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Items: 1 to 50 of 85

1.

Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein.

Pinho R, Paiva I, Jercic KG, Fonseca-Ornelas L, Gerhardt E, Fahlbusch C, Garcia-Esparcia P, Kerimoglu C, Pavlou MAS, Villar-Piqué A, Szego É, Lopes da Fonseca T, Odoardi F, Soeroes S, Rego AC, Fischle W, Schwamborn JC, Meyer T, Kügler S, Ferrer I, Attems J, Fischer A, Becker S, Zweckstetter M, Borovecki F, Outeiro TF.

Hum Mol Genet. 2019 Jan 1;28(1):31-50. doi: 10.1093/hmg/ddy326.

PMID:
30219847
2.

Chemistry meets epigenetics: from chromatin tools to small molecules affecting the readout of our genomes.

Fischle W, Schwarzer D.

Curr Opin Chem Biol. 2018 Aug;45:vii-ix. doi: 10.1016/j.cbpa.2018.07.024. No abstract available.

PMID:
30075837
3.

Oxidative stress signaling to chromatin in health and disease.

Kreuz S, Fischle W.

Epigenomics. 2016 Jun;8(6):843-62. doi: 10.2217/epi-2016-0002. Epub 2016 Jun 20. Review.

4.

Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.

Hiragami-Hamada K, Soeroes S, Nikolov M, Wilkins B, Kreuz S, Chen C, De La Rosa-Velázquez IA, Zenn HM, Kost N, Pohl W, Chernev A, Schwarzer D, Jenuwein T, Lorincz M, Zimmermann B, Walla PJ, Neumann H, Baubec T, Urlaub H, Fischle W.

Nat Commun. 2016 Apr 19;7:11310. doi: 10.1038/ncomms11310.

5.

Probing Chromatin-modifying Enzymes with Chemical Tools.

Fischle W, Schwarzer D.

ACS Chem Biol. 2016 Mar 18;11(3):689-705. doi: 10.1021/acschembio.5b01023. Epub 2016 Feb 4. Review.

PMID:
26845102
6.

Modulations of DNA Contacts by Linker Histones and Post-translational Modifications Determine the Mobility and Modifiability of Nucleosomal H3 Tails.

Stützer A, Liokatis S, Kiesel A, Schwarzer D, Sprangers R, Söding J, Selenko P, Fischle W.

Mol Cell. 2016 Jan 21;61(2):247-59. doi: 10.1016/j.molcel.2015.12.015. Epub 2016 Jan 14.

7.

Synthetic histone code.

Fischle W, Mootz HD, Schwarzer D.

Curr Opin Chem Biol. 2015 Oct;28:131-40. doi: 10.1016/j.cbpa.2015.07.005. Epub 2015 Aug 6. Review.

PMID:
26256563
8.

Histone H3 Serine 28 Is Essential for Efficient Polycomb-Mediated Gene Repression in Drosophila.

Yung PY, Stuetzer A, Fischle W, Martinez AM, Cavalli G.

Cell Rep. 2015 Jun 9;11(9):1437-45. doi: 10.1016/j.celrep.2015.04.055. Epub 2015 May 21.

9.

A multilaboratory comparison of calibration accuracy and the performance of external references in analytical ultracentrifugation.

Zhao H, Ghirlando R, Alfonso C, Arisaka F, Attali I, Bain DL, Bakhtina MM, Becker DF, Bedwell GJ, Bekdemir A, Besong TM, Birck C, Brautigam CA, Brennerman W, Byron O, Bzowska A, Chaires JB, Chaton CT, Cölfen H, Connaghan KD, Crowley KA, Curth U, Daviter T, Dean WL, Díez AI, Ebel C, Eckert DM, Eisele LE, Eisenstein E, England P, Escalante C, Fagan JA, Fairman R, Finn RM, Fischle W, de la Torre JG, Gor J, Gustafsson H, Hall D, Harding SE, Cifre JG, Herr AB, Howell EE, Isaac RS, Jao SC, Jose D, Kim SJ, Kokona B, Kornblatt JA, Kosek D, Krayukhina E, Krzizike D, Kusznir EA, Kwon H, Larson A, Laue TM, Le Roy A, Leech AP, Lilie H, Luger K, Luque-Ortega JR, Ma J, May CA, Maynard EL, Modrak-Wojcik A, Mok YF, Mücke N, Nagel-Steger L, Narlikar GJ, Noda M, Nourse A, Obsil T, Park CK, Park JK, Pawelek PD, Perdue EE, Perkins SJ, Perugini MA, Peterson CL, Peverelli MG, Piszczek G, Prag G, Prevelige PE, Raynal BD, Rezabkova L, Richter K, Ringel AE, Rosenberg R, Rowe AJ, Rufer AC, Scott DJ, Seravalli JG, Solovyova AS, Song R, Staunton D, Stoddard C, Stott K, Strauss HM, Streicher WW, Sumida JP, Swygert SG, Szczepanowski RH, Tessmer I, Toth RT 4th, Tripathy A, Uchiyama S, Uebel SF, Unzai S, Gruber AV, von Hippel PH, Wandrey C, Wang SH, Weitzel SE, Wielgus-Kutrowska B, Wolberger C, Wolff M, Wright E, Wu YS, Wubben JM, Schuck P.

