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Fulvestrant and palbociclib combination in heavily pretreated hormone receptor-positive, HER2-negative metastatic breast cancer patients.

Herrscher H, Velten M, Leblanc J, Kalish-Weindling M, Fischbach C, Exinger D, Pivot X, Petit T.

Breast Cancer Res Treat. 2019 Oct 14. doi: 10.1007/s10549-019-05439-x. [Epub ahead of print]


Hydroxyapatite mineral enhances malignant potential in a tissue-engineered model of ductal carcinoma in situ (DCIS).

He F, Springer NL, Whitman MA, Pathi SP, Lee Y, Mohanan S, Marcott S, Chiou AE, Blank BS, Iyengar N, Morris PG, Jochelson M, Hudis CA, Shah P, Kunitake JAMR, Estroff LA, Lammerding J, Fischbach C.

Biomaterials. 2019 Dec;224:119489. doi: 10.1016/j.biomaterials.2019.119489. Epub 2019 Sep 11.


Obesity-Associated Extracellular Matrix Remodeling Promotes a Macrophage Phenotype Similar to Tumor-Associated Macrophages.

Springer NL, Iyengar NM, Bareja R, Verma A, Jochelson MS, Giri DD, Zhou XK, Elemento O, Dannenberg AJ, Fischbach C.

Am J Pathol. 2019 Oct;189(10):2019-2035. doi: 10.1016/j.ajpath.2019.06.005. Epub 2019 Jul 16.


Physical confinement induces malignant transformation in mammary epithelial cells.

Lu YC, Chu T, Hall MS, Fu DJ, Shi Q, Chiu A, An D, Wang LH, Pardo Y, Southard T, Danko CG, Liphardt J, Nikitin AY, Wu M, Fischbach C, Coonrod S, Ma M.

Biomaterials. 2019 Oct;217:119307. doi: 10.1016/j.biomaterials.2019.119307. Epub 2019 Jun 26.


Endothelial cells promote 3D invasion of GBM by IL-8-dependent induction of cancer stem cell properties.

McCoy MG, Nyanyo D, Hung CK, Goerger JP, R Zipfel W, Williams RM, Nishimura N, Fischbach C.

Sci Rep. 2019 Jun 21;9(1):9069. doi: 10.1038/s41598-019-45535-y.


Mapping and Profiling Lipid Distribution in a 3D Model of Breast Cancer Progression.

Vidavsky N, Kunitake JAMR, Diaz-Rubio ME, Chiou AE, Loh HC, Zhang S, Masic A, Fischbach C, Estroff LA.

ACS Cent Sci. 2019 May 22;5(5):768-780. doi: 10.1021/acscentsci.8b00932. Epub 2019 Apr 19.


The Physics of Cancer.

White FM, Gatenby RA, Fischbach C.

Cancer Res. 2019 May 1;79(9):2107-2110. doi: 10.1158/0008-5472.CAN-18-3937. Epub 2019 Apr 24.


Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.

Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA.

Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11.


Studying biomineralization pathways in a 3D culture model of breast cancer microcalcifications.

Vidavsky N, Kunitake JA, Chiou AE, Northrup PA, Porri TJ, Ling L, Fischbach C, Estroff LA.

Biomaterials. 2018 Oct;179:71-82. doi: 10.1016/j.biomaterials.2018.06.030. Epub 2018 Jun 22.


Cancer metabolism gets physical.

DelNero P, Hopkins BD, Cantley LC, Fischbach C.

Sci Transl Med. 2018 May 23;10(442). pii: eaaq1011. doi: 10.1126/scitranslmed.aaq1011. Review.


Intrafibrillar, bone-mimetic collagen mineralization regulates breast cancer cell adhesion and migration.

Choi S, Friedrichs J, Song YH, Werner C, Estroff LA, Fischbach C.

Biomaterials. 2019 Apr;198:95-106. doi: 10.1016/j.biomaterials.2018.05.002. Epub 2018 May 7.


Biophysical Properties of Extracellular Matrix: Linking Obesity and Cancer.

