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Items: 1 to 50 of 57


DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP.

Deshpande RA, Myler LR, Soniat MM, Makharashvili N, Lee L, Lees-Miller SP, Finkelstein IJ, Paull TT.

Sci Adv. 2020 Jan 8;6(2):eaay0922. doi: 10.1126/sciadv.aay0922. eCollection 2020 Jan.


Human cohesin compacts DNA by loop extrusion.

Kim Y, Shi Z, Zhang H, Finkelstein IJ, Yu H.

Science. 2019 Dec 13;366(6471):1345-1349. doi: 10.1126/science.aaz4475. Epub 2019 Nov 28.


Systematic Discovery of Endogenous Human Ribonucleoprotein Complexes.

Mallam AL, Sae-Lee W, Schaub JM, Tu F, Battenhouse A, Jang YJ, Kim J, Wallingford JB, Finkelstein IJ, Marcotte EM, Drew K.

Cell Rep. 2019 Oct 29;29(5):1351-1368.e5. doi: 10.1016/j.celrep.2019.09.060.


Retrons and their applications in genome engineering.

Simon AJ, Ellington AD, Finkelstein IJ.

Nucleic Acids Res. 2019 Dec 2;47(21):11007-11019. doi: 10.1093/nar/gkz865.


Functional metagenomics-guided discovery of potent Cas9 inhibitors in the human microbiome.

Forsberg KJ, Bhatt IV, Schmidtke DT, Javanmardi K, Dillard KE, Stoddard BL, Finkelstein IJ, Kaiser BK, Malik HS.

Elife. 2019 Sep 10;8. pii: e46540. doi: 10.7554/eLife.46540.


Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks.

Caron MC, Sharma AK, O'Sullivan J, Myler LR, Ferreira MT, Rodrigue A, Coulombe Y, Ethier C, Gagné JP, Langelier MF, Pascal JM, Finkelstein IJ, Hendzel MJ, Poirier GG, Masson JY.

Nat Commun. 2019 Jul 4;10(1):2954. doi: 10.1038/s41467-019-10741-9.


RPA Phosphorylation Inhibits DNA Resection.

Soniat MM, Myler LR, Kuo HC, Paull TT, Finkelstein IJ.

Mol Cell. 2019 Jul 11;75(1):145-153.e5. doi: 10.1016/j.molcel.2019.05.005. Epub 2019 May 29.


Purification and Biophysical Characterization of the Mre11-Rad50-Nbs1 Complex.

Myler LR, Soniat MM, Zhang X, Deshpande RA, Paull TT, Finkelstein IJ.

Methods Mol Biol. 2019;2004:269-287. doi: 10.1007/978-1-4939-9520-2_20.


Assembling the Human Resectosome on DNA Curtains.

Soniat MM, Myler LR, Finkelstein IJ.

Methods Mol Biol. 2019;1999:225-244. doi: 10.1007/978-1-4939-9500-4_14.


Sortase-mediated fluorescent labeling of CRISPR complexes.

Dillard KE, Schaub JM, Brown MW, Saifuddin FA, Xiao Y, Hernandez E, Dahlhauser SD, Anslyn EV, Ke A, Finkelstein IJ.

Methods Enzymol. 2019;616:43-59. doi: 10.1016/bs.mie.2018.10.031. Epub 2018 Dec 17.


Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.

Kim Y, Furman CM, Manhart CM, Alani E, Finkelstein IJ.

Nucleic Acids Res. 2019 Feb 28;47(4):1823-1835. doi: 10.1093/nar/gky1244.


Phage Mu Gam protein promotes NHEJ in concert with Escherichia coli ligase.

Bhattacharyya S, Soniat MM, Walker D, Jang S, Finkelstein IJ, Harshey RM.

Proc Natl Acad Sci U S A. 2018 Dec 11;115(50):E11614-E11622. doi: 10.1073/pnas.1816606115. Epub 2018 Nov 28.


