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Items: 44


mTOR drives cerebrovascular, synaptic, and cognitive dysfunction in normative aging.

Van Skike CE, Lin AL, Roberts Burbank R, Halloran JJ, Hernandez SF, Cuvillier J, Soto VY, Hussong SA, Jahrling JB, Javors MA, Hart MJ, Fischer KE, Austad SN, Galvan V.

Aging Cell. 2020 Jan;19(1):e13057. doi: 10.1111/acel.13057. Epub 2019 Nov 6.


Lifelong reduction in complex IV induces tissue-specific metabolic effects but does not reduce lifespan or healthspan in mice.

Deepa SS, Pharaoh G, Kinter M, Diaz V, Fok WC, Riddle K, Pulliam D, Hill S, Fischer KE, Soto V, Georgescu C, Wren JD, Viscomi C, Richardson A, Van Remmen H.

Aging Cell. 2018 Aug;17(4):e12769. doi: 10.1111/acel.12769. Epub 2018 Apr 25.


Sex Differences in Aging: Genomic Instability.

Fischer KE, Riddle NC.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):166-174. doi: 10.1093/gerona/glx105. Review.


Sustained NFκB inhibition improves insulin sensitivity but is detrimental to muscle health.

Zhang N, Valentine JM, Zhou Y, Li ME, Zhang Y, Bhattacharya A, Walsh ME, Fischer KE, Austad SN, Osmulski P, Gaczynska M, Shoelson SE, Van Remmen H, Chen HI, Chen Y, Liang H, Musi N.

Aging Cell. 2017 Aug;16(4):847-858. doi: 10.1111/acel.12613. Epub 2017 May 29.


Sco2 deficient mice develop increased adiposity and insulin resistance.

Hill S, Deepa SS, Sataranatarajan K, Premkumar P, Pulliam D, Liu Y, Soto VY, Fischer KE, Van Remmen H.

Mol Cell Endocrinol. 2017 Nov 5;455:103-114. doi: 10.1016/j.mce.2017.03.019. Epub 2017 Apr 18.


The impact of physician-level drug budgets on prescribing behavior.

Fischer KE, Koch T, Kostev K, Stargardt T.

Eur J Health Econ. 2018 Mar;19(2):213-222. doi: 10.1007/s10198-017-0875-9. Epub 2017 Feb 13.


Drug safety and the impact of drug warnings: An interrupted time series analysis of diabetes drug prescriptions in Germany and Denmark.

Hostenkamp G, Fischer KE, Borch-Johnsen K.

Health Policy. 2016 Dec;120(12):1404-1411. doi: 10.1016/j.healthpol.2016.09.020. Epub 2016 Oct 11.


A cross-sectional study of male and female C57BL/6Nia mice suggests lifespan and healthspan are not necessarily correlated.

Fischer KE, Hoffman JM, Sloane LB, Gelfond JA, Soto VY, Richardson AG, Austad SN.

Aging (Albany NY). 2016 Oct 2;8(10):2370-2391. doi: 10.18632/aging.101059.


Health benefit assessment of pharmaceuticals: An international comparison of decisions from Germany, England, Scotland and Australia.

Fischer KE, Heisser T, Stargardt T.

Health Policy. 2016 Oct;120(10):1115-1122. doi: 10.1016/j.healthpol.2016.08.001. Epub 2016 Aug 9.


Sex Differences in Lifespan.

Austad SN, Fischer KE.

Cell Metab. 2016 Jun 14;23(6):1022-1033. doi: 10.1016/j.cmet.2016.05.019. Review.


Dispensing behaviour of pharmacies in prescription drug markets.

Guhl D, Stargardt T, Schneider U, Fischer KE.

Health Policy. 2016 Feb;120(2):190-7. doi: 10.1016/j.healthpol.2016.01.010. Epub 2016 Jan 21.


Salt-sensitivity of σ(H) and Spo0A prevents sporulation of Bacillus subtilis at high osmolarity avoiding death during cellular differentiation.

Widderich N, Rodrigues CD, Commichau FM, Fischer KE, Ramirez-Guadiana FH, Rudner DZ, Bremer E.

Mol Microbiol. 2016 Apr;100(1):108-24. doi: 10.1111/mmi.13304. Epub 2016 Jan 18.


The diffusion of generics after patent expiry in Germany.

Fischer KE, Stargardt T.

Eur J Health Econ. 2016 Nov;17(8):1027-1040. Epub 2015 Nov 16.


Measures of Healthspan as Indices of Aging in Mice-A Recommendation.

