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Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.

Zhao S, Dejanovic D, Yao P, Bhilocha S, Sadler T, Schirbel A, West G, Doyon G, Lopez R, Mao R, Kurada S, El Ouali S, Grassl G, Fox PL, Cruise M, Worthley DL, de la Motte C, Fiocchi C, Rieder F.

Mucosal Immunol. 2020 Feb 4. doi: 10.1038/s41385-020-0259-9. [Epub ahead of print]


Corrigendum to: Recurrence of Crohn's Disease After Small Bowel Transplantation: Fact or Fiction.

Fahad H, Abu-Elmagd K, Lashner B, Fiocchi C.

Inflamm Bowel Dis. 2019 Dec 17. pii: izz314. doi: 10.1093/ibd/izz314. [Epub ahead of print] No abstract available.


Recurrence of Crohn's Disease After Small Bowel Transplantation: Fact or Fiction.

Fahad H, Abu-Elmagd K, Lashner B, Fiocchi C.

Inflamm Bowel Dis. 2020 Jan 1;26(1):21-23. doi: 10.1093/ibd/izz248.


Complete Genome Sequence of a Parabacteroides distasonis Strain (CavFT hAR46) Isolated from a Gut Wall-Cavitating Microlesion in a Patient with Severe Crohn's Disease.

Yang F, Kumar A, Davenport KW, Kelliher JM, Ezeji JC, Good CE, Jacobs MR, Conger M, West G, Fiocchi C, Cominelli F, Dichosa AEK, Rodriguez-Palacios A.

Microbiol Resour Announc. 2019 Sep 5;8(36). pii: e00585-19. doi: 10.1128/MRA.00585-19.


Acupuncture in Inflammatory Bowel Disease.

Song G, Fiocchi C, Achkar JP.

Inflamm Bowel Dis. 2019 Jun 18;25(7):1129-1139. doi: 10.1093/ibd/izy371.


Mutual Regulation of TLR/NLR and CEACAM1 in the Intestinal Microvasculature: Implications for IBD Pathogenesis and Therapy.

Schirbel A, Rebert N, Sadler T, West G, Rieder F, Wagener C, Horst A, Sturm A, de la Motte C, Fiocchi C.

Inflamm Bowel Dis. 2019 Jan 10;25(2):294-305. doi: 10.1093/ibd/izy316.


Inflammatory Bowel Disease: Complexity and Variability Need Integration.

Fiocchi C.

Front Med (Lausanne). 2018 Mar 21;5:75. doi: 10.3389/fmed.2018.00075. eCollection 2018. No abstract available.


Network Medicine: A Mandatory Next Step for Inflammatory Bowel Disease.

de Souza HSP, Fiocchi C.

Inflamm Bowel Dis. 2018 Mar 19;24(4):671-679. doi: 10.1093/ibd/izx111. Review.


Fibrosis in ulcerative colitis is directly linked to severity and chronicity of mucosal inflammation.

Gordon IO, Agrawal N, Willis E, Goldblum JR, Lopez R, Allende D, Liu X, Patil DY, Yerian L, El-Khider F, Fiocchi C, Rieder F.

Aliment Pharmacol Ther. 2018 Apr;47(7):922-939. doi: 10.1111/apt.14526. Epub 2018 Feb 6.


Inclusion of the Mesentery in Ileocolic Resection for Crohn's Disease is Associated With Reduced Surgical Recurrence.

Coffey CJ, Kiernan MG, Sahebally SM, Jarrar A, Burke JP, Kiely PA, Shen B, Waldron D, Peirce C, Moloney M, Skelly M, Tibbitts P, Hidayat H, Faul PN, Healy V, O'Leary PD, Walsh LG, Dockery P, O'Connell RP, Martin ST, Shanahan F, Fiocchi C, Dunne CP.

J Crohns Colitis. 2018 Nov 9;12(10):1139-1150. doi: 10.1093/ecco-jcc/jjx187.


Environmental triggers in IBD: a review of progress and evidence.

Ananthakrishnan AN, Bernstein CN, Iliopoulos D, Macpherson A, Neurath MF, Ali RAR, Vavricka SR, Fiocchi C.

Nat Rev Gastroenterol Hepatol. 2018 Jan;15(1):39-49. doi: 10.1038/nrgastro.2017.136. Epub 2017 Oct 11. Review.


Layilin is critical for mediating hyaluronan 35kDa-induced intestinal epithelial tight junction protein ZO-1 in vitro and in vivo.

