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Items: 1 to 50 of 264

1.

EGFR Trafficking in Physiology and Cancer.

Caldieri G, Malabarba MG, Di Fiore PP, Sigismund S.

Prog Mol Subcell Biol. 2018;57:235-272. doi: 10.1007/978-3-319-96704-2_9.

PMID:
30097778
2.

A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility.

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G.

J Cell Biol. 2018 Sep 3;217(9):3161-3182. doi: 10.1083/jcb.201802023. Epub 2018 Jul 30.

PMID:
30061108
3.

Unraveling the role of low-frequency mutated genes in breast cancer.

Lusito E, Felice B, D'Ario G, Ogier A, Montani F, Di Fiore PP, Bianchi F.

Bioinformatics. 2018 Jun 29. doi: 10.1093/bioinformatics/bty520. [Epub ahead of print]

PMID:
29961866
4.

Retraction for Fusco et al., "A mos Oncogene-Containing Retrovirus, Myeloproliferative Sarcoma Virus, Transforms Rat Thyroid Epithelial Cells and Irreversibly Blocks Their Differentiation Pattern".

Fusco A, Portella G, Di Fiore PP, Berlingieri MT, Di Lauro R, Schneider AB, Vecchio G.

J Virol. 2018 Feb 26;92(6). pii: e02169-17. doi: 10.1128/JVI.02169-17. eCollection 2018 Mar 15.

5.

Author Correction: A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G.

Nat Commun. 2018 May 22;9(1):2085. doi: 10.1038/s41467-018-04515-y.

6.

High USP6NL Levels in Breast Cancer Sustain Chronic AKT Phosphorylation and GLUT1 Stability Fueling Aerobic Glycolysis.

Avanzato D, Pupo E, Ducano N, Isella C, Bertalot G, Luise C, Pece S, Bruna A, Rueda OM, Caldas C, Di Fiore PP, Sapino A, Lanzetti L.

Cancer Res. 2018 Jul 1;78(13):3432-3444. doi: 10.1158/0008-5472.CAN-17-3018. Epub 2018 Apr 24.

7.

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration.

Corallino S, Malinverno C, Neumann B, Tischer C, Palamidessi A, Frittoli E, Panagiotakopoulou M, Disanza A, Malet-Engra G, Nastaly P, Galli C, Luise C, Bertalot G, Pece S, Di Fiore PP, Gauthier N, Ferrari A, Maiuri P, Scita G.

Nat Commun. 2018 Apr 16;9(1):1475. doi: 10.1038/s41467-018-03571-8. Erratum in: Nat Commun. 2018 May 22;9(1):2085.

8.

Author Correction: The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, di Cantogno LV, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P.

Nat Commun. 2018 Mar 30;9:16203. doi: 10.1038/ncomms16203.

9.

MicroRNA expression profile in primary lung cancer cells lines obtained by endobronchial ultrasound transbronchial needle aspiration.

Guarize J, Bianchi F, Marino E, Belloni E, Vecchi M, Donghi S, Lo Iacono G, Casadio C, Cuttano R, Barberis M, Di Fiore PP, Petrella F, Spaggiari L.

J Thorac Dis. 2018 Jan;10(1):408-415. doi: 10.21037/jtd.2017.12.69.

10.

HOXB7 overexpression in lung cancer is a hallmark of acquired stem-like phenotype.

Monterisi S, Lo Riso P, Russo K, Bertalot G, Vecchi M, Testa G, Di Fiore PP, Bianchi F.

Oncogene. 2018 Jun;37(26):3575-3588. doi: 10.1038/s41388-018-0229-9. Epub 2018 Mar 26.

PMID:
29576613
11.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2018 Mar 15;37(6). pii: e99170. doi: 10.15252/embj.201899170. No abstract available.

12.

A Numb-Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer.

Colaluca IN, Basile A, Freiburger L, D'Uva V, Disalvatore D, Vecchi M, Confalonieri S, Tosoni D, Cecatiello V, Malabarba MG, Yang CJ, Kainosho M, Sattler M, Mapelli M, Pece S, Di Fiore PP.

