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Amanda E. I. Proudfoot 1949-2019.

Fish EN.

Nat Immunol. 2020 Mar;21(3):241. doi: 10.1038/s41590-020-0603-y. No abstract available.


Global virus outbreaks: Interferons as 1st responders.

Wang BX, Fish EN.

Semin Immunol. 2019 Jun;43:101300. doi: 10.1016/j.smim.2019.101300. Review.


Identification and targeting of novel CDK9 complexes in acute myeloid leukemia.

Beauchamp EM, Abedin SM, Radecki SG, Fischietti M, Arslan AD, Blyth GT, Yang A, Lantz C, Nelson A, Goo YA, Akpan I, Eklund EA, Frankfurt O, Fish EN, Thomas PM, Altman JK, Platanias LC.

Blood. 2019 Mar 14;133(11):1171-1185. doi: 10.1182/blood-2018-08-870089. Epub 2018 Dec 26.


Sirtuin 2-mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses.

Kosciuczuk EM, Mehrotra S, Saleiro D, Kroczynska B, Majchrzak-Kita B, Lisowski P, Driehaus C, Rogalska A, Turner A, Lienhoop T, Gius D, Fish EN, Vassilopoulos A, Platanias LC.

J Biol Chem. 2019 Jan 18;294(3):827-837. doi: 10.1074/jbc.RA118.005956. Epub 2018 Nov 28.


IFN-γ-inducible antiviral responses require ULK1-mediated activation of MLK3 and ERK5.

Saleiro D, Blyth GT, Kosciuczuk EM, Ozark PA, Majchrzak-Kita B, Arslan AD, Fischietti M, Reddy NK, Horvath CM, Davis RJ, Fish EN, Platanias LC.

Sci Signal. 2018 Nov 20;11(557). pii: eaap9921. doi: 10.1126/scisignal.aap9921.


Chemokines in breast cancer: Regulating metabolism.

Gao D, Fish EN.

Cytokine. 2018 Sep;109:57-64. doi: 10.1016/j.cyto.2018.02.010. Review.


Slfn2 Regulates Type I Interferon Responses by Modulating the NF-κB Pathway.

Fischietti M, Arslan AD, Sassano A, Saleiro D, Majchrzak-Kita B, Ebine K, Munshi HG, Fish EN, Platanias LC.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00053-18. doi: 10.1128/MCB.00053-18. Print 2018 Aug 15.


CCL5-CCR5 interactions modulate metabolic events during tumor onset to promote tumorigenesis.

Gao D, Cazares LH, Fish EN.

BMC Cancer. 2017 Dec 8;17(1):834. doi: 10.1186/s12885-017-3817-0.


Interleukin-34 Promotes Fibrocyte Proliferation.

Galligan CL, Fish EN.

J Interferon Cytokine Res. 2017 Oct;37(10):440-448. doi: 10.1089/jir.2017.0063. Epub 2017 Oct 3.


Cutting Edge: Endogenous IFN-β Regulates Survival and Development of Transitional B Cells.

Hamilton JA, Wu Q, Yang P, Luo B, Liu S, Hong H, Li J, Walter MR, Fish EN, Hsu HC, Mountz JD.

J Immunol. 2017 Oct 15;199(8):2618-2623. doi: 10.4049/jimmunol.1700888. Epub 2017 Sep 13.


Human SLFN5 is a transcriptional co-repressor of STAT1-mediated interferon responses and promotes the malignant phenotype in glioblastoma.

Arslan AD, Sassano A, Saleiro D, Lisowski P, Kosciuczuk EM, Fischietti M, Eckerdt F, Fish EN, Platanias LC.

Oncogene. 2017 Oct 26;36(43):6006-6019. doi: 10.1038/onc.2017.205. Epub 2017 Jul 3.


Interferon-β regulates dendritic cell activation and migration in experimental autoimmune encephalomyelitis.

Pennell LM, Fish EN.

Immunology. 2017 Nov;152(3):439-450. doi: 10.1111/imm.12781. Epub 2017 Jul 21.


Residues F103 and M106 within the influenza A virus NS1 CPSF4-binding region regulate interferon-stimulated gene translation initiation.

