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Uses for humanised mouse models in precision medicine for neurodegenerative disease.

Nair RR, Corrochano S, Gasco S, Tibbit C, Thompson D, Maduro C, Ali Z, Fratta P, Arozena AA, Cunningham TJ, Fisher EMC.

Mamm Genome. 2019 Jun 15. doi: 10.1007/s00335-019-09807-2. [Epub ahead of print] Review.


Gene expression dysregulation domains are not a specific feature of Down syndrome.

Ahlfors H, Anyanwu N, Pakanavicius E, Dinischiotu N, Lana-Elola E, Watson-Scales S, Tosh J, Wiseman F, Briscoe J, Page K, Fisher EMC, Tybulewicz VLJ.

Nat Commun. 2019 Jun 6;10(1):2489. doi: 10.1038/s41467-019-10129-9.


Mouse models of neurodegeneration: Know your question, know your mouse.

Fisher EMC, Bannerman DM.

Sci Transl Med. 2019 May 22;11(493). pii: eaaq1818. doi: 10.1126/scitranslmed.aaq1818. Review.


Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.

Granno S, Nixon-Abell J, Berwick DC, Tosh J, Heaton G, Almudimeegh S, Nagda Z, Rain JC, Zanda M, Plagnol V, Tybulewicz VLJ, Cleverley K, Wiseman FK, Fisher EMC, Harvey K.

Sci Rep. 2019 May 13;9(1):7322. doi: 10.1038/s41598-019-43820-4.


Humanising the mouse genome piece by piece.

Zhu F, Nair RR, Fisher EMC, Cunningham TJ.

Nat Commun. 2019 Apr 23;10(1):1845. doi: 10.1038/s41467-019-09716-7. Review.


A Control Banding Framework for Protecting the US Workforce from Aerosol Transmissible Infectious Disease Outbreaks with High Public Health Consequences.

Sietsema M, Radonovich L, Hearl FJ, Fisher EM, Brosseau LM, Shaffer RE, Koonin LM.

Health Secur. 2019 Mar/Apr;17(2):124-132. doi: 10.1089/hs.2018.0103. Epub 2019 Apr 3.


Transgenic and physiological mouse models give insights into different aspects of amyotrophic lateral sclerosis.

De Giorgio F, Maduro C, Fisher EMC, Acevedo-Arozena A.

Dis Model Mech. 2019 Jan 2;12(1). pii: dmm037424. doi: 10.1242/dmm.037424. Review.


Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years.

Hithersay R, Startin CM, Hamburg S, Mok KY, Hardy J, Fisher EMC, Tybulewicz VLJ, Nizetic D, Strydom A.

JAMA Neurol. 2019 Feb 1;76(2):152-160. doi: 10.1001/jamaneurol.2018.3616.


TDP-43 mutations increase HNRNP A1-7B through gain of splicing function.

Sivakumar P, De Giorgio F, Ule AM, Neeves J, Nair RR, Bentham M, Birsa N, Humphrey J, Plagnol V, Acevedo-Arozena A, Cunningham TJ, Fisher EMC, Fratta P.

Brain. 2018 Dec 1;141(12):e83. doi: 10.1093/brain/awy260. No abstract available.


The integration site of the APP transgene in the J20 mouse model of Alzheimer's disease.

Tosh JL, Rickman M, Rhymes E, Norona FE, Clayton E, Mucke L, Isaacs AM, Fisher EMC, Wiseman FK.

Version 2. Wellcome Open Res. 2018 Oct 10 [revised 2018 Jan 1];2:84. doi: 10.12688/wellcomeopenres.12237.2. eCollection 2017.


Healthcare personnel exposure in an emergency department during influenza season.

Rule AM, Apau O, Ahrenholz SH, Brueck SE, Lindsley WG, de Perio MA, Noti JD, Shaffer RE, Rothman R, Grigorovitch A, Noorbakhsh B, Beezhold DH, Yorio PL, Perl TM, Fisher EM.

PLoS One. 2018 Aug 31;13(8):e0203223. doi: 10.1371/journal.pone.0203223. eCollection 2018.


Assessment of environmental and surgical mask contamination at a student health center - 2012-2013 influenza season.

Ahrenholz SH, Brueck SE, Rule AM, Noti JD, Noorbakhsh B, Blachere FM, de Perio MA, Lindsley WG, Shaffer RE, Fisher EM.