J Cell Biol. 2018 Feb 5;217(2):745-762. doi: 10.1083/jcb.201709092. Epub 2017 Dec 21.

13.

Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

Gulluni F, Martini M, De Santis MC, Campa CC, Ghigo A, Margaria JP, Ciraolo E, Franco I, Ala U, Annaratone L, Disalvatore D, Bertalot G, Viale G, Noatynska A, Compagno M, Sigismund S, Montemurro F, Thelen M, Fan F, Meraldi P, Marchiò C, Pece S, Sapino A, Chiarle R, Di Fiore PP, Hirsch E.

Cancer Cell. 2017 Oct 9;32(4):444-459.e7. doi: 10.1016/j.ccell.2017.09.002.

14.

Reticulon 3-dependent ER-PM contact sites control EGFR nonclathrin endocytosis.

Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, Verhoef LGGC, Confalonieri S, Malabarba MG, Bianchi F, Cuomo A, Bonaldi T, Martini E, Mazza D, Pinton P, Tacchetti C, Polo S, Di Fiore PP, Sigismund S.

Science. 2017 May 12;356(6338):617-624. doi: 10.1126/science.aah6152.

15.

Behind the Scenes: Endo/Exocytosis in the Acquisition of Metastatic Traits.

Lanzetti L, Di Fiore PP.

Cancer Res. 2017 Apr 15;77(8):1813-1817. doi: 10.1158/0008-5472.CAN-16-3403. Epub 2017 Apr 3. Review.

16.

The scaffold protein p140Cap limits ERBB2-mediated breast cancer progression interfering with Rac GTPase-controlled circuitries.

Grasso S, Chapelle J, Salemme V, Aramu S, Russo I, Vitale N, Verdun di Cantogno L, Dallaglio K, Castellano I, Amici A, Centonze G, Sharma N, Lunardi S, Cabodi S, Cavallo F, Lamolinara A, Stramucci L, Moiso E, Provero P, Albini A, Sapino A, Staaf J, Di Fiore PP, Bertalot G, Pece S, Tosoni D, Confalonieri S, Iezzi M, Di Stefano P, Turco E, Defilippi P.

Nat Commun. 2017 Mar 16;8:14797. doi: 10.1038/ncomms14797. Erratum in: Nat Commun. 2018 Mar 30;9:16203.

17.

Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.

Tosoni D, Pambianco S, Ekalle Soppo B, Zecchini S, Bertalot G, Pruneri G, Viale G, Di Fiore PP, Pece S.

EMBO Mol Med. 2017 May;9(5):655-671. doi: 10.15252/emmm.201606940.

18.

The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.

Reiterer V, Figueras-Puig C, Le Guerroue F, Confalonieri S, Vecchi M, Jalapothu D, Kanse SM, Deshaies RJ, Di Fiore PP, Behrends C, Farhan H.

EMBO J. 2017 Feb 1;36(3):260-273. doi: 10.15252/embj.201694795. Epub 2016 Dec 22. Erratum in: EMBO J. 2018 Mar 15;37(6):.

19.

Modelling TFE renal cell carcinoma in mice reveals a critical role of WNT signaling.

Calcagnì A, Kors L, Verschuren E, De Cegli R, Zampelli N, Nusco E, Confalonieri S, Bertalot G, Pece S, Settembre C, Malouf GG, Leemans JC, de Heer E, Salvatore M, Peters DJ, Di Fiore PP, Ballabio A.

Elife. 2016 Sep 26;5. pii: e17047. doi: 10.7554/eLife.17047.

20.

An Aggressive Subtype of Stage I Lung Adenocarcinoma with Molecular and Prognostic Characteristics Typical of Advanced Lung Cancers.

Dama E, Melocchi V, Dezi F, Pirroni S, Carletti RM, Brambilla D, Bertalot G, Casiraghi M, Maisonneuve P, Barberis M, Viale G, Vecchi M, Spaggiari L, Bianchi F, Di Fiore PP.

