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Items: 1 to 50 of 156

2.

Artemisinin disrupts androgen responsiveness of human prostate cancer cells by stimulating the 26S proteasome-mediated degradation of the androgen receptor protein.

Steely AM, Willoughby JA Sr, Sundar SN, Aivaliotis VI, Firestone GL.

Anticancer Drugs. 2017 Oct;28(9):1018-1031. doi: 10.1097/CAD.0000000000000547.

PMID:
28708672
3.

Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells.

Quirit JG, Lavrenov SN, Poindexter K, Xu J, Kyauk C, Durkin KA, Aronchik I, Tomasiak T, Solomatin YA, Preobrazhenskaya MN, Firestone GL.

Biochem Pharmacol. 2017 Mar 1;127:13-27. doi: 10.1016/j.bcp.2016.12.007. Epub 2016 Dec 12.

PMID:
27979631
4.

Cooperative antiproliferative signaling by aspirin and indole-3-carbinol targets microphthalmia-associated transcription factor gene expression and promoter activity in human melanoma cells.

Poindexter KM, Matthew S, Aronchik I, Firestone GL.

Cell Biol Toxicol. 2016 Apr;32(2):103-19. doi: 10.1007/s10565-016-9321-5. Epub 2016 Apr 7.

5.

Inhibition of oncogenic BRAF activity by indole-3-carbinol disrupts microphthalmia-associated transcription factor expression and arrests melanoma cell proliferation.

Kundu A, Quirit JG, Khouri MG, Firestone GL.

Mol Carcinog. 2017 Jan;56(1):49-61. doi: 10.1002/mc.22472. Epub 2016 Feb 15.

6.

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Block KI, Gyllenhaal C, Lowe L, Amedei A, Amin ARMR, Amin A, Aquilano K, Arbiser J, Arreola A, Arzumanyan A, Ashraf SS, Azmi AS, Benencia F, Bhakta D, Bilsland A, Bishayee A, Blain SW, Block PB, Boosani CS, Carey TE, Carnero A, Carotenuto M, Casey SC, Chakrabarti M, Chaturvedi R, Chen GZ, Chen H, Chen S, Chen YC, Choi BK, Ciriolo MR, Coley HM, Collins AR, Connell M, Crawford S, Curran CS, Dabrosin C, Damia G, Dasgupta S, DeBerardinis RJ, Decker WK, Dhawan P, Diehl AME, Dong JT, Dou QP, Drew JE, Elkord E, El-Rayes B, Feitelson MA, Felsher DW, Ferguson LR, Fimognari C, Firestone GL, Frezza C, Fujii H, Fuster MM, Generali D, Georgakilas AG, Gieseler F, Gilbertson M, Green MF, Grue B, Guha G, Halicka D, Helferich WG, Heneberg P, Hentosh P, Hirschey MD, Hofseth LJ, Holcombe RF, Honoki K, Hsu HY, Huang GS, Jensen LD, Jiang WG, Jones LW, Karpowicz PA, Keith WN, Kerkar SP, Khan GN, Khatami M, Ko YH, Kucuk O, Kulathinal RJ, Kumar NB, Kwon BS, Le A, Lea MA, Lee HY, Lichtor T, Lin LT, Locasale JW, Lokeshwar BL, Longo VD, Lyssiotis CA, MacKenzie KL, Malhotra M, Marino M, Martinez-Chantar ML, Matheu A, Maxwell C, McDonnell E, Meeker AK, Mehrmohamadi M, Mehta K, Michelotti GA, Mohammad RM, Mohammed SI, Morre DJ, Muralidhar V, Muqbil I, Murphy MP, Nagaraju GP, Nahta R, Niccolai E, Nowsheen S, Panis C, Pantano F, Parslow VR, Pawelec G, Pedersen PL, Poore B, Poudyal D, Prakash S, Prince M, Raffaghello L, Rathmell JC, Rathmell WK, Ray SK, Reichrath J, Rezazadeh S, Ribatti D, Ricciardiello L, Robey RB, Rodier F, Rupasinghe HPV, Russo GL, Ryan EP, Samadi AK, Sanchez-Garcia I, Sanders AJ, Santini D, Sarkar M, Sasada T, Saxena NK, Shackelford RE, Shantha Kumara HMC, Sharma D, Shin DM, Sidransky D, Siegelin MD, Signori E, Singh N, Sivanand S, Sliva D, Smythe C, Spagnuolo C, Stafforini DM, Stagg J, Subbarayan PR, Sundin T, Talib WH, Thompson SK, Tran PT, Ungefroren H, Vander Heiden MG, Venkateswaran V, Vinay DS, Vlachostergios PJ, Wang Z, Wellen KE, Whelan RL, Yang ES, Yang H, Yang X, Yaswen P, Yedjou C, Yin X, Zhu J, Zollo M.