Druso JE, Fischbach C.

Trends Cancer. 2018 Apr;4(4):271-273. doi: 10.1016/j.trecan.2018.02.001. Epub 2018 Mar 10. Review.


CD44v6 increases gastric cancer malignant phenotype by modulating adipose stromal cell-mediated ECM remodeling.

Lourenço BN, Springer NL, Ferreira D, Oliveira C, Granja PL, Fischbach C.

Integr Biol (Camb). 2018 Mar 1;10(3):145-158. doi: 10.1039/c7ib00179g. Epub 2018 Feb 16.


Correlative imaging reveals physiochemical heterogeneity of microcalcifications in human breast carcinomas.

Kunitake JAMR, Choi S, Nguyen KX, Lee MM, He F, Sudilovsky D, Morris PG, Jochelson MS, Hudis CA, Muller DA, Fratzl P, Fischbach C, Masic A, Estroff LA.

J Struct Biol. 2018 Apr;202(1):25-34. doi: 10.1016/j.jsb.2017.12.002. Epub 2017 Dec 6.


Multiscale characterization of the mineral phase at skeletal sites of breast cancer metastasis.

He F, Chiou AE, Loh HC, Lynch M, Seo BR, Song YH, Lee MJ, Hoerth R, Bortel EL, Willie BM, Duda GN, Estroff LA, Masic A, Wagermaier W, Fratzl P, Fischbach C.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10542-10547. doi: 10.1073/pnas.1708161114. Epub 2017 Sep 18.


Single-energy pediatric chest computed tomography with spectral filtration at 100 kVp: effects on radiation parameters and image quality.

Bodelle B, Fischbach C, Booz C, Yel I, Frellesen C, Kaup M, Beeres M, Vogl TJ, Scholtz JE.

Pediatr Radiol. 2017 Jun;47(7):831-837. doi: 10.1007/s00247-017-3813-1. Epub 2017 Mar 28.


Free-breathing high-pitch 80kVp dual-source computed tomography of the pediatric chest: Image quality, presence of motion artifacts and radiation dose.

Bodelle B, Fischbach C, Booz C, Yel I, Frellesen C, Beeres M, Vogl TJ, Scholtz JE.

Eur J Radiol. 2017 Apr;89:208-214. doi: 10.1016/j.ejrad.2017.01.027. Epub 2017 Feb 6.


Protein-crystal interface mediates cell adhesion and proangiogenic secretion.

Wu F, Chen W, Gillis B, Fischbach C, Estroff LA, Gourdon D.

Biomaterials. 2017 Feb;116:174-185. doi: 10.1016/j.biomaterials.2016.11.043. Epub 2016 Nov 25.


Breast cancer-derived extracellular vesicles stimulate myofibroblast differentiation and pro-angiogenic behavior of adipose stem cells.

Song YH, Warncke C, Choi SJ, Choi S, Chiou AE, Ling L, Liu HY, Daniel S, Antonyak MA, Cerione RA, Fischbach C.

Matrix Biol. 2017 Jul;60-61:190-205. doi: 10.1016/j.matbio.2016.11.008. Epub 2016 Nov 29.


Influencing the Tumor Microenvironment: A Phase II Study of Copper Depletion Using Tetrathiomolybdate in Patients with Breast Cancer at High Risk for Recurrence and in Preclinical Models of Lung Metastases.

Chan N, Willis A, Kornhauser N, Ward MM, Lee SB, Nackos E, Seo BR, Chuang E, Cigler T, Moore A, Donovan D, Vallee Cobham M, Fitzpatrick V, Schneider S, Wiener A, Guillaume-Abraham J, Aljom E, Zelkowitz R, Warren JD, Lane ME, Fischbach C, Mittal V, Vahdat L.

Clin Cancer Res. 2017 Feb 1;23(3):666-676. doi: 10.1158/1078-0432.CCR-16-1326. Epub 2016 Oct 21.


Collagen I hydrogel microstructure and composition conjointly regulate vascular network formation.

