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Items: 1 to 50 of 127

1.

A high-content cytokine screen identifies myostatin propeptide as a positive regulator of primitive chronic myeloid leukemia cells.

von Palffy S, Landberg N, Sandén C, Zacharaki D, Shah M, Nakamichi N, Hansen N, Askmyr M, Lilljebjörn H, Rissler M, Karlsson C, Scheding S, Richter J, Eaves CJ, Bhatia R, Järås M, Fioretos T.

Haematologica. 2019 Oct 3. pii: haematol.2019.220434. doi: 10.3324/haematol.2019.220434. [Epub ahead of print]

2.

PAX5 is part of a functional transcription factor network targeted in lymphoid leukemia.

Okuyama K, Strid T, Kuruvilla J, Somasundaram R, Cristobal S, Smith E, Prasad M, Fioretos T, Lilljebjörn H, Soneji S, Lang S, Ungerbäck J, Sigvardsson M.

PLoS Genet. 2019 Aug 5;15(8):e1008280. doi: 10.1371/journal.pgen.1008280. eCollection 2019 Aug.

3.

Genetic profiling of a chondroblastoma-like osteosarcoma/malignant phosphaturic mesenchymal tumor of bone reveals a homozygous deletion of CDKN2A, intragenic deletion of DMD, and a targetable FN1-FGFR1 gene fusion.

Saba KH, Cornmark L, Rissler M, Fioretos T, Åström K, Haglund F, Rosenberg AE, Brosjö O, Nord KH.

Genes Chromosomes Cancer. 2019 Oct;58(10):731-736. doi: 10.1002/gcc.22764. Epub 2019 May 15.

PMID:
31066955
4.

Proteogenomics and Hi-C reveal transcriptional dysregulation in high hyperdiploid childhood acute lymphoblastic leukemia.

Yang M, Vesterlund M, Siavelis I, Moura-Castro LH, Castor A, Fioretos T, Jafari R, Lilljebjörn H, Odom DT, Olsson L, Ravi N, Woodward EL, Harewood L, Lehtiö J, Paulsson K.

Nat Commun. 2019 Apr 3;10(1):1519. doi: 10.1038/s41467-019-09469-3.

5.

Arrayed molecular barcoding identifies TNFSF13 as a positive regulator of acute myeloid leukemia-initiating cells.

Chapellier M, Peña-Martínez P, Ramakrishnan R, Eriksson M, Talkhoncheh MS, Orsmark-Pietras C, Lilljebjörn H, Högberg C, Hagström-Andersson A, Fioretos T, Larsson J, Järås M.

Haematologica. 2019 Oct;104(10):2006-2016. doi: 10.3324/haematol.2018.192062. Epub 2019 Feb 28.

6.

Transcriptional landscape of B cell precursor acute lymphoblastic leukemia based on an international study of 1,223 cases.

Li JF, Dai YT, Lilljebjörn H, Shen SH, Cui BW, Bai L, Liu YF, Qian MX, Kubota Y, Kiyoi H, Matsumura I, Miyazaki Y, Olsson L, Tan AM, Ariffin H, Chen J, Takita J, Yasuda T, Mano H, Johansson B, Yang JJ, Yeoh AE, Hayakawa F, Chen Z, Pui CH, Fioretos T, Chen SJ, Huang JY.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11711-E11720. doi: 10.1073/pnas.1814397115. Epub 2018 Nov 28.

7.

Telomere shortening correlates with leukemic stem cell burden at diagnosis of chronic myeloid leukemia.

Bouillon AS, Ventura Ferreira MS, Awad SA, Richter J, Hochhaus A, Kunzmann V, Dengler J, Janssen J, Ossenkoppele G, Westerweel PE, Te Boekhorst PAW, Mahon FX, Hjorth-Hansen H, Isfort S, Fioretos T, Hummel S, Schemionek M, Wilop S, Koschmieder S, Saußele S, Mustjoki S, Beier F, Brümmendorf TH.