Wang BX, Brown EG, Fish EN.

Virology. 2017 Aug;508:170-179. doi: 10.1016/j.virol.2017.05.009. Epub 2017 May 26.


Interactions Between NS1 of Influenza A Viruses and Interferon-α/β: Determinants for Vaccine Development.

Wang BX, Fish EN.

J Interferon Cytokine Res. 2017 Aug;37(8):331-341. doi: 10.1089/jir.2017.0032. Epub 2017 May 17. Review.


A Conserved Residue, Tyrosine (Y) 84, in H5N1 Influenza A Virus NS1 Regulates IFN Signaling Responses to Enhance Viral Infection.

Wang BX, Wei L, Kotra LP, Brown EG, Fish EN.

Viruses. 2017 May 12;9(5). pii: E107. doi: 10.3390/v9050107.


Interferon-Stimulated Gene Expression as a Preferred Biomarker for Disease Activity in Aicardi-Goutières Syndrome.

Wang BX, Grover SA, Kannu P, Yoon G, Laxer RM, Yeh EA, Fish EN.

J Interferon Cytokine Res. 2017 Apr;37(4):147-152. doi: 10.1089/jir.2016.0117. Epub 2017 Feb 17.


Interferon β-1a for the treatment of Ebola virus disease: A historically controlled, single-arm proof-of-concept trial.

Konde MK, Baker DP, Traore FA, Sow MS, Camara A, Barry AA, Mara D, Barry A, Cone M, Kaba I, Richard AA, Beavogui AH, Günther S; European Mobile Laboratory Consortium, Pintilie M, Fish EN.

PLoS One. 2017 Feb 22;12(2):e0169255. doi: 10.1371/journal.pone.0169255. eCollection 2017. Erratum in: PLoS One. 2017 Apr 12;12 (4):e0175930.


Central Regulatory Role for SIN1 in Interferon γ (IFNγ) Signaling and Generation of Biological Responses.

Kroczynska B, Blyth GT, Rafidi RL, Majchrzak-Kita B, Xu L, Saleiro D, Kosciuczuk EM, Jemielity J, Su B, Altman JK, Eklund EA, Fish EN, Platanias LC.

J Biol Chem. 2017 Mar 17;292(11):4743-4752. doi: 10.1074/jbc.M116.757666. Epub 2017 Feb 7.


CCL5 activation of CCR5 regulates cell metabolism to enhance proliferation of breast cancer cells.

Gao D, Rahbar R, Fish EN.

Open Biol. 2016 Jun;6(6). pii: 160122. doi: 10.1098/rsob.160122.


Changing oral vaccine to inactivated polio vaccine might increase mortality.

Fish EN, Flanagan KL, Furman D, Klein SL, Kollmann TR, Jeppesen DL, Levy O, Marchant A, Namachivayam S, Netea MG, Plebanski M, Rowland-Jones SL, Selin LK, Shann F, Whittle HC.

Lancet. 2016 Mar 12;387(10023):1054-1055. doi: 10.1016/S0140-6736(16)00661-9. No abstract available.


Fibrocyte and T cell interactions promote disease pathogenesis in rheumatoid arthritis.

Galligan CL, Keystone EC, Fish EN.

J Autoimmun. 2016 May;69:38-50. doi: 10.1016/j.jaut.2016.02.008. Epub 2016 Mar 3.


A Rapid Screening Assay Identifies Monotherapy with Interferon-ß and Combination Therapies with Nucleoside Analogs as Effective Inhibitors of Ebola Virus.

McCarthy SD, Majchrzak-Kita B, Racine T, Kozlowski HN, Baker DP, Hoenen T, Kobinger GP, Fish EN, Branch DR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004364. doi: 10.1371/journal.pntd.0004364. eCollection 2016 Jan.


Small Molecule Agonists for the Type I Interferon Receptor: An In Silico Approach.

Wei L, Bello AM, Majchrzak-Kita B, Salum N, Lewis MM, Kotra LP, Fish EN.

J Interferon Cytokine Res. 2016 Mar;36(3):180-91. doi: 10.1089/jir.2015.0123. Epub 2015 Dec 24.


Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.