Assembly and Translocation of a CRISPR-Cas Primed Acquisition Complex.

Dillard KE, Brown MW, Johnson NV, Xiao Y, Dolan A, Hernandez E, Dahlhauser SD, Kim Y, Myler LR, Anslyn EV, Ke A, Finkelstein IJ.

Cell. 2018 Nov 1;175(4):934-946.e15. doi: 10.1016/j.cell.2018.09.039. Epub 2018 Oct 18.


Kinetic Basis for DNA Target Specificity of CRISPR-Cas12a.

Strohkendl I, Saifuddin FA, Rybarski JR, Finkelstein IJ, Russell R.

Mol Cell. 2018 Sep 6;71(5):816-824.e3. doi: 10.1016/j.molcel.2018.06.043. Epub 2018 Aug 2.


Assessing Protein Dynamics on Low-Complexity Single-Stranded DNA Curtains.

Schaub JM, Zhang H, Soniat MM, Finkelstein IJ.

Langmuir. 2018 Dec 11;34(49):14882-14890. doi: 10.1021/acs.langmuir.8b01812. Epub 2018 Aug 2.


Noncoding RNA-nucleated heterochromatin spreading is intrinsically labile and requires accessory elements for epigenetic stability.

Greenstein RA, Jones SK, Spivey EC, Rybarski JR, Finkelstein IJ, Al-Sady B.

Elife. 2018 Jul 18;7. pii: e32948. doi: 10.7554/eLife.32948.


Indel-correcting DNA barcodes for high-throughput sequencing.

Hawkins JA, Jones SK Jr, Finkelstein IJ, Press WH.

Proc Natl Acad Sci U S A. 2018 Jul 3;115(27):E6217-E6226. doi: 10.1073/pnas.1802640115. Epub 2018 Jun 20.


Distinct roles of XPF-ERCC1 and Rad1-Rad10-Saw1 in replication-coupled and uncoupled inter-strand crosslink repair.

Seol JH, Holland C, Li X, Kim C, Li F, Medina-Rivera M, Eichmiller R, Gallardo IF, Finkelstein IJ, Hasty P, Shim EY, Surtees JA, Lee SE.

Nat Commun. 2018 May 23;9(1):2025. doi: 10.1038/s41467-018-04327-0.


A Microfluidic Device for Massively Parallel, Whole-lifespan Imaging of Single Fission Yeast Cells.

Jones SK Jr, Spivey EC, Rybarski JR, Finkelstein IJ.

Bio Protoc. 2018 Apr 5;8(7). pii: e2783. doi: 10.21769/BioProtoc.2783.


Coordination of Rad1-Rad10 interactions with Msh2-Msh3, Saw1 and RPA is essential for functional 3' non-homologous tail removal.

Eichmiller R, Medina-Rivera M, DeSanto R, Minca E, Kim C, Holland C, Seol JH, Schmit M, Oramus D, Smith J, Gallardo IF, Finkelstein IJ, Lee SE, Surtees JA.

Nucleic Acids Res. 2018 Jun 1;46(10):5075-5096. doi: 10.1093/nar/gky254.


Single-Molecule Imaging Reveals How Mre11-Rad50-Nbs1 Initiates DNA Break Repair.

Myler LR, Gallardo IF, Soniat MM, Deshpande RA, Gonzalez XB, Kim Y, Paull TT, Finkelstein IJ.

Mol Cell. 2017 Sep 7;67(5):891-898.e4. doi: 10.1016/j.molcel.2017.08.002. Epub 2017 Aug 31.


Next-Generation DNA Curtains for Single-Molecule Studies of Homologous Recombination.

Soniat MM, Myler LR, Schaub JM, Kim Y, Gallardo IF, Finkelstein IJ.

Methods Enzymol. 2017;592:259-281. doi: 10.1016/bs.mie.2017.03.011. Epub 2017 Apr 17.


Massively Parallel Biophysical Analysis of CRISPR-Cas Complexes on Next Generation Sequencing Chips.

