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Anatomically specific reactive oxygen species production participates in Marfan syndrome aneurysm formation.

Emrich F, Penov K, Arakawa M, Dhablania N, Burdon G, Pedroza AJ, Koyano TK, Kim YM, Raaz U, Connolly AJ, Iosef C, Fischbein MP.

J Cell Mol Med. 2019 Aug 11. doi: 10.1111/jcmm.14587. [Epub ahead of print]


Current evidence for prosthesis selection: What can we really say?

Chiu P, Goldstone AB, Fischbein MP, Woo YJ.

J Thorac Cardiovasc Surg. 2019 Aug;158(2):368-375. doi: 10.1016/j.jtcvs.2019.03.094. Epub 2019 Apr 13. No abstract available.


Endovascular Versus Open Repair of Intact Descending Thoracic Aortic Aneurysms.

Chiu P, Goldstone AB, Schaffer JM, Lingala B, Miller DC, Mitchell RS, Woo YJ, Fischbein MP, Dake MD.

J Am Coll Cardiol. 2019 Feb 19;73(6):643-651. doi: 10.1016/j.jacc.2018.10.086.


Time-to-operation does not predict outcome in acute type A aortic dissection complicated by neurologic injury at presentation.

Chiu P, Rotto TJ, Goldstone AB, Whisenant JB, Woo YJ, Fischbein MP.

J Thorac Cardiovasc Surg. 2019 Sep;158(3):665-672. doi: 10.1016/j.jtcvs.2018.12.023. Epub 2018 Dec 19.


Statins Reduce Thoracic Aortic Aneurysm Growth in Marfan Syndrome Mice via Inhibition of the Ras-Induced ERK (Extracellular Signal-Regulated Kinase) Signaling Pathway.

Sato T, Arakawa M, Tashima Y, Tsuboi E, Burdon G, Trojan J, Koyano T, Youn YN, Penov K, Pedroza AJ, Shabazzi M, Palmon I, Nguyen MN, Connolly AJ, Yamaguchi A, Fischbein MP.

J Am Heart Assoc. 2018 Nov 6;7(21):e008543. doi: 10.1161/JAHA.118.008543.


Acute Limited Intimal Tears of the Thoracic Aorta.

Chin AS, Willemink MJ, Kino A, Hinostroza V, Sailer AM, Fischbein MP, Mitchell RS, Berry GJ, Miller DC, Fleischmann D.

J Am Coll Cardiol. 2018 Jun 19;71(24):2773-2785. doi: 10.1016/j.jacc.2018.03.531.


Immediate operation for acute type A aortic dissection complicated by visceral or peripheral malperfusion.

Chiu P, Tsou S, Goldstone AB, Louie M, Woo YJ, Fischbein MP.

J Thorac Cardiovasc Surg. 2018 Jul;156(1):18-24.e3. doi: 10.1016/j.jtcvs.2018.01.096. Epub 2018 Feb 21.


Impact of Discordant Views in the Management of Descending Thoracic Aortic Aneurysm.

Chiu P, Sailer AM, Baiocchi M, Goldstone AB, Schaffer JM, Trojan J, Fleischmann D, Mitchell RS, Miller DC, Dake MD, Woo YJ, Lee JT, Fischbein MP.

Semin Thorac Cardiovasc Surg. 2017 Autumn;29(3):283-291. doi: 10.1053/j.semtcvs.2017.05.009. Epub 2017 May 29.


Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement.

Goldstone AB, Chiu P, Baiocchi M, Lingala B, Patrick WL, Fischbein MP, Woo YJ.

N Engl J Med. 2017 Nov 9;377(19):1847-1857. doi: 10.1056/NEJMoa1613792.


Two-stage surgical approach for ruptured Salmonella aortitis.

Brewer ZE, Dake MD, Fischbein MP.

J Thorac Cardiovasc Surg. 2018 Mar;155(3):e87-e89. doi: 10.1016/j.jtcvs.2017.09.102. Epub 2017 Sep 30. No abstract available.