Blood Adv. 2018 Jul 10;2(13):1572-1579. doi: 10.1182/bloodadvances.2018017772.

8.

Whole-exome sequencing exploration of acquired uniparental disomies in B-cell precursor acute lymphoblastic leukemia.

Lundin-Ström KB, Biloglav A, Lilljebjörn H, Rissler M, Fioretos T, Hansson M, Behrendtz M, Castor A, Olsson L, Johansson B.

Leukemia. 2018 Sep;32(9):2058-2062. doi: 10.1038/s41375-018-0191-0. Epub 2018 Jul 2. No abstract available.

9.

Mutation, methylation, and gene expression profiles in dup(1q)-positive pediatric B-cell precursor acute lymphoblastic leukemia.

Gunnarsson R, Dilorenzo S, Lundin-Ström KB, Olsson L, Biloglav A, Lilljebjörn H, Rissler M, Wahlberg P, Lundmark A, Castor A, Behrendtz M, Fioretos T, Paulsson K, Isaksson A, Johansson B.

Leukemia. 2018 Oct;32(10):2117-2125. doi: 10.1038/s41375-018-0092-2. Epub 2018 Mar 12.

10.

Agonistic targeting of TLR1/TLR2 induces p38 MAPK-dependent apoptosis and NFκB-dependent differentiation of AML cells.

Eriksson M, Peña-Martínez P, Ramakrishnan R, Chapellier M, Högberg C, Glowacki G, Orsmark-Pietras C, Velasco-Hernández T, Lazarević VL, Juliusson G, Cammenga J, Mulloy JC, Richter J, Fioretos T, Ebert BL, Järås M.

Blood Adv. 2017 Oct 18;1(23):2046-2057. doi: 10.1182/bloodadvances.2017006148. eCollection 2017 Oct 24.

11.

CD36 defines primitive chronic myeloid leukemia cells less responsive to imatinib but vulnerable to antibody-based therapeutic targeting.

Landberg N, von Palffy S, Askmyr M, Lilljebjörn H, Sandén C, Rissler M, Mustjoki S, Hjorth-Hansen H, Richter J, Ågerstam H, Järås M, Fioretos T.

Haematologica. 2018 Mar;103(3):447-455. doi: 10.3324/haematol.2017.169946. Epub 2017 Dec 28.

12.

A field guide for cancer diagnostics using cell-free DNA: From principles to practice and clinical applications.

Volckmar AL, Sültmann H, Riediger A, Fioretos T, Schirmacher P, Endris V, Stenzinger A, Dietz S.

Genes Chromosomes Cancer. 2018 Mar;57(3):123-139. doi: 10.1002/gcc.22517. Epub 2017 Dec 20. Review.

PMID:
29205637
13.

Isolated myelosarcoma is characterized by recurrent NFE2 mutations and concurrent preleukemic clones in the bone marrow.

Lazarevic V, Orsmark-Pietras C, Lilljebjörn H, Pettersson L, Rissler M, Lübking A, Ehinger M, Juliusson G, Fioretos T.

Blood. 2018 Feb 1;131(5):577-581. doi: 10.1182/blood-2017-07-793620. Epub 2017 Nov 30. No abstract available.

PMID:
29191917
14.

Transgenic expression of human cytokines in immunodeficient mice does not facilitate myeloid expansion of BCR-ABL1 transduced human cord blood cells.

Askmyr M, von Palffy S, Hansen N, Landberg N, Högberg C, Rissler M, Ågerstam H, Fioretos T.

PLoS One. 2017 Oct 12;12(10):e0186035. doi: 10.1371/journal.pone.0186035. eCollection 2017.

15.

Interleukin 4 induces apoptosis of acute myeloid leukemia cells in a Stat6-dependent manner.

Peña-Martínez P, Eriksson M, Ramakrishnan R, Chapellier M, Högberg C, Orsmark-Pietras C, Richter J, Andersson A, Fioretos T, Järås M.