J Occup Environ Hyg. 2018 Sep;15(9):664-675. doi: 10.1080/15459624.2018.1486509.


Assessment of influenza virus exposure and recovery from contaminated surgical masks and N95 respirators.

Blachere FM, Lindsley WG, McMillen CM, Beezhold DH, Fisher EM, Shaffer RE, Noti JD.

J Virol Methods. 2018 Oct;260:98-106. doi: 10.1016/j.jviromet.2018.05.009. Epub 2018 Jul 17.


Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP.

Wiseman FK, Pulford LJ, Barkus C, Liao F, Portelius E, Webb R, Chávez-Gutiérrez L, Cleverley K, Noy S, Sheppard O, Collins T, Powell C, Sarell CJ, Rickman M, Choong X, Tosh JL, Siganporia C, Whittaker HT, Stewart F, Szaruga M; London Down syndrome consortium, Murphy MP, Blennow K, de Strooper B, Zetterberg H, Bannerman D, Holtzman DM, Tybulewicz VLJ, Fisher EMC; LonDownS Consortium.

Brain. 2018 Aug 1;141(8):2457-2474. doi: 10.1093/brain/awy159. Erratum in: Brain. 2019 Jun 1;142(6):e25.


Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis.

Fratta P, Sivakumar P, Humphrey J, Lo K, Ricketts T, Oliveira H, Brito-Armas JM, Kalmar B, Ule A, Yu Y, Birsa N, Bodo C, Collins T, Conicella AE, Mejia Maza A, Marrero-Gagliardi A, Stewart M, Mianne J, Corrochano S, Emmett W, Codner G, Groves M, Fukumura R, Gondo Y, Lythgoe M, Pauws E, Peskett E, Stanier P, Teboul L, Hallegger M, Calvo A, Chiò A, Isaacs AM, Fawzi NL, Wang E, Housman DE, Baralle F, Greensmith L, Buratti E, Plagnol V, Fisher EM, Acevedo-Arozena A.

EMBO J. 2018 Jun 1;37(11). pii: e98684. doi: 10.15252/embj.201798684. Epub 2018 May 15.


Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.

Watson-Scales S, Kalmar B, Lana-Elola E, Gibbins D, La Russa F, Wiseman F, Williamson M, Saccon R, Slender A, Olerinyova A, Mahmood R, Nye E, Cater H, Wells S, Yu YE, Bennett DLH, Greensmith L, Fisher EMC, Tybulewicz VLJ.

PLoS Genet. 2018 May 10;14(5):e1007383. doi: 10.1371/journal.pgen.1007383. eCollection 2018 May.


Do I take the job?: Assessing fit with the organization.

Fisher EM, Wilmoth MC.

J Prof Nurs. 2018 Mar - Apr;34(2):82-86. doi: 10.1016/j.profnurs.2017.08.003. Epub 2017 Aug 12.


In vivo and ex vivo analyses of amyloid toxicity in the Tc1 mouse model of Down syndrome.

Naert G, Ferré V, Keller E, Slender A, Gibbins D, Fisher EM, Tybulewicz VL, Maurice T.

J Psychopharmacol. 2018 Feb;32(2):174-190. doi: 10.1177/0269881117743484. Epub 2017 Dec 7.


Humanized mutant FUS drives progressive motor neuron degeneration without aggregation in 'FUSDelta14' knockin mice.

Devoy A, Kalmar B, Stewart M, Park H, Burke B, Noy SJ, Redhead Y, Humphrey J, Lo K, Jaeger J, Mejia Maza A, Sivakumar P, Bertolin C, Soraru G, Plagnol V, Greensmith L, Acevedo Arozena A, Isaacs AM, Davies B, Fratta P, Fisher EMC.

Brain. 2017 Nov 1;140(11):2797-2805. doi: 10.1093/brain/awx248.


Rodent models in Down syndrome research: impact and future opportunities.

Herault Y, Delabar JM, Fisher EMC, Tybulewicz VLJ, Yu E, Brault V.

Dis Model Mech. 2017 Oct 1;10(10):1165-1186. doi: 10.1242/dmm.029728. Review.


Transfer of bacteriophage MS2 and fluorescein from N95 filtering facepiece respirators to hands: Measuring fomite potential.

Brady TM, Strauch AL, Almaguer CM, Niezgoda G, Shaffer RE, Yorio PL, Fisher EM.