Semin Cancer Biol. 2015 Dec;35 Suppl:S276-S304. doi: 10.1016/j.semcancer.2015.09.007. Review.

7.

Therapeutic targeting of replicative immortality.

Yaswen P, MacKenzie KL, Keith WN, Hentosh P, Rodier F, Zhu J, Firestone GL, Matheu A, Carnero A, Bilsland A, Sundin T, Honoki K, Fujii H, Georgakilas AG, Amedei A, Amin A, Helferich B, Boosani CS, Guha G, Ciriolo MR, Chen S, Mohammed SI, Azmi AS, Bhakta D, Halicka D, Niccolai E, Aquilano K, Ashraf SS, Nowsheen S, Yang X.

Semin Cancer Biol. 2015 Dec;35 Suppl:S104-S128. doi: 10.1016/j.semcancer.2015.03.007. Epub 2015 Apr 11. Review.

8.

Phytochemical regulation of the tumor suppressive microRNA, miR-34a, by p53-dependent and independent responses in human breast cancer cells.

Hargraves KG, He L, Firestone GL.

Mol Carcinog. 2016 May;55(5):486-98. doi: 10.1002/mc.22296. Epub 2015 Mar 19.

9.
10.

Minireview: Steroid/nuclear receptor-regulated dynamics of occluding and anchoring junctions.

Firestone GL, Kapadia BJ.

Mol Endocrinol. 2014 Nov;28(11):1769-84. doi: 10.1210/me.2014-1037. Epub 2014 Sep 9. Review.

11.

The antiproliferative response of indole-3-carbinol in human melanoma cells is triggered by an interaction with NEDD4-1 and disruption of wild-type PTEN degradation.

Aronchik I, Kundu A, Quirit JG, Firestone GL.

Mol Cancer Res. 2014 Nov;12(11):1621-1634. doi: 10.1158/1541-7786.MCR-14-0018. Epub 2014 Jul 9.

13.

3,3'-diindolylmethane rapidly and selectively inhibits hepatocyte growth factor/c-Met signaling in breast cancer cells.

Nicastro HL, Firestone GL, Bjeldanes LF.

J Nutr Biochem. 2013 Nov;24(11):1882-8. doi: 10.1016/j.jnutbio.2013.05.004. Epub 2013 Aug 19.

15.

Minireview: regulation of gap junction dynamics by nuclear hormone receptors and their ligands.

Firestone GL, Kapadia BJ.

Mol Endocrinol. 2012 Nov;26(11):1798-807. doi: 10.1210/me.2012-1065. Epub 2012 Aug 30. Review.

16.

Indole-3-carbinol disrupts estrogen receptor-alpha dependent expression of insulin-like growth factor-1 receptor and insulin receptor substrate-1 and proliferation of human breast cancer cells.

Marconett CN, Singhal AK, Sundar SN, Firestone GL.

Mol Cell Endocrinol. 2012 Nov 5;363(1-2):74-84. doi: 10.1016/j.mce.2012.07.008. Epub 2012 Jul 24.

17.

Antiproliferative effects of artemisinin on human breast cancer cells requires the downregulated expression of the E2F1 transcription factor and loss of E2F1-target cell cycle genes.

Tin AS, Sundar SN, Tran KQ, Park AH, Poindexter KM, Firestone GL.

Anticancer Drugs. 2012 Apr;23(4):370-9. doi: 10.1097/CAD.0b013e32834f6ea8.

PMID:
22185819
18.

Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling.

Aronchik I, Chen T, Durkin KA, Horwitz MS, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Mol Carcinog. 2012 Nov;51(11):881-94. doi: 10.1002/mc.20857. Epub 2011 Oct 19.

PMID:
22012859
19.

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells.

Marconett CN, Sundar SN, Tseng M, Tin AS, Tran KQ, Mahuron KM, Bjeldanes LF, Firestone GL.

Carcinogenesis. 2011 Sep;32(9):1315-23. doi: 10.1093/carcin/bgr116. Epub 2011 Jun 21.

20.

Unraveling the intricacies of receptor activated cell signaling and transcriptional cascades enhance opportunities to develop new therapeutic targets for endocrine and metabolic diseases.

Firestone GL.