Richardson A, Fischer KE, Speakman JR, de Cabo R, Mitchell SJ, Peterson CA, Rabinovitch P, Chiao YA, Taffet G, Miller RA, Rentería RC, Bower J, Ingram DK, Ladiges WC, Ikeno Y, Sierra F, Austad SN.

J Gerontol A Biol Sci Med Sci. 2016 Apr;71(4):427-30. doi: 10.1093/gerona/glv080. Epub 2015 Aug 22.


Health Effects of Long-Term Rapamycin Treatment: The Impact on Mouse Health of Enteric Rapamycin Treatment from Four Months of Age throughout Life.

Fischer KE, Gelfond JA, Soto VY, Han C, Someya S, Richardson A, Austad SN.

PLoS One. 2015 May 15;10(5):e0126644. doi: 10.1371/journal.pone.0126644. eCollection 2015.


Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice.

Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB.

Arch Biochem Biophys. 2015 Jun 15;576:39-48. doi: 10.1016/ Epub 2015 Jan 3.


Use of Nerve Conduction Velocity to Assess Peripheral Nerve Health in Aging Mice.

Walsh ME, Sloane LB, Fischer KE, Austad SN, Richardson A, Van Remmen H.

J Gerontol A Biol Sci Med Sci. 2015 Nov;70(11):1312-9. doi: 10.1093/gerona/glu208. Epub 2014 Dec 3.


Prescription of Rosiglitazone and Pioglitazone Folowing Safety Warnings: A Comparative Analysis of Trends in Dispensing Patterns in Denmark and Germany From 2007 To 2013.

Hostenkamp G, Fischer KE.

Value Health. 2014 Nov;17(7):A359. doi: 10.1016/j.jval.2014.08.774. Epub 2014 Oct 26. No abstract available.


Early benefit assessment of pharmaceuticals in Germany: manufacturers' expectations versus the Federal Joint Committee's decisions.

Fischer KE, Stargardt T.

Med Decis Making. 2014 Nov;34(8):1030-47. doi: 10.1177/0272989X14546377. Epub 2014 Aug 22.


Funding decisions for newborn screening: a comparative review of 22 decision processes in Europe.

Fischer KE, Rogowski WH.

Int J Environ Res Public Health. 2014 May 19;11(5):5403-30. doi: 10.3390/ijerph110505403. Review.


Analysing coverage decision-making: opening Pandora's box?

Fischer KE, Leidl R.

Eur J Health Econ. 2014 Dec;15(9):899-906. doi: 10.1007/s10198-014-0566-8. Epub 2014 Feb 6. No abstract available.


eRapa restores a normal life span in a FAP mouse model.

Hasty P, Livi CB, Dodds SG, Jones D, Strong R, Javors M, Fischer KE, Sloane L, Murthy K, Hubbard G, Sun L, Hurez V, Curiel TJ, Sharp ZD.

Cancer Prev Res (Phila). 2014 Jan;7(1):169-78. doi: 10.1158/1940-6207.CAPR-13-0299. Epub 2013 Nov 26.


Link between process and appraisal in coverage decisions: an analysis with structural equation modeling.

Fischer KE, Stollenwerk B, Rogowski WH.

Med Decis Making. 2013 Nov;33(8):1009-25. doi: 10.1177/0272989X13490837. Epub 2013 Jun 14.


Transparency vs. closed-door policy: do process characteristics have an impact on the outcomes of coverage decisions? A statistical analysis.

Fischer KE, Rogowski WH, Leidl R, Stollenwerk B.

Health Policy. 2013 Oct;112(3):187-96. doi: 10.1016/j.healthpol.2013.04.011. Epub 2013 May 10.


Nanostructure-mediated transport of biologics across epithelial tissue: enhancing permeability via nanotopography.

Kam KR, Walsh LA, Bock SM, Koval M, Fischer KE, Ross RF, Desai TA.

Nano Lett. 2013 Jan 9;13(1):164-71. doi: 10.1021/nl3037799. Epub 2012 Dec 24.


Modulation of methuselah expression targeted to Drosophila insulin-producing cells extends life and enhances oxidative stress resistance.

Gimenez LE, Ghildyal P, Fischer KE, Hu H, Ja WW, Eaton BA, Wu Y, Austad SN, Ranjan R.

Aging Cell. 2013 Feb;12(1):121-9. doi: 10.1111/acel.12027. Epub 2012 Dec 6.


Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices.

Uskoković V, Lee K, Lee PP, Fischer KE, Desai TA.

ACS Nano. 2012 Sep 25;6(9):7832-41. Epub 2012 Aug 24.