Kim Y, West GA, Ray G, Kessler SP, Petrey AC, Fiocchi C, McDonald C, Longworth MS, Nagy LE, de la Motte CA.

Matrix Biol. 2018 Mar;66:93-109. doi: 10.1016/j.matbio.2017.09.003. Epub 2017 Oct 1.


The IBD interactome: an integrated view of aetiology, pathogenesis and therapy.

de Souza HSP, Fiocchi C, Iliopoulos D.

Nat Rev Gastroenterol Hepatol. 2017 Dec;14(12):739-749. doi: 10.1038/nrgastro.2017.110. Epub 2017 Aug 23. Review.


IBD: the need for sweeping new concepts in pathogenesis and therapy.

Fiocchi C.

Curr Opin Gastroenterol. 2017 Jul;33(4):219-221. doi: 10.1097/MOG.0000000000000375. No abstract available.


Crohn's Disease Fibroblasts Overproduce the Novel Protein KIAA1199 to Create Proinflammatory Hyaluronan Fragments.

Soroosh A, Albeiroti S, West GA, Willard B, Fiocchi C, de la Motte CA.

Cell Mol Gastroenterol Hepatol. 2016 Jan 13;2(3):358-368.e4. eCollection 2016 May.


A Distinct Colon-Derived Breath Metabolome is Associated with Inflammatory Bowel Disease, but not its Complications.

Rieder F, Kurada S, Grove D, Cikach F, Lopez R, Patel N, Singh A, Alkhouri N, Shen B, Brzezinski A, Baker M, Fiocchi C, Dweik RA.

Clin Transl Gastroenterol. 2016 Nov 10;7(11):e201. doi: 10.1038/ctg.2016.57.


Mechanisms, Management, and Treatment of Fibrosis in Patients With Inflammatory Bowel Diseases.

Rieder F, Fiocchi C, Rogler G.

Gastroenterology. 2017 Feb;152(2):340-350.e6. doi: 10.1053/j.gastro.2016.09.047. Epub 2016 Oct 5. Review.


A Pleiotropic Missense Variant in SLC39A8 Is Associated With Crohn's Disease and Human Gut Microbiome Composition.

Li D, Achkar JP, Haritunians T, Jacobs JP, Hui KY, D'Amato M, Brand S, Radford-Smith G, Halfvarson J, Niess JH, Kugathasan S, Büning C, Schumm LP, Klei L, Ananthakrishnan A, Aumais G, Baidoo L, Dubinsky M, Fiocchi C, Glas J, Milgrom R, Proctor DD, Regueiro M, Simms LA, Stempak JM, Targan SR, Törkvist L, Sharma Y, Devlin B, Borneman J, Hakonarson H, Xavier RJ, Daly M, Brant SR, Rioux JD, Silverberg MS, Cho JH, Braun J, McGovern DP, Duerr RH.

Gastroenterology. 2016 Oct;151(4):724-32. doi: 10.1053/j.gastro.2016.06.051. Epub 2016 Aug 1.


Drug development in IBD: from novel target identification to early clinical trials.

Danese S, Fiocchi C, Panés J.

Gut. 2016 Aug;65(8):1233-9. doi: 10.1136/gutjnl-2016-311717. Epub 2016 May 10. No abstract available.


Endothelial Cell-Immune Cell Interaction in IBD.

Danese S, Fiocchi C.

Dig Dis. 2016;34(1-2):43-50. doi: 10.1159/000442925. Epub 2016 Mar 16. Review.


Immunopathogenesis of IBD: current state of the art.

de Souza HS, Fiocchi C.

Nat Rev Gastroenterol Hepatol. 2016 Jan;13(1):13-27. doi: 10.1038/nrgastro.2015.186. Epub 2015 Dec 2. Review.


Identification of Endothelial-to-Mesenchymal Transition as a Potential Participant in Radiation Proctitis.

Mintet E, Rannou E, Buard V, West G, Guipaud O, Tarlet G, Sabourin JC, Benderitter M, Fiocchi C, Milliat F, François A.

Am J Pathol. 2015 Sep;185(9):2550-62. doi: 10.1016/j.ajpath.2015.04.028. Epub 2015 Jul 14.


The epithelial danger signal IL-1α is a potent activator of fibroblasts and reactivator of intestinal inflammation.

Scarpa M, Kessler S, Sadler T, West G, Homer C, McDonald C, de la Motte C, Fiocchi C, Stylianou E.

Am J Pathol. 2015 Jun;185(6):1624-37. doi: 10.1016/j.ajpath.2015.02.018. Epub 2015 Apr 10.


