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Items: 1 to 50 of 92

1.

Microbial Transplantation With Human Gut Commensals Containing CutC Is Sufficient to Transmit Enhanced Platelet Reactivity and Thrombosis Potential.

Skye SM, Zhu W, Romano KA, Guo CJ, Wang Z, Jia X, Kirsop J, Haag B, Lang JM, DiDonato JA, Tang WHW, Lusis AJ, Rey FE, Fischbach MA, Hazen SL.

Circ Res. 2018 Oct 26;123(10):1164-1176. doi: 10.1161/CIRCRESAHA.118.313142.

PMID:
30359185
2.

Microbiome: Focus on Causation and Mechanism.

Fischbach MA.

Cell. 2018 Aug 9;174(4):785-790. doi: 10.1016/j.cell.2018.07.038. Review.

3.

Mapping the Genetic Landscape of Human Cells.

Horlbeck MA, Xu A, Wang M, Bennett NK, Park CY, Bogdanoff D, Adamson B, Chow ED, Kampmann M, Peterson TR, Nakamura K, Fischbach MA, Weissman JS, Gilbert LA.

Cell. 2018 Aug 9;174(4):953-967.e22. doi: 10.1016/j.cell.2018.06.010. Epub 2018 Jul 19.

4.

Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion.

Bhattarai Y, Williams BB, Battaglioli EJ, Whitaker WR, Till L, Grover M, Linden DR, Akiba Y, Kandimalla KK, Zachos NC, Kaunitz JD, Sonnenburg JL, Fischbach MA, Farrugia G, Kashyap PC.

Cell Host Microbe. 2018 Jun 13;23(6):775-785.e5. doi: 10.1016/j.chom.2018.05.004.

5.

Erratum: Skin microbiota-host interactions.

Chen YE, Fischbach MA, Belkaid Y.

Nature. 2018 Mar 21;555(7697):543. doi: 10.1038/nature25994.

PMID:
29565366
6.

The Biosynthesis of Lipooligosaccharide from Bacteroides thetaiotaomicron.

Jacobson AN, Choudhury BP, Fischbach MA.

MBio. 2018 Mar 13;9(2). pii: e02289-17. doi: 10.1128/mBio.02289-17.

7.

A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology.

Casini A, Chang FY, Eluere R, King AM, Young EM, Dudley QM, Karim A, Pratt K, Bristol C, Forget A, Ghodasara A, Warden-Rothman R, Gan R, Cristofaro A, Borujeni AE, Ryu MH, Li J, Kwon YC, Wang H, Tatsis E, Rodriguez-Lopez C, O'Connor S, Medema MH, Fischbach MA, Jewett MC, Voigt C, Gordon DB.

J Am Chem Soc. 2018 Mar 28;140(12):4302-4316. doi: 10.1021/jacs.7b13292. Epub 2018 Mar 16.

PMID:
29480720
8.

Contextual control of skin immunity and inflammation by Corynebacterium.

Ridaura VK, Bouladoux N, Claesen J, Chen YE, Byrd AL, Constantinides MG, Merrill ED, Tamoutounour S, Fischbach MA, Belkaid Y.

J Exp Med. 2018 Mar 5;215(3):785-799. doi: 10.1084/jem.20171079. Epub 2018 Jan 30.

9.

Skin microbiota-host interactions.

Chen YE, Fischbach MA, Belkaid Y.

Nature. 2018 Jan 24;553(7689):427-436. doi: 10.1038/nature25177. Review. Erratum in: Nature. 2018 Mar 21;555(7697):543.

10.

A gut bacterial pathway metabolizes aromatic amino acids into nine circulating metabolites.

Dodd D, Spitzer MH, Van Treuren W, Merrill BD, Hryckowian AJ, Higginbottom SK, Le A, Cowan TM, Nolan GP, Fischbach MA, Sonnenburg JL.

Nature. 2017 Nov 30;551(7682):648-652. doi: 10.1038/nature24661. Epub 2017 Nov 22.

11.

Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases.

