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Items: 1 to 50 of 58

1.

Annexin A5 regulates surface αvβ5 integrin for retinal clearance phagocytosis.

Yu C, Muñoz LE, Mallavarapu M, Herrmann M, Finnemann SC.

J Cell Sci. 2019 Oct 16;132(20). pii: jcs232439. doi: 10.1242/jcs.232439.

PMID:
31515275
2.

Non-invasive in vivo fluorescence imaging of apoptotic retinal photoreceptors.

Mazzoni F, Müller C, DeAssis J, Lew D, Leevy WM, Finnemann SC.

Sci Rep. 2019 Feb 7;9(1):1590. doi: 10.1038/s41598-018-38363-z.

3.

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration.

Lenis TL, Hu J, Ng SY, Jiang Z, Sarfare S, Lloyd MB, Esposito NJ, Samuel W, Jaworski C, Bok D, Finnemann SC, Radeke MJ, Redmond TM, Travis GH, Radu RA.

Proc Natl Acad Sci U S A. 2018 Nov 20;115(47):E11120-E11127. doi: 10.1073/pnas.1802519115. Epub 2018 Nov 5.

4.

Advanced Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture.

Mazzoni F, Mao Y, Finnemann SC.

Methods Mol Biol. 2019;1834:95-108. doi: 10.1007/978-1-4939-8669-9_7.

PMID:
30324439
5.

Expression and characterization of αvβ5 integrin on intestinal macrophages.

Kumawat AK, Yu C, Mann EA, Schridde A, Finnemann SC, Mowat AM.

Eur J Immunol. 2018 Jul;48(7):1181-1187. doi: 10.1002/eji.201747318. Epub 2018 May 8.

6.

Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium.

Müller C, Charniga C, Temple S, Finnemann SC.

Stem Cell Reports. 2018 Mar 13;10(3):1075-1087. doi: 10.1016/j.stemcr.2018.01.017. Epub 2018 Feb 15.

7.

The Developmental Stage of Adult Human Stem Cell-Derived Retinal Pigment Epithelium Cells Influences Transplant Efficacy for Vision Rescue.

Davis RJ, Alam NM, Zhao C, Müller C, Saini JS, Blenkinsop TA, Mazzoni F, Campbell M, Borden SM, Charniga CJ, Lederman PL, Aguilar V, Naimark M, Fiske M, Boles N, Temple S, Finnemann SC, Prusky GT, Stern JH.

Stem Cell Reports. 2017 Jul 11;9(1):42-49. doi: 10.1016/j.stemcr.2017.05.016. Epub 2017 Jun 15.

8.

Semaphorin4D-PlexinB1 Signaling Attenuates Photoreceptor Outer Segment Phagocytosis by Reducing Rac1 Activity of RPE Cells.

Bulloj A, Maminishkis A, Mizui M, Finnemann SC.

Mol Neurobiol. 2018 May;55(5):4320-4332. doi: 10.1007/s12035-017-0649-5. Epub 2017 Jun 17.

9.

Retinal Pre-Conditioning by CD59a Knockout Protects against Light-Induced Photoreceptor Degeneration.

Song D, Wilson B, Zhao L, Bhuyan R, Bandyopadhyay M, Lyubarsky A, Yu C, Li Y, Kanu L, Miwa T, Song WC, Finnemann SC, Rohrer B, Dunaief JL.

PLoS One. 2016 Nov 28;11(11):e0166348. doi: 10.1371/journal.pone.0166348. eCollection 2016.

10.

Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.

Ploier B, Caro LN, Morizumi T, Pandey K, Pearring JN, Goren MA, Finnemann SC, Graumann J, Arshavsky VY, Dittman JS, Ernst OP, Menon AK.

Nat Commun. 2016 Oct 3;7:12832. doi: 10.1038/ncomms12832.

11.

Regulation of Phagolysosomal Digestion by Caveolin-1 of the Retinal Pigment Epithelium Is Essential for Vision.

Sethna S, Chamakkala T, Gu X, Thompson TC, Cao G, Elliott MH, Finnemann SC.

J Biol Chem. 2016 Mar 18;291(12):6494-506. doi: 10.1074/jbc.M115.687004. Epub 2016 Jan 26.

12.

Efficiency of Membrane Protein Expression Following Infection with Recombinant Adenovirus of Polarized Non-Transformed Human Retinal Pigment Epithelial Cells.