Jung C, Hawkins JA, Jones SK Jr, Xiao Y, Rybarski JR, Dillard KE, Hussmann J, Saifuddin FA, Savran CA, Ellington AD, Ke A, Press WH, Finkelstein IJ.

Cell. 2017 Jun 29;170(1):35-47.e13. doi: 10.1016/j.cell.2017.05.044.


Efficient modification of λ-DNA substrates for single-molecule studies.

Kim Y, de la Torre A, Leal AA, Finkelstein IJ.

Sci Rep. 2017 May 18;7(1):2071. doi: 10.1038/s41598-017-01984-x.


An aging-independent replicative lifespan in a symmetrically dividing eukaryote.

Spivey EC, Jones SK Jr, Rybarski JR, Saifuddin FA, Finkelstein IJ.

Elife. 2017 Jan 31;6. pii: e20340. doi: 10.7554/eLife.20340.


Inserting Extrahelical Structures into Long DNA Substrates for Single-Molecule Studies of DNA Mismatch Repair.

Brown MW, de la Torre A, Finkelstein IJ.

Methods Enzymol. 2017;582:221-238. doi: 10.1016/bs.mie.2016.08.006. Epub 2016 Oct 24.


Eukaryotic resectosomes: A single-molecule perspective.

Myler LR, Finkelstein IJ.

Prog Biophys Mol Biol. 2017 Aug;127:119-129. doi: 10.1016/j.pbiomolbio.2016.08.001. Epub 2016 Aug 3. Review.


Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome.

Yu H, Singh Gautam AK, Wilmington SR, Wylie D, Martinez-Fonts K, Kago G, Warburton M, Chavali S, Inobe T, Finkelstein IJ, Babu MM, Matouschek A.

J Biol Chem. 2016 Jul 8;291(28):14526-39. doi: 10.1074/jbc.M116.727578. Epub 2016 May 17.


Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins.

Myler LR, Gallardo IF, Zhou Y, Gong F, Yang SH, Wold MS, Miller KM, Paull TT, Finkelstein IJ.

Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1170-9. doi: 10.1073/pnas.1516674113. Epub 2016 Feb 16.


Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.

Brown MW, Kim Y, Williams GM, Huck JD, Surtees JA, Finkelstein IJ.

Nat Commun. 2016 Feb 3;7:10607. doi: 10.1038/ncomms10607.


High-Throughput Universal DNA Curtain Arrays for Single-Molecule Fluorescence Imaging.

Gallardo IF, Pasupathy P, Brown M, Manhart CM, Neikirk DP, Alani E, Finkelstein IJ.

Langmuir. 2015 Sep 22;31(37):10310-7. doi: 10.1021/acs.langmuir.5b02416. Epub 2015 Sep 8.


3D-printed microfluidic microdissector for high-throughput studies of cellular aging.

Spivey EC, Xhemalce B, Shear JB, Finkelstein IJ.

Anal Chem. 2014 Aug 5;86(15):7406-12. doi: 10.1021/ac500893a. Epub 2014 Jul 17.


High-throughput single-molecule studies of protein-DNA interactions.

Robison AD, Finkelstein IJ.

FEBS Lett. 2014 Oct 1;588(19):3539-46. doi: 10.1016/j.febslet.2014.05.021. Epub 2014 May 21. Review.


Single-molecule imaging of FtsK translocation reveals mechanistic features of protein-protein collisions on DNA.

Lee JY, Finkelstein IJ, Arciszewska LK, Sherratt DJ, Greene EC.

Mol Cell. 2014 Jun 5;54(5):832-43. doi: 10.1016/j.molcel.2014.03.033. Epub 2014 Apr 24.


Rapid prototyping of multichannel microfluidic devices for single-molecule DNA curtain imaging.

Robison AD, Finkelstein IJ.

Anal Chem. 2014 May 6;86(9):4157-63. doi: 10.1021/ac500267v. Epub 2014 Apr 23.