McCoy MG, Seo BR, Choi S, Fischbach C.

Acta Biomater. 2016 Oct 15;44:200-8. doi: 10.1016/j.actbio.2016.08.028. Epub 2016 Aug 18.


Breast cancer cells alter the dynamics of stromal fibronectin-collagen interactions.

Wang K, Wu F, Seo BR, Fischbach C, Chen W, Hsu L, Gourdon D.

Matrix Biol. 2017 Jul;60-61:86-95. doi: 10.1016/j.matbio.2016.08.001. Epub 2016 Aug 6.


Three-Dimensional Mechanical Loading Modulates the Osteogenic Response of Mesenchymal Stem Cells to Tumor-Derived Soluble Signals.

Lynch ME, Chiou AE, Lee MJ, Marcott SC, Polamraju PV, Lee Y, Fischbach C.

Tissue Eng Part A. 2016 Aug;22(15-16):1006-15. doi: 10.1089/ten.TEA.2016.0153. Epub 2016 Aug 1.


Biomaterials approaches to modeling macrophage-extracellular matrix interactions in the tumor microenvironment.

Springer NL, Fischbach C.

Curr Opin Biotechnol. 2016 Aug;40:16-23. doi: 10.1016/j.copbio.2016.02.003. Epub 2016 Feb 25. Review.


Fibronectin Mechanobiology Regulates Tumorigenesis.

Wang K, Seo BR, Fischbach C, Gourdon D.

Cell Mol Bioeng. 2016;9:1-11. Epub 2015 Aug 15. Review.


Engineered tumours: Roll-on scaffolds.

DelNero P, Fischbach C.

Nat Mater. 2016 Feb;15(2):138-9. doi: 10.1038/nmat4549. No abstract available.


Adipose-derived stem cells increase angiogenesis through matrix metalloproteinase-dependent collagen remodeling.

Song YH, Shon SH, Shan M, Stroock AD, Fischbach C.

Integr Biol (Camb). 2016 Feb;8(2):205-15. doi: 10.1039/c5ib00277j. Epub 2016 Jan 13.


Lung inflammation promotes metastasis through neutrophil protease-mediated degradation of Tsp-1.

El Rayes T, Catena R, Lee S, Stawowczyk M, Joshi N, Fischbach C, Powell CA, Dannenberg AJ, Altorki NK, Gao D, Mittal V.

Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):16000-5. doi: 10.1073/pnas.1507294112. Epub 2015 Dec 14.


3D Conducting Polymer Platforms for Electrical Control of Protein Conformation and Cellular Functions.

Wan AM, Inal S, Williams T, Wang K, Leleux P, Estevez L, Giannelis EP, Fischbach C, Malliaras GG, Gourdon D.

J Mater Chem B. 2015 Jul 7;3(25):5040-5048.


Obesity-dependent changes in interstitial ECM mechanics promote breast tumorigenesis.

Seo BR, Bhardwaj P, Choi S, Gonzalez J, Andresen Eguiluz RC, Wang K, Mohanan S, Morris PG, Du B, Zhou XK, Vahdat LT, Verma A, Elemento O, Hudis CA, Williams RM, Gourdon D, Dannenberg AJ, Fischbach C.

Sci Transl Med. 2015 Aug 19;7(301):301ra130. doi: 10.1126/scitranslmed.3010467.


Effect of the Materials Properties of Hydroxyapatite Nanoparticles on Fibronectin Deposition and Conformation.

Wu F, Lin DD, Chang JH, Fischbach C, Estroff LA, Gourdon D.

Cryst Growth Des. 2015 May 6;15(5):2452-2460. Epub 2015 Apr 14.


Chemical and physical properties of carbonated hydroxyapatite affect breast cancer cell behavior.

Choi S, Coonrod S, Estroff L, Fischbach C.

Acta Biomater. 2015 Sep;24:333-42. doi: 10.1016/j.actbio.2015.06.001. Epub 2015 Jun 10.