Leukemia. 2018 Mar;32(3):588-596. doi: 10.1038/leu.2017.261. Epub 2017 Aug 18.

16.

New oncogenic subtypes in pediatric B-cell precursor acute lymphoblastic leukemia.

Lilljebjörn H, Fioretos T.

Blood. 2017 Sep 21;130(12):1395-1401. doi: 10.1182/blood-2017-05-742643. Epub 2017 Aug 4. Review.

PMID:
28778863
17.

Loss of the tumour suppressor gene AIP mediates the browning of human brown fat tumours.

Magnusson L, Hansen N, Saba KH, Nilsson J, Fioretos T, Rissler P, Nord KH.

J Pathol. 2017 Oct;243(2):160-164. doi: 10.1002/path.4945. Epub 2017 Aug 29.

PMID:
28722204
18.

Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms.

Tesi B, Davidsson J, Voss M, Rahikkala E, Holmes TD, Chiang SCC, Komulainen-Ebrahim J, Gorcenco S, Rundberg Nilsson A, Ripperger T, Kokkonen H, Bryder D, Fioretos T, Henter JI, Möttönen M, Niinimäki R, Nilsson L, Pronk CJ, Puschmann A, Qian H, Uusimaa J, Moilanen J, Tedgård U, Cammenga J, Bryceson YT.

Blood. 2017 Apr 20;129(16):2266-2279. doi: 10.1182/blood-2016-10-743302. Epub 2017 Feb 15.

19.

Clonal conversion of B lymphoid leukemia reveals cross-lineage transfer of malignant states.

Somasundaram R, Åhsberg J, Okuyama K, Ungerbäck J, Lilljebjörn H, Fioretos T, Strid T, Sigvardsson M.

Genes Dev. 2016 Nov 15;30(22):2486-2499. Epub 2016 Dec 2.

20.

IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models.

Ågerstam H, Hansen N, von Palffy S, Sandén C, Reckzeh K, Karlsson C, Lilljebjörn H, Landberg N, Askmyr M, Högberg C, Rissler M, Porkka K, Wadenvik H, Mustjoki S, Richter J, Järås M, Fioretos T.

Blood. 2016 Dec 8;128(23):2683-2693. Epub 2016 Sep 12.

PMID:
27621309
21.

Distinct global binding patterns of the Wilms tumor gene 1 (WT1) -KTS and +KTS isoforms in leukemic cells.

Ullmark T, Järvstråt L, Sandén C, Montano G, Jernmark-Nilsson H, Lilljebjörn H, Lennartsson A, Fioretos T, Drott K, Vidovic K, Nilsson B, Gullberg U.

Haematologica. 2017 Feb;102(2):336-345. doi: 10.3324/haematol.2016.149815. Epub 2016 Sep 9.

22.

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia.

Lilljebjörn H, Henningsson R, Hyrenius-Wittsten A, Olsson L, Orsmark-Pietras C, von Palffy S, Askmyr M, Rissler M, Schrappe M, Cario G, Castor A, Pronk CJ, Behrendtz M, Mitelman F, Johansson B, Paulsson K, Andersson AK, Fontes M, Fioretos T.

Nat Commun. 2016 Jun 6;7:11790. doi: 10.1038/ncomms11790.

23.

Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy.

Thielen N, Richter J, Baldauf M, Barbany G, Fioretos T, Giles F, Gjertsen BT, Hochhaus A, Schuurhuis GJ, Sopper S, Stenke L, Thunberg S, Wolf D, Ossenkoppele G, Porkka K, Janssen J, Mustjoki S.

Clin Cancer Res. 2016 Aug 15;22(16):4030-8. doi: 10.1158/1078-0432.CCR-15-2791. Epub 2016 Mar 22.

24.

Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.

Ågerstam H, Karlsson C, Hansen N, Sandén C, Askmyr M, von Palffy S, Högberg C, Rissler M, Wunderlich M, Juliusson G, Richter J, Sjöström K, Bhatia R, Mulloy JC, Järås M, Fioretos T.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10786-91. doi: 10.1073/pnas.1422749112. Epub 2015 Aug 10.

