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Items: 1 to 50 of 140

1.

RIG-I activation is critical for responsiveness to checkpoint blockade.

Heidegger S, Wintges A, Stritzke F, Bek S, Steiger K, Koenig PA, Göttert S, Engleitner T, Öllinger R, Nedelko T, Fischer JC, Makarov V, Winter C, Rad R, van den Brink MRM, Ruland J, Bassermann F, Chan TA, Haas T, Poeck H.

Sci Immunol. 2019 Sep 13;4(39). pii: eaau8943. doi: 10.1126/sciimmunol.aau8943.

PMID:
31519811
2.

Sensitivity of point-of-care testing C reactive protein and procalcitonin to diagnose urinary tract infections in Dutch nursing homes: PROGRESS study protocol.

Kuil SD, Hidad S, Fischer JC, Harting J, Hertogh CM, Prins JM, van Leth F, de Jong MD, Schneeberger C.

BMJ Open. 2019 Aug 10;9(8):e031269. doi: 10.1136/bmjopen-2019-031269.

3.

Diagnostic Leukapheresis Enables Reliable Transcriptomic Profiling of Single Circulating Tumor Cells to Characterize Inter-Cellular Heterogeneity in Terms of Endocrine Resistance.

Reinhardt F, Franken A, Meier-Stiegen F, Driemel C, Stoecklein NH, Fischer JC, Niederacher D, Ruckhaeberle E, Fehm T, Neubauer H.

Cancers (Basel). 2019 Jun 28;11(7). pii: E903. doi: 10.3390/cancers11070903.

4.

From in vitro to ex vivo: subcellular localization and uptake of graphene quantum dots into solid tumors.

Kersting D, Fasbender S, Pilch R, Kurth J, Franken A, Ludescher M, Naskou J, Hallenberger A, Gall CV, Mohr CJ, Lukowski R, Raba K, Jaschinski S, Esposito I, Fischer JC, Fehm T, Niederacher D, Neubauer H, Heinzel T.

Nanotechnology. 2019 Sep 27;30(39):395101. doi: 10.1088/1361-6528/ab2cb4. Epub 2019 Jun 26.

PMID:
31239418
5.

Targeting intrinsic RIG-I signaling turns melanoma cells into type I interferon-releasing cellular antitumor vaccines.

Bek S, Stritzke F, Wintges A, Nedelko T, Böhmer DFR, Fischer JC, Haas T, Poeck H, Heidegger S.

Oncoimmunology. 2019 Feb 11;8(4):e1570779. doi: 10.1080/2162402X.2019.1570779. eCollection 2019.

6.

RIG-I activating immunostimulatory RNA boosts the efficacy of anticancer vaccines and synergizes with immune checkpoint blockade.

Heidegger S, Kreppel D, Bscheider M, Stritzke F, Nedelko T, Wintges A, Bek S, Fischer JC, Graalmann T, Kalinke U, Bassermann F, Haas T, Poeck H.

EBioMedicine. 2019 Mar;41:146-155. doi: 10.1016/j.ebiom.2019.02.056. Epub 2019 Mar 6.

7.

Low-Fidelity Spectral Analysis Utilizing a Binomial Discriminator for Weak-Source Detection Decisions.

Lindsay J, Meengs M, Fischer JC, Brogan J, Brandl A.

Health Phys. 2019 May;116(5):727-735. doi: 10.1097/HP.0000000000001009.

PMID:
30747756
8.

Label-Free Enrichment and Molecular Characterization of Viable Circulating Tumor Cells from Diagnostic Leukapheresis Products.

Franken A, Driemel C, Behrens B, Meier-Stiegen F, Endris V, Stenzinger A, Niederacher D, Fischer JC, Stoecklein NH, Ruckhaeberle E, Fehm T, Neubauer H.

Clin Chem. 2019 Apr;65(4):549-558. doi: 10.1373/clinchem.2018.296814. Epub 2019 Feb 8.

PMID:
30737205
9.

Biomechanical Stability and Osteogenesis in a Tibial Bone Defect Treated by Autologous Ovine Cord Blood Cells-A Pilot Study.

Herten M, Zilkens C, Thorey F, Tassemeier T, Lensing-Höhn S, Fischer JC, Sager M, Krauspe R, Jäger M.

Molecules. 2019 Jan 15;24(2). pii: E295. doi: 10.3390/molecules24020295.

10.

XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice.

Müller N, Fischer JC, Yabal M, Haas T, Poeck H, Jost PJ.

Eur J Immunol. 2019 Mar;49(3):504-507. doi: 10.1002/eji.201847818. Epub 2019 Jan 3.