Inflammatory bowel disease pathogenesis: where are we?

Fiocchi C.

J Gastroenterol Hepatol. 2015 Mar;30 Suppl 1:12-8. doi: 10.1111/jgh.12751. Review.


Letter: volatile metabolomics of exhaled breath or faecal gas? - authors' reply.

Kurada S, Alkhouri N, Fiocchi C, Dweik R, Rieder F.

Aliment Pharmacol Ther. 2015 Apr;41(7):704. doi: 10.1111/apt.13127. No abstract available.


Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitis-associated fibrosis.

Yoo JH, Ho S, Tran DH, Cheng M, Bakirtzi K, Kukota Y, Ichikawa R, Su B, Tran DH, Hing TC, Chang I, Shih DQ, Issacson RE, Gallo RL, Fiocchi C, Pothoulakis C, Koon HW.

Cell Mol Gastroenterol Hepatol. 2015 Jan;1(1):55-74.e1.


Chromosome-associated protein D3 promotes bacterial clearance in human intestinal epithelial cells by repressing expression of amino acid transporters.

Schuster AT, Homer CR, Kemp JR, Nickerson KP, Deutschman E, Kim Y, West G, Sadler T, Stylianou E, Krokowski D, Hatzoglou M, de la Motte C, Rubin BP, Fiocchi C, McDonald C, Longworth MS.

Gastroenterology. 2015 Jun;148(7):1405-1416.e3. doi: 10.1053/j.gastro.2015.02.013. Epub 2015 Feb 18.


Integrating omics: the future of IBD?

Fiocchi C.

Dig Dis. 2014;32 Suppl 1:96-102. doi: 10.1159/000367836. Epub 2014 Dec 17. Review.


Review article: breath analysis in inflammatory bowel diseases.

Kurada S, Alkhouri N, Fiocchi C, Dweik R, Rieder F.

Aliment Pharmacol Ther. 2015 Feb;41(4):329-41. doi: 10.1111/apt.13050. Epub 2014 Dec 19. Review.


The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis.

Bakirtzi K, West G, Fiocchi C, Law IK, Iliopoulos D, Pothoulakis C.

Am J Pathol. 2014 Dec;184(12):3405-14. doi: 10.1016/j.ajpath.2014.08.015. Epub 2014 Oct 7.


Impact of abdominal visceral adipose tissue on disease outcome in pediatric Crohn's disease.

Uko V, Vortia E, Achkar JP, Karakas P, Fiocchi C, Worley S, Kay MH.

Inflamm Bowel Dis. 2014 Dec;20(12):2286-91. doi: 10.1097/MIB.0000000000000200.


VEGF-C-dependent stimulation of lymphatic function ameliorates experimental inflammatory bowel disease.

D'Alessio S, Correale C, Tacconi C, Gandelli A, Pietrogrande G, Vetrano S, Genua M, Arena V, Spinelli A, Peyrin-Biroulet L, Fiocchi C, Danese S.

J Clin Invest. 2014 Sep;124(9):3863-78. doi: 10.1172/JCI72189. Epub 2014 Aug 8.


Fibrosis in ulcerative colitis: mechanisms, features, and consequences of a neglected problem.

Gordon IO, Agrawal N, Goldblum JR, Fiocchi C, Rieder F.

Inflamm Bowel Dis. 2014 Nov;20(11):2198-206. doi: 10.1097/MIB.0000000000000080. Review.


IL-13Rα2-bearing, type II NKT cells reactive to sulfatide self-antigen populate the mucosa of ulcerative colitis.

Fuss IJ, Joshi B, Yang Z, Degheidy H, Fichtner-Feigl S, de Souza H, Rieder F, Scaldaferri F, Schirbel A, Scarpa M, West G, Yi C, Xu L, Leland P, Yao M, Mannon P, Puri RK, Fiocchi C, Strober W.

Gut. 2014 Nov;63(11):1728-36. doi: 10.1136/gutjnl-2013-305671. Epub 2014 Feb 10.


T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis.

Rieder F, Nonevski I, Ma J, Ouyang Z, West G, Protheroe C, DePetris G, Schirbel A, Lapinski J, Goldblum J, Bonfield T, Lopez R, Harnett K, Lee J, Hirano I, Falk G, Biancani P, Fiocchi C.

Gastroenterology. 2014 May;146(5):1266-77.e1-9. doi: 10.1053/j.gastro.2014.01.051. Epub 2014 Jan 28.


Gene-gene and gene-environment interactions in ulcerative colitis.