PLoS One. 2015 May 21;10(5):e0126420. doi: 10.1371/journal.pone.0126420. eCollection 2015.

10.

Chemical biology: Chromatin chemistry goes cellular.

Fischle W, Schwarzer D, Mootz HD.

Nat Chem. 2015 May;7(5):371-3. doi: 10.1038/nchem.2249. No abstract available.

PMID:
25901809
11.

Conserved linker regions and their regulation determine multiple chromatin-binding modes of UHRF1.

Tauber M, Fischle W.

Nucleus. 2015;6(2):123-32. doi: 10.1080/19491034.2015.1026022. Review.

12.

The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.

Stijf-Bultsma Y, Sommer L, Tauber M, Baalbaki M, Giardoglou P, Jones DR, Gelato KA, van Pelt J, Shah Z, Rahnamoun H, Toma C, Anderson KE, Hawkins P, Lauberth SM, Haramis AP, Hart D, Fischle W, Divecha N.

Mol Cell. 2015 May 7;58(3):453-67. doi: 10.1016/j.molcel.2015.03.009. Epub 2015 Apr 9.

13.

Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure.

Kost N, Kaiser S, Ostwal Y, Riedel D, Stützer A, Nikolov M, Rathke C, Renkawitz-Pohl R, Fischle W.

Nucleic Acids Res. 2015 Mar 31;43(6):3033-45. doi: 10.1093/nar/gkv015. Epub 2015 Mar 3.

14.

N-terminal phosphorylation of HP1α increases its nucleosome-binding specificity.

Nishibuchi G, Machida S, Osakabe A, Murakoshi H, Hiragami-Hamada K, Nakagawa R, Fischle W, Nishimura Y, Kurumizaka H, Tagami H, Nakayama J.

Nucleic Acids Res. 2014 Nov 10;42(20):12498-511. doi: 10.1093/nar/gku995. Epub 2014 Oct 20.

15.

Analysis of phosphorylation-dependent protein-protein interactions of histone h3.

Klingberg R, Jost JO, Schümann M, Gelato KA, Fischle W, Krause E, Schwarzer D.

ACS Chem Biol. 2015 Jan 16;10(1):138-45. doi: 10.1021/cb500563n. Epub 2014 Nov 5.

PMID:
25330109
16.

Molecular mechanisms of histone modification function.

Fischle W.

Biochim Biophys Acta. 2014 Aug;1839(8):621-2. doi: 10.1016/j.bbagrm.2014.06.003. Epub 2014 Jun 12. No abstract available.

PMID:
24929071
17.

Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.

Gelato KA, Tauber M, Ong MS, Winter S, Hiragami-Hamada K, Sindlinger J, Lemak A, Bultsma Y, Houliston S, Schwarzer D, Divecha N, Arrowsmith CH, Fischle W.

Mol Cell. 2014 Jun 19;54(6):905-19. doi: 10.1016/j.molcel.2014.04.004. Epub 2014 May 8.

18.

A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

Alpatov R, Lesch BJ, Nakamoto-Kinoshita M, Blanco A, Chen S, Stützer A, Armache KJ, Simon MD, Xu C, Ali M, Murn J, Prisic S, Kutateladze TG, Vakoc CR, Min J, Kingston RE, Fischle W, Warren ST, Page DC, Shi Y.

Cell. 2014 May 8;157(4):869-81. doi: 10.1016/j.cell.2014.03.040.

19.

RNAs - physical and functional modulators of chromatin reader proteins.

Hiragami-Hamada K, Fischle W.

Biochim Biophys Acta. 2014 Aug;1839(8):737-42. doi: 10.1016/j.bbagrm.2014.03.015. Epub 2014 Apr 2. Review.

PMID:
24704208
20.

Characterization of the effects of phosphorylation by CK2 on the structure and binding properties of human HP1β.

Munari F, Gajda MJ, Hiragami-Hamada K, Fischle W, Zweckstetter M.

FEBS Lett. 2014 Apr 2;588(7):1094-9. doi: 10.1016/j.febslet.2014.02.019. Epub 2014 Feb 20.

21.

A cascade of histone modifications induces chromatin condensation in mitosis.