25.

IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome.

Landberg N, Hansen N, Askmyr M, Ågerstam H, Lassen C, Rissler M, Hjorth-Hansen H, Mustjoki S, Järås M, Richter J, Fioretos T.

Leukemia. 2016 Jan;30(1):253-7. doi: 10.1038/leu.2015.135. Epub 2015 Jun 12. No abstract available.

PMID:
26067823
26.

The emerging complexity of gene fusions in cancer.

Mertens F, Johansson B, Fioretos T, Mitelman F.

Nat Rev Cancer. 2015 Jun;15(6):371-81. doi: 10.1038/nrc3947. Review.

PMID:
25998716
27.

The genomic landscape of high hyperdiploid childhood acute lymphoblastic leukemia.

Paulsson K, Lilljebjörn H, Biloglav A, Olsson L, Rissler M, Castor A, Barbany G, Fogelstrand L, Nordgren A, Sjögren H, Fioretos T, Johansson B.

Nat Genet. 2015 Jun;47(6):672-6. doi: 10.1038/ng.3301. Epub 2015 May 11.

PMID:
25961940
28.

Deep sequencing and SNP array analyses of pediatric T-cell acute lymphoblastic leukemia reveal NOTCH1 mutations in minor subclones and a high incidence of uniparental isodisomies affecting CDKN2A.

Karrman K, Castor A, Behrendtz M, Forestier E, Olsson L, Ehinger M, Biloglav A, Fioretos T, Paulsson K, Johansson B.

J Hematol Oncol. 2015 Apr 24;8:42. doi: 10.1186/s13045-015-0138-0.

29.

Ebf1 heterozygosity results in increased DNA damage in pro-B cells and their synergistic transformation by Pax5 haploinsufficiency.

Prasad MA, Ungerbäck J, Åhsberg J, Somasundaram R, Strid T, Larsson M, Månsson R, De Paepe A, Lilljebjörn H, Fioretos T, Hagman J, Sigvardsson M.

Blood. 2015 Jun 25;125(26):4052-9. doi: 10.1182/blood-2014-12-617282. Epub 2015 Apr 2.

30.

The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias.

Andersson AK, Ma J, Wang J, Chen X, Gedman AL, Dang J, Nakitandwe J, Holmfeldt L, Parker M, Easton J, Huether R, Kriwacki R, Rusch M, Wu G, Li Y, Mulder H, Raimondi S, Pounds S, Kang G, Shi L, Becksfort J, Gupta P, Payne-Turner D, Vadodaria B, Boggs K, Yergeau D, Manne J, Song G, Edmonson M, Nagahawatte P, Wei L, Cheng C, Pei D, Sutton R, Venn NC, Chetcuti A, Rush A, Catchpoole D, Heldrup J, Fioretos T, Lu C, Ding L, Pui CH, Shurtleff S, Mullighan CG, Mardis ER, Wilson RK, Gruber TA, Zhang J, Downing JR; St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project.

Nat Genet. 2015 Apr;47(4):330-7. doi: 10.1038/ng.3230. Epub 2015 Mar 2.

31.

Intratumoral genome diversity parallels progression and predicts outcome in pediatric cancer.

Mengelbier LH, Karlsson J, Lindgren D, Valind A, Lilljebjörn H, Jansson C, Bexell D, Braekeveldt N, Ameur A, Jonson T, Kultima HG, Isaksson A, Asmundsson J, Versteeg R, Rissler M, Fioretos T, Sandstedt B, Börjesson A, Backman T, Pal N, Øra I, Mayrhofer M, Gisselsson D.

Nat Commun. 2015 Jan 27;6:6125. doi: 10.1038/ncomms7125.

PMID:
25625758
32.

Modeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells.

Askmyr M, Ågerstam H, Lilljebjörn H, Hansen N, Karlsson C, von Palffy S, Landberg N, Högberg C, Lassen C, Rissler M, Richter J, Ehinger M, Järås M, Fioretos T.

