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Items: 1 to 50 of 247

1.

Phosphodiesterase PdeD, dynacortin, and a Kelch repeat-containing protein are direct GSK3 substrates in Dictyostelium that contribute to chemotaxis towards cAMP.

Baumgardner K, Lin C, Firtel RA, Lacal J.

Environ Microbiol. 2018 May;20(5):1888-1903. doi: 10.1111/1462-2920.14126.

PMID:
29626371
2.

The Dictyostelium GSK3 kinase GlkA coordinates signal relay and chemotaxis in response to growth conditions.

Lacal Romero J, Shen Z, Baumgardner K, Wei J, Briggs SP, Firtel RA.

Dev Biol. 2018 Mar 1;435(1):56-72. doi: 10.1016/j.ydbio.2018.01.007. Epub 2018 Jan 20.

3.

Two-Layer Elastographic 3-D Traction Force Microscopy.

Álvarez-González B, Zhang S, Gómez-González M, Meili R, Firtel RA, Lasheras JC, Del Álamo JC.

Sci Rep. 2017 Jan 11;7:39315. doi: 10.1038/srep39315.

4.

Connecting G protein signaling to chemoattractant-mediated cell polarity and cytoskeletal reorganization.

Liu Y, Lacal J, Firtel RA, Kortholt A.

Small GTPases. 2018 Jul 4;9(4):360-364. doi: 10.1080/21541248.2016.1235390. Epub 2016 Oct 14. Review.

5.

A Gα-Stimulated RapGEF Is a Receptor-Proximal Regulator of Dictyostelium Chemotaxis.

Liu Y, Lacal J, Veltman DM, Fusetti F, van Haastert PJ, Firtel RA, Kortholt A.

Dev Cell. 2016 Jun 6;37(5):458-72. doi: 10.1016/j.devcel.2016.05.001. Epub 2016 May 26.

6.

Cooperative cell motility during tandem locomotion of amoeboid cells.

Bastounis E, Álvarez-González B, del Álamo JC, Lasheras JC, Firtel RA.

Mol Biol Cell. 2016 Apr 15;27(8):1262-71. doi: 10.1091/mbc.E15-12-0836. Epub 2016 Feb 24.

7.

Three-dimensional balance of cortical tension and axial contractility enables fast amoeboid migration.

Álvarez-González B, Meili R, Bastounis E, Firtel RA, Lasheras JC, Del Álamo JC.

Biophys J. 2015 Feb 17;108(4):821-832. doi: 10.1016/j.bpj.2014.11.3478.

8.

Both contractile axial and lateral traction force dynamics drive amoeboid cell motility.

Bastounis E, Meili R, Álvarez-González B, Francois J, del Álamo JC, Firtel RA, Lasheras JC.

J Cell Biol. 2014 Mar 17;204(6):1045-61. doi: 10.1083/jcb.201307106.

9.

Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.

Sumita K, Yoshino H, Sasaki M, Majd N, Kahoud ER, Takahashi H, Takeuchi K, Kuroda T, Lee S, Charest PG, Takeda K, Asara JM, Firtel RA, Anastasiou D, Sasaki AT.

J Biol Chem. 2014 Feb 14;289(7):3950-9. doi: 10.1074/jbc.M113.531178. Epub 2013 Dec 13.

10.

Daydreamer, a Ras effector and GSK-3 substrate, is important for directional sensing and cell motility.

Kölsch V, Shen Z, Lee S, Plak K, Lotfi P, Chang J, Charest PG, Romero JL, Jeon TJ, Kortholt A, Briggs SP, Firtel RA.

Mol Biol Cell. 2013 Jan;24(2):100-14. doi: 10.1091/mbc.E12-04-0271. Epub 2012 Nov 7.

11.

Adaptation in a eukaryotic pathway: combining experiments with modeling.

Rappel WJ, Firtel RA.

Cell Cycle. 2012 Mar 15;11(6):1051-2. doi: 10.4161/cc.11.6.19715. Epub 2012 Mar 15. No abstract available.

12.

Incoherent feedforward control governs adaptation of activated ras in a eukaryotic chemotaxis pathway.

Takeda K, Shao D, Adler M, Charest PG, Loomis WF, Levine H, Groisman A, Rappel WJ, Firtel RA.

Sci Signal. 2012 Jan 3;5(205):ra2. doi: 10.1126/scisignal.2002413.

13.

An Oscillatory Contractile Pole-Force Component Dominates the Traction Forces Exerted by Migrating Amoeboid Cells.

Alonso-Latorre B, Del Álamo JC, Meili R, Firtel RA, Lasheras JC.

Cell Mol Bioeng. 2011 Dec;4(4):603-615. Epub 2011 Jun 29.

14.

The SCAR/WAVE complex is necessary for proper regulation of traction stresses during amoeboid motility.

Bastounis E, Meili R, Alonso-Latorre B, del Álamo JC, Lasheras JC, Firtel RA.