Wilkins BJ, Rall NA, Ostwal Y, Kruitwagen T, Hiragami-Hamada K, Winkler M, Barral Y, Fischle W, Neumann H.

Science. 2014 Jan 3;343(6166):77-80. doi: 10.1126/science.1244508.

PMID:
24385627
22.

Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity.

Ferrari KJ, Scelfo A, Jammula S, Cuomo A, Barozzi I, Stützer A, Fischle W, Bonaldi T, Pasini D.

Mol Cell. 2014 Jan 9;53(1):49-62. doi: 10.1016/j.molcel.2013.10.030. Epub 2013 Nov 27.

23.

Probing the acetylation code of histone H4.

Lang D, Schümann M, Gelato K, Fischle W, Schwarzer D, Krause E.

Proteomics. 2013 Oct;13(20):2989-97. doi: 10.1002/pmic.201200568.

PMID:
23970329
24.

Systematic identification of proteins binding to chromatin-embedded ubiquitylated H2B reveals recruitment of SWI/SNF to regulate transcription.

Shema-Yaacoby E, Nikolov M, Haj-Yahya M, Siman P, Allemand E, Yamaguchi Y, Muchardt C, Urlaub H, Brik A, Oren M, Fischle W.

Cell Rep. 2013 Aug 15;4(3):601-8. doi: 10.1016/j.celrep.2013.07.014. Epub 2013 Aug 8.

25.

A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.

Sun XJ, Wang Z, Wang L, Jiang Y, Kost N, Soong TD, Chen WY, Tang Z, Nakadai T, Elemento O, Fischle W, Melnick A, Patel DJ, Nimer SD, Roeder RG.

Nature. 2013 Aug 1;500(7460):93-7. doi: 10.1038/nature12287. Epub 2013 Jun 30.

26.

Convergent chemical synthesis of histone H2B protein for the site-specific ubiquitination at Lys34.

Siman P, Karthikeyan SV, Nikolov M, Fischle W, Brik A.

Angew Chem Int Ed Engl. 2013 Jul 29;52(31):8059-63. doi: 10.1002/anie.201303844. Epub 2013 Jun 21. No abstract available.

PMID:
23794525
27.

Structural plasticity in human heterochromatin protein 1β.

Munari F, Rezaei-Ghaleh N, Xiang S, Fischle W, Zweckstetter M.

PLoS One. 2013 Apr 9;8(4):e60887. doi: 10.1371/journal.pone.0060887. Print 2013.

28.

Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases.

Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard DB, Verdin E, Urlaub H, Jedrusik-Bode M, Fischle W.

Mitochondrion. 2013 Nov;13(6):705-20. doi: 10.1016/j.mito.2013.02.002. Epub 2013 Feb 21.

29.

One, two, three: how histone methylation is read.

Fischle W.

Epigenomics. 2012 Dec;4(6):641-53. doi: 10.2217/epi.12.56. Review.

PMID:
23244309
30.

Systematic analysis of histone modification readout.

Nikolov M, Fischle W.

Mol Biosyst. 2013 Feb 2;9(2):182-94. doi: 10.1039/c2mb25328c. Epub 2012 Dec 4. Review.

PMID:
23212710
31.

Asymmetrically modified nucleosomes expand the histone code.

van Rossum B, Fischle W, Selenko P.

Nat Struct Mol Biol. 2012 Nov;19(11):1064-6. doi: 10.1038/nsmb.2433. No abstract available.

PMID:
23132382
32.

Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome.

Munari F, Soeroes S, Zenn HM, Schomburg A, Kost N, Schröder S, Klingberg R, Rezaei-Ghaleh N, Stützer A, Gelato KA, Walla PJ, Becker S, Schwarzer D, Zimmermann B, Fischle W, Zweckstetter M.

J Biol Chem. 2012 Sep 28;287(40):33756-65. Epub 2012 Jul 19.

33.

Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events.

Liokatis S, Stützer A, Elsässer SJ, Theillet FX, Klingberg R, van Rossum B, Schwarzer D, Allis CD, Fischle W, Selenko P.

Nat Struct Mol Biol. 2012 Aug;19(8):819-23. doi: 10.1038/nsmb.2310. Epub 2012 Jul 15.

PMID:
22796964
34.

Heterochromatin protein 1 forms distinct complexes to direct histone deacetylation and DNA methylation.

Honda S, Lewis ZA, Shimada K, Fischle W, Sack R, Selker EU.

Nat Struct Mol Biol. 2012 Apr 15;19(5):471-7, S1. doi: 10.1038/nsmb.2274.

35.

Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches.

Seeliger D, Soeroes S, Klingberg R, Schwarzer D, Grubmüller H, Fischle W.

ACS Chem Biol. 2012 Jan 20;7(1):150-4. doi: 10.1021/cb200363r. Epub 2011 Oct 18.

36.