Blood Cancer J. 2014 Dec 12;4:e269. doi: 10.1038/bcj.2014.89.

33.

Activation of human telomerase reverse transcriptase through gene fusion in clear cell sarcoma of the kidney.

Karlsson J, Lilljebjörn H, Holmquist Mengelbier L, Valind A, Rissler M, Øra I, Fioretos T, Gisselsson D.

Cancer Lett. 2015 Feb 28;357(2):498-501. doi: 10.1016/j.canlet.2014.11.057. Epub 2014 Dec 3.

PMID:
25481751
34.

Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytoma.

Płaszczyca A, Nilsson J, Magnusson L, Brosjö O, Larsson O, Vult von Steyern F, Domanski HA, Lilljebjörn H, Fioretos T, Tayebwa J, Mandahl N, Nord KH, Mertens F.

Int J Biochem Cell Biol. 2014 Aug;53:475-81. doi: 10.1016/j.biocel.2014.03.027. Epub 2014 Apr 8.

PMID:
24721208
35.

A glioma classification scheme based on coexpression modules of EGFR and PDGFRA.

Sun Y, Zhang W, Chen D, Lv Y, Zheng J, Lilljebjörn H, Ran L, Bao Z, Soneson C, Sjögren HO, Salford LG, Ji J, French PJ, Fioretos T, Jiang T, Fan X.

Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3538-43. doi: 10.1073/pnas.1313814111. Epub 2014 Feb 18.

36.

A novel SERPINE1-FOSB fusion gene results in transcriptional up-regulation of FOSB in pseudomyogenic haemangioendothelioma.

Walther C, Tayebwa J, Lilljebjörn H, Magnusson L, Nilsson J, von Steyern FV, Øra I, Domanski HA, Fioretos T, Nord KH, Fletcher CD, Mertens F.

J Pathol. 2014 Apr;232(5):534-40. doi: 10.1002/path.4322. Epub 2014 Jan 29.

PMID:
24374978
37.

RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib.

Lilljebjörn H, Ågerstam H, Orsmark-Pietras C, Rissler M, Ehrencrona H, Nilsson L, Richter J, Fioretos T.

Leukemia. 2014 Apr;28(4):977-9. doi: 10.1038/leu.2013.324. Epub 2013 Nov 4. No abstract available.

PMID:
24186003
38.

Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

Askmyr M, Ågerstam H, Hansen N, Gordon S, Arvanitakis A, Rissler M, Juliusson G, Richter J, Järås M, Fioretos T.

Blood. 2013 May 2;121(18):3709-13. doi: 10.1182/blood-2012-09-458935. Epub 2013 Mar 11.

PMID:
23479569
39.

Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients.

Mustjoki S, Richter J, Barbany G, Ehrencrona H, Fioretos T, Gedde-Dahl T, Gjertsen BT, Hovland R, Hernesniemi S, Josefsen D, Koskenvesa P, Dybedal I, Markevärn B, Olofsson T, Olsson-Strömberg U, Rapakko K, Thunberg S, Stenke L, Simonsson B, Porkka K, Hjorth-Hansen H; Nordic CML Study Group (NCMLSG).

Leukemia. 2013 Jul;27(7):1520-6. doi: 10.1038/leu.2013.19. Epub 2013 Jan 18.

PMID:
23328954
40.

SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.

Hansen N, Ågerstam H, Wahlestedt M, Landberg N, Askmyr M, Ehinger M, Rissler M, Lilljebjörn H, Johnels P, Ishiko J, Melo JV, Alexander WS, Bryder D, Järås M, Fioretos T.

Leukemia. 2013 Jan;27(1):130-5. doi: 10.1038/leu.2012.169. Epub 2012 Jun 22.

41.

Whole-exome sequencing of pediatric acute lymphoblastic leukemia.