Mol Biol Cell. 2011 Nov;22(21):3995-4003. doi: 10.1091/mbc.E11-03-0278. Epub 2011 Sep 7.

15.

Activated membrane patches guide chemotactic cell motility.

Hecht I, Skoge ML, Charest PG, Ben-Jacob E, Firtel RA, Loomis WF, Levine H, Rappel WJ.

PLoS Comput Biol. 2011 Jun;7(6):e1002044. doi: 10.1371/journal.pcbi.1002044. Epub 2011 Jun 30.

16.

The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton.

Kicka S, Shen Z, Annesley SJ, Fisher PR, Lee S, Briggs S, Firtel RA.

Mol Biol Cell. 2011 Jul 1;22(13):2198-211. doi: 10.1091/mbc.E10-12-0937. Epub 2011 May 5.

17.

"TORCing" neutrophil chemotaxis.

Charest PG, Firtel RA.

Dev Cell. 2010 Dec 14;19(6):795-6. doi: 10.1016/j.devcel.2010.11.017.

18.

A Ras signaling complex controls the RasC-TORC2 pathway and directed cell migration.

Charest PG, Shen Z, Lakoduk A, Sasaki AT, Briggs SP, Firtel RA.

Dev Cell. 2010 May 18;18(5):737-49. doi: 10.1016/j.devcel.2010.03.017.

19.

Involvement of the cytoskeleton in controlling leading-edge function during chemotaxis.

Lee S, Shen Z, Robinson DN, Briggs S, Firtel RA.

Mol Biol Cell. 2010 Jun 1;21(11):1810-24. doi: 10.1091/mbc.E10-01-0009. Epub 2010 Apr 7.

20.

Myosin II is essential for the spatiotemporal organization of traction forces during cell motility.

Meili R, Alonso-Latorre B, del Alamo JC, Firtel RA, Lasheras JC.

Mol Biol Cell. 2010 Feb 1;21(3):405-17. doi: 10.1091/mbc.E09-08-0703. Epub 2009 Dec 2.

21.

Spatiotemporal regulation of Ras-GTPases during chemotaxis.

Sasaki AT, Firtel RA.

Methods Mol Biol. 2009;571:333-48. doi: 10.1007/978-1-60761-198-1_23.

PMID:
19763978
22.

Mechanosensing through cooperative interactions between myosin II and the actin crosslinker cortexillin I.

Ren Y, Effler JC, Norstrom M, Luo T, Firtel RA, Iglesias PA, Rock RS, Robinson DN.

Curr Biol. 2009 Sep 15;19(17):1421-8. doi: 10.1016/j.cub.2009.07.018. Epub 2009 Jul 30.

23.

Regulation of Dictyostelium morphogenesis by RapGAP3.

Jeon TJ, Lee S, Weeks G, Firtel RA.

Dev Biol. 2009 Apr 15;328(2):210-20. doi: 10.1016/j.ydbio.2009.01.016. Epub 2009 Jan 22.

24.

Dictyostelium Dock180-related RacGEFs regulate the actin cytoskeleton during cell motility.

Para A, Krischke M, Merlot S, Shen Z, Oberholzer M, Lee S, Briggs S, Firtel RA.

Mol Biol Cell. 2009 Jan;20(2):699-707. doi: 10.1091/mbc.E08-09-0899. Epub 2008 Nov 26.

25.

Spatiotemporal regulation of Ras activity provides directional sensing.

Zhang S, Charest PG, Firtel RA.

Curr Biol. 2008 Oct 28;18(20):1587-1593. doi: 10.1016/j.cub.2008.08.069.

26.

Regulation of contractile vacuole formation and activity in Dictyostelium.

Du F, Edwards K, Shen Z, Sun B, De Lozanne A, Briggs S, Firtel RA.

EMBO J. 2008 Aug 6;27(15):2064-76. doi: 10.1038/emboj.2008.131. Epub 2008 Jul 17.

27.

Directional sensing during chemotaxis.

Janetopoulos C, Firtel RA.

FEBS Lett. 2008 Jun 18;582(14):2075-85. doi: 10.1016/j.febslet.2008.04.035. Epub 2008 Apr 29. Review.

28.

Evidence that DIF-1 and hyper-osmotic stress activate a Dictyostelium STAT by inhibiting a specific protein tyrosine phosphatase.

Araki T, Langenick J, Gamper M, Firtel RA, Williams JG.

Development. 2008 Apr;135(7):1347-53. doi: 10.1242/dev.009936. Epub 2008 Feb 27.

29.

The regulation of cell motility and chemotaxis by phospholipid signaling.

Kölsch V, Charest PG, Firtel RA.

J Cell Sci. 2008 Mar 1;121(Pt 5):551-9. doi: 10.1242/jcs.023333. Review.

30.

Regulation of Rap1 activity by RapGAP1 controls cell adhesion at the front of chemotaxing cells.