Curr Opin Pharmacol. 2010 Dec;10(6):607-12. doi: 10.1016/j.coph.2010.10.001. Epub 2010 Oct 28. No abstract available.

PMID:
21036104
21.
22.

BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype.

Marconett CN, Morgenstern TJ, San Roman AK, Sundar SN, Singhal AK, Firestone GL.

Cancer Biol Ther. 2010 Aug 15;10(4):397-405. Epub 2010 Aug 20.

23.

1-Benzyl-indole-3-carbinol is a novel indole-3-carbinol derivative with significantly enhanced potency of anti-proliferative and anti-estrogenic properties in human breast cancer cells.

Nguyen HH, Lavrenov SN, Sundar SN, Nguyen DH, Tseng M, Marconett CN, Kung J, Staub RE, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Chem Biol Interact. 2010 Aug 5;186(3):255-66. doi: 10.1016/j.cbi.2010.05.015. Epub 2010 Jun 2.

24.

Direct inhibition of elastase activity by indole-3-carbinol triggers a CD40-TRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.

Aronchik I, Bjeldanes LF, Firestone GL.

Cancer Res. 2010 Jun 15;70(12):4961-71. doi: 10.1158/0008-5472.CAN-09-3349. Epub 2010 Jun 8.

25.

Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane.

Vivar OI, Saunier EF, Leitman DC, Firestone GL, Bjeldanes LF.

Endocrinology. 2010 Apr;151(4):1662-7. doi: 10.1210/en.2009-1028. Epub 2010 Feb 16.

26.

Indole-3-carbinol triggers aryl hydrocarbon receptor-dependent estrogen receptor (ER)alpha protein degradation in breast cancer cells disrupting an ERalpha-GATA3 transcriptional cross-regulatory loop.

Marconett CN, Sundar SN, Poindexter KM, Stueve TR, Bjeldanes LF, Firestone GL.

Mol Biol Cell. 2010 Apr 1;21(7):1166-77. doi: 10.1091/mbc.E09-08-0689. Epub 2010 Feb 3.

27.

Anticancer activities of artemisinin and its bioactive derivatives.

Firestone GL, Sundar SN.

Expert Rev Mol Med. 2009 Oct 30;11:e32. doi: 10.1017/S1462399409001239. Review.

PMID:
19883518
28.

Minireview: modulation of hormone receptor signaling by dietary anticancer indoles.

Firestone GL, Sundar SN.

Mol Endocrinol. 2009 Dec;23(12):1940-7. doi: 10.1210/me.2009-0149. Epub 2009 Oct 16. Review.

29.

3,3'-Diindolylmethane induces a G(1) arrest in human prostate cancer cells irrespective of androgen receptor and p53 status.

Vivar OI, Lin CL, Firestone GL, Bjeldanes LF.

Biochem Pharmacol. 2009 Sep 1;78(5):469-76. doi: 10.1016/j.bcp.2009.05.008. Epub 2009 May 9.

30.

Indole-3-carbinol inhibits MDA-MB-231 breast cancer cell motility and induces stress fibers and focal adhesion formation by activation of Rho kinase activity.

Brew CT, Aronchik I, Kosco K, McCammon J, Bjeldanes LF, Firestone GL.

Int J Cancer. 2009 May 15;124(10):2294-302. doi: 10.1002/ijc.24210.

31.

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Nguyen HH, Aronchik I, Brar GA, Nguyen DH, Bjeldanes LF, Firestone GL.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19750-5. doi: 10.1073/pnas.0806581105. Epub 2008 Dec 8.

32.

Cell type- and estrogen receptor-subtype specific regulation of selective estrogen receptor modulator regulatory elements.

Ball LJ, Levy N, Zhao X, Griffin C, Tagliaferri M, Cohen I, Ricke WA, Speed TP, Firestone GL, Leitman DC.

Mol Cell Endocrinol. 2009 Feb 27;299(2):204-11. doi: 10.1016/j.mce.2008.10.050. Epub 2008 Nov 18.

33.

Artemisinin blocks prostate cancer growth and cell cycle progression by disrupting Sp1 interactions with the cyclin-dependent kinase-4 (CDK4) promoter and inhibiting CDK4 gene expression.

Willoughby JA Sr, Sundar SN, Cheung M, Tin AS, Modiano J, Firestone GL.

J Biol Chem. 2009 Jan 23;284(4):2203-13. doi: 10.1074/jbc.M804491200. Epub 2008 Nov 17.

34.

Artemisinin selectively decreases functional levels of estrogen receptor-alpha and ablates estrogen-induced proliferation in human breast cancer cells.

