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Topical treatment strategies to manipulate human skin pigmentation.

Rachmin I, Ostrowski SM, Weng QY, Fisher DE.

Adv Drug Deliv Rev. 2020 Feb 21. pii: S0169-409X(20)30008-9. doi: 10.1016/j.addr.2020.02.002. [Epub ahead of print]


Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells.

Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC.

Nature. 2020 Jan;577(7792):676-681. doi: 10.1038/s41586-020-1935-3. Epub 2020 Jan 22.


FOXD3 Regulates VISTA Expression in Melanoma.

Rosenbaum SR, Knecht M, Mollaee M, Zhong Z, Erkes DA, McCue PA, Chervoneva I, Berger AC, Lo JA, Fisher DE, Gershenwald JE, Davies MA, Purwin TJ, Aplin AE.

Cell Rep. 2020 Jan 14;30(2):510-524.e6. doi: 10.1016/j.celrep.2019.12.036.


Rational Combination Therapy for Melanoma with Dinaciclib by Targeting BAK-Dependent Cell Death.

Xu X, Eshima S, Kato S, Fisher DE, Sakurai H, Hayakawa Y, Yokoyama S.

Mol Cancer Ther. 2020 Feb;19(2):627-636. doi: 10.1158/1535-7163.MCT-19-0451. Epub 2019 Nov 19.


Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies.

Montero J, Gstalder C, Kim DJ, Sadowicz D, Miles W, Manos M, Cidado JR, Paul Secrist J, Tron AE, Flaherty K, Stephen Hodi F, Yoon CH, Letai A, Fisher DE, Haq R.

Nat Commun. 2019 Nov 14;10(1):5157. doi: 10.1038/s41467-019-12477-y.


Sun exposure and protection practices in children after allogeneic hematopoietic stem cell transplantation: A Survey-Based Cross-Sectional Cohort Study.

Li EB, Song JS, Huang JT, Hawryluk EB, London WB, Guo D, Sridharan M, Fisher DE, Rea CJ, Lehmann LE, Duncan CN.

Pediatr Dermatol. 2019 Nov;36(6):882-886. doi: 10.1111/pde.13984. Epub 2019 Aug 13.


A ROCK inhibitor promotes keratinocyte survival and paracrine secretion, enhancing establishment of primary human melanocytes and melanocyte-keratinocyte co-cultures.

Mi J, Feng Y, Wen J, Su Y, Xu L, Zu T, Liu C, Fisher DE, Wu X.

Pigment Cell Melanoma Res. 2020 Jan;33(1):16-29. doi: 10.1111/pcmr.12816. Epub 2019 Aug 22.


Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy.

Chow MT, Ozga AJ, Servis RL, Frederick DT, Lo JA, Fisher DE, Freeman GJ, Boland GM, Luster AD.

Immunity. 2019 Jun 18;50(6):1498-1512.e5. doi: 10.1016/j.immuni.2019.04.010. Epub 2019 May 13.


Cell-state dynamics and therapeutic resistance in melanoma from the perspective of MITF and IFNγ pathways.

Bai X, Fisher DE, Flaherty KT.

Nat Rev Clin Oncol. 2019 Sep;16(9):549-562. doi: 10.1038/s41571-019-0204-6. Review.


Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential: (Trends Endocrinol. Metab. 29, 723-735, 2018).

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2019 Jun;30(6):407. doi: 10.1016/j.tem.2019.01.009. Epub 2019 Mar 2. No abstract available.


Hand and knee osteoarthritis are associated with reduced diameters in retinal vessels: the AGES-Reykjavik study.

Jonsson H, Fisher DE, Eiriksdottir G, Aspelund T, Klein R, Gudnason V, Cotch MF.

Rheumatol Int. 2019 Apr;39(4):669-677. doi: 10.1007/s00296-019-04243-6. Epub 2019 Jan 22.


Lineage-specific control of TFIIH by MITF determines transcriptional homeostasis and DNA repair.

Seoane M, Buhs S, Iglesias P, Strauss J, Puller AC, Müller J, Gerull H, Feldhaus S, Alawi M, Brandner JM, Eggert D, Du J, Thomale J, Wild PJ, Zimmermann M, Sternsdorf T, Schumacher U, Nollau P, Fisher DE, Horstmann MA.

Oncogene. 2019 May;38(19):3616-3635. doi: 10.1038/s41388-018-0661-x. Epub 2019 Jan 16.


Microphthalmia-associated transcription factor phosphorylation: Cross talk between GSK3 and MAPK signaling.

Rachmin I, Fisher DE.

Pigment Cell Melanoma Res. 2019 May;32(3):345-347. doi: 10.1111/pcmr.12765. Epub 2019 Jan 24. No abstract available.