J Occup Environ Hyg. 2017 Nov;14(11):898-906. doi: 10.1080/15459624.2017.1346799.


Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models.

Dekker AD, Vermeiren Y, Albac C, Lana-Elola E, Watson-Scales S, Gibbins D, Aerts T, Van Dam D, Fisher EMC, Tybulewicz VLJ, Potier MC, De Deyn PP.

Neurobiol Dis. 2017 Sep;105:235-244. doi: 10.1016/j.nbd.2017.06.007. Epub 2017 Jun 15.


Comparison of In Vivo and Ex Vivo MRI for the Detection of Structural Abnormalities in a Mouse Model of Tauopathy.

Holmes HE, Powell NM, Ma D, Ismail O, Harrison IF, Wells JA, Colgan N, O'Callaghan JM, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, O'Neill MJ, Collins EC, Fisher EM, Ourselin S, Lythgoe MF.

Front Neuroinform. 2017 Mar 31;11:20. doi: 10.3389/fninf.2017.00020. eCollection 2017.


Evidence for evolutionary divergence of activity-dependent gene expression in developing neurons.

Qiu J, McQueen J, Bilican B, Dando O, Magnani D, Punovuori K, Selvaraj BT, Livesey M, Haghi G, Heron S, Burr K, Patani R, Rajan R, Sheppard O, Kind PC, Simpson TI, Tybulewicz VL, Wyllie DJ, Fisher EM, Lowell S, Chandran S, Hardingham GE.

Elife. 2016 Oct 1;5. pii: e20337. doi: 10.7554/eLife.20337.


Fully-Automated μMRI Morphometric Phenotyping of the Tc1 Mouse Model of Down Syndrome.

Powell NM, Modat M, Cardoso MJ, Ma D, Holmes HE, Yu Y, O'Callaghan J, Cleary JO, Sinclair B, Wiseman FK, Tybulewicz VL, Fisher EM, Lythgoe MF, Ourselin S.

PLoS One. 2016 Sep 22;11(9):e0162974. doi: 10.1371/journal.pone.0162974. eCollection 2016.


A Syntenic Cross Species Aneuploidy Genetic Screen Links RCAN1 Expression to β-Cell Mitochondrial Dysfunction in Type 2 Diabetes.

Peiris H, Duffield MD, Fadista J, Jessup CF, Kashmir V, Genders AJ, McGee SL, Martin AM, Saiedi M, Morton N, Carter R, Cousin MA, Kokotos AC, Oskolkov N, Volkov P, Hough TA, Fisher EM, Tybulewicz VL, Busciglio J, Coskun PE, Becker A, Belichenko PV, Mobley WC, Ryan MT, Chan JY, Laybutt DR, Coates PT, Yang S, Ling C, Groop L, Pritchard MA, Keating DJ.

PLoS Genet. 2016 May 19;12(5):e1006033. doi: 10.1371/journal.pgen.1006033. eCollection 2016 May.


To Stay or to Leave: Factors Influencing Victims' Decisions to Stay or Leave a Domestic Violence Emergency Shelter.

Fisher EM, Stylianou AM.

J Interpers Violence. 2019 Feb;34(4):785-811. doi: 10.1177/0886260516645816. Epub 2016 Apr 28.


Assessing the efficacy of tabs on filtering facepiece respirator straps to increase proper doffing techniques while reducing contact transmission of pathogens.

Strauch AL, Brady TM, Niezgoda G, Almaguer CM, Shaffer RE, Fisher EM.

J Occup Environ Hyg. 2016 Oct 2;13(10):794-801. doi: 10.1080/15459624.2016.1179386.


Imaging the accumulation and suppression of tau pathology using multiparametric MRI.

Holmes HE, Colgan N, Ismail O, Ma D, Powell NM, O'Callaghan JM, Harrison IF, Johnson RA, Murray TK, Ahmed Z, Heggenes M, Fisher A, Cardoso MJ, Modat M, Walker-Samuel S, Fisher EM, Ourselin S, O'Neill MJ, Wells JA, Collins EC, Lythgoe MF.

Neurobiol Aging. 2016 Mar;39:184-94. doi: 10.1016/j.neurobiolaging.2015.12.001. Epub 2015 Dec 15.


Tc1 mouse model of trisomy-21 dissociates properties of short- and long-term recognition memory.

Hall JH, Wiseman FK, Fisher EM, Tybulewicz VL, Harwood JL, Good MA.