Wang MH, Fiocchi C, Zhu X, Ripke S, Kamboh MI, Rebert N, Duerr RH, Achkar JP.

Hum Genet. 2014 May;133(5):547-58. doi: 10.1007/s00439-013-1395-z. Epub 2013 Nov 17.


Advances in therapeutic interventions targeting the vascular and lymphatic endothelium in inflammatory bowel disease.

D'Alessio S, Tacconi C, Fiocchi C, Danese S.

Curr Opin Gastroenterol. 2013 Nov;29(6):608-13. doi: 10.1097/MOG.0b013e328365d37c. Review.


Mechanisms of tissue remodeling in inflammatory bowel disease.

Rieder F, Fiocchi C.

Dig Dis. 2013;31(2):186-93. doi: 10.1159/000353364. Epub 2013 Sep 6. Review.


Characterization of PTPN2 and its use as a biomarker.

Bussières-Marmen S, Hutchins AP, Schirbel A, Rebert N, Tiganis T, Fiocchi C, Miranda-Saavedra D, Tremblay ML.

Methods. 2014 Jan 15;65(2):239-46. doi: 10.1016/j.ymeth.2013.08.020. Epub 2013 Aug 30.


Inflammatory bowel disease: evolutionary concepts in biology, epidemiology, mechanisms and therapy.

Fiocchi C.

Curr Opin Gastroenterol. 2013 Jul;29(4):347-9. doi: 10.1097/MOG.0b013e3283622b73. No abstract available.


A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease.

Wang MH, Fiocchi C, Ripke S, Zhu X, Duerr RH, Achkar JP.

Inflamm Bowel Dis. 2013 Aug;19(9):1799-808. doi: 10.1097/MIB.0b013e31828706a0.


Genes and 'in-vironment': how will our concepts on the pathophysiology of inflammatory bowel disease develop in the future?

Fiocchi C.

Dig Dis. 2012;30 Suppl 3:2-11. doi: 10.1159/000342585. Epub 2013 Jan 3. Review.


Pro-angiogenic activity of TLRs and NLRs: a novel link between gut microbiota and intestinal angiogenesis.

Schirbel A, Kessler S, Rieder F, West G, Rebert N, Asosingh K, McDonald C, Fiocchi C.

Gastroenterology. 2013 Mar;144(3):613-623.e9. doi: 10.1053/j.gastro.2012.11.005. Epub 2012 Nov 10.


Animal models of intestinal fibrosis: new tools for the understanding of pathogenesis and therapy of human disease.

Rieder F, Kessler S, Sans M, Fiocchi C.

Am J Physiol Gastrointest Liver Physiol. 2012 Oct;303(7):G786-801. doi: 10.1152/ajpgi.00059.2012. Epub 2012 Aug 9. Review.


Towards a 'cure' for IBD.

Fiocchi C.

Dig Dis. 2012;30(4):428-33. doi: 10.1159/000338148. Epub 2012 Jul 12. Review.


HCl-induced and ATP-dependent upregulation of TRPV1 receptor expression and cytokine production by human esophageal epithelial cells.

Ma J, Altomare A, Guarino M, Cicala M, Rieder F, Fiocchi C, Li D, Cao W, Behar J, Biancani P, Harnett KM.

Am J Physiol Gastrointest Liver Physiol. 2012 Sep 1;303(5):G635-45. doi: 10.1152/ajpgi.00097.2012. Epub 2012 Jul 12.


Increased levels of survivin, via association with heat shock protein 90, in mucosal T cells from patients with Crohn's disease.

de Souza HS, West GA, Rebert N, de la Motte C, Drazba J, Fiocchi C.

Gastroenterology. 2012 Oct;143(4):1017-26.e9. doi: 10.1053/j.gastro.2012.06.039. Epub 2012 Jun 26.


Platelet-activating factor and distinct chemokines are elevated in mucosal biopsies of erosive compared with non-erosive reflux disease patients and controls.

Altomare A, Ma J, Guarino MP, Cheng L, Rieder F, Ribolsi M, Fiocchi C, Biancani P, Harnett K, Cicala M.

Neurogastroenterol Motil. 2012 Oct;24(10):943-e463. doi: 10.1111/j.1365-2982.2012.01963.x. Epub 2012 Jun 26.


IBD: advances in pathogenesis, complications, diagnosis, and therapy.

Fiocchi C.

Curr Opin Gastroenterol. 2012 Jul;28(4):297-300. doi: 10.1097/MOG.0b013e328354d81c. No abstract available.


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