3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways.

DelNero P, Lane M, Verbridge SS, Kwee B, Kermani P, Hempstead B, Stroock A, Fischbach C.

Biomaterials. 2015 Jul;55:110-8. doi: 10.1016/j.biomaterials.2015.03.035. Epub 2015 Apr 13.


Stiffening and unfolding of early deposited-fibronectin increase proangiogenic factor secretion by breast cancer-associated stromal cells.

Wang K, Andresen Eguiluz RC, Wu F, Seo BR, Fischbach C, Gourdon D.

Biomaterials. 2015 Jun;54:63-71. doi: 10.1016/j.biomaterials.2015.03.019. Epub 2015 Mar 29.


Biomechanical forces in the skeleton and their relevance to bone metastasis: biology and engineering considerations.

Lynch ME, Fischbach C.

Adv Drug Deliv Rev. 2014 Dec 15;79-80:119-34. doi: 10.1016/j.addr.2014.08.009. Epub 2014 Aug 29. Review.


Abstract 153: A Novel 3D Platform to Investigate Neoangiogenesis, Transendothelial Migration and Metastasis of Breast Cancer Cells.

Hooper RC, Hernandez KA, Joyce J, Jacoby A, Asanbe O, Weinreb R, Fischbach C.

Plast Reconstr Surg. 2014 Mar;133(3 Suppl):169. doi: 10.1097/01.prs.0000444981.22066.a3. No abstract available.


In vitro models of tumor vessels and matrix: engineering approaches to investigate transport limitations and drug delivery in cancer.

Seo BR, DelNero P, Fischbach C.

Adv Drug Deliv Rev. 2014 Apr;69-70:205-216. doi: 10.1016/j.addr.2013.11.011. Epub 2013 Dec 2. Review.


Glioblastoma stem cells are regulated by interleukin-8 signaling in a tumoral perivascular niche.

Infanger DW, Cho Y, Lopez BS, Mohanan S, Liu SC, Gursel D, Boockvar JA, Fischbach C.

Cancer Res. 2013 Dec 1;73(23):7079-89. doi: 10.1158/0008-5472.CAN-13-1355. Epub 2013 Oct 11.


Formation of microvascular networks in vitro.

Morgan JP, Delnero PF, Zheng Y, Verbridge SS, Chen J, Craven M, Choi NW, Diaz-Santana A, Kermani P, Hempstead B, López JA, Corso TN, Fischbach C, Stroock AD.

Nat Protoc. 2013 Sep;8(9):1820-36. doi: 10.1038/nprot.2013.110. Epub 2013 Aug 29.


In vivo tibial compression decreases osteolysis and tumor formation in a human metastatic breast cancer model.

Lynch ME, Brooks D, Mohanan S, Lee MJ, Polamraju P, Dent K, Bonassar LJ, van der Meulen MC, Fischbach C.

J Bone Miner Res. 2013 Nov;28(11):2357-67. doi: 10.1002/jbmr.1966.


Engineered culture models for studies of tumor-microenvironment interactions.

Infanger DW, Lynch ME, Fischbach C.

Annu Rev Biomed Eng. 2013;15:29-53. doi: 10.1146/annurev-bioeng-071811-150028. Epub 2013 Apr 29. Review.


A physical sciences network characterization of non-tumorigenic and metastatic cells.