Local genomic features predict the distinct and overlapping binding patterns of the bHLH-Zip family oncoproteins MITF and MYC-MAX.

Hejna M, Moon WM, Cheng J, Kawakami A, Fisher DE, Song JS.

Pigment Cell Melanoma Res. 2019 Jul;32(4):500-509. doi: 10.1111/pcmr.12762. Epub 2018 Dec 21.


The lncRNA RMEL3 protects immortalized cells from serum withdrawal-induced growth arrest and promotes melanoma cell proliferation and tumor growth.

Cardoso C, Serafim RB, Kawakami A, Gonçalves Pereira C, Roszik J, Valente V, Vazquez VL, Fisher DE, Espreafico EM.

Pigment Cell Melanoma Res. 2019 Mar;32(2):303-314. doi: 10.1111/pcmr.12751. Epub 2018 Dec 16.


Chemoprevention agents for melanoma: A path forward into phase 3 clinical trials.

Jeter JM, Bowles TL, Curiel-Lewandrowski C, Swetter SM, Filipp FV, Abdel-Malek ZA, Geskin LJ, Brewer JD, Arbiser JL, Gershenwald JE, Chu EY, Kirkwood JM, Box NF, Funchain P, Fisher DE, Kendra KL, Marghoob AA, Chen SC, Ming ME, Albertini MR, Vetto JT, Margolin KA, Pagoto SL, Hay JL, Grossman D, Ellis DL, Kashani-Sabet M, Mangold AR, Markovic SN, Nelson KC, Powers JG, Robinson JK, Sahni D, Sekulic A, Sondak VK, Wei ML, Zager JS, Dellavalle RP, Thompson JA, Weinstock MA, Leachman SA, Cassidy PB.

Cancer. 2019 Jan 1;125(1):18-44. doi: 10.1002/cncr.31719. Epub 2018 Oct 3. Review. Erratum in: Cancer. 2019 Aug 1;125(15):2706.


miRNA-211 stops the clock.

Levy C, Golan T, Fisher DE.

Noncoding RNA Investig. 2018 May;2. pii: 25. doi: 10.21037/ncri.2018.04.05. Epub 2018 May 6. No abstract available.


ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells.

Chang F, Zhang Y, Mi J, Zhou Q, Bai F, Xu X, Fisher DE, Sun Q, Wu X.

Cancer Sci. 2018 Nov;109(11):3428-3437. doi: 10.1111/cas.13786. Epub 2018 Sep 23.


Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential.

Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM.

Trends Endocrinol Metab. 2018 Oct;29(10):723-735. doi: 10.1016/j.tem.2018.08.004. Epub 2018 Aug 24. Review. Erratum in: Trends Endocrinol Metab. 2019 Mar 2;:.


MITF and UV responses in skin: From pigmentation to addiction.

Nguyen NT, Fisher DE.

Pigment Cell Melanoma Res. 2019 Mar;32(2):224-236. doi: 10.1111/pcmr.12726. Epub 2018 Aug 3. Review. Erratum in: Pigment Cell Melanoma Res. 2020 Mar;33(2):383.


Protection from UV light is an evolutionarily conserved feature of the haematopoietic niche.

Kapp FG, Perlin JR, Hagedorn EJ, Gansner JM, Schwarz DE, O'Connell LA, Johnson NS, Amemiya C, Fisher DE, Wölfle U, Trompouki E, Niemeyer CM, Driever W, Zon LI.

Nature. 2018 Jun;558(7710):445-448. doi: 10.1038/s41586-018-0213-0. Epub 2018 Jun 13.


Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion.

McConnell AM, Mito JK, Ablain J, Dang M, Formichella L, Fisher DE, Zon LI.

Dev Biol. 2019 May 15;449(2):107-114. doi: 10.1016/j.ydbio.2018.05.026. Epub 2018 Jun 5.


Targeting the (Un)differentiated State of Cancer.

Kemeny LV, Fisher DE.

Cancer Cell. 2018 May 14;33(5):793-795. doi: 10.1016/j.ccell.2018.04.007.


Nonmalignant late cutaneous changes after allogeneic hematopoietic stem cell transplant in children.

Huang JT, Song JS, Hawryluk EB, London WB, Guo D, Sridharan M, Fisher DE, Lehmann LE, Duncan CN.

J Am Acad Dermatol. 2018 Aug;79(2):230-237. doi: 10.1016/j.jaad.2018.03.029. Epub 2018 Mar 26.


Pathways in melanoma development.

Erlich TH, Fisher DE.

G Ital Dermatol Venereol. 2018 Feb;153(1):68-76. doi: 10.23736/S0392-0488.17.05795-9. Review.


Differential associations between retinal signs and CMBs by location: The AGES-Reykjavik Study.

