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Chronic isolation stress is associated with increased colonic and motor symptoms in the A53T mouse model of Parkinson's disease.

Diwakarla S, Finkelstein DI, Constable R, Artaiz O, Di Natale M, McQuade RM, Lei E, Chai XY, Ringuet MT, Fothergill LJ, Lawson VA, Ellett LJ, Berger JP, Furness JB.

Neurogastroenterol Motil. 2019 Nov 10:e13755. doi: 10.1111/nmo.13755. [Epub ahead of print]


α-Synuclein Regulates Development and Function of Cholinergic Enteric Neurons in the Mouse Colon.

Swaminathan M, Fung C, Finkelstein DI, Bornstein JC, Foong JPP.

Neuroscience. 2019 Nov 6. pii: S0306-4522(19)30721-3. doi: 10.1016/j.neuroscience.2019.10.029. [Epub ahead of print]


Exercise and physical activity for people with Progressive Supranuclear Palsy: a systematic review.

Slade SC, Finkelstein DI, McGinley JL, Morris ME.

Clin Rehabil. 2019 Sep 27:269215519877235. doi: 10.1177/0269215519877235. [Epub ahead of print]


The Down Syndrome-Associated Protein, Regulator of Calcineurin-1, is Altered in Alzheimer's Disease and Dementia with Lewy Bodies.

N M; AIBL Research Group, C F, I V, Ca M, Rc K, Ai B, A R, Ma P, DI F, Pa A.

J Alzheimers Dis Parkinsonism. 2019;9(2). pii: 462. doi: 10.4172/2161-0460.1000462. Epub 2019 Mar 6.


The role of lipids in α-synuclein misfolding and neurotoxicity.

Ugalde CL, Lawson VA, Finkelstein DI, Hill AF.

J Biol Chem. 2019 Jun 7;294(23):9016-9028. doi: 10.1074/jbc.REV119.007500. Epub 2019 May 7. Review.


Early existence and biochemical evolution characterise acutely synaptotoxic PrPSc.

Foliaki ST, Lewis V, Islam AMT, Ellett LJ, Senesi M, Finkelstein DI, Roberts B, Lawson VA, Adlard PA, Collins SJ.

PLoS Pathog. 2019 Apr 10;15(4):e1007712. doi: 10.1371/journal.ppat.1007712. eCollection 2019 Apr.


l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.

Billings JL, Gordon SL, Rawling T, Doble PA, Bush AI, Adlard PA, Finkelstein DI, Hare DJ.

J Neurochem. 2019 Jul;150(1):88-106. doi: 10.1111/jnc.14676. Epub 2019 Mar 28.


Metal chaperones: a novel therapeutic strategy for brain injury?

Portbury SD, Sedjahtera A, Perrones K, Sgambelloni C, Zhang M, Crack PJ, Finkelstein DI, Adlard PA.

Brain Inj. 2019;33(3):305-312. doi: 10.1080/02699052.2018.1552988. Epub 2018 Dec 3.


Targeting metals rescues the phenotype in an animal model of tauopathy.

Sedjahtera A, Gunawan L, Bray L, Hung LW, Parsons J, Okamura N, Villemagne VL, Yanai K, Liu XM, Chan J, Bush AI, Finkelstein DI, Barnham KJ, Cherny RA, Adlard PA.

Metallomics. 2018 Sep 19;10(9):1339-1347. doi: 10.1039/c8mt00153g.


Prion acute synaptotoxicity is largely driven by protease-resistant PrPSc species.

Foliaki ST, Lewis V, Finkelstein DI, Lawson V, Coleman HA, Senesi M, Islam AMT, Chen F, Sarros S, Roberts B, Adlard PA, Collins SJ.

PLoS Pathog. 2018 Aug 8;14(8):e1007214. doi: 10.1371/journal.ppat.1007214. eCollection 2018 Aug.


Modulating Protein Phosphatase 2A Rescues Disease Phenotype in Neurodegenerative Tauopathies.

McKenzie-Nickson S, Chan J, Perez K, Hung LW, Cheng L, Sedjahtera A, Gunawan L, Adlard PA, Hayne DJ, McInnes LE, Donnelly PS, Finkelstein DI, Hill AF, Barnham KJ.

ACS Chem Neurosci. 2018 Nov 21;9(11):2731-2740. doi: 10.1021/acschemneuro.8b00161. Epub 2018 Jul 3.


Trehalose elevates brain zinc levels following controlled cortical impact in a mouse model of traumatic brain injury.

Portbury SD, Hare DJ, Bishop DP, Finkelstein DI, Doble PA, Adlard PA.

Metallomics. 2018 Jun 20;10(6):846-853. doi: 10.1039/c8mt00068a.


Acute Neurotoxicity Models of Prion Disease.

T Islam AM, Adlard PA, Finkelstein DI, Lewis V, Biggi S, Biasini E, Collins SJ.

ACS Chem Neurosci. 2018 Mar 21;9(3):431-445. doi: 10.1021/acschemneuro.7b00517. Epub 2018 Feb 14. Review.


Trehalose Improves Cognition in the Transgenic Tg2576 Mouse Model of Alzheimer's Disease.

Portbury SD, Hare DJ, Sgambelloni C, Perronnes K, Portbury AJ, Finkelstein DI, Adlard PA.

J Alzheimers Dis. 2017;60(2):549-560. doi: 10.3233/JAD-170322.


Trehalose improves traumatic brain injury-induced cognitive impairment.

Portbury SD, Hare DJ, Finkelstein DI, Adlard PA.

PLoS One. 2017 Aug 24;12(8):e0183683. doi: 10.1371/journal.pone.0183683. eCollection 2017.