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells.

Stojic L, Jasencakova Z, Prezioso C, Stützer A, Bodega B, Pasini D, Klingberg R, Mozzetta C, Margueron R, Puri PL, Schwarzer D, Helin K, Fischle W, Orlando V.

Epigenetics Chromatin. 2011 Sep 5;4:16. doi: 10.1186/1756-8935-4-16.

37.

Chromatin affinity purification and quantitative mass spectrometry defining the interactome of histone modification patterns.

Nikolov M, Stützer A, Mosch K, Krasauskas A, Soeroes S, Stark H, Urlaub H, Fischle W.

Mol Cell Proteomics. 2011 Nov;10(11):M110.005371. doi: 10.1074/mcp.M110.005371. Epub 2011 Aug 11.

38.

A dual role of H4K16 acetylation in the establishment of yeast silent chromatin.

Oppikofer M, Kueng S, Martino F, Soeroes S, Hancock SM, Chin JW, Fischle W, Gasser SM.

EMBO J. 2011 Jun 10;30(13):2610-21. doi: 10.1038/emboj.2011.170.

39.

Histone methylation by PRC2 is inhibited by active chromatin marks.

Schmitges FW, Prusty AB, Faty M, Stützer A, Lingaraju GM, Aiwazian J, Sack R, Hess D, Li L, Zhou S, Bunker RD, Wirth U, Bouwmeester T, Bauer A, Ly-Hartig N, Zhao K, Chan H, Gu J, Gut H, Fischle W, Müller J, Thomä NH.

Mol Cell. 2011 May 6;42(3):330-41. doi: 10.1016/j.molcel.2011.03.025.

40.

H3K9me2/3 binding of the MBT domain protein LIN-61 is essential for Caenorhabditis elegans vulva development.

Koester-Eiserfunke N, Fischle W.

PLoS Genet. 2011 Mar;7(3):e1002017. doi: 10.1371/journal.pgen.1002017. Epub 2011 Mar 17.

41.

HP1 recruits activity-dependent neuroprotective protein to H3K9me3 marked pericentromeric heterochromatin for silencing of major satellite repeats.

Mosch K, Franz H, Soeroes S, Singh PB, Fischle W.

PLoS One. 2011 Jan 18;6(1):e15894. doi: 10.1371/journal.pone.0015894.

42.

Molecular epigenetics: connecting human biology and disease with little marks.

Jeltsch A, Fischle W.

Chembiochem. 2011 Jan 24;12(2):183-4. doi: 10.1002/cbic.201000779. No abstract available.

PMID:
21243707
43.

TRIM24 links a non-canonical histone signature to breast cancer.

Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC.

Nature. 2010 Dec 16;468(7326):927-32. doi: 10.1038/nature09542.

44.

Epigenetic markers and their cross-talk.

Winter S, Fischle W.

Essays Biochem. 2010 Sep 20;48(1):45-61. doi: 10.1042/bse0480045. Review.

PMID:
20822485
45.

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail.

Zhang Y, Jurkowska R, Soeroes S, Rajavelu A, Dhayalan A, Bock I, Rathert P, Brandt O, Reinhardt R, Fischle W, Jeltsch A.

Nucleic Acids Res. 2010 Jul;38(13):4246-53. doi: 10.1093/nar/gkq147. Epub 2010 Mar 11.

46.

Molecular architecture of the human Prp19/CDC5L complex.

Grote M, Wolf E, Will CL, Lemm I, Agafonov DE, Schomburg A, Fischle W, Urlaub H, Lührmann R.

Mol Cell Biol. 2010 May;30(9):2105-19. doi: 10.1128/MCB.01505-09. Epub 2010 Feb 22.

47.

Tip60-ing the balance in DSB repair.

Fischle W.

Nat Cell Biol. 2009 Nov;11(11):1279-81. doi: 10.1038/ncb1109-1279. No abstract available.

PMID:
19884884
48.

Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association.

Franz H, Mosch K, Soeroes S, Urlaub H, Fischle W.

J Biol Chem. 2009 Dec 11;284(50):35049-59. doi: 10.1074/jbc.M109.052332. Epub 2009 Oct 5. Erratum in: J Biol Chem. 2010 Apr 9;285(15):11754.

49.

HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line.

Wirth M, Paap F, Fischle W, Wenzel D, Agafonov DE, Samatov TR, Wisniewski JR, Jedrusik-Bode M.

Mol Cell Biol. 2009 Jul;29(13):3700-9. doi: 10.1128/MCB.00018-09. Epub 2009 Apr 20.

50.

Talk is cheap--cross-talk in establishment, maintenance, and readout of chromatin modifications.

Fischle W.

Genes Dev. 2008 Dec 15;22(24):3375-82. doi: 10.1101/gad.1759708.

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