PMID:
30585320
11.

Improved assay protocol for measurement of ammonia on the Roche Cobas 8000 automated platform.

Kaplon J, de Groot JJ, van Straalen JP, Heckman M, Fischer JC.

Pract Lab Med. 2018 Dec 7;13:e00115. doi: 10.1016/j.plabm.2018.e00115. eCollection 2019 Jan.

12.

Diagnostic leukapheresis for CTC analysis in breast cancer patients: CTC frequency, clinical experiences and recommendations for standardized reporting.

Fehm TN, Meier-Stiegen F, Driemel C, Jäger B, Reinhardt F, Naskou J, Franken A, Neubauer H, Neves RPL, van Dalum G, Ruckhäberle E, Niederacher D, Rox JM, Fischer JC, Stoecklein NH.

Cytometry A. 2018 Dec;93(12):1213-1219. doi: 10.1002/cyto.a.23669.

PMID:
30551262
13.

Regeneration After Radiation- and Immune-Mediated Tissue Injury Is Not Enhanced by Type III Interferon Signaling.

Fischer JC, Lin CC, Heidegger S, Wintges A, Schlapschy M, Beudert M, Combs SE, Bassermann F, Skerra A, Haas T, Poeck H.

Int J Radiat Oncol Biol Phys. 2019 Mar 15;103(4):970-976. doi: 10.1016/j.ijrobp.2018.11.038. Epub 2018 Nov 29.

PMID:
30503785
14.

Genome-wide hypomethylation of LINE-1 and Alu retroelements in cell-free DNA of blood is an epigenetic biomarker of human aging.

Erichsen L, Beermann A, Arauzo-Bravo MJ, Hassan M, Dkhil MA, Al-Quraishy S, Hafiz TA, Fischer JC, Santourlidis S.

Saudi J Biol Sci. 2018 Sep;25(6):1220-1226. doi: 10.1016/j.sjbs.2018.02.005. Epub 2018 Feb 13.

15.

Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap).

Andree KC, Mentink A, Zeune LL, Terstappen LWMM, Stoecklein NH, Neves RP, Driemel C, Lampignano R, Yang L, Neubauer H, Fehm T, Fischer JC, Rossi E, Manicone M, Basso U, Marson P, Zamarchi R, Loriot Y, Lapierre V, Faugeroux V, Oulhen M, Farace F, Fowler G, Sousa Fontes M, Ebbs B, Lambros M, Crespo M, Flohr P, de Bono JS.

Int J Cancer. 2018 Nov 15;143(10):2584-2591. doi: 10.1002/ijc.31752. Epub 2018 Sep 19.

16.

Targeting RIG-I or STING promotes epithelial regeneration.

Fischer JC, Poeck H.

Oncotarget. 2017 Dec 6;8(70):114418-114419. doi: 10.18632/oncotarget.22994. eCollection 2017 Dec 29. No abstract available.

17.

Isolation of circulating tumor cells from pancreatic cancer by automated filtration.

Brychta N, Drosch M, Driemel C, Fischer JC, Neves RP, Esposito I, Knoefel W, Möhlendick B, Hille C, Stresemann A, Krahn T, Kassack MU, Stoecklein NH, von Ahsen O.

Oncotarget. 2017 Sep 16;8(49):86143-86156. doi: 10.18632/oncotarget.21026. eCollection 2017 Oct 17.

18.

A20 Restrains Thymic Regulatory T Cell Development.

Fischer JC, Otten V, Kober M, Drees C, Rosenbaum M, Schmickl M, Heidegger S, Beyaert R, van Loo G, Li XC, Peschel C, Schmidt-Supprian M, Haas T, Spoerl S, Poeck H.

J Immunol. 2017 Oct 1;199(7):2356-2365. doi: 10.4049/jimmunol.1602102. Epub 2017 Aug 25.

19.

Minimally manipulated murine regulatory T cells purified by reversible Fab Multimers are potent suppressors for adoptive T-cell therapy.

Mohr F, Fischer JC, Nikolaus M, Stemberger C, Dreher S, Verschoor A, Haas T, Poeck H, Busch DH.

Eur J Immunol. 2017 Dec;47(12):2153-2162. doi: 10.1002/eji.201747137. Epub 2017 Sep 15.

20.

A20 deletion in T cells modulates acute graft-versus-host disease in mice.

Fischer JC, Otten V, Steiger K, Schmickl M, Slotta-Huspenina J, Beyaert R, van Loo G, Peschel C, Poeck H, Haas T, Spoerl S.

Eur J Immunol. 2017 Nov;47(11):1982-1988. doi: 10.1002/eji.201646911. Epub 2017 Sep 15.

