

Oncotarget. 2016 Oct 25;7(43):69159-69172. doi: 10.18632/oncotarget.12473.


Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2).

DiMartini A, Dew MA, Liu Q, Simpson MA, Ladner DP, Smith AR, Zee J, Abbey S, Gillespie BW, Weinrieb R, Mandell MS, Fisher RA, Emond JC, Freise CE, Sherker AH, Butt Z.

Am J Transplant. 2017 Apr;17(4):1081-1096. doi: 10.1111/ajt.14055. Epub 2016 Nov 10.


Scalable Differentiation of Human iPSCs in a Multicellular Spheroid-based 3D Culture into Hepatocyte-like Cells through Direct Wnt/β-catenin Pathway Inhibition.

Pettinato G, Ramanathan R, Fisher RA, Mangino MJ, Zhang N, Wen X.

Sci Rep. 2016 Sep 12;6:32888. doi: 10.1038/srep32888.


Patterns of Early Allograft Dysfunction in Adult Live Donor Liver Transplantation: The A2ALL Experience.

Pomposelli JJ, Goodrich NP, Emond JC, Humar A, Baker TB, Grant DR, Fisher RA, Roberts JP, Olthoff KM, Gillespie BW, Merion RM.

Transplantation. 2016 Jul;100(7):1490-9. doi: 10.1097/TP.0000000000001240.


Molecular genotyping of placental site and epithelioid trophoblastic tumours; female predominance.

Zhao S, Sebire NJ, Kaur B, Seckl MJ, Fisher RA.

Gynecol Oncol. 2016 Sep;142(3):501-7. doi: 10.1016/j.ygyno.2016.05.033. Epub 2016 Jul 4.


Psychosocial Outcomes 3 to 10 Years After Donation in the Adult to Adult Living Donor Liver Transplantation Cohort Study.

Dew MA, DiMartini AF, Ladner DP, Simpson MA, Pomfret EA, Gillespie BW, Merion RM, Zee J, Smith AR, Holtzman S, Sherker AH, Weinrieb R, Fisher RA, Emond JC, Freise CE, Burton JR Jr, Butt Z.

Transplantation. 2016 Jun;100(6):1257-69. doi: 10.1097/TP.0000000000001144.


Risk of recurrent molar pregnancies following complete and partial hydatidiform moles.

Eagles N, Sebire NJ, Short D, Savage PM, Seckl MJ, Fisher RA.

Hum Reprod. 2016 Jun;31(6):1379. doi: 10.1093/humrep/dew079. Epub 2016 Apr 12. No abstract available.


RGS6 as a Novel Therapeutic Target in CNS Diseases and Cancer.

Ahlers KE, Chakravarti B, Fisher RA.

AAPS J. 2016 May;18(3):560-72. doi: 10.1208/s12248-016-9899-9. Epub 2016 Mar 22. Review.


Circulating Cell Free DNA in the Diagnosis of Trophoblastic Tumors.

Openshaw MR, Harvey RA, Sebire NJ, Kaur B, Sarwar N, Seckl MJ, Fisher RA.

EBioMedicine. 2015 Dec 29;4:146-52. doi: 10.1016/j.ebiom.2015.12.022. eCollection 2016 Feb.


Global-scale environmental control of plant photosynthetic capacity.

Ali AA, Xu C, Rogers A, McDowell NG, Medlyn BE, Fisher RA, Wullschleger SD, Reich PB, Vrugt JA, Bauerle WL, Santiago LS, Wilson CJ.

Ecol Appl. 2015 Dec;25(8):2349-65.


Abnormal villous morphology mimicking a hydatidiform mole associated with paternal trisomy of chromosomes 3,7,8 and unipaternal disomy of chromosome 11.

Sebire NJ, May PC, Kaur B, Seckl MJ, Fisher RA.

Diagn Pathol. 2016 Feb 4;11:20. doi: 10.1186/s13000-016-0471-9.


Paternal Hemizygosity in 11p15 in Mole-like Conceptuses: Two Case Reports.

Sunde L, Lund H, J Sebire N, Grove A, Fisher RA, Niemann I, Kjeldsen E, Andreasen L, Hansen ES, Bojesen A, Bolund L, Nyegaard M.

Medicine (Baltimore). 2015 Nov;94(44):e1776. doi: 10.1097/MD.0000000000001776.


Analysis of Macrophage-Induced Salmonella Persisters.

Fisher RA, Cheverton AM, Helaine S.

Methods Mol Biol. 2016;1333:177-87. doi: 10.1007/978-1-4939-2854-5_15.


Complications and Their Resolution in Recipients of Deceased and Living Donor Liver Transplants: Findings From the A2ALL Cohort Study.

Samstein B, Smith AR, Freise CE, Zimmerman MA, Baker T, Olthoff KM, Fisher RA, Merion RM.

Am J Transplant. 2016 Feb;16(2):594-602. doi: 10.1111/ajt.13479. Epub 2015 Oct 13.


Defining long-term outcomes with living donor liver transplantation in North America.

Olthoff KM, Smith AR, Abecassis M, Baker T, Emond JC, Berg CL, Beil CA, Burton JR Jr, Fisher RA, Freise CE, Gillespie BW, Grant DR, Humar A, Kam I, Merion RM, Pomfret EA, Samstein B, Shaked A.

Ann Surg. 2015 Sep;262(3):465-75; discussion 473-5. doi: 10.1097/SLA.0000000000001383.

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