Clin Cancer Res. 2017 Jan 1;23(1):62-72. doi: 10.1158/1078-0432.CCR-15-3005. Epub 2016 Jun 29.

21.

RAB2A controls MT1-MMP endocytic and E-cadherin polarized Golgi trafficking to promote invasive breast cancer programs.

Kajiho H, Kajiho Y, Frittoli E, Confalonieri S, Bertalot G, Viale G, Di Fiore PP, Oldani A, Garre M, Beznoussenko GV, Palamidessi A, Vecchi M, Chavrier P, Perez F, Scita G.

EMBO Rep. 2016 Jul;17(7):1061-80. doi: 10.15252/embr.201642032. Epub 2016 Jun 2.

22.

Sensitive and affordable diagnostic assay for the quantitative detection of anaplastic lymphoma kinase (ALK) alterations in patients with non-small cell lung cancer.

Dama E, Tillhon M, Bertalot G, de Santis F, Troglio F, Pessina S, Passaro A, Pece S, de Marinis F, Dell'Orto P, Viale G, Spaggiari L, Di Fiore PP, Bianchi F, Barberis M, Vecchi M.

Oncotarget. 2016 Jun 14;7(24):37160-37176. doi: 10.18632/oncotarget.9471.

23.

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.

Pozzi C, Cuomo A, Spadoni I, Magni E, Silvola A, Conte A, Sigismund S, Ravenda PS, Bonaldi T, Zampino MG, Cancelliere C, Di Fiore PP, Bardelli A, Penna G, Rescigno M.

Nat Med. 2016 Jun;22(6):624-31. doi: 10.1038/nm.4078. Epub 2016 May 2.

PMID:
27135741
24.

Optimization and Standardization of Circulating MicroRNA Detection for Clinical Application: The miR-Test Case.

Marzi MJ, Montani F, Carletti RM, Dezi F, Dama E, Bonizzi G, Sandri MT, Rampinelli C, Bellomi M, Maisonneuve P, Spaggiari L, Veronesi G, Bianchi F, Di Fiore PP, Nicassio F.

Clin Chem. 2016 May;62(5):743-54. doi: 10.1373/clinchem.2015.251942.

25.

Endocytic control of signaling at the plasma membrane.

Barbieri E, Di Fiore PP, Sigismund S.

Curr Opin Cell Biol. 2016 Apr;39:21-7. doi: 10.1016/j.ceb.2016.01.012. Epub 2016 Feb 10. Review.

26.

USP9X Controls EGFR Fate by Deubiquitinating the Endocytic Adaptor Eps15.

Savio MG, Wollscheid N, Cavallaro E, Algisi V, Di Fiore PP, Sigismund S, Maspero E, Polo S.

Curr Biol. 2016 Jan 25;26(2):173-183. doi: 10.1016/j.cub.2015.11.050. Epub 2015 Dec 31.

27.

The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.

Tosoni D, Zecchini S, Coazzoli M, Colaluca I, Mazzarol G, Rubio A, Caccia M, Villa E, Zilian O, Di Fiore PP, Pece S.

J Cell Biol. 2015 Nov 23;211(4):845-62. doi: 10.1083/jcb.201505037.

28.

The alternative splicing factor Nova2 regulates vascular development and lumen formation.

Giampietro C, Deflorian G, Gallo S, Di Matteo A, Pradella D, Bonomi S, Belloni E, Nyqvist D, Quaranta V, Confalonieri S, Bertalot G, Orsenigo F, Pisati F, Ferrero E, Biamonti G, Fredrickx E, Taveggia C, Wyatt CD, Irimia M, Di Fiore PP, Blencowe BJ, Dejana E, Ghigna C.

Nat Commun. 2015 Oct 8;6:8479. doi: 10.1038/ncomms9479.

29.

A Trust-Based Pact in Research Biobanks. From Theory to Practice.