Limited root repair in acute type A aortic dissection is safe but results in increased risk of reoperation.

Chiu P, Trojan J, Tsou S, Goldstone AB, Woo YJ, Fischbein MP.

J Thorac Cardiovasc Surg. 2018 Jan;155(1):1-7.e1. doi: 10.1016/j.jtcvs.2017.08.137. Epub 2017 Sep 19.


Prognostic significance of early aortic remodeling in acute uncomplicated type B aortic dissection and intramural hematoma.

Sailer AM, Nelemans PJ, Hastie TJ, Chin AS, Huininga M, Chiu P, Fischbein MP, Dake MD, Miller DC, Schurink GW, Fleischmann D.

J Thorac Cardiovasc Surg. 2017 Oct;154(4):1192-1200. doi: 10.1016/j.jtcvs.2017.04.064. Epub 2017 May 16.


Long-term miR-29b suppression reduces aneurysm formation in a Marfan mouse model.

Okamura H, Emrich F, Trojan J, Chiu P, Dalal AR, Arakawa M, Sato T, Penov K, Koyano T, Pedroza A, Connolly AJ, Rabinovitch M, Alvira C, Fischbein MP.

Physiol Rep. 2017 Apr;5(8). pii: e13257. doi: 10.14814/phy2.13257. Epub 2017 Apr 28.


Gene expression profiling of acute type A aortic dissection combined with in vitro assessment.

Kimura N, Futamura K, Arakawa M, Okada N, Emrich F, Okamura H, Sato T, Shudo Y, Koyano TK, Yamaguchi A, Adachi H, Matsuda A, Kawahito K, Matsumoto K, Fischbein MP.

Eur J Cardiothorac Surg. 2017 Oct 1;52(4):810-817. doi: 10.1093/ejcts/ezx095.


Computed Tomography Imaging Features in Acute Uncomplicated Stanford Type-B Aortic Dissection Predict Late Adverse Events.

Sailer AM, van Kuijk SM, Nelemans PJ, Chin AS, Kino A, Huininga M, Schmidt J, Mistelbauer G, Bäumler K, Chiu P, Fischbein MP, Dake MD, Miller DC, Schurink GW, Fleischmann D.

Circ Cardiovasc Imaging. 2017 Apr;10(4). pii: e005709. doi: 10.1161/CIRCIMAGING.116.005709.


Giant saphenous vein graft aneurysm compressing the lingular bronchus.

Chiu P, Palmon I, Fischbein MP.

J Thorac Cardiovasc Surg. 2017 Jan;153(1):e1-e3. doi: 10.1016/j.jtcvs.2016.08.062. Epub 2016 Sep 17. No abstract available.


Surgical Unroofing of Hemodynamically Significant Left Anterior Descending Myocardial Bridges.

Boyd JH, Pargaonkar VS, Scoville DH, Rogers IS, Kimura T, Tanaka S, Yamada R, Fischbein MP, Tremmel JA, Mitchell RS, Schnittger I.

Ann Thorac Surg. 2017 May;103(5):1443-1450. doi: 10.1016/j.athoracsur.2016.08.035. Epub 2016 Oct 13.


Branched Endovascular Therapy of the Distal Aortic Arch: Preliminary Results of the Feasibility Multicenter Trial of the Gore Thoracic Branch Endoprosthesis.

Patel HJ, Dake MD, Bavaria JE, Singh MJ, Filinger M, Fischbein MP, Williams DM, Matsumura JS, Oderich G.

Ann Thorac Surg. 2016 Oct;102(4):1190-8. doi: 10.1016/j.athoracsur.2016.03.091. Epub 2016 Jun 2.


Salvage Extracorporeal Membrane Oxygenation Prior to "Bridge" Transcatheter Aortic Valve Replacement.

Chiu P, Fearon WF, Raleigh LA, Burdon G, Rao V, Boyd JH, Yeung AC, Miller DC, Fischbein MP.

J Card Surg. 2016 Jun;31(6):403-5. doi: 10.1111/jocs.12750. Epub 2016 Apr 24.


