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Items: 28


Natural Killer Cells Integrate Signals Received from Tumour Interactions and IL2 to Induce Robust and Prolonged Anti-Tumour and Metabolic Responses.

Kedia-Mehta N, Choi C, McCrudden A, Littwitz-Salomon E, Fox PG, Gardiner CM, Finlay DK.

Immunometabolism. 2019;1:e190014. doi: 10.20900/immunometab20190014. Epub 2019 Sep 25.


Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.

O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE.

J Immunol. 2019 Jun 15;202(12):3404-3411. doi: 10.4049/jimmunol.1801600. Epub 2019 May 10.


Competition for nutrients and its role in controlling immune responses.

Kedia-Mehta N, Finlay DK.

Nat Commun. 2019 May 9;10(1):2123. doi: 10.1038/s41467-019-10015-4. Review.


Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation.

Jones N, Vincent EE, Cronin JG, Panetti S, Chambers M, Holm SR, Owens SE, Francis NJ, Finlay DK, Thornton CA.

Nat Commun. 2019 May 3;10(1):2042. doi: 10.1038/s41467-019-10023-4.


Immunometabolism and natural killer cell responses.

O'Brien KL, Finlay DK.

Nat Rev Immunol. 2019 May;19(5):282-290. doi: 10.1038/s41577-019-0139-2. Review.


N-myristoylation of AMPK controls T cell inflammatory function.

Finlay DK.

Nat Immunol. 2019 Mar;20(3):252-254. doi: 10.1038/s41590-019-0322-4. No abstract available.


Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.

Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK.

Nat Commun. 2018 Jun 14;9(1):2341. doi: 10.1038/s41467-018-04719-2.


Canonical TGF-β Signaling Pathway Represses Human NK Cell Metabolism.

Zaiatz-Bittencourt V, Finlay DK, Gardiner CM.

J Immunol. 2018 Jun 15;200(12):3934-3941. doi: 10.4049/jimmunol.1701461. Epub 2018 May 2.


NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient.

Tobin LM, Mavinkurve M, Carolan E, Kinlen D, O'Brien EC, Little MA, Finlay DK, Cody D, Hogan AE, O'Shea D.

JCI Insight. 2017 Dec 21;2(24). pii: 94939. doi: 10.1172/jci.insight.94939.


Sugar or Fat?-Metabolic Requirements for Immunity to Viral Infections.

Shehata HM, Murphy AJ, Lee MKS, Gardiner CM, Crowe SM, Sanjabi S, Finlay DK, Palmer CS.

Front Immunol. 2017 Oct 16;8:1311. doi: 10.3389/fimmu.2017.01311. eCollection 2017. Review.


Srebp-controlled glucose metabolism is essential for NK cell functional responses.

Assmann N, O'Brien KL, Donnelly RP, Dyck L, Zaiatz-Bittencourt V, Loftus RM, Heinrich P, Oefner PJ, Lynch L, Gardiner CM, Dettmer K, Finlay DK.

Nat Immunol. 2017 Nov;18(11):1197-1206. doi: 10.1038/ni.3838. Epub 2017 Sep 18.


Glucose represses dendritic cell-induced T cell responses.

Lawless SJ, Kedia-Mehta N, Walls JF, McGarrigle R, Convery O, Sinclair LV, Navarro MN, Murray J, Finlay DK.

Nat Commun. 2017 May 30;8:15620. doi: 10.1038/ncomms15620.


What Fuels Natural Killers? Metabolism and NK Cell Responses.

Gardiner CM, Finlay DK.

Front Immunol. 2017 Apr 3;8:367. doi: 10.3389/fimmu.2017.00367. eCollection 2017. Review.


Metabolic regulation of immune responses: therapeutic opportunities.

Assmann N, Finlay DK.

J Clin Invest. 2016 Jun 1;126(6):2031-9. doi: 10.1172/JCI83005. Epub 2016 Jun 1. Review.


Metabolic Reprogramming Supports IFN-γ Production by CD56bright NK Cells.

Keating SE, Zaiatz-Bittencourt V, Loftus RM, Keane C, Brennan K, Finlay DK, Gardiner CM.

J Immunol. 2016 Mar 15;196(6):2552-60. doi: 10.4049/jimmunol.1501783. Epub 2016 Feb 12.


Metabolic regulation of natural killer cells.

Finlay DK.

Biochem Soc Trans. 2015 Aug;43(4):758-62. doi: 10.1042/BST20150116. Epub 2015 Aug 3. Review.


Immunometabolism: Cellular Metabolism Turns Immune Regulator.

Loftus RM, Finlay DK.

J Biol Chem. 2016 Jan 1;291(1):1-10. doi: 10.1074/jbc.R115.693903. Epub 2015 Nov 3. Review.


Glucose, glycolysis and lymphocyte responses.

Donnelly RP, Finlay DK.

Mol Immunol. 2015 Dec;68(2 Pt C):513-9. doi: 10.1016/j.molimm.2015.07.034. Epub 2015 Aug 7. Review.


Starved human T lymphocytes keep fighting.

Finlay DK.

Eur J Immunol. 2015 Sep;45(9):2480-3. doi: 10.1002/eji.201545885.


mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function.

Donnelly RP, Loftus RM, Keating SE, Liou KT, Biron CA, Gardiner CM, Finlay DK.

J Immunol. 2014 Nov 1;193(9):4477-84. doi: 10.4049/jimmunol.1401558. Epub 2014 Sep 26.


Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.

Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA.

PLoS One. 2014 Sep 2;9(9):e106710. doi: 10.1371/journal.pone.0106710. eCollection 2014.


mTORC1 regulates CD8+ T-cell glucose metabolism and function independently of PI3K and PKB.

Finlay DK.

Biochem Soc Trans. 2013 Apr;41(2):681-6. doi: 10.1042/BST20120359. Review.


AMPKα1: a glucose sensor that controls CD8 T-cell memory.

Rolf J, Zarrouk M, Finlay DK, Foretz M, Viollet B, Cantrell DA.

Eur J Immunol. 2013 Apr;43(4):889-96. doi: 10.1002/eji.201243008. Epub 2013 Feb 13.


PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.

Finlay DK, Rosenzweig E, Sinclair LV, Feijoo-Carnero C, Hukelmann JL, Rolf J, Panteleyev AA, Okkenhaug K, Cantrell DA.

J Exp Med. 2012 Dec 17;209(13):2441-53. doi: 10.1084/jem.20112607. Epub 2012 Nov 26.


Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases.

Finlay DK.

Front Immunol. 2012 Aug 7;3:247. doi: 10.3389/fimmu.2012.00247. eCollection 2012.


Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells.

Finlay DK, Kelly AP, Clarke R, Sinclair LV, Deak M, Alessi DR, Cantrell DA.

J Immunol. 2010 Nov 15;185(10):5973-82. doi: 10.4049/jimmunol.1000827. Epub 2010 Oct 13.


Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.

Finlay DK, Sinclair LV, Feijoo C, Waugh CM, Hagenbeek TJ, Spits H, Cantrell DA.

J Exp Med. 2009 Oct 26;206(11):2441-54. doi: 10.1084/jem.20090219. Epub 2009 Oct 5.


Notch-induced T cell development requires phosphoinositide-dependent kinase 1.

Kelly AP, Finlay DK, Hinton HJ, Clarke RG, Fiorini E, Radtke F, Cantrell DA.

EMBO J. 2007 Jul 25;26(14):3441-50. Epub 2007 Jun 28.

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