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Catalytic Cycle of Glycoside Hydrolase BglX from Pseudomonas aeruginosa and Its Implications for Biofilm Formation.

Mahasenan KV, Batuecas MT, De Benedetti S, Kim C, Rana N, Lee M, Hesek D, Fisher JF, Sanz-Aparicio J, Hermoso JA, Mobashery S.

ACS Chem Biol. 2020 Jan 17;15(1):189-196. doi: 10.1021/acschembio.9b00754. Epub 2020 Jan 7.


Constructing and deconstructing the bacterial cell wall.

Fisher JF, Mobashery S.

Protein Sci. 2019 Oct 6. doi: 10.1002/pro.3737. [Epub ahead of print] Review.


Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams against Methicillin-Resistant Staphylococcus aureus.

Speri E, Kim C, De Benedetti S, Qian Y, Lastochkin E, Fishovitz J, Fisher JF, Mobashery S.

ACS Med Chem Lett. 2019 Jul 1;10(8):1148-1153. doi: 10.1021/acsmedchemlett.9b00169. eCollection 2019 Aug 8.


Slt, MltD, and MltG of Pseudomonas aeruginosa as Targets of Bulgecin A in Potentiation of β-Lactam Antibiotics.

Dik DA, Madukoma CS, Tomoshige S, Kim C, Lastochkin E, Boggess WC, Fisher JF, Shrout JD, Mobashery S.

ACS Chem Biol. 2019 Feb 15;14(2):296-303. doi: 10.1021/acschembio.8b01025. Epub 2019 Jan 18.


A Structural Dissection of the Active Site of the Lytic Transglycosylase MltE from Escherichia coli.

Dik DA, Batuecas MT, Lee M, Mahasenan KV, Marous DR, Lastochkin E, Fisher JF, Hermoso JA, Mobashery S.

Biochemistry. 2018 Oct 23;57(42):6090-6098. doi: 10.1021/acs.biochem.8b00800. Epub 2018 Oct 10.


A positive positive to negative.

Fisher JF, Mobashery S.

Nat Chem. 2018 Oct;10(10):998-1000. doi: 10.1038/s41557-018-0148-y. No abstract available.


Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.

Dik DA, Fisher JF, Mobashery S.

Chem Rev. 2018 Jun 27;118(12):5952-5984. doi: 10.1021/acs.chemrev.8b00277. Epub 2018 May 30. Review.


Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the β-Lactam Antibiotics.

Tomoshige S, Dik DA, Akabane-Nakata M, Madukoma CS, Fisher JF, Shrout JD, Mobashery S.

ACS Infect Dis. 2018 Jun 8;4(6):860-867. doi: 10.1021/acsinfecdis.8b00105. Epub 2018 May 7.


Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly.

Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.

Sci Rep. 2018 Mar 7;8(1):4110. doi: 10.1038/s41598-018-22527-y.


Synthesis and shift-reagent-assisted full NMR assignment of bacterial (Z8,E2,ω)-undecaprenol.

Lee M, Hesek D, Zajíček J, Fisher JF, Mobashery S.

Chem Commun (Camb). 2017 Nov 28;53(95):12774-12777. doi: 10.1039/c7cc06781j.


Lytic transglycosylases: concinnity in concision of the bacterial cell wall.

Dik DA, Marous DR, Fisher JF, Mobashery S.

Crit Rev Biochem Mol Biol. 2017 Oct;52(5):503-542. doi: 10.1080/10409238.2017.1337705. Epub 2017 Jun 23. Review.


From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas aeruginosa.

Lee M, Hesek D, Dik DA, Fishovitz J, Lastochkin E, Boggess B, Fisher JF, Mobashery S.

Angew Chem Int Ed Engl. 2017 Mar 1;56(10):2735-2739. doi: 10.1002/anie.201611279. Epub 2017 Jan 27.


Conformational Dynamics in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus, Allosteric Communication Network and Enablement of Catalysis.

Mahasenan KV, Molina R, Bouley R, Batuecas MT, Fisher JF, Hermoso JA, Chang M, Mobashery S.

J Am Chem Soc. 2017 Feb 8;139(5):2102-2110. doi: 10.1021/jacs.6b12565. Epub 2017 Jan 27.


Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.

Dik DA, Domínguez-Gil T, Lee M, Hesek D, Byun B, Fishovitz J, Boggess B, Hellman LM, Fisher JF, Hermoso JA, Mobashery S.

J Am Chem Soc. 2017 Feb 1;139(4):1448-1451. doi: 10.1021/jacs.6b12819. Epub 2017 Jan 17.


Endless Resistance. Endless Antibiotics?

Fisher JF, Mobashery S.

Medchemcomm. 2016 Jan 1;7(1):37-49. Epub 2015 Nov 3.


Pulmonary Cryptococcosis in the Immunocompetent Patient-Many Questions, Some Answers.

Fisher JF, Valencia-Rey PA, Davis WB.

Open Forum Infect Dis. 2016 Sep 3;3(3):ofw167. eCollection 2016 Sep. Erratum in: Open Forum Infect Dis. 2017 Jan 31;4(1):ofw218.


Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.

Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA.

Structure. 2016 Oct 4;24(10):1729-1741. doi: 10.1016/j.str.2016.07.019. Epub 2016 Sep 8.


Ensemble of Pinanones from the Permanganate Oxidation of Myrtenal.

Clay JM, Hesek D, Oliver AG, Lee M, Fisher JF.

J Org Chem. 2016 Jul 1;81(13):5705-9. doi: 10.1021/acs.joc.6b00756. Epub 2016 Jun 23.


Permanent resident.

Fisher JF.

Med Educ Online. 2016 May 17;21:31160. doi: 10.3402/meo.v21.31160. eCollection 2016.


β-Lactam Resistance Mechanisms: Gram-Positive Bacteria and Mycobacterium tuberculosis.

Fisher JF, Mobashery S.

Cold Spring Harb Perspect Med. 2016 May 2;6(5). pii: a025221. doi: 10.1101/cshperspect.a025221. Review.


Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.

Leemans E, Mahasenan KV, Kumarasiri M, Spink E, Ding D, O'Daniel PI, Boudreau MA, Lastochkin E, Testero SA, Yamaguchi T, Lee M, Hesek D, Fisher JF, Chang M, Mobashery S.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):1011-1015. doi: 10.1016/j.bmcl.2015.12.041. Epub 2015 Dec 12.


Regioselective Control of the SNAr Amination of 5-Substituted-2,4-Dichloropyrimidines Using Tertiary Amine Nucleophiles.

Lee M, Rucil T, Hesek D, Oliver AG, Fisher JF, Mobashery S.

J Org Chem. 2015 Aug 7;80(15):7757-63. doi: 10.1021/acs.joc.5b01044. Epub 2015 Jul 17.


The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA).

Fishovitz J, Taghizadeh N, Fisher JF, Chang M, Mobashery S.

J Am Chem Soc. 2015 May 27;137(20):6500-5. doi: 10.1021/jacs.5b01374. Epub 2015 May 18.


[Prosthetic hip infection due to Listeria monocytogenes: review of the literature and case report].

Hessler R, Lunebourg A, Fisher JF, Trachsel S, Cometta A.

Rev Med Suisse. 2014 Nov 12;10(450):2164-7. Review. French.


Catalytic spectrum of the penicillin-binding protein 4 of Pseudomonas aeruginosa, a nexus for the induction of β-lactam antibiotic resistance.

Lee M, Hesek D, Blázquez B, Lastochkin E, Boggess B, Fisher JF, Mobashery S.

J Am Chem Soc. 2015 Jan 14;137(1):190-200. doi: 10.1021/ja5111706. Epub 2014 Dec 31.


Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli.

Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA.

ACS Chem Biol. 2014 Sep 19;9(9):2058-66. doi: 10.1021/cb500439c. Epub 2014 Jul 10.


The sentinel role of peptidoglycan recycling in the β-lactam resistance of the Gram-negative Enterobacteriaceae and Pseudomonas aeruginosa.

Fisher JF, Mobashery S.

Bioorg Chem. 2014 Oct;56:41-8. doi: 10.1016/j.bioorg.2014.05.011. Epub 2014 Jun 4. Review. Erratum in: Bioorg Chem. 2014 Aug ;55:78.


Protonation states of active-site lysines of penicillin-binding protein 6 from Escherichia coli and the mechanistic implications.

Kumarasiri M, Zhang W, Shi Q, Fisher JF, Mobashery S.

Proteins. 2014 Jul;82(7):1348-58. doi: 10.1002/prot.24501. Epub 2014 Feb 6.


Acquired Class D β-Lactamases.

Antunes NT, Fisher JF.

Antibiotics (Basel). 2014 Aug 21;3(3):398-434. doi: 10.3390/antibiotics3030398. Review.


Recreational vehicle water tanks as a possible source for legionella infections.

Litwin CM, Asebiomo B, Wilson K, Hafez M, Stevens V, Fliermans CB, Fields BS, Fisher JF.

Case Rep Infect Dis. 2013;2013:286347. doi: 10.1155/2013/286347. Epub 2013 Nov 26.


Use of silver carbonate in the Wittig reaction.

Jedinak L, Rush L, Lee M, Hesek D, Fisher JF, Boggess B, Noll BC, Mobashery S.

J Org Chem. 2013 Dec 6;78(23):12224-8. doi: 10.1021/jo401972a. Epub 2013 Nov 26.


How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.

Otero LH, Rojas-Altuve A, Llarrull LI, Carrasco-López C, Kumarasiri M, Lastochkin E, Fishovitz J, Dawley M, Hesek D, Lee M, Johnson JW, Fisher JF, Chang M, Mobashery S, Hermoso JA.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16808-13. doi: 10.1073/pnas.1300118110. Epub 2013 Oct 1.


Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in β-lactam resistance.

Smith JD, Kumarasiri M, Zhang W, Hesek D, Lee M, Toth M, Vakulenko S, Fisher JF, Mobashery S, Chen Y.