Physical Sciences - Oncology Centers Network, Agus DB, Alexander JF, Arap W, Ashili S, Aslan JE, Austin RH, Backman V, Bethel KJ, Bonneau R, Chen WC, Chen-Tanyolac C, Choi NC, Curley SA, Dallas M, Damania D, Davies PC, Decuzzi P, Dickinson L, Estevez-Salmeron L, Estrella V, Ferrari M, Fischbach C, Foo J, Fraley SI, Frantz C, Fuhrmann A, Gascard P, Gatenby RA, Geng Y, Gerecht S, Gillies RJ, Godin B, Grady WM, Greenfield A, Hemphill C, Hempstead BL, Hielscher A, Hillis WD, Holland EC, Ibrahim-Hashim A, Jacks T, Johnson RH, Joo A, Katz JE, Kelbauskas L, Kesselman C, King MR, Konstantopoulos K, Kraning-Rush CM, Kuhn P, Kung K, Kwee B, Lakins JN, Lambert G, Liao D, Licht JD, Liphardt JT, Liu L, Lloyd MC, Lyubimova A, Mallick P, Marko J, McCarty OJ, Meldrum DR, Michor F, Mumenthaler SM, Nandakumar V, O'Halloran TV, Oh S, Pasqualini R, Paszek MJ, Philips KG, Poultney CS, Rana K, Reinhart-King CA, Ros R, Semenza GL, Senechal P, Shuler ML, Srinivasan S, Staunton JR, Stypula Y, Subramanian H, Tlsty TD, Tormoen GW, Tseng Y, van Oudenaarden A, Verbridge SS, Wan JC, Weaver VM, Widom J, Will C, Wirtz D, Wojtkowiak J, Wu PH.

Sci Rep. 2013;3:1449. doi: 10.1038/srep01449.


Fibronectin conformation regulates the proangiogenic capability of tumor-associated adipogenic stromal cells.

Wan AM, Chandler EM, Madhavan M, Infanger DW, Ober CK, Gourdon D, Malliaras GG, Fischbach C.

Biochim Biophys Acta. 2013 Sep;1830(9):4314-20. doi: 10.1016/j.bbagen.2013.03.033. Epub 2013 Apr 6.


Physicochemical regulation of endothelial sprouting in a 3D microfluidic angiogenesis model.

Verbridge SS, Chakrabarti A, DelNero P, Kwee B, Varner JD, Stroock AD, Fischbach C.

J Biomed Mater Res A. 2013 Oct;101(10):2948-56. doi: 10.1002/jbm.a.34587. Epub 2013 Apr 5.


Microengineered tumor models: insights & opportunities from a physical sciences-oncology perspective.

DelNero P, Song YH, Fischbach C.

Biomed Microdevices. 2013 Aug;15(4):583-593. doi: 10.1007/s10544-013-9763-y. Review.


Multiscale models of breast cancer progression.

Chakrabarti A, Verbridge S, Stroock AD, Fischbach C, Varner JD.

Ann Biomed Eng. 2012 Nov;40(11):2488-500. doi: 10.1007/s10439-012-0655-8. Epub 2012 Sep 25. Review.


Implanted adipose progenitor cells as physicochemical regulators of breast cancer.

Chandler EM, Seo BR, Califano JP, Andresen Eguiluz RC, Lee JS, Yoon CJ, Tims DT, Wang JX, Cheng L, Mohanan S, Buckley MR, Cohen I, Nikitin AY, Williams RM, Gourdon D, Reinhart-King CA, Fischbach C.

Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):9786-91. doi: 10.1073/pnas.1121160109. Epub 2012 Jun 4.


Electrical control of protein conformation.

Wan AM, Schur RM, Ober CK, Fischbach C, Gourdon D, Malliaras GG.

Adv Mater. 2012 May 8;24(18):2501-5. doi: 10.1002/adma.201200436. Epub 2012 Apr 10.


Phosphorescent nanoparticles for quantitative measurements of oxygen profiles in vitro and in vivo.

Choi NW, Verbridge SS, Williams RM, Chen J, Kim JY, Schmehl R, Farnum CE, Zipfel WR, Fischbach C, Stroock AD.

Biomaterials. 2012 Mar;33(9):2710-22. doi: 10.1016/j.biomaterials.2011.11.048. Epub 2012 Jan 10.


Hydroxyapatite nanoparticle-containing scaffolds for the study of breast cancer bone metastasis.

Pathi SP, Lin DD, Dorvee JR, Estroff LA, Fischbach C.

Biomaterials. 2011 Aug;32(22):5112-22. doi: 10.1016/j.biomaterials.2011.03.055. Epub 2011 Apr 20.

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