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Derivation and identification of a mechanistic model for a branched enzyme-catalyzed carboligation.

Ohs R, Fischer K, Schöpping M, Spiess AC.

Biotechnol Prog. 2019 Jun 17:e2868. doi: 10.1002/btpr.2868. [Epub ahead of print]


Sequencing of mRNA from Whole Blood using Nanopore Sequencing.

Mueller A, Fischer K, Suluku R, Hoenen T.

J Vis Exp. 2019 Jun 3;(148). doi: 10.3791/59377.


Timing of inhibitor development in >1000 previously untreated patients with severe hemophilia A.

van den Berg HM, Fischer K, Carcao M, Chambost H, Kenet G, Kurnik K, Königs C, Male C, Santagostino E, Ljung R.

Blood. 2019 Jun 11. pii: blood.2019000658. doi: 10.1182/blood.2019000658. [Epub ahead of print] No abstract available.


Polygenic prediction of breast cancer: comparison of genetic predictors and implications for risk stratification.

Läll K, Lepamets M, Palover M, Esko T, Metspalu A, Tõnisson N, Padrik P, Mägi R, Fischer K.

BMC Cancer. 2019 Jun 10;19(1):557. doi: 10.1186/s12885-019-5783-1.


Cochlea-Specific Deletion of Cav1.3 Calcium Channels Arrests Inner Hair Cell Differentiation and Unravels Pitfalls of Conditional Mouse Models.

Eckrich S, Hecker D, Sorg K, Blum K, Fischer K, Münkner S, Wenzel G, Schick B, Engel J.

Front Cell Neurosci. 2019 May 22;13:225. doi: 10.3389/fncel.2019.00225. eCollection 2019.


Venetoclax and Obinutuzumab in Patients with CLL and Coexisting Conditions.

Fischer K, Al-Sawaf O, Bahlo J, Fink AM, Tandon M, Dixon M, Robrecht S, Warburton S, Humphrey K, Samoylova O, Liberati AM, Pinilla-Ibarz J, Opat S, Sivcheva L, Le Dû K, Fogliatto LM, Niemann CU, Weinkove R, Robinson S, Kipps TJ, Boettcher S, Tausch E, Humerickhouse R, Eichhorst B, Wendtner CM, Langerak AW, Kreuzer KA, Ritgen M, Goede V, Stilgenbauer S, Mobasher M, Hallek M.

N Engl J Med. 2019 Jun 6;380(23):2225-2236. doi: 10.1056/NEJMoa1815281. Epub 2019 Jun 4.


Food neophobia associates with poorer dietary quality, metabolic risk factors, and increased disease outcome risk in population-based cohorts in a metabolomics study.

Sarin HV, Taba N, Fischer K, Esko T, Kanerva N, Moilanen L, Saltevo J, Joensuu A, Borodulin K, Männistö S, Kristiansson K, Perola M.

Am J Clin Nutr. 2019 Jun 4. pii: nqz100. doi: 10.1093/ajcn/nqz100. [Epub ahead of print]


Stimulation of subchondral bone cyst healing by placement of a transcondylar screw in the equine medial femoral condyle.

Frazer LL, Santschi EM, Fischer KJ.

Vet Surg. 2019 Jun 2. doi: 10.1111/vsu.13247. [Epub ahead of print]


Effect of 2000 IU compared with 800 IU vitamin D on cognitive performance among adults age 60 years and older: a randomized controlled trial.

Schietzel S, Fischer K, Brugger P, Orav EJ, Renerts K, Gagesch M, Freystaetter G, Stähelin HB, Egli A, Bischoff-Ferrari HA.

Am J Clin Nutr. 2019 Jun 1. pii: nqz081. doi: 10.1093/ajcn/nqz081. [Epub ahead of print]


Cerebellar Transcranial Direct Current Stimulation Enhances Motor Learning in a Complex Overhand Throwing Task.

Jackson AK, de Albuquerque LL, Pantovic M, Fischer KM, Guadagnoli MA, Riley ZA, Poston B.

Cerebellum. 2019 May 18. doi: 10.1007/s12311-019-01040-6. [Epub ahead of print]


Small Lymphocytic Lymphoma: Analysis of Two Cohorts Including Patients in Clinical Trials of the German Chronic Lymphocytic Leukemia Study Group (GCLLSG) or in "Real-Life" Outside of Clinical Trials.