Midterm Outcomes of Open Descending Thoracic Aortic Repair in More Than 5,000 Medicare Patients.

Schaffer JM, Lingala B, Fischbein MP, Dake MD, Woo YJ, Mitchell RS, Miller DC.

Ann Thorac Surg. 2015 Dec;100(6):2087-94; discussion 2094. doi: 10.1016/j.athoracsur.2015.06.068. Epub 2015 Oct 1.


Outcomes after transfemoral transcatheter aortic valve replacement: a comparison of the randomized PARTNER (Placement of AoRTic TraNscathetER Valves) trial with the NRCA (Nonrandomized Continued Access) registry.

Fearon WF, Kodali S, Doshi D, Fischbein MP, Yeung AC, Tuzcu EM, Rihal CS, Babaliaros V, Zajarias A, Herrmann HC, Brown DL, Mack M, Teirstein PS, Whisenant BK, Makkar R, Kapadia S, Leon MB; PARTNER Trial Investigators.

JACC Cardiovasc Interv. 2014 Nov;7(11):1245-51. doi: 10.1016/j.jcin.2014.05.033. Epub 2014 Nov 17.


Enhanced caspase activity contributes to aortic wall remodeling and early aneurysm development in a murine model of Marfan syndrome.

Emrich FC, Okamura H, Dalal AR, Penov K, Merk DR, Raaz U, Hennigs JK, Chin JT, Miller MO, Pedroza AJ, Craig JK, Koyano TK, Blankenberg FG, Connolly AJ, Mohr FW, Alvira CM, Rabinovitch M, Fischbein MP.

Arterioscler Thromb Vasc Biol. 2015 Jan;35(1):146-54. doi: 10.1161/ATVBAHA.114.304364. Epub 2014 Oct 30.


Tirone David procedure for bicuspid aortic valve disease: impact of root geometry and valve type on mid-term outcomes.

Kari FA, Kvitting JP, Stephens EH, Liang DH, Merk DR, Fischbein MP, Mitchell RS, Miller DC.

Interact Cardiovasc Thorac Surg. 2014 Sep;19(3):375-81; discussion 381. doi: 10.1093/icvts/ivu123. Epub 2014 Jun 5.


Assessment of elastin deficit in a Marfan mouse aneurysm model using an elastin-specific magnetic resonance imaging contrast agent.

Okamura H, Pisani LJ, Dalal AR, Emrich F, Dake BA, Arakawa M, Onthank DC, Cesati RR, Robinson SP, Milanesi M, Kotek G, Smit H, Connolly AJ, Adachi H, McConnell MV, Fischbein MP.

Circ Cardiovasc Imaging. 2014 Jul;7(4):690-6. doi: 10.1161/CIRCIMAGING.114.001658. Epub 2014 May 9.


Incidence and progression of mild aortic regurgitation after Tirone David reimplantation valve-sparing aortic root replacement.

Stephens EH, Liang DH, Kvitting JP, Kari FA, Fischbein MP, Mitchell RS, Miller DC.

J Thorac Cardiovasc Surg. 2014 Jan;147(1):169-77, 178.e1-178.e3. doi: 10.1016/j.jtcvs.2013.09.009. Epub 2013 Oct 29.


A common rejection module (CRM) for acute rejection across multiple organs identifies novel therapeutics for organ transplantation.

Khatri P, Roedder S, Kimura N, De Vusser K, Morgan AA, Gong Y, Fischbein MP, Robbins RC, Naesens M, Butte AJ, Sarwal MM.

J Exp Med. 2013 Oct 21;210(11):2205-21. doi: 10.1084/jem.20122709. Epub 2013 Oct 14.


Open aortic valve replacement in a patient with Glanzmann's thrombasthenia: a multidisciplinary strategy to minimize perioperative bleeding.

Sheikh AY, Hill CC, Goodnough LT, Leung LL, Fischbein MP.

Transfusion. 2014 Feb;54(2):300-5. doi: 10.1111/trf.12275. Epub 2013 May 27.