21.

Metabolic acidosis caused by concomitant use of paracetamol (acetaminophen) and flucloxacillin? A case report and a retrospective study.

Berbee JK, Lammers LA, Krediet CTP, Fischer JC, Kemper EM.

Eur J Clin Pharmacol. 2017 Nov;73(11):1459-1465. doi: 10.1007/s00228-017-2311-6. Epub 2017 Aug 7.

22.

Disseminated tumour cells with highly aberrant genomes are linked to poor prognosis in operable oesophageal adenocarcinoma.

Schumacher S, Bartenhagen C, Hoffmann M, Will D, Fischer JC, Baldus SE, Vay C, Fluegen G, Dizdar L, Vallböhmer D, Klein CA, Knoefel WT, Stoecklein NH, Möhlendick B.

Br J Cancer. 2017 Aug 22;117(5):725-733. doi: 10.1038/bjc.2017.233. Epub 2017 Jul 20.

23.

Treatment of high-grade osteoblastic osteosarcoma of the humerus in a 5-year-old boy with cystic fibrosis: A case report.

Okuda KV, Hammermann J, Lange BS, Fischer JC, Thielemann F, Knöfler R, Suttorp M.

Mol Clin Oncol. 2017 Jul;7(1):148-150. doi: 10.3892/mco.2017.1274. Epub 2017 May 29.

24.

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

Fischer JC, Bscheider M, Eisenkolb G, Lin CC, Wintges A, Otten V, Lindemans CA, Heidegger S, Rudelius M, Monette S, Porosnicu Rodriguez KA, Calafiore M, Liebermann S, Liu C, Lienenklaus S, Weiss S, Kalinke U, Ruland J, Peschel C, Shono Y, Docampo M, Velardi E, Jenq RR, Hanash AM, Dudakov JA, Haas T, van den Brink MRM, Poeck H.

Sci Transl Med. 2017 Apr 19;9(386). pii: eaag2513. doi: 10.1126/scitranslmed.aag2513.

25.

Assessment of mucosal integrity by quantifying neutrophil granulocyte influx in murine models of acute intestinal injury.

Fischer JC, Wintges A, Haas T, Poeck H.

Cell Immunol. 2017 Jun;316:70-76. doi: 10.1016/j.cellimm.2017.04.003. Epub 2017 Apr 11.

PMID:
28413062
26.

Card9 controls Dectin-1-induced T-cell cytotoxicity and tumor growth in mice.

Haas T, Heidegger S, Wintges A, Bscheider M, Bek S, Fischer JC, Eisenkolb G, Schmickl M, Spoerl S, Peschel C, Poeck H, Ruland J.

Eur J Immunol. 2017 May;47(5):872-879. doi: 10.1002/eji.201646775. Epub 2017 Apr 10.

27.

Roquin Paralogs Differentially Regulate Functional NKT Cell Subsets.

Drees C, Vahl JC, Bortoluzzi S, Heger KD, Fischer JC, Wunderlich FT, Peschel C, Schmidt-Supprian M.

J Immunol. 2017 Apr 1;198(7):2747-2759. doi: 10.4049/jimmunol.1601732. Epub 2017 Feb 10.

28.

EphrinB1/EphB3b Coordinate Bidirectional Epithelial-Mesenchymal Interactions Controlling Liver Morphogenesis and Laterality.

Cayuso J, Dzementsei A, Fischer JC, Karemore G, Caviglia S, Bartholdson J, Wright GJ, Ober EA.

Dev Cell. 2016 Nov 7;39(3):316-328. doi: 10.1016/j.devcel.2016.10.009.

29.

Recipient HLA-C Haplotypes and microRNA 148a/b Binding Sites Have No Impact on Allogeneic Hematopoietic Cell Transplantation Outcomes.

Hoff GA, Fischer JC, Hsu K, Cooley S, Miller JS, Wang T, Haagenson M, Spellman S, Lee SJ, Uhrberg M, Venstrom JM, Verneris MR.

Biol Blood Marrow Transplant. 2017 Jan;23(1):153-160. doi: 10.1016/j.bbmt.2016.09.028. Epub 2016 Oct 13.

30.

Human glioblastoma stem-like cells accumulate protoporphyrin IX when subjected to exogenous 5-aminolaevulinic acid, rendering them sensitive to photodynamic treatment.

Schimanski A, Ebbert L, Sabel MC, Finocchiaro G, Lamszus K, Ewelt C, Etminan N, Fischer JC, Sorg RV.