Sachanas S, Pangalis GA, Fink AM, Bahlo J, Fischer K, Levidou G, Kyrtsonis MC, Bartzi V, Vassilakopoulos TP, Kalpadakis C, Koulieris E, Moschogiannis M, Yiakoumis X, Tsirkinidis P, Angelopoulou MK, Eichhorst B, Hallek M.

Anticancer Res. 2019 May;39(5):2591-2598. doi: 10.21873/anticanres.13382.


Parents of early-maturing girls die younger.

Hõrak P, Valge M, Fischer K, Mägi R, Kaart T.

Evol Appl. 2019 Mar 23;12(5):1050-1061. doi: 10.1111/eva.12780. eCollection 2019 Jun.


An acute application of transcranial random noise stimulation does not enhance motor skill acquisition or retention in a golf putting task.

Albuquerque LL, Fischer KM, Pauls AL, Pantovic M, Guadagnoli MA, Riley ZA, Poston B.

Hum Mov Sci. 2019 May 9;66:241-248. doi: 10.1016/j.humov.2019.04.017. [Epub ahead of print]


New insights into the natural course and clinical relevance of Modic changes over 2 years following lumbar limited discectomy: analysis of prospective collected data.

Bostelmann R, Petridis A, Fischer K, Vajkoczy P, Bostelmann T, Barth M.

Eur Spine J. 2019 May 4. doi: 10.1007/s00586-019-05988-1. [Epub ahead of print]


[Geriatric patients in orthopedics].

Fischer K.

Orthopade. 2019 May;48(5):441-450. doi: 10.1007/s00132-019-03723-8. German.


Evaluating the Effects of Various Decalcification Protocols on Immunohistochemical Staining in Zebrafish (Danio rerio).

Meritet DM, Spagnoli ST, Fischer KA, Löhr CV.

Zebrafish. 2019 Jun;16(3):280-290. doi: 10.1089/zeb.2018.1697. Epub 2019 Apr 24.


The evolution of the plastid phosphate translocator family.

Bockwoldt M, Heiland I, Fischer K.

Planta. 2019 Jul;250(1):245-261. doi: 10.1007/s00425-019-03161-y. Epub 2019 Apr 16.


Henipaviruses at the Interface Between Bats, Livestock and Human Population in Africa: A Review.

Mbu'u CM, Mbacham WF, Gontao P, Sado Kamdem SL, Nlôga AMN, Groschup MH, Wade A, Fischer K, Balkema-Buschmann A.

Vector Borne Zoonotic Dis. 2019 Apr 13. doi: 10.1089/vbz.2018.2365. [Epub ahead of print]


A splice donor variant in CCDC189 is associated with asthenospermia in Nordic Red dairy cattle.

Iso-Touru T, Wurmser C, Venhoranta H, Hiltpold M, Savolainen T, Sironen A, Fischer K, Flisikowski K, Fries R, Vicente-Carrillo A, Alvarez-Rodriguez M, Nagy S, Mutikainen M, Peippo J, Taponen J, Sahana G, Guldbrandtsen B, Simonen H, Rodriguez-Martinez H, Andersson M, Pausch H.

BMC Genomics. 2019 Apr 11;20(1):286. doi: 10.1186/s12864-019-5628-y.


Timeline of functional recovery after hip fracture in seniors aged 65 and older: a prospective observational analysis.

Fischer K, Trombik M, Freystätter G, Egli A, Theiler R, Bischoff-Ferrari HA.

Osteoporos Int. 2019 Apr 2. doi: 10.1007/s00198-019-04944-5. [Epub ahead of print]


Prominent Postsynaptic and Dendritic Exocytosis of Endogenous BDNF Vesicles in BDNF-GFP Knock-in Mice.

Leschik J, Eckenstaler R, Endres T, Munsch T, Edelmann E, Richter K, Kobler O, Fischer KD, Zuschratter W, Brigadski T, Lutz B, Lessmann V.

Mol Neurobiol. 2019 Mar 30. doi: 10.1007/s12035-019-1551-0. [Epub ahead of print]


Deletion of neuronal GLT-1 in mice reveals its role in synaptic glutamate homeostasis and mitochondrial function.

McNair LF, Andersen JV, Aldana B, Hohnholt MC, Nissen JD, Sun Y, Fischer KD, Sonnewald U, Nyberg N, Webster SC, Kapur K, Rimmele TS, Barone I, Hawks-Mayer H, Lipton JO, Hodgson NW, Aoki CJ, Rosenberg PA, Waagepetersen HS.

J Neurosci. 2019 Mar 29. pii: 0894-18. doi: 10.1523/JNEUROSCI.0894-18.2019. [Epub ahead of print]


Short telomeres are associated with inferior outcome, genomic complexity, and clonal evolution in chronic lymphocytic leukemia.