Guo CJ, Chang FY, Wyche TP, Backus KM, Acker TM, Funabashi M, Taketani M, Donia MS, Nayfach S, Pollard KS, Craik CS, Cravatt BF, Clardy J, Voigt CA, Fischbach MA.

Cell. 2017 Jan 26;168(3):517-526.e18. doi: 10.1016/j.cell.2016.12.021. Epub 2017 Jan 19.

12.

Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota.

Devlin AS, Marcobal A, Dodd D, Nayfach S, Plummer N, Meyer T, Pollard KS, Sonnenburg JL, Fischbach MA.

Cell Host Microbe. 2016 Dec 14;20(6):709-715. doi: 10.1016/j.chom.2016.10.021. Epub 2016 Dec 1.

13.

Signaling in Host-Associated Microbial Communities.

Fischbach MA, Segre JA.

Cell. 2016 Mar 10;164(6):1288-1300. doi: 10.1016/j.cell.2016.02.037. Review.

14.

Synthetic biology to access and expand nature's chemical diversity.

Smanski MJ, Zhou H, Claesen J, Shen B, Fischbach MA, Voigt CA.

Nat Rev Microbiol. 2016 Mar;14(3):135-49. doi: 10.1038/nrmicro.2015.24. Review.

15.

A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.

Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD.

Immunity. 2015 Nov 17;43(5):1011-21. doi: 10.1016/j.immuni.2015.10.016.

16.

Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.

Wilks J, Lien E, Jacobson AN, Fischbach MA, Qureshi N, Chervonsky AV, Golovkina TV.

Cell Host Microbe. 2015 Oct 14;18(4):456-62. doi: 10.1016/j.chom.2015.09.005.

17.

A Phase-Variable Surface Layer from the Gut Symbiont Bacteroides thetaiotaomicron.

Taketani M, Donia MS, Jacobson AN, Lambris JD, Fischbach MA.

MBio. 2015 Sep 29;6(5):e01339-15. doi: 10.1128/mBio.01339-15.

18.

Computational approaches to natural product discovery.

Medema MH, Fischbach MA.

Nat Chem Biol. 2015 Sep;11(9):639-48. doi: 10.1038/nchembio.1884.

19.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

20.

Genome-Directed Lead Discovery: Biosynthesis, Structure Elucidation, and Biological Evaluation of Two Families of Polyene Macrolactams against Trypanosoma brucei.

Schulze CJ, Donia MS, Siqueira-Neto JL, Ray D, Raskatov JA, Green RE, McKerrow JH, Fischbach MA, Linington RG.

ACS Chem Biol. 2015 Oct 16;10(10):2373-81. doi: 10.1021/acschembio.5b00308. Epub 2015 Aug 13.

PMID:
26270237
21.

HUMAN MICROBIOTA. Small molecules from the human microbiota.

Donia MS, Fischbach MA.

Science. 2015 Jul 24;349(6246):1254766. doi: 10.1126/science.1254766. Epub 2015 Jul 23. Review.

22.

A biosynthetic pathway for a prominent class of microbiota-derived bile acids.

Devlin AS, Fischbach MA.

Nat Chem Biol. 2015 Sep;11(9):685-90. doi: 10.1038/nchembio.1864. Epub 2015 Jul 20.

23.

IMG-ABC: A Knowledge Base To Fuel Discovery of Biosynthetic Gene Clusters and Novel Secondary Metabolites.

Hadjithomas M, Chen IM, Chu K, Ratner A, Palaniappan K, Szeto E, Huang J, Reddy TB, Cimermančič P, Fischbach MA, Ivanova NN, Markowitz VM, Kyrpides NC, Pati A.

MBio. 2015 Jul 14;6(4):e00932. doi: 10.1128/mBio.00932-15.

24.

MetaQuery: a web server for rapid annotation and quantitative analysis of specific genes in the human gut microbiome.

Nayfach S, Fischbach MA, Pollard KS.

Bioinformatics. 2015 Oct 15;31(20):3368-70. doi: 10.1093/bioinformatics/btv382. Epub 2015 Jun 22.

25.

antiSMASH 3.0-a comprehensive resource for the genome mining of biosynthetic gene clusters.