Müller C, Blenkinsop TA, Stern JH, Finnemann SC.

Adv Exp Med Biol. 2016;854:731-7. doi: 10.1007/978-3-319-17121-0_97.

13.
14.

Regulation of phagocytosis by Rho GTPases.

Mao Y, Finnemann SC.

Small GTPases. 2015;6(2):89-99. doi: 10.4161/21541248.2014.989785. Epub 2015 May 5. Review.

15.

Large-scale purification of porcine or bovine photoreceptor outer segments for phagocytosis assays on retinal pigment epithelial cells.

Parinot C, Rieu Q, Chatagnon J, Finnemann SC, Nandrot EF.

J Vis Exp. 2014 Dec 12;(94). doi: 10.3791/52100.

16.

Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture.

Mazzoni F, Safa H, Finnemann SC.

Exp Eye Res. 2014 Sep;126:51-60. doi: 10.1016/j.exer.2014.01.010. Epub 2014 Apr 26. Review.

18.

Independent roles of methionine sulfoxide reductase A in mitochondrial ATP synthesis and as antioxidant in retinal pigment epithelial cells.

Dun Y, Vargas J, Brot N, Finnemann SC.

Free Radic Biol Med. 2013 Dec;65:1340-1351. doi: 10.1016/j.freeradbiomed.2013.10.006. Epub 2013 Oct 10.

19.

PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells.

Bulloj A, Duan W, Finnemann SC.

Exp Eye Res. 2013 Aug;113:9-18. doi: 10.1016/j.exer.2013.05.002. Epub 2013 May 10.

20.

Analysis of photoreceptor outer segment phagocytosis by RPE cells in culture.

Mao Y, Finnemann SC.

Methods Mol Biol. 2013;935:285-95. doi: 10.1007/978-1-62703-080-9_20.

21.

Analysis of photoreceptor rod outer segment phagocytosis by RPE cells in situ.

Sethna S, Finnemann SC.

Methods Mol Biol. 2013;935:245-54. doi: 10.1007/978-1-62703-080-9_17.

22.

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5-/- or Mfge8-/- mouse retina.

Ruggiero L, Connor MP, Chen J, Langen R, Finnemann SC.

Proc Natl Acad Sci U S A. 2012 May 22;109(21):8145-8. doi: 10.1073/pnas.1121101109. Epub 2012 May 7.

23.

Retinal pigment epithelial cells use a MerTK-dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin.

Nandrot EF, Silva KE, Scelfo C, Finnemann SC.

Biol Cell. 2012 Jun;104(6):326-41. doi: 10.1111/boc.201100076. Epub 2012 Mar 5.

24.
25.

αvβ5 integrin-dependent diurnal phagocytosis of shed photoreceptor outer segments by RPE cells is independent of the integrin coreceptor transglutaminase-2.

Ruggiero L, Sarang Z, Szondy Z, Finnemann SC.

Adv Exp Med Biol. 2012;723:731-7. doi: 10.1007/978-1-4614-0631-0_93. No abstract available.

26.

Expression of the integrin coreceptor transglutaminase-2 in the RPE in vivo and in culture.

Ruggiero L, Finnemann SC.

Adv Exp Med Biol. 2012;723:709-15. doi: 10.1007/978-1-4614-0631-0_90. No abstract available.

27.

Dietary antioxidants prevent age-related retinal pigment epithelium actin damage and blindness in mice lacking αvβ5 integrin.

Yu CC, Nandrot EF, Dun Y, Finnemann SC.

Free Radic Biol Med. 2012 Feb 1;52(3):660-670. doi: 10.1016/j.freeradbiomed.2011.11.021. Epub 2011 Dec 8.

28.

Neural retina and MerTK-independent apical polarity of alphavbeta5 integrin receptors in the retinal pigment epithelium.

Mallavarapu M, Finnemann SC.

Adv Exp Med Biol. 2010;664:123-31. doi: 10.1007/978-1-4419-1399-9_15.

29.

The age lipid A2E and mitochondrial dysfunction synergistically impair phagocytosis by retinal pigment epithelial cells.

Vives-Bauza C, Anand M, Shiraz AK, Magrane J, Gao J, Vollmer-Snarr HR, Manfredi G, Finnemann SC.

J Biol Chem. 2008 Sep 5;283(36):24770-80. doi: 10.1074/jbc.M800706200. Epub 2008 Jul 10. Erratum in: J Biol Chem. 2013 Nov 8;288(45):32639. Shirazi, Arash K [corrected to Shiraz, Ashton K].