Jeon TJ, Lee DJ, Lee S, Weeks G, Firtel RA.

J Cell Biol. 2007 Dec 3;179(5):833-43. Epub 2007 Nov 26.

31.

Spatio-temporal analysis of eukaryotic cell motility by improved force cytometry.

Del Alamo JC, Meili R, Alonso-Latorre B, Rodríguez-Rodríguez J, Aliseda A, Firtel RA, Lasheras JC.

Proc Natl Acad Sci U S A. 2007 Aug 14;104(33):13343-8. Epub 2007 Aug 7.

32.

G protein-independent Ras/PI3K/F-actin circuit regulates basic cell motility.

Sasaki AT, Janetopoulos C, Lee S, Charest PG, Takeda K, Sundheimer LW, Meili R, Devreotes PN, Firtel RA.

J Cell Biol. 2007 Jul 16;178(2):185-91.

33.

Rap1 controls cell adhesion and cell motility through the regulation of myosin II.

Jeon TJ, Lee DJ, Merlot S, Weeks G, Firtel RA.

J Cell Biol. 2007 Mar 26;176(7):1021-33. Epub 2007 Mar 19.

34.

MEK1 and protein phosphatase 4 coordinate Dictyostelium development and chemotaxis.

Mendoza MC, Booth EO, Shaulsky G, Firtel RA.

Mol Cell Biol. 2007 May;27(10):3817-27. Epub 2007 Mar 12.

35.

Role of phosphatidylinositol 3-kinases in chemotaxis in Dictyostelium.

Takeda K, Sasaki AT, Ha H, Seung HA, Firtel RA.

J Biol Chem. 2007 Apr 20;282(16):11874-84. Epub 2007 Mar 1.

36.

Big roles for small GTPases in the control of directed cell movement.

Charest PG, Firtel RA.

Biochem J. 2007 Jan 15;401(2):377-90. Review.

37.

Assaying chemotaxis of Dictyostelium cells.

Mendoza MC, Firtel RA.

Methods Mol Biol. 2006;346:393-405.

PMID:
16957303
38.

Feedback signaling controls leading-edge formation during chemotaxis.

Charest PG, Firtel RA.

Curr Opin Genet Dev. 2006 Aug;16(4):339-47. Epub 2006 Jun 27. Review.

PMID:
16806895
39.

Regulation of chemotaxis by the orchestrated activation of Ras, PI3K, and TOR.

Sasaki AT, Firtel RA.

Eur J Cell Biol. 2006 Sep;85(9-10):873-95. Epub 2006 Jun 5. Review.

PMID:
16740339
40.

Finding the way: directional sensing and cell polarization through Ras signalling.

Sasaki AT, Firtel RA.

Novartis Found Symp. 2005;269:73-87; discussion 87-91, 223-30.

PMID:
16355536
41.

Loss of SMEK, a novel, conserved protein, suppresses MEK1 null cell polarity, chemotaxis, and gene expression defects.

Mendoza MC, Du F, Iranfar N, Tang N, Ma H, Loomis WF, Firtel RA.

Mol Cell Biol. 2005 Sep;25(17):7839-53.

42.

TOR complex 2 integrates cell movement during chemotaxis and signal relay in Dictyostelium.

Lee S, Comer FI, Sasaki A, McLeod IX, Duong Y, Okumura K, Yates JR 3rd, Parent CA, Firtel RA.

Mol Biol Cell. 2005 Oct;16(10):4572-83. Epub 2005 Aug 3.

43.

Rho Rocks PTEN.

Meili R, Sasaki AT, Firtel RA.

Nat Cell Biol. 2005 Apr;7(4):334-5. No abstract available.

PMID:
15803130
44.

A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.

Myers SA, Han JW, Lee Y, Firtel RA, Chung CY.

Mol Biol Cell. 2005 May;16(5):2191-206. Epub 2005 Feb 23.

45.

Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement.

Sasaki AT, Chun C, Takeda K, Firtel RA.

J Cell Biol. 2004 Nov 8;167(3):505-18.

46.

Dictyostelium PAKc is required for proper chemotaxis.

Lee S, Rivero F, Park KC, Huang E, Funamoto S, Firtel RA.

Mol Biol Cell. 2004 Dec;15(12):5456-69. Epub 2004 Oct 13.

47.

Rac regulation of chemotaxis and morphogenesis in Dictyostelium.

Park KC, Rivero F, Meili R, Lee S, Apone F, Firtel RA.

EMBO J. 2004 Oct 27;23(21):4177-89. Epub 2004 Oct 7.

48.
49.

Insights into morphogenesis from a simple developmental system.

Chisholm RL, Firtel RA.

Nat Rev Mol Cell Biol. 2004 Jul;5(7):531-41. Review. No abstract available.

PMID:
15232571
50.

Cell migration: integrating signals from front to back.

Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR.

Science. 2003 Dec 5;302(5651):1704-9. Review.

PMID:
14657486

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