Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 280

1.

Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study.

Boyle DL, DePrimo SE, Calderon C, Chen D, Dunford PJ, Barchuk W, Firestein GS, Thurmond RL.

Inflamm Res. 2019 Feb 9. doi: 10.1007/s00011-019-01218-y. [Epub ahead of print]

PMID:
30739130
2.

Accrual to Clinical Trials (ACT): A Clinical and Translational Science Award Consortium Network.

Visweswaran S, Becich MJ, D'Itri VS, Sendro ER, MacFadden D, Anderson NR, Allen KA, Ranganathan D, Murphy SN, Morrato EH, Pincus HA, Toto R, Firestein GS, Nadler LM, Reis SE.

JAMIA Open. 2018 Oct;1(2):147-152. doi: 10.1093/jamiaopen/ooy033. Epub 2018 Aug 21.

3.

Development of a game-based learning tool for applied team science communication in a virtual clinical trial.

Depp CA, Howland A, Dumbauld J, Fontanesi J, Firestein D, Firestein GS.

J Clin Transl Sci. 2018 Jun;2(3):169-172. doi: 10.1017/cts.2018.8. Epub 2018 Sep 13.

4.

The Cytokine Profile in Acute Chikungunya Infection is Predictive of Chronic Arthritis 20 Months Post Infection.

Chang AY, Tritsch S, Reid SP, Martins K, Encinales L, Pacheco N, Amdur RL, Porras-Ramirez A, Rico-Mendoza A, Li G, Peng J, Firestein GS, Simon GL, Bethony JM.

Diseases. 2018 Oct 20;6(4). pii: E95. doi: 10.3390/diseases6040095.

5.
6.

Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis.

Bustamante MF, Oliveira PG, Garcia-Carbonell R, Croft AP, Smith JM, Serrano RL, Sanchez-Lopez E, Liu X, Kisseleva T, Hay N, Buckley CD, Firestein GS, Murphy AN, Miyamoto S, Guma M.

Ann Rheum Dis. 2018 Nov;77(11):1636-1643. doi: 10.1136/annrheumdis-2018-213103. Epub 2018 Jul 30.

PMID:
30061164
7.

Reply.

Chang AY, Bethony JM, Simon GL, Encinales L, Firestein GS.

Arthritis Rheumatol. 2018 Nov;70(11):1891-1892. doi: 10.1002/art.40663. Epub 2018 Aug 27. No abstract available.

PMID:
30003712
8.

Reply.

Chang AY, Bethony JM, Simon GL, Reid SP, Encinales L, Firestein GS.

Arthritis Rheumatol. 2018 Nov;70(11):1893. doi: 10.1002/art.40664. Epub 2018 Aug 27. No abstract available.

PMID:
30003684
9.

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue.

Donlin LT, Rao DA, Wei K, Slowikowski K, McGeachy MJ, Turner JD, Meednu N, Mizoguchi F, Gutierrez-Arcelus M, Lieb DJ, Keegan J, Muskat K, Hillman J, Rozo C, Ricker E, Eisenhaure TM, Li S, Browne EP, Chicoine A, Sutherby D, Noma A; Accelerating Medicines Partnership RA/SLE Network, Nusbaum C, Kelly S, Pernis AB, Ivashkiv LB, Goodman SM, Robinson WH, Utz PJ, Lederer JA, Gravallese EM, Boyce BF, Hacohen N, Pitzalis C, Gregersen PK, Firestein GS, Raychaudhuri S, Moreland LW, Holers VM, Bykerk VP, Filer A, Boyle DL, Brenner MB, Anolik JH.

Arthritis Res Ther. 2018 Jul 11;20(1):139. doi: 10.1186/s13075-018-1631-y.

10.

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes.

Ai R, Laragione T, Hammaker D, Boyle DL, Wildberg A, Maeshima K, Palescandolo E, Krishna V, Pocalyko D, Whitaker JW, Bai Y, Nagpal S, Bachman KE, Ainsworth RI, Wang M, Ding B, Gulko PS, Wang W, Firestein GS.

Nat Commun. 2018 May 15;9(1):1921. doi: 10.1038/s41467-018-04310-9.

11.

Rheumatoid arthritis.

Smolen JS, Aletaha D, Barton A, Burmester GR, Emery P, Firestein GS, Kavanaugh A, McInnes IB, Solomon DH, Strand V, Yamamoto K.