Lilljebjörn H, Rissler M, Lassen C, Heldrup J, Behrendtz M, Mitelman F, Johansson B, Fioretos T.

Leukemia. 2012 Jul;26(7):1602-7. doi: 10.1038/leu.2011.333. Epub 2011 Nov 18.

PMID:
22094584
42.

Myeloid malignancies with acquired trisomy 21 as the sole cytogenetic change are clinically highly variable and display a heterogeneous pattern of copy number alterations and mutations.

Larsson N, Lilljebjörn H, Lassen C, Johansson B, Fioretos T.

Eur J Haematol. 2012 Feb;88(2):136-43. doi: 10.1111/j.1600-0609.2011.01710.x. Epub 2011 Nov 17.

PMID:
21933280
43.

Smad4 binds Hoxa9 in the cytoplasm and protects primitive hematopoietic cells against nuclear activation by Hoxa9 and leukemia transformation.

Quéré R, Karlsson G, Hertwig F, Rissler M, Lindqvist B, Fioretos T, Vandenberghe P, Slovak ML, Cammenga J, Karlsson S.

Blood. 2011 Jun 2;117(22):5918-30. doi: 10.1182/blood-2010-08-301879. Epub 2011 Apr 6.

PMID:
21471525
44.

Fusion gene microarray reveals cancer type-specificity among fusion genes.

Løvf M, Thomassen GO, Bakken AC, Celestino R, Fioretos T, Lind GE, Lothe RA, Skotheim RI.

Genes Chromosomes Cancer. 2011 May;50(5):348-57. doi: 10.1002/gcc.20860. Epub 2011 Feb 8.

PMID:
21305644
45.

Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein.

Järås M, Johnels P, Hansen N, Agerstam H, Tsapogas P, Rissler M, Lassen C, Olofsson T, Bjerrum OW, Richter J, Fioretos T.

Proc Natl Acad Sci U S A. 2010 Sep 14;107(37):16280-5. doi: 10.1073/pnas.1004408107. Epub 2010 Aug 30.

46.

Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice.

Agerstam H, Järås M, Andersson A, Johnels P, Hansen N, Lassen C, Rissler M, Gisselsson D, Olofsson T, Richter J, Fan X, Ehinger M, Fioretos T.

Blood. 2010 Sep 23;116(12):2103-11. doi: 10.1182/blood-2009-05-217182. Epub 2010 Jun 16.

PMID:
20554971
47.

The correlation pattern of acquired copy number changes in 164 ETV6/RUNX1-positive childhood acute lymphoblastic leukemias.

Lilljebjörn H, Soneson C, Andersson A, Heldrup J, Behrendtz M, Kawamata N, Ogawa S, Koeffler HP, Mitelman F, Johansson B, Fontes M, Fioretos T.

Hum Mol Genet. 2010 Aug 15;19(16):3150-8. doi: 10.1093/hmg/ddq224. Epub 2010 May 31.

48.

Genetic analysis of dasatinib-treated chronic myeloid leukemia rapidly developing into acute myeloid leukemia with monosomy 7 in Philadelphia-negative cells.

Larsson N, Billström R, Lilljebjörn H, Lassen C, Richter J, Ekblom M, Fioretos T.

Cancer Genet Cytogenet. 2010 Jun;199(2):89-95. doi: 10.1016/j.cancergencyto.2010.02.005.

PMID:
20471511
49.

Integrative analysis of gene expression and copy number alterations using canonical correlation analysis.

Soneson C, Lilljebjörn H, Fioretos T, Fontes M.

BMC Bioinformatics. 2010 Apr 15;11:191. doi: 10.1186/1471-2105-11-191.

50.

Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations.

Davidsson J, Paulsson K, Lindgren D, Lilljebjörn H, Chaplin T, Forestier E, Andersen MK, Nordgren A, Rosenquist R, Fioretos T, Young BD, Johansson B.

Leukemia. 2010 May;24(5):924-31. doi: 10.1038/leu.2010.39. Epub 2010 Mar 18.

PMID:
20237506

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