Qiu C, Ding J, Sigurdsson S, Fisher DE, Zhang Q, Eiriksdottir G, Klein R, van Buchem MA, Gudnason V, Cotch MF, Launer LJ.

Neurology. 2018 Jan 9;90(2):e142-e148. doi: 10.1212/WNL.0000000000004792. Epub 2017 Dec 13.


Non-Euclidean phasor analysis for quantification of oxidative stress in ex vivo human skin exposed to sun filters using fluorescence lifetime imaging microscopy.

Osseiran S, Roider EM, Wang H, Suita Y, Murphy M, Fisher DE, Evans CL.

J Biomed Opt. 2017 Dec;22(12):1-10. doi: 10.1117/1.JBO.22.12.125004.


Negative Regulation of Skin Pigmentation in Three-Dimensional Reconstructs by Adipose-Derived Mesenchymal Cells.

Wu X, Fisher DE.

J Invest Dermatol. 2017 Dec;137(12):2464-2466. doi: 10.1016/j.jid.2017.08.001.


Erratum for Salma et al., "Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice".

Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE.

Mol Cell Biol. 2017 Oct 13;37(21). pii: e00466-17. doi: 10.1128/MCB.00466-17. Print 2017 Nov 1. No abstract available.


MSX1-Induced Neural Crest-Like Reprogramming Promotes Melanoma Progression.

Heppt MV, Wang JX, Hristova DM, Wei Z, Li L, Evans B, Beqiri M, Zaman S, Zhang J, Irmler M, Berking C, Besch R, Beckers J, Rauscher FJ 3rd, Sturm RA, Fisher DE, Herlyn M, Fukunaga-Kalabis M.

J Invest Dermatol. 2018 Jan;138(1):141-149. doi: 10.1016/j.jid.2017.05.038. Epub 2017 Sep 18.


Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis.

Dai J, Choo MK, Park JM, Fisher DE.

J Invest Dermatol. 2017 Dec;137(12):2523-2531. doi: 10.1016/j.jid.2017.07.819. Epub 2017 Jul 31.


Skin cancer screening: recommendations for data-driven screening guidelines and a review of the US Preventive Services Task Force controversy.

Johnson MM, Leachman SA, Aspinwall LG, Cranmer LD, Curiel-Lewandrowski C, Sondak VK, Stemwedel CE, Swetter SM, Vetto J, Bowles T, Dellavalle RP, Geskin LJ, Grossman D, Grossmann KF, Hawkes JE, Jeter JM, Kim CC, Kirkwood JM, Mangold AR, Meyskens F, Ming ME, Nelson KC, Piepkorn M, Pollack BP, Robinson JK, Sober AJ, Trotter S, Venna SS, Agarwala S, Alani R, Averbook B, Bar A, Becevic M, Box N, E Carson W 3rd, Cassidy PB, Chen SC, Chu EY, Ellis DL, Ferris LK, Fisher DE, Kendra K, Lawson DH, Leming PD, Margolin KA, Markovic S, Martini MC, Miller D, Sahni D, Sharfman WH, Stein J, Stratigos AJ, Tarhini A, Taylor MH, Wisco OJ, Wong MK.

Melanoma Manag. 2017 Mar;4(1):13-37. doi: 10.2217/mmt-2016-0022. Epub 2017 Mar 1. Review.


In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target.

Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, LaFleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN.

Nature. 2017 Jul 27;547(7664):413-418. doi: 10.1038/nature23270. Epub 2017 Jul 19.


The Alkylating Chemotherapeutic Temozolomide Induces Metabolic Stress in IDH1-Mutant Cancers and Potentiates NAD+ Depletion-Mediated Cytotoxicity.

Tateishi K, Higuchi F, Miller JJ, Koerner MVA, Lelic N, Shankar GM, Tanaka S, Fisher DE, Batchelor TT, Iafrate AJ, Wakimoto H, Chi AS, Cahill DP.

Cancer Res. 2017 Aug 1;77(15):4102-4115. doi: 10.1158/0008-5472.CAN-16-2263. Epub 2017 Jun 16.


A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin.

Mujahid N, Liang Y, Murakami R, Choi HG, Dobry AS, Wang J, Suita Y, Weng QY, Allouche J, Kemeny LV, Hermann AL, Roider EM, Gray NS, Fisher DE.

Cell Rep. 2017 Jun 13;19(11):2177-2184. doi: 10.1016/j.celrep.2017.05.042.


Immune and molecular correlates in melanoma treated with immune checkpoint blockade.

Byrne EH, Fisher DE.

Cancer. 2017 Jun 1;123(S11):2143-2153. doi: 10.1002/cncr.30444. Review.


Tfe3 and Tfeb Transcriptionally Regulate Peroxisome Proliferator-Activated Receptor γ2 Expression in Adipocytes and Mediate Adiponectin and Glucose Levels in Mice.