Sundar SN, Marconett CN, Doan VB, Willoughby JA Sr, Firestone GL.

Carcinogenesis. 2008 Dec;29(12):2252-8. doi: 10.1093/carcin/bgn214. Epub 2008 Sep 10.

35.

3,3'-diindolylmethane reduces levels of HIF-1alpha and HIF-1 activity in hypoxic cultured human cancer cells.

Riby JE, Firestone GL, Bjeldanes LF.

Biochem Pharmacol. 2008 May 1;75(9):1858-67. doi: 10.1016/j.bcp.2008.01.017. Epub 2008 Feb 7.

36.

DEVD-NucView488: a novel class of enzyme substrates for real-time detection of caspase-3 activity in live cells.

Cen H, Mao F, Aronchik I, Fuentes RJ, Firestone GL.

FASEB J. 2008 Jul;22(7):2243-52. doi: 10.1096/fj.07-099234. Epub 2008 Feb 8.

PMID:
18263700
37.

N-Alkoxy derivatization of indole-3-carbinol increases the efficacy of the G1 cell cycle arrest and of I3C-specific regulation of cell cycle gene transcription and activity in human breast cancer cells.

Jump SM, Kung J, Staub R, Kinseth MA, Cram EJ, Yudina LN, Preobrazhenskaya MN, Bjeldanes LF, Firestone GL.

Biochem Pharmacol. 2008 Feb 1;75(3):713-24. Epub 2007 Oct 2.

38.

3,3'-Diindolylmethane stimulates murine immune function in vitro and in vivo.

Xue L, Pestka JJ, Li M, Firestone GL, Bjeldanes LF.

J Nutr Biochem. 2008 May;19(5):336-44. Epub 2007 Aug 17.

41.

Selective glucocorticoid control of Rho kinase isoforms regulate cell-cell interactions.

Rubenstein NM, Callahan JA, Lo DH, Firestone GL.

Biochem Biophys Res Commun. 2007 Mar 9;354(2):603-7. Epub 2007 Jan 12.

42.

Indole-3-carbinol mediated cell cycle arrest of LNCaP human prostate cancer cells requires the induced production of activated p53 tumor suppressor protein.

Hsu JC, Dev A, Wing A, Brew CT, Bjeldanes LF, Firestone GL.

Biochem Pharmacol. 2006 Dec 15;72(12):1714-23. Epub 2006 Sep 12.

PMID:
16970927
43.

Indole-3-carbinol selectively uncouples expression and activity of estrogen receptor subtypes in human breast cancer cells.

Sundar SN, Kerekatte V, Equinozio CN, Doan VB, Bjeldanes LF, Firestone GL.

Mol Endocrinol. 2006 Dec;20(12):3070-82. Epub 2006 Aug 10.

PMID:
16901971
45.
46.

Activation and potentiation of interferon-gamma signaling by 3,3'-diindolylmethane in MCF-7 breast cancer cells.

Riby JE, Xue L, Chatterji U, Bjeldanes EL, Firestone GL, Bjeldanes LF.

Mol Pharmacol. 2006 Feb;69(2):430-9. Epub 2005 Nov 2.

PMID:
16267208
47.

Inhibition of growth factor-induced Ras signaling in vascular endothelial cells and angiogenesis by 3,3'-diindolylmethane.

Chang X, Firestone GL, Bjeldanes LF.

Carcinogenesis. 2006 Mar;27(3):541-50. Epub 2005 Sep 30.

PMID:
16199440
48.

Indole-3-carbinol activates the ATM signaling pathway independent of DNA damage to stabilize p53 and induce G1 arrest of human mammary epithelial cells.

Brew CT, Aronchik I, Hsu JC, Sheen JH, Dickson RB, Bjeldanes LF, Firestone GL.

Int J Cancer. 2006 Feb 15;118(4):857-68.

49.

Indole-3-carbinol inhibition of androgen receptor expression and downregulation of androgen responsiveness in human prostate cancer cells.

Hsu JC, Zhang J, Dev A, Wing A, Bjeldanes LF, Firestone GL.

Carcinogenesis. 2005 Nov;26(11):1896-904. Epub 2005 Jun 15.

PMID:
15958518
50.

Rnd3/RhoE induces tight junction formation in mammary epithelial tumor cells.

Rubenstein NM, Chan JF, Kim JY, Hansen SH, Firestone GL.

Exp Cell Res. 2005 Apr 15;305(1):74-82. Epub 2005 Jan 27.

PMID:
15777789

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