Nucleosome acidic patch promotes RNF168- and RING1B/BMI1-dependent H2AX and H2A ubiquitination and DNA damage signaling.

Leung JW, Agarwal P, Canny MD, Gong F, Robison AD, Finkelstein IJ, Durocher D, Miller KM.

PLoS Genet. 2014 Mar 6;10(3):e1004178. doi: 10.1371/journal.pgen.1004178. eCollection 2014 Mar.


From cradle to grave: high-throughput studies of aging in model organisms.

Spivey EC, Finkelstein IJ.

Mol Biosyst. 2014 Jul;10(7):1658-67. doi: 10.1039/c3mb70604d. Epub 2014 Feb 18. Review.


Molecular traffic jams on DNA.

Finkelstein IJ, Greene EC.

Annu Rev Biophys. 2013;42:241-63. doi: 10.1146/annurev-biophys-083012-130304. Epub 2013 Feb 28. Review.


The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion.

Wang F, Redding S, Finkelstein IJ, Gorman J, Reichman DR, Greene EC.

Nat Struct Mol Biol. 2013 Feb;20(2):174-81. doi: 10.1038/nsmb.2472. Epub 2012 Dec 23.


Single-stranded DNA curtains for real-time single-molecule visualization of protein-nucleic acid interactions.

Gibb B, Silverstein TD, Finkelstein IJ, Greene EC.

Anal Chem. 2012 Sep 18;84(18):7607-12. doi: 10.1021/ac302117z. Epub 2012 Sep 6.


Single-molecule imaging of DNA curtains reveals mechanisms of KOPS sequence targeting by the DNA translocase FtsK.

Lee JY, Finkelstein IJ, Crozat E, Sherratt DJ, Greene EC.

Proc Natl Acad Sci U S A. 2012 Apr 24;109(17):6531-6. doi: 10.1073/pnas.1201613109. Epub 2012 Apr 9.


Supported lipid bilayers and DNA curtains for high-throughput single-molecule studies.

Finkelstein IJ, Greene EC.

Methods Mol Biol. 2011;745:447-61. doi: 10.1007/978-1-61779-129-1_26.


Single-molecule imaging reveals mechanisms of protein disruption by a DNA translocase.

Finkelstein IJ, Visnapuu ML, Greene EC.

Nature. 2010 Dec 16;468(7326):983-7. doi: 10.1038/nature09561. Epub 2010 Nov 24.


XPD helicase speeds through a molecular traffic jam.

Finkelstein IJ, Greene EC.

Mol Cell. 2009 Sep 11;35(5):549-50. doi: 10.1016/j.molcel.2009.08.012.


Single molecule studies of homologous recombination.

Finkelstein IJ, Greene EC.

Mol Biosyst. 2008 Nov;4(11):1094-104. doi: 10.1039/b811681b. Epub 2008 Sep 29. Review.


Neuroglobin dynamics observed with ultrafast 2D-IR vibrational echo spectroscopy.

Ishikawa H, Finkelstein IJ, Kim S, Kwak K, Chung JK, Wakasugi K, Massari AM, Fayer MD.

Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16116-21. Epub 2007 Oct 4.


Viscosity-dependent protein dynamics.

Finkelstein IJ, Massari AM, Fayer MD.

Biophys J. 2007 May 15;92(10):3652-62.


Probing dynamics of complex molecular systems with ultrafast 2D IR vibrational echo spectroscopy.

Finkelstein IJ, Zheng J, Ishikawa H, Kim S, Kwak K, Fayer MD.

Phys Chem Chem Phys. 2007 Apr 7;9(13):1533-49. Epub 2007 Feb 20.


Substrate binding and protein conformational dynamics measured by 2D-IR vibrational echo spectroscopy.

Finkelstein IJ, Ishikawa H, Kim S, Massari AM, Fayer MD.

Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2637-42. Epub 2007 Feb 12.

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