Tirone David valve-sparing aortic root replacement and cusp repair for bicuspid aortic valve disease.

Kari FA, Liang DH, Kvitting JP, Stephens EH, Mitchell RS, Fischbein MP, Miller DC.

J Thorac Cardiovasc Surg. 2013 Mar;145(3 Suppl):S35-40.e1-2. doi: 10.1016/j.jtcvs.2012.11.043. Epub 2012 Dec 20.


David valve-sparing aortic root replacement: equivalent mid-term outcome for different valve types with or without connective tissue disorder.

Kvitting JP, Kari FA, Fischbein MP, Liang DH, Beraud AS, Stephens EH, Mitchell RS, Miller DC.

J Thorac Cardiovasc Surg. 2013 Jan;145(1):117-26, 127.e1-5; discussion 126-7. doi: 10.1016/j.jtcvs.2012.09.013. Epub 2012 Oct 17.


Bicuspid aortic valve configuration and aortopathy pattern might represent different pathophysiologic substrates.

Kari FA, Fazel SS, Mitchell RS, Fischbein MP, Miller DC.

J Thorac Cardiovasc Surg. 2012 Aug;144(2):516-7. doi: 10.1016/j.jtcvs.2012.05.035. Epub 2012 Jun 13. No abstract available.


Potential role of γδ T cell-derived IL-17 in acute cardiac allograft rejection.

Kimura N, Nakae S, Itoh S, Merk DR, Wang X, Gong Y, Okamura H, Chang PA, Adachi H, Robbins RC, Fischbein MP.

Ann Thorac Surg. 2012 Aug;94(2):542-8. doi: 10.1016/j.athoracsur.2012.03.049. Epub 2012 May 5.


Molecular imaging of bone marrow mononuclear cell survival and homing in murine peripheral artery disease.

van der Bogt KE, Hellingman AA, Lijkwan MA, Bos EJ, de Vries MR, van Rappard JR, Fischbein MP, Quax PH, Robbins RC, Hamming JF, Wu JC.

JACC Cardiovasc Imaging. 2012 Jan;5(1):46-55. doi: 10.1016/j.jcmg.2011.07.011.


miR-29b participates in early aneurysm development in Marfan syndrome.

Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP.

Circ Res. 2012 Jan 20;110(2):312-24. doi: 10.1161/CIRCRESAHA.111.253740. Epub 2011 Nov 23.


Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model.

Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP.

J Heart Lung Transplant. 2011 Dec;30(12):1409-17. doi: 10.1016/j.healun.2011.08.017.


In vivo functional and transcriptional profiling of bone marrow stem cells after transplantation into ischemic myocardium.

Sheikh AY, Huber BC, Narsinh KH, Spin JM, van der Bogt K, de Almeida PE, Ransohoff KJ, Kraft DL, Fajardo G, Ardigo D, Ransohoff J, Bernstein D, Fischbein MP, Robbins RC, Wu JC.

Arterioscler Thromb Vasc Biol. 2012 Jan;32(1):92-102. doi: 10.1161/ATVBAHA.111.238618. Epub 2011 Oct 27.


Interleukin-17 accelerates allograft rejection by suppressing regulatory T cell expansion.

Itoh S, Kimura N, Axtell RC, Velotta JB, Gong Y, Wang X, Kajiwara N, Nambu A, Shimura E, Adachi H, Iwakura Y, Saito H, Okumura K, Sudo K, Steinman L, Robbins RC, Nakae S, Fischbein MP.

Circulation. 2011 Sep 13;124(11 Suppl):S187-96. doi: 10.1161/CIRCULATIONAHA.110.014852.


αB-crystallin improves murine cardiac function and attenuates apoptosis in human endothelial cells exposed to ischemia-reperfusion.

Velotta JB, Kimura N, Chang SH, Chung J, Itoh S, Rothbard J, Yang PC, Steinman L, Robbins RC, Fischbein MP.