J Photochem Photobiol B. 2016 Oct;163:203-10. doi: 10.1016/j.jphotobiol.2016.08.043. Epub 2016 Aug 27.

PMID:
27588717
31.

Point and trend accuracy of a continuous intravenous microdialysis-based glucose-monitoring device in critically ill patients: a prospective study.

Leopold JH, van Hooijdonk RTM, Boshuizen M, Winters T, Bos LD, Abu-Hanna A, Hoek AMT, Fischer JC, van Dongen-Lases EC, Schultz MJ.

Ann Intensive Care. 2016 Dec;6(1):68. doi: 10.1186/s13613-016-0171-3. Epub 2016 Jul 19.

32.

Enoxaparin and rivaroxaban have different effects on human mesenchymal stromal cells in the early stages of bone healing.

Pilge H, Fröbel J, Prodinger PM, Mrotzek SJ, Fischer JC, Zilkens C, Bittersohl B, Krauspe R.

Bone Joint Res. 2016 Mar;5(3):95-100. doi: 10.1302/2046-3758.53.2000595.

33.

Older coronary thrombus is an independent predictor of 1-year mortality in acute myocardial infarction.

Li X, Kramer MC, Damman P, van der Wal AC, Grundeken MJ, van Straalen JP, Koch KT, Henriques JP, Baan J Jr, Vis MM, Piek JJ, Fischer JC, Tijssen JG, de Winter RJ.

Eur J Clin Invest. 2016 Jun;46(6):501-10. doi: 10.1111/eci.12619. Epub 2016 Apr 15.

PMID:
26988709
34.

Effects of thromboprophylaxis on mesenchymal stromal cells during osteogenic differentiation: an in-vitro study comparing enoxaparin with rivaroxaban.

Pilge H, Fröbel J, Mrotzek SJ, Fischer JC, Prodinger PM, Zilkens C, Bittersohl B, Krauspe R.

BMC Musculoskelet Disord. 2016 Mar 1;17:108. doi: 10.1186/s12891-016-0966-2.

35.

Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish.

Koltowska K, Lagendijk AK, Pichol-Thievend C, Fischer JC, Francois M, Ober EA, Yap AS, Hogan BM.

Cell Rep. 2015 Dec 1;13(9):1828-41. doi: 10.1016/j.celrep.2015.10.055. Epub 2015 Nov 19.

36.

Challenges for CTC-based liquid biopsies: low CTC frequency and diagnostic leukapheresis as a potential solution.

Stoecklein NH, Fischer JC, Niederacher D, Terstappen LW.

Expert Rev Mol Diagn. 2016;16(2):147-64. doi: 10.1586/14737159.2016.1123095. Epub 2015 Dec 16. Review.

PMID:
26587751
37.

Selective downregulation of HLA-C and HLA-E in childhood acute lymphoblastic leukaemia.

Reusing SB, Manser AR, Enczmann J, Mulder A, Claas FH, Carrington M, Fischer JC, Borkhardt A, Babor F, Uhrberg M.

Br J Haematol. 2016 Aug;174(3):477-80. doi: 10.1111/bjh.13777. Epub 2015 Nov 3. No abstract available.

38.

Influence of Di(2-ethylhexyl)phthalate on migration rate and differentiation of human hematopoietic stem and progenitor cells (CD34+).

Manz P, Cadeddu RP, Wilk M, Fischer JC, Fritz B, Haas R, Wenzel F.

Clin Hemorheol Microcirc. 2015;61(2):111-8. doi: 10.3233/CH-151984.

PMID:
26410866
39.

Deep serum discoveries: SDF-1α and HSA fragments in myelodysplastic syndromes.

Fröbel J, Hartwig S, Jourdain S, Fischer JC, Zilkens C, Kündgen A, Suckau D, Germing U, Czibere A, Lehr S.

Am J Hematol. 2015 Sep;90(9):E185-7. doi: 10.1002/ajh.24070. Epub 2015 Jul 27. No abstract available.

40.

Age-Related Increase of EED Expression in Early Hematopoietic Progenitor Cells is Associated with Global Increase of the Histone Modification H3K27me3.

Graffmann N, Brands J, Görgens A, Vitoriano da Conceição Castro S, Santourlidis S, Reckert A, Michele I, Ritz-Timme S, Fischer JC, Adjaye J, Kögler G, Giebel B, Uhrberg M.

Stem Cells Dev. 2015 Sep 1;24(17):2018-31. doi: 10.1089/scd.2014.0435. Epub 2015 Jun 23.

PMID:
25961873
41.

Genetic analysis of circulating tumor cells in pancreatic cancer patients: A pilot study.