30.

Lack of alphavbeta5 integrin receptor or its ligand MFG-E8: distinct effects on retinal function.

Nandrot EF, Finnemann SC.

Ophthalmic Res. 2008;40(3-4):120-3. doi: 10.1159/000119861. Epub 2008 Apr 18.

31.

Alphavbeta5 integrin receptors at the apical surface of the RPE: one receptor, two functions.

Nandrot EF, Chang Y, Finnemann SC.

Adv Exp Med Biol. 2008;613:369-75. doi: 10.1007/978-0-387-74904-4_43. Review. No abstract available.

32.

Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis.

Chang Y, Finnemann SC.

J Cell Sci. 2007 Sep 1;120(Pt 17):3053-63. Epub 2007 Aug 7.

33.

Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis.

Nandrot EF, Anand M, Almeida D, Atabai K, Sheppard D, Finnemann SC.

Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):12005-10. Epub 2007 Jul 9.

34.

The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells.

Lakkaraju A, Finnemann SC, Rodriguez-Boulan E.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11026-31. Epub 2007 Jun 19. Erratum in: Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):11032.

35.

MerTK activation during RPE phagocytosis in vivo requires alphaVbeta5 integrin.

Finnemann SC, Nandrot EF.

Adv Exp Med Biol. 2006;572:499-503. No abstract available.

36.

Altered rhythm of photoreceptor outer segment phagocytosis in beta5 integrin knockout mice.

Nandrot EF, Finnemann SC.

Adv Exp Med Biol. 2006;572:119-23. No abstract available.

37.

Light-induced oxidation of photoreceptor outer segment phospholipids generates ligands for CD36-mediated phagocytosis by retinal pigment epithelium: a potential mechanism for modulating outer segment phagocytosis under oxidant stress conditions.

Sun M, Finnemann SC, Febbraio M, Shan L, Annangudi SP, Podrez EA, Hoppe G, Darrow R, Organisciak DT, Salomon RG, Silverstein RL, Hazen SL.

J Biol Chem. 2006 Feb 17;281(7):4222-30. Epub 2005 Dec 13.

38.

Novel role for alphavbeta5-integrin in retinal adhesion and its diurnal peak.

Nandrot EF, Anand M, Sircar M, Finnemann SC.

Am J Physiol Cell Physiol. 2006 Apr;290(4):C1256-62. Epub 2005 Dec 7.

39.

Nonsynaptic localization of the excitatory amino acid transporter 4 in photoreceptors.

Pignataro L, Sitaramayya A, Finnemann SC, Sarthy VP.

Mol Cell Neurosci. 2005 Mar;28(3):440-51.

PMID:
15737735
40.

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin.

Nandrot EF, Kim Y, Brodie SE, Huang X, Sheppard D, Finnemann SC.

J Exp Med. 2004 Dec 20;200(12):1539-45. Epub 2004 Dec 13.

41.

Changes in retinal pigment epithelial gene expression induced by rod outer segment uptake.

Chowers I, Kim Y, Farkas RH, Gunatilaka TL, Hackam AS, Campochiaro PA, Finnemann SC, Zack DJ.

Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2098-106.

PMID:
15223782
42.

Role of alphavbeta5 integrin in regulating phagocytosis by the retinal pigment epithelium.

Finnemann SC.

Adv Exp Med Biol. 2003;533:337-42. Review. No abstract available.

PMID:
15180282
44.
45.
46.
47.

Ezrin promotes morphogenesis of apical microvilli and basal infoldings in retinal pigment epithelium.

Bonilha VL, Finnemann SC, Rodriguez-Boulan E.

J Cell Biol. 1999 Dec 27;147(7):1533-48.

49.

Morphogenesis of the retinal pigment epithelium: toward understanding retinal degenerative diseases.

Marmorstein AD, Finnemann SC, Bonilha VL, Rodriguez-Boulan E.

Ann N Y Acad Sci. 1998 Oct 23;857:1-12. Review.

PMID:
9917828
50.

Apical polarity of N-CAM and EMMPRIN in retinal pigment epithelium resulting from suppression of basolateral signal recognition.

Marmorstein AD, Gan YC, Bonilha VL, Finnemann SC, Csaky KG, Rodriguez-Boulan E.

J Cell Biol. 1998 Aug 10;142(3):697-710.

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