Nat Rev Dis Primers. 2018 Feb 8;4:18001. doi: 10.1038/nrdp.2018.1. Review.

PMID:
29417936
12.

Regulation and function of apoptosis signal-regulating kinase 1 in rheumatoid arthritis.

Nygaard G, Di Paolo JA, Hammaker D, Boyle DL, Budas G, Notte GT, Mikaelian I, Barry V, Firestein GS.

Biochem Pharmacol. 2018 May;151:282-290. doi: 10.1016/j.bcp.2018.01.041. Epub 2018 Feb 6.

PMID:
29408488
13.

Chikungunya Arthritis Mechanisms in the Americas: A Cross-Sectional Analysis of Chikungunya Arthritis Patients Twenty-Two Months After Infection Demonstrating No Detectable Viral Persistence in Synovial Fluid.

Chang AY, Martins KAO, Encinales L, Reid SP, Acuña M, Encinales C, Matranga CB, Pacheco N, Cure C, Shukla B, Ruiz Arteta T, Amdur R, Cazares LH, Gregory M, Ward MD, Porras A, Rico Mendoza A, Dong L, Kenny T, Brueggemann E, Downey LG, Kamalapathy P, Lichtenberger P, Falls O, Simon GL, Bethony JM, Firestein GS.

Arthritis Rheumatol. 2018 Apr;70(4):585-593. doi: 10.1002/art.40383. Epub 2018 Mar 7.

PMID:
29266856
14.

Frequency of Chronic Joint Pain Following Chikungunya Virus Infection: A Colombian Cohort Study.

Chang AY, Encinales L, Porras A, Pacheco N, Reid SP, Martins KAO, Pacheco S, Bravo E, Navarno M, Rico Mendoza A, Amdur R, Kamalapathy P, Firestein GS, Bethony JM, Simon GL.

Arthritis Rheumatol. 2018 Apr;70(4):578-584. doi: 10.1002/art.40384. Epub 2018 Mar 2.

PMID:
29266783
15.

Epigenetics of inflammatory arthritis.

Hammaker D, Firestein GS.

Curr Opin Rheumatol. 2018 Mar;30(2):188-196. doi: 10.1097/BOR.0000000000000471. Review.

PMID:
29194108
16.

A multisite study of performance drivers among institutional review boards.

Caligiuri M, Allen K, Buscher N, Denney L, Gates C, Kantelo K, Magit A, Sak R, Firestein GS, Fontanesi J.

J Clin Transl Sci. 2017 Jun;1(3):192-197. doi: 10.1017/cts.2017.8. Epub 2017 Jul 24.

17.

Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene.

Matsuda S, Hammaker D, Topolewski K, Briegel KJ, Boyle DL, Dowdy S, Wang W, Firestein GS.

J Immunol. 2017 Oct 1;199(7):2316-2322. doi: 10.4049/jimmunol.1700719. Epub 2017 Aug 14.

18.

PUMA gene delivery to synoviocytes reduces inflammation and degeneration of arthritic joints.

Hong SS, Marotte H, Courbon G, Firestein GS, Boulanger P, Miossec P.

Nat Commun. 2017 Jul 27;8(1):146. doi: 10.1038/s41467-017-00142-1.

19.

Histamine and Histamine H4 Receptor Promotes Osteoclastogenesis in Rheumatoid Arthritis.

Kim KW, Kim BM, Lee KA, Lee SH, Firestein GS, Kim HR.

Sci Rep. 2017 Apr 26;7(1):1197. doi: 10.1038/s41598-017-01101-y.

20.

Distinct ON/OFF fluorescence signals from dual-responsive activatable nanoprobes allows detection of inflammation with improved contrast.

Viger ML, Collet G, Lux J, Nguyen Huu VA, Guma M, Foucault-Collet A, Olejniczak J, Joshi-Barr S, Firestein GS, Almutairi A.

Biomaterials. 2017 Jul;133:119-131. doi: 10.1016/j.biomaterials.2017.03.042. Epub 2017 Mar 28.

21.

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Doody KM, Bottini N, Firestein GS.

Epigenomics. 2017 Apr;9(4):479-492. doi: 10.2217/epi-2016-0151. Epub 2017 Mar 21. Review.

22.

Immunopathogenesis of Rheumatoid Arthritis.

Firestein GS, McInnes IB.

Immunity. 2017 Feb 21;46(2):183-196. doi: 10.1016/j.immuni.2017.02.006. Review.