Kroczynska B, Rafidi RL, Majchrzak-Kita B, Kosciuczuk EM, Blyth GT, Jemielity J, Warminska Z, Saleiro D, Mehrotra S, Arslan AD, Fish EN, Platanias LC.

J Biol Chem. 2016 Jan 29;291(5):2389-96. doi: 10.1074/jbc.M115.664995. Epub 2015 Dec 8.


Central role of ULK1 in type I interferon signaling.

Saleiro D, Mehrotra S, Kroczynska B, Beauchamp EM, Lisowski P, Majchrzak-Kita B, Bhagat TD, Stein BL, McMahon B, Altman JK, Kosciuczuk EM, Baker DP, Jie C, Jafari N, Thompson CB, Levine RL, Fish EN, Verma AK, Platanias LC.

Cell Rep. 2015 Apr 28;11(4):605-17. doi: 10.1016/j.celrep.2015.03.056. Epub 2015 Apr 16.


Sex-based differences in immune function and responses to vaccination.

Klein SL, Marriott I, Fish EN.

Trans R Soc Trop Med Hyg. 2015 Jan;109(1):9-15. doi: 10.1093/trstmh/tru167. Review.


Interferon receptor signaling in malignancy: a network of cellular pathways defining biological outcomes.

Fish EN, Platanias LC.

Mol Cancer Res. 2014 Dec;12(12):1691-703. doi: 10.1158/1541-7786.MCR-14-0450. Epub 2014 Sep 12. Review.


Regulatory effects of SKAR in interferon α signaling and its role in the generation of type I IFN responses.

Kroczynska B, Mehrotra S, Majchrzak-Kita B, Arslan AD, Altman JK, Stein BL, McMahon B, Kozlowski P, Kahle PJ, Eklund EA, Fish EN, Platanias LC.

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11377-82. doi: 10.1073/pnas.1405250111. Epub 2014 Jul 21.


LAPCs contribute to the pathogenesis of allergen-induced allergic airway inflammation in mice.

Hawkshaw C, Scott JA, Chow CW, Fish EN.

Allergy. 2014 Jul;69(7):924-35. doi: 10.1111/all.12422. Epub 2014 May 17.


Critical roles for Rictor/Sin1 complexes in interferon-dependent gene transcription and generation of antiproliferative responses.

Kaur S, Kroczynska B, Sharma B, Sassano A, Arslan AD, Majchrzak-Kita B, Stein BL, McMahon B, Altman JK, Su B, Calogero RA, Fish EN, Platanias LC.

J Biol Chem. 2014 Mar 7;289(10):6581-91. doi: 10.1074/jbc.M113.537852. Epub 2014 Jan 27.


Small molecule mimetics of an interferon-α receptor interacting domain.

Bello AM, Wei L, Majchrzak-Kita B, Salum N, Purohit MK, Fish EN, Kotra LP.

Bioorg Med Chem. 2014 Feb 1;22(3):978-85. doi: 10.1016/j.bmc.2013.12.049. Epub 2014 Jan 2.


Beta interferon regulation of glucose metabolism is PI3K/Akt dependent and important for antiviral activity against coxsackievirus B3.

Burke JD, Platanias LC, Fish EN.

J Virol. 2014 Mar;88(6):3485-95. doi: 10.1128/JVI.02649-13. Epub 2014 Jan 8.


SeXX matters in immunity.

Markle JG, Fish EN.

Trends Immunol. 2014 Mar;35(3):97-104. doi: 10.1016/ Epub 2013 Nov 13. Review.


Immunoregulatory effects of interferon-β in suppression of Th17 cells.

Pennell LM, Fish EN.

J Interferon Cytokine Res. 2014 May;34(5):330-41. doi: 10.1089/jir.2013.0088. Epub 2013 Oct 31.


Essential role for the Mnk pathway in the inhibitory effects of type I interferons on myeloproliferative neoplasm (MPN) precursors.

Mehrotra S, Sharma B, Joshi S, Kroczynska B, Majchrzak B, Stein BL, McMahon B, Altman JK, Licht JD, Baker DP, Eklund EA, Wickrema A, Verma A, Fish EN, Platanias LC.