Weber T, Blin K, Duddela S, Krug D, Kim HU, Bruccoleri R, Lee SY, Fischbach MA, Müller R, Wohlleben W, Breitling R, Takano E, Medema MH.

Nucleic Acids Res. 2015 Jul 1;43(W1):W237-43. doi: 10.1093/nar/gkv437. Epub 2015 May 6.

26.

A systematic computational analysis of biosynthetic gene cluster evolution: lessons for engineering biosynthesis.

Medema MH, Cimermancic P, Sali A, Takano E, Fischbach MA.

PLoS Comput Biol. 2014 Dec 4;10(12):e1004016. doi: 10.1371/journal.pcbi.1004016. eCollection 2014 Dec. Erratum in: PLoS Comput Biol. 2016 Mar;12(3):e1004767.

27.

Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine.

Williams BB, Van Benschoten AH, Cimermancic P, Donia MS, Zimmermann M, Taketani M, Ishihara A, Kashyap PC, Fraser JS, Fischbach MA.

Cell Host Microbe. 2014 Oct 8;16(4):495-503. doi: 10.1016/j.chom.2014.09.001. Epub 2014 Sep 25.

28.

A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics.

Donia MS, Cimermancic P, Schulze CJ, Wieland Brown LC, Martin J, Mitreva M, Clardy J, Linington RG, Fischbach MA.

Cell. 2014 Sep 11;158(6):1402-1414. doi: 10.1016/j.cell.2014.08.032.

29.

Synthetic microbes as drug delivery systems.

Claesen J, Fischbach MA.

ACS Synth Biol. 2015 Apr 17;4(4):358-64. doi: 10.1021/sb500258b. Epub 2014 Aug 13. Review.

30.

Propionibacterium-produced coproporphyrin III induces Staphylococcus aureus aggregation and biofilm formation.

Wollenberg MS, Claesen J, Escapa IF, Aldridge KL, Fischbach MA, Lemon KP.

MBio. 2014 Jul 22;5(4):e01286-14. doi: 10.1128/mBio.01286-14.

31.

Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.

Cimermancic P, Medema MH, Claesen J, Kurita K, Wieland Brown LC, Mavrommatis K, Pati A, Godfrey PA, Koehrsen M, Clardy J, Birren BW, Takano E, Sali A, Linington RG, Fischbach MA.

Cell. 2014 Jul 17;158(2):412-421. doi: 10.1016/j.cell.2014.06.034.

32.

Key applications of plant metabolic engineering.

Lau W, Fischbach MA, Osbourn A, Sattely ES.

PLoS Biol. 2014 Jun 10;12(6):e1001879. doi: 10.1371/journal.pbio.1001879. eCollection 2014 Jun.

33.

The prevalence of species and strains in the human microbiome: a resource for experimental efforts.

Kraal L, Abubucker S, Kota K, Fischbach MA, Mitreva M.

PLoS One. 2014 May 14;9(5):e97279. doi: 10.1371/journal.pone.0097279. eCollection 2014.

34.

Diet rapidly and reproducibly alters the human gut microbiome.

David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, Ling AV, Devlin AS, Varma Y, Fischbach MA, Biddinger SB, Dutton RJ, Turnbaugh PJ.

Nature. 2014 Jan 23;505(7484):559-63. doi: 10.1038/nature12820. Epub 2013 Dec 11.

35.

What Lives On Our Skin: Ecology, Genomics and Therapeutic Opportunities Of the Skin Microbiome.

Scharschmidt TC, Fischbach MA.

Drug Discov Today Dis Mech. 2013 Dec 1;10(3-4). pii: e83-e89.

36.

Production of α-galactosylceramide by a prominent member of the human gut microbiota.

Wieland Brown LC, Penaranda C, Kashyap PC, Williams BB, Clardy J, Kronenberg M, Sonnenburg JL, Comstock LE, Bluestone JA, Fischbach MA.

PLoS Biol. 2013 Jul;11(7):e1001610. doi: 10.1371/journal.pbio.1001610. Epub 2013 Jul 16.

37.

A metabolomic view of how the human gut microbiota impacts the host metabolome using humanized and gnotobiotic mice.