23.

LBH Gene Transcription Regulation by the Interplay of an Enhancer Risk Allele and DNA Methylation in Rheumatoid Arthritis.

Hammaker D, Whitaker JW, Maeshima K, Boyle DL, Ekwall AH, Wang W, Firestein GS.

Arthritis Rheumatol. 2016 Nov;68(11):2637-2645. doi: 10.1002/art.39746.

24.

Rheumatoid Arthritis Naive T Cells Share Hypermethylation Sites With Synoviocytes.

Rhead B, Holingue C, Cole M, Shao X, Quach HL, Quach D, Shah K, Sinclair E, Graf J, Link T, Harrison R, Rahmani E, Halperin E, Wang W, Firestein GS, Barcellos LF, Criswell LA.

Arthritis Rheumatol. 2017 Mar;69(3):550-559. doi: 10.1002/art.39952.

25.

Joint-specific DNA methylation and transcriptome signatures in rheumatoid arthritis identify distinct pathogenic processes.

Ai R, Hammaker D, Boyle DL, Morgan R, Walsh AM, Fan S, Firestein GS, Wang W.

Nat Commun. 2016 Jun 10;7:11849. doi: 10.1038/ncomms11849.

26.

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS.

JCI Insight. 2016 May 19;1(7). pii: e86580.

27.

Cellular electrophysiological principles that modulate secretion from synovial fibroblasts.

Clark RB, Schmidt TA, Sachse FB, Boyle D, Firestein GS, Giles WR.

J Physiol. 2017 Feb 1;595(3):635-645. doi: 10.1113/JP270209. Epub 2017 Jan 5. Review.

28.

Metabolomics in rheumatic diseases: desperately seeking biomarkers.

Guma M, Tiziani S, Firestein GS.

Nat Rev Rheumatol. 2016 May;12(5):269-81. doi: 10.1038/nrrheum.2016.1. Epub 2016 Mar 3. Review.

29.

Computationally expanding infinium HumanMethylation450 BeadChip array data to reveal distinct DNA methylation patterns of rheumatoid arthritis.

Fan S, Li C, Ai R, Wang M, Firestein GS, Wang W.

Bioinformatics. 2016 Jun 15;32(12):1773-8. doi: 10.1093/bioinformatics/btw089. Epub 2016 Feb 15.

30.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

31.

Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside.

Bottini N, Firestein GS.

Nat Rev Rheumatol. 2015 Nov;11(11):623-4. doi: 10.1038/nrrheum.2015.126. Epub 2015 Sep 22. No abstract available.

PMID:
26390844
32.

Correction: Integrative Omics Analysis of Rheumatoid Arthritis Identifies Non-Obvious Therapeutic Targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Aug 19;10(8):e0136334. doi: 10.1371/journal.pone.0136334. eCollection 2015. No abstract available.

33.

In appreciation of Joan M. Bathon, MD, Editor, Arthritis & Rheumatology, 2010-2015.

Firestein GS, Diamond JS.

Arthritis Rheumatol. 2015 Jun;67(6):1411. doi: 10.1002/art.39128. No abstract available.

34.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

35.

In memoriam: Nathan J. Zvaifler, MD, 1927-2015.

Firestein GS, Corr M.

Arthritis Rheumatol. 2015 May;67(5):1143. doi: 10.1002/art.39089. No abstract available.

36.

Integrative omics analysis of rheumatoid arthritis identifies non-obvious therapeutic targets.

Whitaker JW, Boyle DL, Bartok B, Ball ST, Gay S, Wang W, Firestein GS.

PLoS One. 2015 Apr 22;10(4):e0124254. doi: 10.1371/journal.pone.0124254. eCollection 2015. Erratum in: PLoS One. 2015;10(8):e0136334.

37.

DNA Methylome Signature in Synoviocytes From Patients With Early Rheumatoid Arthritis Compared to Synoviocytes From Patients With Longstanding Rheumatoid Arthritis.

Ai R, Whitaker JW, Boyle DL, Tak PP, Gerlag DM, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 Jul;67(7):1978-80. doi: 10.1002/art.39123. No abstract available.

38.

Anti-Inflammatory Effects and Joint Protection in Collagen-Induced Arthritis after Treatment with IQ-1S, a Selective c-Jun N-Terminal Kinase Inhibitor.