A systematic review of coverage decision-making on health technologies-evidence from the real world.

Fischer KE.

Health Policy. 2012 Oct;107(2-3):218-30. doi: 10.1016/j.healthpol.2012.07.005. Epub 2012 Aug 4. Review.


Activity of the osmotically regulated yqiHIK promoter from Bacillus subtilis is controlled at a distance.

Fischer KE, Bremer E.

J Bacteriol. 2012 Oct;194(19):5197-208. doi: 10.1128/JB.01041-12. Epub 2012 Jul 27.


Chronic inhibition of mammalian target of rapamycin by rapamycin modulates cognitive and non-cognitive components of behavior throughout lifespan in mice.

Halloran J, Hussong SA, Burbank R, Podlutskaya N, Fischer KE, Sloane LB, Austad SN, Strong R, Richardson A, Hart MJ, Galvan V.

Neuroscience. 2012 Oct 25;223:102-13. doi: 10.1016/j.neuroscience.2012.06.054. Epub 2012 Jun 28. Erratum in: Neuroscience. 2015 Oct 15;306():151.


PEGylated silicon nanowire coated silica microparticles for drug delivery across intestinal epithelium.

Uskoković V, Lee PP, Walsh LA, Fischer KE, Desai TA.

Biomaterials. 2012 Feb;33(5):1663-72. doi: 10.1016/j.biomaterials.2011.11.010. Epub 2011 Nov 23.


The role of health technology assessment in coverage decisions on newborn screening.

Fischer KE, Grosse SD, Rogowski WH.

Int J Technol Assess Health Care. 2011 Oct;27(4):313-21. doi: 10.1017/S0266462311000468.


A structured tool to analyse coverage decisions: development and feasibility test in the field of cancer screening and prevention.

Fischer KE, Leidl R, Rogowski WH.

Health Policy. 2011 Aug;101(3):290-9. doi: 10.1016/j.healthpol.2011.03.002. Epub 2011 May 6.


Attenuation of liver insoluble protein carbonyls: indicator of a longevity determinant?

Bhattacharya A, Leonard S, Tardif S, Buffenstein R, Fischer KE, Richardson A, Austad SN, Chaudhuri AR.

Aging Cell. 2011 Aug;10(4):720-3. doi: 10.1111/j.1474-9726.2011.00712.x. Epub 2011 May 6.


The development of small primate models for aging research.

Fischer KE, Austad SN.

ILAR J. 2011;52(1):78-88. Review.


Hierarchical nanoengineered surfaces for enhanced cytoadhesion and drug delivery.

Fischer KE, Nagaraj G, Hugh Daniels R, Li E, Cowles VE, Miller JL, Bunger MD, Desai TA.

Biomaterials. 2011 May;32(13):3499-506. doi: 10.1016/j.biomaterials.2011.01.022. Epub 2011 Feb 5.


Nanoengineered surfaces enhance drug loading and adhesion.

Fischer KE, Jayagopal A, Nagaraj G, Daniels RH, Li EM, Silvestrini MT, Desai TA.

Nano Lett. 2011 Mar 9;11(3):1076-81. doi: 10.1021/nl103951e. Epub 2011 Jan 31.


Biomimetic nanowire coatings for next generation adhesive drug delivery systems.

Fischer KE, Alemán BJ, Tao SL, Hugh Daniels R, Li EM, Bünger MD, Nagaraj G, Singh P, Zettl A, Desai TA.

Nano Lett. 2009 Feb;9(2):716-20. doi: 10.1021/nl803219f.



Boeré RT, Dibble PW, Fischer KE.

Acta Crystallogr Sect E Struct Rep Online. 2008 Mar 12;64(Pt 4):o686. doi: 10.1107/S1600536808006016.


The relationship of parental alcoholism and family dysfunction to stress among college students.

Fischer KE, Kittleson M, Ogletree R, Welshimer K, Woehlke P, Benshoff J.

J Am Coll Health. 2000 Jan;48(4):151-6.


Primate longevity: Its place in the mammalian scheme.

Austad SN, Fischer KE.

Am J Primatol. 1992;28(4):251-261. doi: 10.1002/ajp.1350280403.


Mammalian aging, metabolism, and ecology: evidence from the bats and marsupials.

Austad SN, Fischer KE.

J Gerontol. 1991 Mar;46(2):B47-53.


Adult children of alcoholics: implications for the nursing profession.

Fischer KE.

Nurs Forum. 1987-1988;23(4):159-63. Review. No abstract available.


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