Jebaraj BMC, Tausch E, Landau DA, Bahlo J, Robrecht S, Taylor-Weiner AN, Bloehdorn J, Scheffold A, Mertens D, Böttcher S, Kneba M, Jäger U, Zenz T, Wenger MK, Fingerle-Rowson G, Wendtner C, Fink AM, Wu CJ, Eichhorst B, Fischer K, Hallek M, Döhner H, Stilgenbauer S.

Leukemia. 2019 Mar 25. doi: 10.1038/s41375-019-0446-4. [Epub ahead of print]


Molecular cloning, expression and characterization of Pekin duck programmed death-1.

Yao Q, Fischer KP, Tyrrell DL, Gutfreund KS.

Gene. 2019 Jun 20;702:182-193. doi: 10.1016/j.gene.2019.03.035. Epub 2019 Mar 22.


Microsolvation Structures of Protonated Glycine and l-Alanine.

Fischer KC, Sherman SL, Voss JM, Zhou J, Garand E.

J Phys Chem A. 2019 Apr 18;123(15):3355-3366. doi: 10.1021/acs.jpca.9b01578. Epub 2019 Apr 8.


Pirt deficiency has subtle female-specific effects on energy and glucose metabolism in mice.

Jall S, Finan B, Collden G, Fischer K, Dong X, Tschöp MH, Müller TD, Clemmensen C.

Mol Metab. 2019 May;23:75-81. doi: 10.1016/j.molmet.2019.02.011. Epub 2019 Mar 7.


What's in a name: Participatory epidemiology.

Fischer K, Chenais E.

Prev Vet Med. 2019 Apr 1;165:34-35. doi: 10.1016/j.prevetmed.2019.01.009. Epub 2019 Feb 10. No abstract available.


Mapping of lymphatic filariasis in loiasis areas: A new strategy shows no evidence for Wuchereria bancrofti endemicity in Cameroon.

Wanji S, Esum ME, Njouendou AJ, Mbeng AA, Chounna Ndongmo PW, Abong RA, Fru J, Fombad FF, Nchanji GT, Ngongeh G, Ngandjui NV, Enyong PI, Storey H, Curtis KC, Fischer K, Fauver JR, Lew D, Goss CW, Fischer PU.

PLoS Negl Trop Dis. 2019 Mar 8;13(3):e0007192. doi: 10.1371/journal.pntd.0007192. eCollection 2019 Mar.


Origin of the low-frequency plateau and the light-scattering slow mode in semidilute poly(ethylene glycol) solutions.

Koziol M, Fischer K, Seiffert S.

Soft Matter. 2019 Mar 20;15(12):2666-2676. doi: 10.1039/c8sm02263a.


Minimal Associations Between Clinical Data and Children's Self-Reported Health-Related Quality of Life in Children With Chronic Conditions-A Cross-Sectional Study.

Fischer KI, Barthel D, Otto C, Ravens-Sieberer U, Thyen U, Klein M, Walter O, Rose M, Nolte S.

Front Pediatr. 2019 Feb 5;7:17. doi: 10.3389/fped.2019.00017. eCollection 2019.


The impact of pathological high-frequency oscillations on hippocampal network activity in rats with chronic epilepsy.

Ewell LA, Fischer KB, Leibold C, Leutgeb S, Leutgeb JK.

Elife. 2019 Feb 22;8. pii: e42148. doi: 10.7554/eLife.42148.


Venetoclax plus rituximab or obinutuzumab after allogeneic hematopoietic stem cell transplantation in chronic lymphocytic leukemia.

Al-Sawaf O, Herling CD, Holtick U, Scheid C, Cramer P, Sasse S, von Tresckow B, Tuchscherer A, Fischer K, Eichhorst B, Hallek M, Frenzel LP.

Haematologica. 2019 May;104(5):e224-e226. doi: 10.3324/haematol.2018.212837. Epub 2019 Feb 21. No abstract available.


Cytoplasmic and periplasmic expression of recombinant shark VNAR antibody in Escherichia coli.

Leow HC, Fischer K, Leow YC, Braet K, Cheng Q, McCarthy J.

Prep Biochem Biotechnol. 2019;49(4):315-327. doi: 10.1080/10826068.2019.1566145. Epub 2019 Feb 15.


Discovery of 3-hydroxy-3-pyrrolin-2-one-based mPGES-1 inhibitors using a multi-step virtual screening protocol.