Sanchini V, Bonizzi G, Disalvatore D, Monturano M, Pece S, Viale G, Di Fiore PP, Boniolo G.

Bioethics. 2016 May;30(4):260-71. doi: 10.1111/bioe.12184. Epub 2015 Aug 26.

PMID:
26307361
30.

Quantitative analysis reveals how EGFR activation and downregulation are coupled in normal but not in cancer cells.

Capuani F, Conte A, Argenzio E, Marchetti L, Priami C, Polo S, Di Fiore PP, Sigismund S, Ciliberto A.

Nat Commun. 2015 Aug 12;6:7999. doi: 10.1038/ncomms8999.

31.

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.

De Luca M, Cogli L, Progida C, Nisi V, Pascolutti R, Sigismund S, Di Fiore PP, Bucci C.

J Cell Sci. 2015 Jul 15;128(14):2565. doi: 10.1242/jcs.175323. No abstract available.

32.

Correction: eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M.

PLoS Biol. 2015 Jun 3;13(6):e1002184. doi: 10.1371/journal.pbio.1002184. eCollection 2015 Jun. No abstract available.

33.

Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer.

Chiaradonna F, Barozzi I, Miccolo C, Bucci G, Palorini R, Fornasari L, Botrugno OA, Pruneri G, Masullo M, Passafaro A, Galimberti VE, Fantin VR, Richon VM, Pece S, Viale G, Di Fiore PP, Draetta G, Pelicci PG, Minucci S, Chiocca S.

Antioxid Redox Signal. 2015 Jul 1;23(1):15-29. doi: 10.1089/ars.2014.6189. Epub 2015 May 27.

34.

Whole exome sequencing identifies driver mutations in asymptomatic computed tomography-detected lung cancers with normal karyotype.

Belloni E, Veronesi G, Rotta L, Volorio S, Sardella D, Bernard L, Pece S, Di Fiore PP, Fumagalli C, Barberis M, Spaggiari L, Pelicci PG, Riva L.

Cancer Genet. 2015 Apr;208(4):152-5. doi: 10.1016/j.cancergen.2015.02.004. Epub 2015 Feb 20.

PMID:
25850996
35.

miR-Test: a blood test for lung cancer early detection.

Montani F, Marzi MJ, Dezi F, Dama E, Carletti RM, Bonizzi G, Bertolotti R, Bellomi M, Rampinelli C, Maisonneuve P, Spaggiari L, Veronesi G, Nicassio F, Di Fiore PP, Bianchi F.

J Natl Cancer Inst. 2015 Mar 19;107(6):djv063. doi: 10.1093/jnci/djv063. Print 2015 Jun.

PMID:
25794889
36.

The role of non-coding RNAs in the regulation of stem cells and progenitors in the normal mammary gland and in breast tumors.

Tordonato C, Di Fiore PP, Nicassio F.

Front Genet. 2015 Feb 27;6:72. doi: 10.3389/fgene.2015.00072. eCollection 2015. Review.

37.

Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries.

Corallino S, Malabarba MG, Zobel M, Di Fiore PP, Scita G.

Front Oncol. 2015 Feb 26;5:45. doi: 10.3389/fonc.2015.00045. eCollection 2015. Review.

38.

Mining cancer gene expression databases for latent information on intronic microRNAs.

Monterisi S, D'Ario G, Dama E, Rotmensz N, Confalonieri S, Tordonato C, Troglio F, Bertalot G, Maisonneuve P, Viale G, Nicassio F, Vecchi M, Di Fiore PP, Bianchi F.

Mol Oncol. 2015 Feb;9(2):473-87. doi: 10.1016/j.molonc.2014.10.001. Epub 2014 Oct 15.

39.

DEPDC1B coordinates de-adhesion events and cell-cycle progression at mitosis.

Marchesi S, Montani F, Deflorian G, D'Antuono R, Cuomo A, Bologna S, Mazzoccoli C, Bonaldi T, Di Fiore PP, Nicassio F.

