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Items: 20

1.

Meeting Proceedings from ICBS 2018- Toward Translational Impact.

Mayerthaler F, Finley MF, Pfeifer TA, Antolin AA.

ACS Chem Biol. 2019 Apr 19;14(4):567-578. doi: 10.1021/acschembio.9b00169. Epub 2019 Mar 12. No abstract available.

PMID:
30860357
2.

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain.

Wall MJ, Subasinghe NL, Winters MP, Lubin ML, Finley MFA, Qin N, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3780-3783. doi: 10.1016/j.bmcl.2018.10.007. Epub 2018 Oct 12.

PMID:
30337231
3.

Prospective Assessment of Virtual Screening Heuristics Derived Using a Novel Fusion Score.

Pertusi DA, O'Donnell G, Homsher MF, Solly K, Patel A, Stahler SL, Riley D, Finley MF, Finger EN, Adam GC, Meng J, Bell DJ, Zuck PD, Hudak EM, Weber MJ, Nothstein JE, Locco L, Quinn C, Amoss A, Squadroni B, Hartnett M, Heo MR, White T, May SA, Boots E, Roberts K, Cocchiarella P, Wolicki A, Kreamer A, Kutchukian PS, Wassermann AM, Uebele VN, Glick M, Rusinko A 3rd, Culberson JC.

SLAS Discov. 2017 Sep;22(8):995-1006. doi: 10.1177/2472555217706058. Epub 2017 Apr 20.

PMID:
28426940
4.

High-Throughput Agonist Shift Assay Development for the Analysis of M1-Positive Allosteric Modulators.

Homsher MF, Beshore DC, Cassaday J, Squadroni B, Mohammed E, Hartnett M, Day S, Ma L, Pechter D, Smith MD, Monsma F, Zuck P, Finley MF, Uebele VN, Hermes JD.

SLAS Discov. 2017 Sep;22(8):1060-1066. doi: 10.1177/2472555217705373. Epub 2017 Apr 20.

PMID:
28426939
5.

Corrigendum to "Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects" [Bioorg. Med. Chem. Lett. 26 (2016) 5724-5728].

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333. doi: 10.1016/j.bmcl.2017.01.082. Epub 2017 Feb 4. No abstract available.

PMID:
28169160
6.

Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects.

Lombardo M, Bender K, London C, Plotkin MA, Kirkland M, Mane J, Pachanski M, Geissler W, Cummings J, Habulihaz B, Akiyama TE, Di Salvo J, Madeira M, Pols J, Powles MA, Finley MF, Johnson E, Roussel T, Uebele VN, Crespo A, Leung D, Alleyne C, Trusca D, Lei Y, Howard AD, Ujjainwalla F, Tata JR, Sinz CJ.

Bioorg Med Chem Lett. 2016 Dec 1;26(23):5724-5728. doi: 10.1016/j.bmcl.2016.10.054. Epub 2016 Oct 24. Erratum in: Bioorg Med Chem Lett. 2017 Mar 1;27(5):1333.

PMID:
27815121
7.

High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays.

Solly K, Klein R, Rudd M, Holloway MK, Johnson EN, Henze D, Finley MF.

J Biomol Screen. 2015 Jul;20(6):708-19. doi: 10.1177/1087057115570580. Epub 2015 Feb 19.

PMID:
25700884
8.

Discovery and SAR of a novel series of 2,4,5,6-tetrahydrocyclopenta[c]pyrazoles as N-type calcium channel inhibitors.

Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2014 May 1;24(9):2057-61. doi: 10.1016/j.bmcl.2014.03.063. Epub 2014 Mar 28.

PMID:
24726803
9.

Discovery and SAR of novel tetrahydropyrrolo[3,4-c]pyrazoles as inhibitors of the N-type calcium channel.

Winters MP, Subasinghe N, Wall M, Beck E, Brandt MR, Finley MF, Liu Y, Lubin ML, Neeper MP, Qin N, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2014 May 1;24(9):2053-6. doi: 10.1016/j.bmcl.2014.03.062. Epub 2014 Mar 27.

PMID:
24726802
10.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: pharmacological properties of (S)-N-[(6-chloro-2,3-dihydrobenzo[1,4]dioxin-2-yl)methyl]sulfamide (JNJ-26489112).

McComsey DF, Smith-Swintosky VL, Parker MH, Brenneman DE, Malatynska E, White HS, Klein BD, Wilcox KS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Reitz AB, Maryanoff BE.

J Med Chem. 2013 Nov 27;56(22):9019-30. doi: 10.1021/jm400894u. Epub 2013 Nov 11.

11.

A novel series of pyrazolylpiperidine N-type calcium channel blockers.

Subasinghe NL, Wall MJ, Winters MP, Qin N, Lubin ML, Finley MF, Brandt MR, Neeper MP, Schneider CR, Colburn RW, Flores CM, Sui Z.

Bioorg Med Chem Lett. 2012 Jun 15;22(12):4080-3. doi: 10.1016/j.bmcl.2012.04.075. Epub 2012 May 2.

PMID:
22608964
12.

An integrated multiassay approach to the discovery of small-molecule N-type voltage-gated calcium channel antagonists.

Finley MF, Lubin ML, Neeper MP, Beck E, Liu Y, Flores CM, Qin N.

Assay Drug Dev Technol. 2010 Dec;8(6):685-94. doi: 10.1089/adt.2010.0311. Epub 2010 Nov 4.

PMID:
21050074
13.

Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

Parker MH, Smith-Swintosky VL, McComsey DF, Huang Y, Brenneman D, Klein B, Malatynska E, White HS, Milewski ME, Herb M, Finley MF, Liu Y, Lubin ML, Qin N, Iannucci R, Leclercq L, Cuyckens F, Reitz AB, Maryanoff BE.

J Med Chem. 2009 Dec 10;52(23):7528-36. doi: 10.1021/jm801432r.

PMID:
19388676
14.

SNAP-25 Ser187 does not mediate phorbol ester enhancement of hippocampal synaptic transmission.

Finley MF, Scheller RH, Madison DV.

Neuropharmacology. 2003 Nov;45(6):857-62.

PMID:
14529723
15.
16.

Cell biology. Fusion without SNAREs?

Scales SJ, Finley MF, Scheller RH.

Science. 2001 Nov 2;294(5544):1015-6.

PMID:
11691976
17.

BMP-4 inhibits neural differentiation of murine embryonic stem cells.

Finley MF, Devata S, Huettner JE.

J Neurobiol. 1999 Sep 5;40(3):271-87.

PMID:
10440729
18.

Glutamate receptor-mediated calcium entry in neurons derived from P19 embryonal carcinoma cells.

Canzoniero LM, Sensi SL, Turetsky DM, Finley MF, Choi DW, Huettner JE.

J Neurosci Res. 1996 Aug 1;45(3):226-36.

PMID:
8841983
19.
20.

Alveolar Abscess.

Finley MF.

Am J Dent Sci. 1880 Jun;14(2):58-62. No abstract available.

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