Lauro G, Cantone V, Potenza M, Fischer K, Koeberle A, Werz O, Riccio R, Bifulco G.

Medchemcomm. 2018 Nov 20;9(12):2028-2036. doi: 10.1039/c8md00497h. eCollection 2018 Dec 1.


Monocytes Represent One Source of Bacterial Shielding from Antibiotics following Influenza Virus Infection.

Fischer KJ, Yajjala VK, Bansal S, Bauer C, Chen R, Sun K.

J Immunol. 2019 Apr 1;202(7):2027-2034. doi: 10.4049/jimmunol.1801471. Epub 2019 Feb 11.


Effects of a simple home exercise program and vitamin D supplementation on health-related quality of life after a hip fracture: a randomized controlled trial.

Renerts K, Fischer K, Dawson-Hughes B, Orav EJ, Freystaetter G, Simmen HP, Pape HC, Egli A, Theiler R, Bischoff-Ferrari HA.

Qual Life Res. 2019 May;28(5):1377-1386. doi: 10.1007/s11136-019-02100-4. Epub 2019 Feb 9.


Patterns of TIGIT Expression in Lymphatic Tissue, Inflammation, and Cancer.

Blessin NC, Simon R, Kluth M, Fischer K, Hube-Magg C, Li W, Makrypidi-Fraune G, Wellge B, Mandelkow T, Debatin NF, Höflmayer D, Lennartz M, Sauter G, Izbicki JR, Minner S, Büscheck F, Uhlig R, Dum D, Krech T, Luebke AM, Wittmer C, Jacobsen F, Burandt EC, Steurer S, Wilczak W, Hinsch A.

Dis Markers. 2019 Jan 10;2019:5160565. doi: 10.1155/2019/5160565. eCollection 2019.


Acute Moraxella catarrhalis Airway Infection of Chronically Smoke-Exposed Mice Increases Mechanisms of Emphysema Development: A Pilot Study.

Fischer K, Doehn JM, Herr C, Lachner C, Heinrich A, Kershaw O, Voss M, Jacobson MH, Gruber AD, Clauss M, Witzenrath M, Bals R, Gutbier B, Slevogt H.

Eur J Microbiol Immunol (Bp). 2018 Dec 11;8(4):128-134. doi: 10.1556/1886.2018.00019. eCollection 2018 Dec 23.


Spectrum of Microbial Sequences and a Bacterial Cell Wall Antigen in Primary Demyelination Brain Specimens Obtained from Living Patients.

Kriesel JD, Bhetariya P, Wang ZM, Renner D, Palmer C, Fischer KF.

Sci Rep. 2019 Feb 4;9(1):1387. doi: 10.1038/s41598-018-38198-8.


Sports participation and physical activity in adult Dutch and Swedish patients with severe haemophilia: A comparison between intermediate- and high-dose prophylaxis.

Versloot O, Berntorp E, Petrini P, Ljung R, Astermark J, Holmström M, de Kleijn P, Fischer K.

Haemophilia. 2019 Mar;25(2):244-251. doi: 10.1111/hae.13683. Epub 2019 Jan 28.


Effects of adult temperature on gene expression in a butterfly: identifying pathways associated with thermal acclimation.

Franke K, Karl I, Centeno TP, Feldmeyer B, Lassek C, Oostra V, Riedel K, Stanke M, Wheat CW, Fischer K.

BMC Evol Biol. 2019 Jan 23;19(1):32. doi: 10.1186/s12862-019-1362-y.


Relationship between myocardial oxygenation and blood pressure: Experimental validation using oxygenation-sensitive cardiovascular magnetic resonance.

Guensch DP, Fischer K, Jung C, Hurni S, Winkler BM, Jung B, Vogt AP, Eberle B.

PLoS One. 2019 Jan 16;14(1):e0210098. doi: 10.1371/journal.pone.0210098. eCollection 2019.


Genomics of 1 million parent lifespans implicates novel pathways and common diseases and distinguishes survival chances.