Dev Cell. 2014 Nov 24;31(4):420-33. doi: 10.1016/j.devcel.2014.09.009. Epub 2014 Nov 24.

40.

Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis.

Baschieri F, Confalonieri S, Bertalot G, Di Fiore PP, Dietmaier W, Leist M, Crespo P, Macara IG, Farhan H.

Nat Commun. 2014 Sep 11;5:4839. doi: 10.1038/ncomms5839.

41.

The CDC42-interacting protein 4 controls epithelial cell cohesion and tumor dissemination.

Rolland Y, Marighetti P, Malinverno C, Confalonieri S, Luise C, Ducano N, Palamidessi A, Bisi S, Kajiho H, Troglio F, Shcherbakova OG, Dunn AR, Oldani A, Lanzetti L, Di Fiore PP, Disanza A, Scita G.

Dev Cell. 2014 Sep 8;30(5):553-68. doi: 10.1016/j.devcel.2014.08.006.

42.

Transcription factor PREP1 induces EMT and metastasis by controlling the TGF-β-SMAD3 pathway in non-small cell lung adenocarcinoma.

Risolino M, Mandia N, Iavarone F, Dardaei L, Longobardi E, Fernandez S, Talotta F, Bianchi F, Pisati F, Spaggiari L, Harter PN, Mittelbronn M, Schulte D, Incoronato M, Di Fiore PP, Blasi F, Verde P.

Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):E3775-84. doi: 10.1073/pnas.1407074111. Epub 2014 Aug 25.

43.

Endocytosis, signaling, and beyond.

Di Fiore PP, von Zastrow M.

Cold Spring Harb Perspect Biol. 2014 Aug 1;6(8). pii: a016865. doi: 10.1101/cshperspect.a016865. Review.

44.

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.

Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G.

J Cell Biol. 2014 Jul 21;206(2):307-28. doi: 10.1083/jcb.201403127.

45.

Memo is a copper-dependent redox protein with an essential role in migration and metastasis.

MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE.

Sci Signal. 2014 Jun 10;7(329):ra56. doi: 10.1126/scisignal.2004870.

PMID:
24917593
46.

RILP regulates vacuolar ATPase through interaction with the V1G1 subunit.

De Luca M, Cogli L, Progida C, Nisi V, Pascolutti R, Sigismund S, Di Fiore PP, Bucci C.

J Cell Sci. 2014 Jun 15;127(Pt 12):2697-708. doi: 10.1242/jcs.142604. Epub 2014 Apr 24. Erratum in: J Cell Sci. 2015 Jul 15;128(14):2565.

47.

flowFit: a Bioconductor package to estimate proliferation in cell-tracking dye studies.

Rambaldi D, Pece S, Di Fiore PP.

Bioinformatics. 2014 Jul 15;30(14):2060-5. doi: 10.1093/bioinformatics/btu127. Epub 2014 Mar 27.

PMID:
24681909
48.

Keeping EGFR signaling in check: ubiquitin is the guardian.

Polo S, Di Fiore PP, Sigismund S.

Cell Cycle. 2014;13(5):681-2. doi: 10.4161/cc.27855. Epub 2014 Jan 21. No abstract available.

49.

Recessive cancer genes engage in negative genetic interactions with their functional paralogs.

D'Antonio M, Guerra RF, Cereda M, Marchesi S, Montani F, Nicassio F, Di Fiore PP, Ciccarelli FD.

Cell Rep. 2013 Dec 26;5(6):1519-26. doi: 10.1016/j.celrep.2013.11.033. Epub 2013 Dec 19.

50.

Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.

Bossi D, Carlomagno F, Pallavicini I, Pruneri G, Trubia M, Raviele PR, Marinelli A, Anaganti S, Cox MC, Viale G, Santoro M, Di Fiore PP, Minucci S.

Mol Oncol. 2014 Mar;8(2):221-31. doi: 10.1016/j.molonc.2013.11.004. Epub 2013 Nov 19.

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