Neurobiol Learn Mem. 2016 Apr;130:118-28. doi: 10.1016/j.nlm.2016.02.002. Epub 2016 Feb 8.


Correction: The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL.

PLoS Negl Trop Dis. 2016 Feb 1;10(2):e0004439. doi: 10.1371/journal.pntd.0004439. eCollection 2016 Feb. No abstract available.


Enhanced humoral response to influenza vaccine in aged mice with a novel adjuvant, rOv-ASP-1.

Jiang J, Fisher EM, Concannon M, Lustigman S, Shen H, Murasko DM.

Vaccine. 2016 Feb 10;34(7):887-92. doi: 10.1016/j.vaccine.2016.01.003. Epub 2016 Jan 13.


Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel.

Lana-Elola E, Watson-Scales S, Slender A, Gibbins D, Martineau A, Douglas C, Mohun T, Fisher EM, Tybulewicz VLj.

Elife. 2016 Jan 14;5. pii: e11614. doi: 10.7554/eLife.11614.


The Schistosoma mansoni Cytochrome P450 (CYP3050A1) Is Essential for Worm Survival and Egg Development.

Ziniel PD, Karumudi B, Barnard AH, Fisher EM, Thatcher GR, Podust LM, Williams DL.

PLoS Negl Trop Dis. 2015 Dec 29;9(12):e0004279. doi: 10.1371/journal.pntd.0004279. eCollection 2015 Dec. Erratum in: PLoS Negl Trop Dis. 2016 Feb;10(2):e0004439.


Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration.

Joyce PI, Fratta P, Landman AS, Mcgoldrick P, Wackerhage H, Groves M, Busam BS, Galino J, Corrochano S, Beskina OA, Esapa C, Ryder E, Carter S, Stewart M, Codner G, Hilton H, Teboul L, Tucker J, Lionikas A, Estabel J, Ramirez-Solis R, White JK, Brandner S, Plagnol V, Bennet DL, Abramov AY, Greensmith L, Fisher EM, Acevedo-Arozena A.

Hum Mol Genet. 2016 Jan 15;25(2):291-307. doi: 10.1093/hmg/ddv471. Epub 2015 Nov 24.


Dissecting Alzheimer disease in Down syndrome using mouse models.

Choong XY, Tosh JL, Pulford LJ, Fisher EM.

Front Behav Neurosci. 2015 Oct 13;9:268. doi: 10.3389/fnbeh.2015.00268. eCollection 2015. Review.


Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.

Colgan N, Siow B, O'Callaghan JM, Harrison IF, Wells JA, Holmes HE, Ismail O, Richardson S, Alexander DC, Collins EC, Fisher EM, Johnson R, Schwarz AJ, Ahmed Z, O'Neill MJ, Murray TK, Zhang H, Lythgoe MF.

Neuroimage. 2016 Jan 15;125:739-744. doi: 10.1016/j.neuroimage.2015.10.043. Epub 2015 Oct 23.


CHCHD10 Pro34Ser is not a highly penetrant pathogenic variant for amyotrophic lateral sclerosis and frontotemporal dementia.

Abdelkarim S, Morgan S, Plagnol V, Lu CH, Adamson G, Howard R, Malaspina A, Orrell R, Sharma N, Sidle K, Clarke J, Fox NC, Rossor MN, Warren JD, Clark CN, Rohrer JD, Fisher EM, Mead S, Pittman A, Fratta P.

Brain. 2016 Feb;139(Pt 2):e9. doi: 10.1093/brain/awv223. Epub 2015 Sep 11. No abstract available.


A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome.

Wiseman FK, Al-Janabi T, Hardy J, Karmiloff-Smith A, Nizetic D, Tybulewicz VL, Fisher EM, Strydom A.

Nat Rev Neurosci. 2015 Sep;16(9):564-74. doi: 10.1038/nrn3983. Epub 2015 Aug 5. Review.


Hippocampal circuit dysfunction in the Tc1 mouse model of Down syndrome.

Witton J, Padmashri R, Zinyuk LE, Popov VI, Kraev I, Line SJ, Jensen TP, Tedoldi A, Cummings DM, Tybulewicz VLJ, Fisher EMC, Bannerman DM, Randall AD, Brown JT, Edwards FA, Rusakov DA, Stewart MG, Jones MW.

Nat Neurosci. 2015 Sep;18(9):1291-1298. doi: 10.1038/nn.4072. Epub 2015 Aug 3.