Timmers PR, Mounier N, Lall K, Fischer K, Ning Z, Feng X, Bretherick AD, Clark DW; eQTLGen Consortium, Agbessi M, Ahsan H, Alves I, Andiappan A, Awadalla P, Battle A, Bonder MJ, Boomsma D, Christiansen M, Claringbould A, Deelen P, van Dongen J, Esko T, Favé M, Franke L, Frayling T, Gharib SA, Gibson G, Hemani G, Jansen R, Kalnapenkis A, Kasela S, Kettunen J, Kim Y, Kirsten H, Kovacs P, Krohn K, Kronberg-Guzman J, Kukushkina V, Kutalik Z, Kähönen M, Lee B, Lehtimäki T, Loeffler M, Marigorta U, Metspalu A, van Meurs J, Milani L, Müller-Nurasyid M, Nauck M, Nivard M, Penninx B, Perola M, Pervjakova N, Pierce B, Powell J, Prokisch H, Psaty BM, Raitakari O, Ring S, Ripatti S, Rotzschke O, Ruëger S, Saha A, Scholz M, Schramm K, Seppälä I, Stumvoll M, Sullivan P, Teumer A, Thiery J, Tong L, Tönjes A, Verlouw J, Visscher PM, Võsa U, Völker U, Yaghootkar H, Yang J, Zeng B, Zhang F, Agbessi M, Ahsan H, Alves I, Andiappan A, Awadalla P, Battle A, Bonder MJ, Boomsma D, Christiansen M, Claringbould A, Deelen P, van Dongen J, Esko T, Favé M, Franke L, Frayling T, Gharib SA, Gibson G, Hemani G, Jansen R, Kalnapenkis A, Kasela S, Kettunen J, Kim Y, Kirsten H, Kovacs P, Krohn K, Kronberg-Guzman J, Kukushkina V, Kutalik Z, Kähönen M, Lee B, Lehtimäki T, Loeffler M, Marigorta U, Metspalu A, van Meurs J, Milani L, Müller-Nurasyid M, Nauck M, Nivard M, Penninx B, Perola M, Pervjakova N, Pierce B, Powell J, Prokisch H, Psaty BM, Raitakari O, Ring S, Ripatti S, Rotzschke O, Ruëger S, Saha A, Scholz M, Schramm K, Seppälä I, Stumvoll M, Sullivan P, Teumer A, Thiery J, Tong L, Tönjes A, Verlouw J, Visscher PM, Võsa U, Völker U, Yaghootkar H, Yang J, Zeng B, Zhang F, Shen X, Esko T, Kutalik Z, Wilson JF, Joshi PK.

Elife. 2019 Jan 15;8. pii: e39856. doi: 10.7554/eLife.39856.


PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data.

Hsu YH, Churchhouse C, Pers TH, Mercader JM, Metspalu A, Fischer K, Fortney K, Morgen EK, Gonzalez C, Gonzalez ME, Esko T, Hirschhorn JN.

PLoS Comput Biol. 2019 Jan 14;15(1):e1006734. doi: 10.1371/journal.pcbi.1006734. eCollection 2019 Jan.


Estimating the performance of three cardiovascular disease risk scores: the Estonian Biobank cohort study.

Saar A, Läll K, Alver M, Marandi T, Ainla T, Eha J, Metspalu A, Fischer K.

J Epidemiol Community Health. 2019 Mar;73(3):272-277. doi: 10.1136/jech-2017-209965. Epub 2019 Jan 11.


Brief Commentary: Treating Pain-The Cannabis Conundrum.

Good CB, Parekh N, Fischer K, Schuster J, Manolis C, Shrank W.

Ann Intern Med. 2019 Jan 8. doi: 10.7326/M18-3237. [Epub ahead of print] No abstract available.


Dairy farmers' perspectives on antibiotic use: A qualitative study.

Fischer K, Sjöström K, Stiernström A, Emanuelson U.

J Dairy Sci. 2019 Mar;102(3):2724-2737. doi: 10.3168/jds.2018-15015. Epub 2019 Jan 3.


Case 1: Syncope in a 16-year-old Girl.

Sadanand A, Ladell M, Fischer K.

Pediatr Rev. 2019 Jan;40(1):37-39. doi: 10.1542/pir.2018-0028. No abstract available.


Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.

Jacintho JD, Baccei CS, Bravo Y, Broadhead A, Chen A, Correa L, Fischer K, Laffitte B, Lee C, Lorrain DS, Messmer D, Prasit P, Stebbins KJ, Stock NS.

Bioorg Med Chem Lett. 2019 Feb 1;29(3):503-508. doi: 10.1016/j.bmcl.2018.12.045. Epub 2018 Dec 21.


Evidence of exposure to henipaviruses in domestic pigs in Uganda.

Atherstone C, Diederich S, Weingartl HM, Fischer K, Balkema-Buschmann A, Grace D, Alonso S, Dhand NK, Ward MP, Mor SM.

Transbound Emerg Dis. 2019 Mar;66(2):921-928. doi: 10.1111/tbed.13105. Epub 2019 Jan 19.


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