Ann Thorac Surg. 2011 Jun;91(6):1907-13. doi: 10.1016/j.athoracsur.2011.02.072.


Prevention of transplant coronary artery disease by prenylation inhibitors.

Stein W, Schrepfer S, Itoh S, Kimura N, Velotta J, Palmer O, Bartos J, Wang X, Robbins RC, Fischbein MP.

J Heart Lung Transplant. 2011 Jul;30(7):761-9. doi: 10.1016/j.healun.2011.01.720. Epub 2011 Mar 31.


Micro-CT for characterization of murine CV disease models.

Sheikh AY, van der Bogt KE, Doyle TC, Sheikh MK, Ransohoff KJ, Ali ZA, Palmer OP, Robbins RC, Fischbein MP, Wu JC.

JACC Cardiovasc Imaging. 2010 Jul;3(7):783-5. doi: 10.1016/j.jcmg.2010.01.012. No abstract available.


IL-17 contributes to the development of chronic rejection in a murine heart transplant model.

Itoh S, Nakae S, Axtell RC, Velotta JB, Kimura N, Kajiwara N, Iwakura Y, Saito H, Adachi H, Steinman L, Robbins RC, Fischbein MP.

J Clin Immunol. 2010 Mar;30(2):235-40. doi: 10.1007/s10875-009-9366-9. Epub 2010 Feb 4.


The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice.

Itoh S, Nakae S, Velotta JB, Kosuge H, Connolly A, Tsai M, Adachi H, Galli SJ, Robbins RC, Fischbein MP.

J Heart Lung Transplant. 2010 Apr;29(4):401-9. doi: 10.1016/j.healun.2009.08.019. Epub 2009 Oct 8.


Long-term durability of open thoracic and thoracoabdominal aneurysm repair.

Fischbein MP, Miller DC.

Semin Vasc Surg. 2009 Jun;22(2):74-80. doi: 10.1053/j.semvascsurg.2009.04.001. Review.


Effect of inhaled tacrolimus on cellular and humoral rejection to prevent posttransplant obliterative airway disease.

Schrepfer S, Deuse T, Reichenspurner H, Hoffmann J, Haddad M, Fink J, Fischbein MP, Robbins RC, Pelletier MP.

Am J Transplant. 2007 Jul;7(7):1733-42. Epub 2007 May 26.


Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?

Deuse T, Schrepfer S, Reichenspurner H, Hoyt G, Fischbein MP, Robbins RC, Pelletier MP.

Transpl Immunol. 2007 Jun;17(4):255-61. Epub 2007 Feb 6.


Stem cell transplantation: the lung barrier.

Schrepfer S, Deuse T, Reichenspurner H, Fischbein MP, Robbins RC, Pelletier MP.

Transplant Proc. 2007 Mar;39(2):573-6.


Is the malononitrilamide FK778 better for the prevention of acute or chronic rejection?

Deuse T, Schrepfer S, Pelletier MP, Fischbein MP, Robbins RC, Reichenspurner H.

Transplant Proc. 2007 Mar;39(2):569-72.


CD8 lymphocytes are sufficient for the development of chronic rejection.

Schnickel GT, Whiting D, Hsieh GR, Yun JJ, Fischbein MP, Fishbein MC, Yao W, Shfizadeh A, Ardehali A.

Transplantation. 2004 Dec 15;78(11):1634-9.


Combined blockade of the chemokine receptors CCR1 and CCR5 attenuates chronic rejection.

Yun JJ, Whiting D, Fischbein MP, Banerji A, Irie Y, Stein D, Fishbein MC, Proudfoot AE, Laks H, Berliner JA, Ardehali A.

Circulation. 2004 Feb 24;109(7):932-7. Epub 2004 Feb 2.


Regulated interleukin-10 expression prevents chronic rejection of transplanted hearts.

Fischbein MP, Yun J, Laks H, Irie Y, Oslund-Pinderski L, Fishbein MC, Bonavida B, Ardehali A.

J Thorac Cardiovasc Surg. 2003 Jul;126(1):216-23.

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