Marcobal A, Kashyap PC, Nelson TA, Aronov PA, Donia MS, Spormann A, Fischbach MA, Sonnenburg JL.

ISME J. 2013 Oct;7(10):1933-43. doi: 10.1038/ismej.2013.89. Epub 2013 Jun 6.

38.

antiSMASH 2.0--a versatile platform for genome mining of secondary metabolite producers.

Blin K, Medema MH, Kazempour D, Fischbach MA, Breitling R, Takano E, Weber T.

Nucleic Acids Res. 2013 Jul;41(Web Server issue):W204-12. doi: 10.1093/nar/gkt449. Epub 2013 Jun 3.

39.

Cell-based therapeutics: the next pillar of medicine.

Fischbach MA, Bluestone JA, Lim WA.

Sci Transl Med. 2013 Apr 3;5(179):179ps7. doi: 10.1126/scitranslmed.3005568.

40.

Trehalose biosynthesis promotes Pseudomonas aeruginosa pathogenicity in plants.

Djonović S, Urbach JM, Drenkard E, Bush J, Feinbaum R, Ausubel JL, Traficante D, Risech M, Kocks C, Fischbach MA, Priebe GP, Ausubel FM.

PLoS Pathog. 2013 Mar;9(3):e1003217. doi: 10.1371/journal.ppat.1003217. Epub 2013 Mar 7.

41.

Dyeing to learn more about the gut microbiota.

Donia MS, Fischbach MA.

Cell Host Microbe. 2013 Feb 13;13(2):119-20. doi: 10.1016/j.chom.2013.01.011.

42.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

43.

Molecular insights into the biosynthesis of guadinomine: a type III secretion system inhibitor.

Holmes TC, May AE, Zaleta-Rivera K, Ruby JG, Skewes-Cox P, Fischbach MA, DeRisi JL, Iwatsuki M, Ōmura S, Khosla C.

J Am Chem Soc. 2012 Oct 24;134(42):17797-806. doi: 10.1021/ja308622d. Epub 2012 Oct 10.

44.

Molecular analysis of model gut microbiotas by imaging mass spectrometry and nanodesorption electrospray ionization reveals dietary metabolite transformations.

Rath CM, Alexandrov T, Higginbottom SK, Song J, Milla ME, Fischbach MA, Sonnenburg JL, Dorrestein PC.

Anal Chem. 2012 Nov 6;84(21):9259-67. doi: 10.1021/ac302039u. Epub 2012 Oct 10.

45.

Microbiota-targeted therapies: an ecological perspective.

Lemon KP, Armitage GC, Relman DA, Fischbach MA.

Sci Transl Med. 2012 Jun 6;4(137):137rv5. doi: 10.1126/scitranslmed.3004183. Review.

46.

Eating for two: how metabolism establishes interspecies interactions in the gut.

Fischbach MA, Sonnenburg JL.

Cell Host Microbe. 2011 Oct 20;10(4):336-47. doi: 10.1016/j.chom.2011.10.002. Review.

47.

A mass spectrometry-guided genome mining approach for natural product peptidogenomics.

Kersten RD, Yang YL, Xu Y, Cimermancic P, Nam SJ, Fenical W, Fischbach MA, Moore BS, Dorrestein PC.

Nat Chem Biol. 2011 Oct 9;7(11):794-802. doi: 10.1038/nchembio.684.

48.

Combination therapies for combating antimicrobial resistance.

Fischbach MA.

Curr Opin Microbiol. 2011 Oct;14(5):519-23. doi: 10.1016/j.mib.2011.08.003. Epub 2011 Sep 6. Review.

49.

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences.

Medema MH, Blin K, Cimermancic P, de Jager V, Zakrzewski P, Fischbach MA, Weber T, Takano E, Breitling R.

Nucleic Acids Res. 2011 Jul;39(Web Server issue):W339-46. doi: 10.1093/nar/gkr466. Epub 2011 Jun 14.

50.

Community health care: therapeutic opportunities in the human microbiome.

Sonnenburg JL, Fischbach MA.

Sci Transl Med. 2011 Apr 13;3(78):78ps12. doi: 10.1126/scitranslmed.3001626.

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