Görner K, Bachmann J, Holzhauer C, Kirchner R, Raba K, Fischer JC, Martignoni ME, Schiemann M, Alunni-Fabbroni M.

Genomics. 2015 Jul;106(1):7-14. doi: 10.1016/j.ygeno.2015.02.003. Epub 2015 Mar 24.

42.

Progenitor cells are mobilized by acute psychological stress but not beta-adrenergic receptor agonist infusion.

Riddell NE, Burns VE, Wallace GR, Edwards KM, Drayson M, Redwine LS, Hong S, Bui JC, Fischer JC, Mills PJ, Bosch JA.

Brain Behav Immun. 2015 Oct;49:49-53. doi: 10.1016/j.bbi.2015.02.028. Epub 2015 Mar 6.

43.

Point accuracy and reliability of an interstitial continuous glucose-monitoring device in critically ill patients: a prospective study.

van Hooijdonk RT, Leopold JH, Winters T, Binnekade JM, Juffermans NP, Horn J, Fischer JC, van Dongen-Lases EC, Schultz MJ.

Crit Care. 2015 Feb 5;19:34. doi: 10.1186/s13054-015-0757-4.

44.

Treatment of donor-specific antibody-mediated graft rejection by immunochemotherapy, third-party DLI, plasmapheresis and immunoadsorption.

Wilk CM, Fischer JC, Schieren G, Rox JM, Haas R, Rump LC, Kobbe G, Schroeder T.

Bone Marrow Transplant. 2015 Apr;50(4):613-4. doi: 10.1038/bmt.2014.321. Epub 2015 Jan 26. No abstract available.

PMID:
25621803
45.

Necrotic cell-derived high mobility group box 1 attracts antigen-presenting cells but inhibits hepatocyte growth factor-mediated tropism of mesenchymal stem cells for apoptotic cell death.

Vogel S, Börger V, Peters C, Förster M, Liebfried P, Metzger K, Meisel R, Däubener W, Trapp T, Fischer JC, Gawaz M, Sorg RV.

Cell Death Differ. 2015 Jul;22(7):1219-30. doi: 10.1038/cdd.2014.225. Epub 2015 Jan 9.

46.

Continuous T cell receptor signals maintain a functional regulatory T cell pool.

Vahl JC, Drees C, Heger K, Heink S, Fischer JC, Nedjic J, Ohkura N, Morikawa H, Poeck H, Schallenberg S, Rieß D, Hein MY, Buch T, Polic B, Schönle A, Zeiser R, Schmitt-Gräff A, Kretschmer K, Klein L, Korn T, Sakaguchi S, Schmidt-Supprian M.

Immunity. 2014 Nov 20;41(5):722-36. doi: 10.1016/j.immuni.2014.10.012. Epub 2014 Nov 6.

47.

Genomic high-resolution profiling of single CKpos/CD45neg flow-sorting purified circulating tumor cells from patients with metastatic breast cancer.

Neves RP, Raba K, Schmidt O, Honisch E, Meier-Stiegen F, Behrens B, Möhlendick B, Fehm T, Neubauer H, Klein CA, Polzer B, Sproll C, Fischer JC, Niederacher D, Stoecklein NH.

Clin Chem. 2014 Oct;60(10):1290-7. doi: 10.1373/clinchem.2014.222331.

48.

KIR ligand C2 is associated with increased susceptibility to childhood ALL and confers an elevated risk for late relapse.

Babor F, Manser AR, Fischer JC, Scherenschlich N, Enczmann J, Chazara O, Moffett A, Borkhardt A, Meisel R, Uhrberg M.

Blood. 2014 Oct 2;124(14):2248-51. doi: 10.1182/blood-2014-05-572065. Epub 2014 Aug 27.

PMID:
25163702
49.

Admission lipoprotein-associated phospholipase A2 activity is not associated with long-term clinical outcomes after ST-segment elevation myocardial infarction.

Woudstra P, Damman P, Kuijt WJ, Kikkert WJ, Grundeken MJ, van Brussel PM, Stroobants AK, van Straalen JP, Fischer JC, Koch KT, Henriques JP, Piek JJ, Tijssen JG, de Winter RJ.

PLoS One. 2014 May 1;9(5):e96251. doi: 10.1371/journal.pone.0096251. eCollection 2014.

50.

Accuracy and limitations of continuous glucose monitoring using spectroscopy in critically ill patients.

van Hooijdonk RT, Winters T, Fischer JC, van Dongen-Lases EC, Krinsley JS, Preiser JC, Schultz MJ.

Ann Intensive Care. 2014 Mar 6;4(1):8. doi: 10.1186/2110-5820-4-8.

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