Salma N, Song JS, Kawakami A, Devi SP, Khaled M, Cacicedo JM, Fisher DE.

Mol Cell Biol. 2017 Jul 14;37(15). pii: e00608-16. doi: 10.1128/MCB.00608-16. Print 2017 Aug 1. Erratum in: Mol Cell Biol. 2017 Oct 13;37(21):.


Feasibility of Ultra-High-Throughput Functional Screening of Melanoma Biopsies for Discovery of Novel Cancer Drug Combinations.

Friedman AA, Xia Y, Trippa L, Le LP, Igras V, Frederick DT, Wargo JA, Tanabe KK, Lawrence DP, Neuberg DS, Flaherty KT, Fisher DE.

Clin Cancer Res. 2017 Aug 15;23(16):4680-4692. doi: 10.1158/1078-0432.CCR-16-3029. Epub 2017 Apr 26.


Risk of melanocytic nevi and nonmelanoma skin cancer in children after allogeneic hematopoietic stem cell transplantation.

Song JS, London WB, Hawryluk EB, Guo D, Sridharan M, Fisher DE, Lehmann LE, Duncan CN, Huang JT.

Bone Marrow Transplant. 2017 Jul;52(7):989-997. doi: 10.1038/bmt.2017.57. Epub 2017 Apr 3.


The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology.

Kawakami A, Fisher DE.

Lab Invest. 2017 Jun;97(6):649-656. doi: 10.1038/labinvest.2017.9. Epub 2017 Mar 6. Review.


The melanoma-linked "redhead" MC1R influences dopaminergic neuron survival.

Chen X, Chen H, Cai W, Maguire M, Ya B, Zuo F, Logan R, Li H, Robinson K, Vanderburg CR, Yu Y, Wang Y, Fisher DE, Schwarzschild MA.

Ann Neurol. 2017 Mar;81(3):395-406. doi: 10.1002/ana.24852. Epub 2017 Jan 23.


Immunotherapy in the Precision Medicine Era: Melanoma and Beyond.

Su MY, Fisher DE.

PLoS Med. 2016 Dec 13;13(12):e1002196. doi: 10.1371/journal.pmed.1002196. eCollection 2016 Dec.


Signaling and Immune Regulation in Melanoma Development and Responses to Therapy.

Lin WM, Fisher DE.

Annu Rev Pathol. 2017 Jan 24;12:75-102. doi: 10.1146/annurev-pathol-052016-100208. Epub 2016 Dec 5. Review.


MYO5A Gene Is a Target of MITF in Melanocytes.

Alves CP, Yokoyama S, Goedert L, Pontes CLS, Sousa JF, Fisher DE, Espreafico EM.

J Invest Dermatol. 2017 Apr;137(4):985-989. doi: 10.1016/j.jid.2016.11.026. Epub 2016 Dec 6. No abstract available.


In vivo coherent Raman imaging of the melanomagenesis-associated pigment pheomelanin.

Wang H, Osseiran S, Igras V, Nichols AJ, Roider EM, Pruessner J, Tsao H, Fisher DE, Evans CL.

Sci Rep. 2016 Nov 28;6:37986. doi: 10.1038/srep37986.


Bioinformatic Analysis of Gene Expression for Melanoma Treatment.

Kawakami A, Fisher DE.

J Invest Dermatol. 2016 Dec;136(12):2342-2344. doi: 10.1016/j.jid.2016.09.011. Review.


A phase I trial of panobinostat (LBH589) in patients with metastatic melanoma.

Ibrahim N, Buchbinder EI, Granter SR, Rodig SJ, Giobbie-Hurder A, Becerra C, Tsiaras A, Gjini E, Fisher DE, Hodi FS.

Cancer Med. 2016 Nov;5(11):3041-3050. doi: 10.1002/cam4.862. Epub 2016 Oct 17.


Loss of cohesin complex components STAG2 or STAG3 confers resistance to BRAF inhibition in melanoma.

Shen CH, Kim SH, Trousil S, Frederick DT, Piris A, Yuan P, Cai L, Gu L, Li M, Lee JH, Mitra D, Fisher DE, Sullivan RJ, Flaherty KT, Zheng B.

Nat Med. 2016 Sep;22(9):1056-61. doi: 10.1038/nm.4155. Epub 2016 Aug 8.


Metastatic melanoma and immunotherapy.

Herzberg B, Fisher DE.

Clin Immunol. 2016 Nov;172:105-110. doi: 10.1016/j.clim.2016.07.006. Epub 2016 Jul 16. Review.


Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin.

Xia Y, Li Y, Westover KD, Sun J, Chen H, Zhang J, Fisher DE.

PLoS One. 2016 May 6;11(5):e0155217. doi: 10.1371/journal.pone.0155217. eCollection 2016.

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