Schepetkin IA, Kirpotina LN, Hammaker D, Kochetkova I, Khlebnikov AI, Lyakhov SA, Firestein GS, Quinn MT.

J Pharmacol Exp Ther. 2015 Jun;353(3):505-16. doi: 10.1124/jpet.114.220251. Epub 2015 Mar 17.

39.

The Rheumatoid Arthritis Risk Gene LBH Regulates Growth in Fibroblast-like Synoviocytes.

Ekwall AK, Whitaker JW, Hammaker D, Bugbee WD, Wang W, Firestein GS.

Arthritis Rheumatol. 2015 May;67(5):1193-202. doi: 10.1002/art.39060.

40.

Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Zou G, Chang JT.

Inflamm Bowel Dis. 2015 Feb;21(2):323-30. doi: 10.1097/MIB.0000000000000264.

41.

The JAK inhibitor tofacitinib suppresses synovial JAK1-STAT signalling in rheumatoid arthritis.

Boyle DL, Soma K, Hodge J, Kavanaugh A, Mandel D, Mease P, Shurmur R, Singhal AK, Wei N, Rosengren S, Kaplan I, Krishnaswami S, Luo Z, Bradley J, Firestein GS.

Ann Rheum Dis. 2015 Jun;74(6):1311-6. doi: 10.1136/annrheumdis-2014-206028. Epub 2014 Nov 14.

42.

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM, Aleman Muench GR, Bartok B, Sacchetti C, Kiosses WB, Sharma J, Maestre MF, Bottini M, Mustelin T, Boyle DL, Firestein GS, Bottini N.

Ann Rheum Dis. 2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6.

43.

Choline kinase inhibition in rheumatoid arthritis.

Guma M, Sanchez-Lopez E, Lodi A, Garcia-Carbonell R, Tiziani S, Karin M, Lacal JC, Firestein GS.

Ann Rheum Dis. 2015 Jul;74(7):1399-407. doi: 10.1136/annrheumdis-2014-205696. Epub 2014 Oct 1.

44.

The disease formerly known as rheumatoid arthritis.

Firestein GS.

Arthritis Res Ther. 2014;16(3):114.

45.

Validated gene expression biomarker analysis for biopsy-based clinical trials in ulcerative colitis.

Boland BS, Boyle DL, Sandborn WJ, Firestein GS, Levesque BG, Hillman J, Zhang B, Proudfoot J, Eckmann L, Ernst PB, Rivera-Nieves J, Pola S, Copur-Dahi N, Chang JT.

Aliment Pharmacol Ther. 2014 Sep;40(5):477-85. doi: 10.1111/apt.12862. Epub 2014 Jul 13.

46.

Acid-sensing ion channel 3 decreases phosphorylation of extracellular signal-regulated kinases and induces synoviocyte cell death by increasing intracellular calcium.

Gong W, Kolker SJ, Usachev Y, Walder RY, Boyle DL, Firestein GS, Sluka KA.

Arthritis Res Ther. 2014 Jun 12;16(3):R121. doi: 10.1186/ar4577.

47.

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6.

Hammaker D, Boyle DL, Topolewski K, Firestein GS.

J Inflamm (Lond). 2014 May 16;11:14. doi: 10.1186/1476-9255-11-14. eCollection 2014.

48.

Differential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory pain.

Leinders M, Koehrn FJ, Bartok B, Boyle DL, Shubayev V, Kalcheva I, Yu NK, Park J, Kaang BK, Hefferan MP, Firestein GS, Sorkin LS.

Pain. 2014 Jun;155(6):1150-60. doi: 10.1016/j.pain.2014.03.003. Epub 2014 Mar 12.

49.

Phosphoinositide 3-kinase δ regulates migration and invasion of synoviocytes in rheumatoid arthritis.

Bartok B, Hammaker D, Firestein GS.

J Immunol. 2014 Mar 1;192(5):2063-70. doi: 10.4049/jimmunol.1300950. Epub 2014 Jan 27.

50.

Differential roles of MAPK kinases MKK3 and MKK6 in osteoclastogenesis and bone loss.

Boyle DL, Hammaker D, Edgar M, Zaiss MM, Teufel S, David JP, Schett G, Firestein GS.

PLoS One. 2014 Jan 6;9(1):e84818. doi: 10.1371/journal.pone.0084818. eCollection 2014. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/4fbfa4f0-cb27-4ec4-80d6-3b0ed5e9e8b8.

Supplemental Content

Loading ...
Support Center