J Biol Chem. 2013 Aug 16;288(33):23814-22. doi: 10.1074/jbc.M113.476192. Epub 2013 Jun 28.


The schlafen family of proteins and their regulation by interferons.

Mavrommatis E, Fish EN, Platanias LC.

J Interferon Cytokine Res. 2013 Apr;33(4):206-10. doi: 10.1089/jir.2012.0133.


STAT activation in malignancies: roles in tumor progression and in the generation of antineoplastic effects of IFNs.

Wang BX, Platanias LC, Fish EN.

J Interferon Cytokine Res. 2013 Apr;33(4):181-8. doi: 10.1089/jir.2012.0154. Review.


Sprouty proteins are negative regulators of interferon (IFN) signaling and IFN-inducible biological responses.

Sharma B, Joshi S, Sassano A, Majchrzak B, Kaur S, Aggarwal P, Nabet B, Bulic M, Stein BL, McMahon B, Baker DP, Fukunaga R, Altman JK, Licht JD, Fish EN, Platanias LC.

J Biol Chem. 2012 Dec 7;287(50):42352-60. doi: 10.1074/jbc.M112.400721. Epub 2012 Oct 16.


The role of circulating fibrocytes in inflammation and autoimmunity.

Galligan CL, Fish EN.

J Leukoc Biol. 2013 Jan;93(1):45-50. doi: 10.1189/jlb.0712365. Epub 2012 Sep 19. Review.


LAPCs promote follicular helper T cell differentiation of Ag-primed CD4+ T cells during respiratory virus infection.

Yoo JK, Fish EN, Braciale TJ.

J Exp Med. 2012 Sep 24;209(10):1853-67. Epub 2012 Sep 17.


WFDC1/ps20: a host factor that influences the neutrophil response to murine hepatitis virus (MHV) 1 infection.

Rogers E, Wang BX, Cui Z, Rowley DR, Ressler SJ, Vyakarnam A, Fish EN.

Antiviral Res. 2012 Nov;96(2):158-68. doi: 10.1016/j.antiviral.2012.08.012. Epub 2012 Sep 6.


The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis.

Chan O, Burke JD, Gao DF, Fish EN.

J Biol Chem. 2012 Aug 24;287(35):29406-16. doi: 10.1074/jbc.M112.348946. Epub 2012 Jul 10.


Circulating fibrocytes contribute to the pathogenesis of collagen antibody-induced arthritis.

Galligan CL, Fish EN.

Arthritis Rheum. 2012 Nov;64(11):3583-93. doi: 10.1002/art.34589.


Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses.

Kroczynska B, Sharma B, Eklund EA, Fish EN, Platanias LC.

Mol Cell Biol. 2012 Jul;32(14):2809-22. doi: 10.1128/MCB.00310-12. Epub 2012 May 14. Erratum in: Mol Cell Biol. 2012 Sep;32(17):3608.


Regulatory effects of mTORC2 complexes in type I IFN signaling and in the generation of IFN responses.

Kaur S, Sassano A, Majchrzak-Kita B, Baker DP, Su B, Fish EN, Platanias LC.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7723-8. doi: 10.1073/pnas.1118122109. Epub 2012 May 1.


The yin and yang of viruses and interferons.

Wang BX, Fish EN.

Trends Immunol. 2012 Apr;33(4):190-7. doi: 10.1016/ Epub 2012 Feb 7. Review.


Glomulin: a permissivity factor for vaccinia virus infection.

Rahbar R, Rogers E, Murooka T, Kislinger T, Fish EN.

J Interferon Cytokine Res. 2012 Mar;32(3):127-37. doi: 10.1089/jir.2011.0100. Epub 2012 Jan 26.


Sex affects immunity.

Pennell LM, Galligan CL, Fish EN.

J Autoimmun. 2012 May;38(2-3):J282-91. doi: 10.1016/j.jaut.2011.11.013. Epub 2012 Jan 4. Review.


Interferon: current status and future prospects in cancer therapy.

Wang BX, Rahbar R, Fish EN.

J Interferon Cytokine Res. 2011 Jul;31(7):545-52. doi: 10.1089/jir.2010.0158. Epub 2011 Feb 16. Review.


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