Antimicrob Agents Chemother. 2013 Jul;57(7):3137-46. doi: 10.1128/AAC.00505-13. Epub 2013 Apr 29.


Bacterial cell-wall recycling.

Johnson JW, Fisher JF, Mobashery S.

Ann N Y Acad Sci. 2013 Jan;1277:54-75. doi: 10.1111/j.1749-6632.2012.06813.x. Epub 2012 Nov 16. Review.


Evaluation of salvage techniques for infected baclofen pumps in pediatric patients with cerebral palsy.

Hester SM, Fisher JF, Lee MR, Macomson S, Vender JR.

J Neurosurg Pediatr. 2012 Dec;10(6):548-54. doi: 10.3171/2012.9.PEDS12121. Epub 2012 Oct 5.


Synthesis and NMR characterization of (Z,Z,Z,Z,E,E,ω)-heptaprenol.

Hesek D, Lee M, Zajíček J, Fisher JF, Mobashery S.

J Am Chem Soc. 2012 Aug 22;134(33):13881-8. doi: 10.1021/ja306184m. Epub 2012 Aug 10.


Inhibitors for Bacterial Cell-Wall Recycling.

Yamaguchi T, Blázquez B, Hesek D, Lee M, Llarrull LI, Boggess B, Oliver AG, Fisher JF, Mobashery S.

ACS Med Chem Lett. 2012 Mar 8;3(3):238-242. Epub 2012 Jan 19.


Messenger functions of the bacterial cell wall-derived muropeptides.

Boudreau MA, Fisher JF, Mobashery S.

Biochemistry. 2012 Apr 10;51(14):2974-90. doi: 10.1021/bi300174x. Epub 2012 Mar 27. Review.


Epidemiological expansion, structural studies, and clinical challenges of new β-lactamases from gram-negative bacteria.

Bush K, Fisher JF.

Annu Rev Microbiol. 2011;65:455-78. doi: 10.1146/annurev-micro-090110-102911. Review.


Candida urinary tract infections--treatment.

Fisher JF, Sobel JD, Kauffman CA, Newman CA.

Clin Infect Dis. 2011 May;52 Suppl 6:S457-66. doi: 10.1093/cid/cir112.


Candida urinary tract infections--diagnosis.

Kauffman CA, Fisher JF, Sobel JD, Newman CA.

Clin Infect Dis. 2011 May;52 Suppl 6:S452-6. doi: 10.1093/cid/cir111. Review.


Candida urinary tract infection: pathogenesis.

Fisher JF, Kavanagh K, Sobel JD, Kauffman CA, Newman CA.

Clin Infect Dis. 2011 May;52 Suppl 6:S437-51. doi: 10.1093/cid/cir110.


Candida urinary tract infections--epidemiology.

Sobel JD, Fisher JF, Kauffman CA, Newman CA.

Clin Infect Dis. 2011 May;52 Suppl 6:S433-6. doi: 10.1093/cid/cir109.


Candida urinary tract infections--epidemiology, pathogenesis, diagnosis, and treatment: executive summary.

Fisher JF.

Clin Infect Dis. 2011 May;52 Suppl 6:S429-32. doi: 10.1093/cid/cir108.


A computational evaluation of the mechanism of penicillin-binding protein-catalyzed cross-linking of the bacterial cell wall.

Shi Q, Meroueh SO, Fisher JF, Mobashery S.

J Am Chem Soc. 2011 Apr 13;133(14):5274-83. doi: 10.1021/ja1074739. Epub 2011 Mar 18.


Exploration of mild copper-mediated coupling of organotrifluoroborates in the synthesis of thiirane-based inhibitors of matrix metalloproteinases.

Testero SA, Bouley R, Fisher JF, Chang M, Mobashery S.

Bioorg Med Chem Lett. 2011 May 1;21(9):2675-8. doi: 10.1016/j.bmcl.2010.12.076. Epub 2010 Dec 29.


QM/MM Studies of the Matrix Metalloproteinase 2 (MMP2) Inhibition Mechanism of (S)-SB-3CT and its Oxirane Analogue.

Zhou J, Tao P, Fisher JF, Shi Q, Mobashery S, Schlegel HB.

J Chem Theory Comput. 2010 Nov 9;6(11):3580-3587.


The future of the β-lactams.

Llarrull LI, Testero SA, Fisher JF, Mobashery S.

Curr Opin Microbiol. 2010 Oct;13(5):551-7. doi: 10.1016/j.mib.2010.09.008. Epub 2010 Sep 29. Review.


Unsuspected polymicrobial brain abscess arising from an intra-abdominal source in a patient with hereditary hemorrhagic telangiectasia.

Diaz M, Cuellar J, Valencia-Rey PA, Fisher JF.

South Med J. 2010 Aug;103(8):842-4. doi: 10.1097/SMJ.0b013e3181e6d16e.


Effects of rib raising on the autonomic nervous system: a pilot study using noninvasive biomarkers.

Henderson AT, Fisher JF, Blair J, Shea C, Li TS, Bridges KG.

J Am Osteopath Assoc. 2010 Jun;110(6):324-30.


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