Mary Frances Lyon (1925–2014).

Fisher EM, Peters J.

Cell. 2015 Feb 12;160(4):577-8. No abstract available.


Two new species of Martintella Artigas, 1996 (Diptera, Asilidae, Asilinae) from Costa Rica.

Vieira R, Rafael JA, Fisher EM.

Zootaxa. 2014 Oct 29;3878(5):451-61. doi: 10.11646/zootaxa.3878.5.3.


Increased cerebral vascular reactivity in the tau expressing rTg4510 mouse: evidence against the role of tau pathology to impair vascular health in Alzheimer's disease.

Wells JA, Holmes HE, O'Callaghan JM, Colgan N, Ismail O, Fisher EM, Siow B, Murray TK, Schwarz AJ, O'Neill MJ, Collins EC, Lythgoe MF.

J Cereb Blood Flow Metab. 2015 Mar;35(3):359-62. doi: 10.1038/jcbfm.2014.224. Epub 2014 Dec 17.


SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology: New and Renascent Themes.

Bunton-Stasyshyn RK, Saccon RA, Fratta P, Fisher EM.

Neuroscientist. 2015 Oct;21(5):519-29. doi: 10.1177/1073858414561795. Epub 2014 Dec 9. Review.


A novel SOD1-ALS mutation separates central and peripheral effects of mutant SOD1 toxicity.

Joyce PI, Mcgoldrick P, Saccon RA, Weber W, Fratta P, West SJ, Zhu N, Carter S, Phatak V, Stewart M, Simon M, Kumar S, Heise I, Bros-Facer V, Dick J, Corrochano S, Stanford MJ, Luong TV, Nolan PM, Meyer T, Brandner S, Bennett DL, Ozdinler PH, Greensmith L, Fisher EM, Acevedo-Arozena A.

Hum Mol Genet. 2015 Apr 1;24(7):1883-97. doi: 10.1093/hmg/ddu605. Epub 2014 Dec 2.


Screening a UK amyotrophic lateral sclerosis cohort provides evidence of multiple origins of the C9orf72 expansion.

Fratta P, Polke JM, Newcombe J, Mizielinska S, Lashley T, Poulter M, Beck J, Preza E, Devoy A, Sidle K, Howard R, Malaspina A, Orrell RW, Clarke J, Lu CH, Mok K, Collins T, Shoaii M, Nanji T, Wray S, Adamson G, Pittman A, Renton AE, Traynor BJ, Sweeney MG, Revesz T, Houlden H, Mead S, Isaacs AM, Fisher EM.

Neurobiol Aging. 2015 Jan;36(1):546.e1-7. doi: 10.1016/j.neurobiolaging.2014.07.037. Epub 2014 Aug 1.


C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins.

Mizielinska S, Grönke S, Niccoli T, Ridler CE, Clayton EL, Devoy A, Moens T, Norona FE, Woollacott IOC, Pietrzyk J, Cleverley K, Nicoll AJ, Pickering-Brown S, Dols J, Cabecinha M, Hendrich O, Fratta P, Fisher EMC, Partridge L, Isaacs AM.

Science. 2014 Sep 5;345(6201):1192-1194. doi: 10.1126/science.1256800. Epub 2014 Aug 7.


Correlation of clinical and molecular features in spinal bulbar muscular atrophy.

Fratta P, Nirmalananthan N, Masset L, Skorupinska I, Collins T, Cortese A, Pemble S, Malaspina A, Fisher EM, Greensmith L, Hanna MG.

Neurology. 2014 Jun 10;82(23):2077-84. doi: 10.1212/WNL.0000000000000507. Epub 2014 May 9.


Biofuels from pyrolysis in perspective: trade-offs between energy yields and soil-carbon additions.

Woolf D, Lehmann J, Fisher EM, Angenent LT.

Environ Sci Technol. 2014 Jun 3;48(11):6492-9. doi: 10.1021/es500474q. Epub 2014 May 13.


DYNC1H1 mutation alters transport kinetics and ERK1/2-cFos signalling in a mouse model of distal spinal muscular atrophy.

Garrett CA, Barri M, Kuta A, Soura V, Deng W, Fisher EM, Schiavo G, Hafezparast M.

Brain. 2014 Jul;137(Pt 7):1883-93. doi: 10.1093/brain/awu097. Epub 2014 Apr 22.


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