The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease.

Finkelstein DI, Billings JL, Adlard PA, Ayton S, Sedjahtera A, Masters CL, Wilkins S, Shackleford DM, Charman SA, Bal W, Zawisza IA, Kurowska E, Gundlach AL, Ma S, Bush AI, Hare DJ, Doble PA, Crawford S, Gautier EC, Parsons J, Huggins P, Barnham KJ, Cherny RA.

Acta Neuropathol Commun. 2017 Jun 28;5(1):53. doi: 10.1186/s40478-017-0456-2.


Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease.

Hare DJ, Cardoso BR, Raven EP, Double KL, Finkelstein DI, Szymlek-Gay EA, Biggs BA.

NPJ Parkinsons Dis. 2017 Jan 5;3:1. doi: 10.1038/s41531-016-0004-y. eCollection 2017.


Analogues of desferrioxamine B designed to attenuate iron-mediated neurodegeneration: synthesis, characterisation and activity in the MPTP-mouse model of Parkinson's disease.

Gotsbacher MP, Telfer TJ, Witting PK, Double KL, Finkelstein DI, Codd R.

Metallomics. 2017 Jul 19;9(7):852-864. doi: 10.1039/c7mt00039a.


In vivo prion models and the disconnection between transmissibility and neurotoxicity.

Senesi M, Lewis V, Kim JH, Adlard PA, Finkelstein DI, Collins SJ.

Ageing Res Rev. 2017 Jul;36:156-164. doi: 10.1016/j.arr.2017.03.007. Epub 2017 Apr 24. Review.


Pramipexole restores depressed transmission in the ventral hippocampus following MPTP-lesion.

Castro-Hernández J, Adlard PA, Finkelstein DI.

Sci Rep. 2017 Mar 14;7:44426. doi: 10.1038/srep44426.


Age modulates the injury-induced metallomic profile in the brain.

Portbury SD, Hare DJ, Sgambelloni CJ, Bishop DP, Finkelstein DI, Doble PA, Adlard PA.

Metallomics. 2017 Apr 19;9(4):402-410. doi: 10.1039/c6mt00260a.


Ferroptosis and cell death mechanisms in Parkinson's disease.

Guiney SJ, Adlard PA, Bush AI, Finkelstein DI, Ayton S.

Neurochem Int. 2017 Mar;104:34-48. doi: 10.1016/j.neuint.2017.01.004. Epub 2017 Jan 9. Review.


Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.

Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, Finkelstein DI, Hellstrom J, Hergt JM, Woodhead JD, Doble PA.

Chem Sci. 2016 Oct 1;7(10):6576. doi: 10.1039/c6sc90060g. Epub 2016 Sep 7.


Transferrin protects against Parkinsonian neurotoxicity and is deficient in Parkinson's substantia nigra.

Ayton S, Lei P, Mclean C, Bush AI, Finkelstein DI.

Signal Transduct Target Ther. 2016 Sep 2;1:16015. doi: 10.1038/sigtrans.2016.15. eCollection 2016.


Pathogenic mechanisms of prion protein, amyloid-β and α-synuclein misfolding: the prion concept and neurotoxicity of protein oligomers.

Ugalde CL, Finkelstein DI, Lawson VA, Hill AF.

J Neurochem. 2016 Oct;139(2):162-180. doi: 10.1111/jnc.13772. Epub 2016 Sep 15. Review.


Metals in Alzheimer's and Parkinson's Disease: Relevance to Dementia with Lewy Bodies.

McAllum EJ, Finkelstein DI.

J Mol Neurosci. 2016 Nov;60(3):279-288. Epub 2016 Aug 8. Review.


Restoration of intestinal function in an MPTP model of Parkinson's Disease.

Ellett LJ, Hung LW, Munckton R, Sherratt NA, Culvenor J, Grubman A, Furness JB, White AR, Finkelstein DI, Barnham KJ, Lawson VA.

Sci Rep. 2016 Jul 29;6:30269. doi: 10.1038/srep30269.


Lithium suppression of tau induces brain iron accumulation and neurodegeneration.

Lei P, Ayton S, Appukuttan AT, Moon S, Duce JA, Volitakis I, Cherny R, Wood SJ, Greenough M, Berger G, Pantelis C, McGorry P, Yung A, Finkelstein DI, Bush AI.

Mol Psychiatry. 2017 Mar;22(3):396-406. doi: 10.1038/mp.2016.96. Epub 2016 Jul 12.


N-acetylcysteine modulates glutamatergic dysfunction and depressive behavior in Huntington's disease.

Wright DJ, Gray LJ, Finkelstein DI, Crouch PJ, Pow D, Pang TY, Li S, Smith ZM, Francis PS, Renoir T, Hannan AJ.

Hum Mol Genet. 2016 Jul 15;25(14):2923-2933. Epub 2016 May 14.


Graphene Functionalized Scaffolds Reduce the Inflammatory Response and Supports Endogenous Neuroblast Migration when Implanted in the Adult Brain.

Zhou K, Motamed S, Thouas GA, Bernard CC, Li D, Parkington HC, Coleman HA, Finkelstein DI, Forsythe JS.

PLoS One. 2016 Mar 15;11(3):e0151589. doi: 10.1371/journal.pone.0151589. eCollection 2016.


Iron Regulates Apolipoprotein E Expression and Secretion in Neurons and Astrocytes.

Xu H, Perreau VM, Dent KA, Bush AI, Finkelstein DI, Adlard PA.

J Alzheimers Dis. 2016;51(2):471-87. doi: 10.3233/JAD-150797.


Effects of Neonatal Iron Feeding and Chronic Clioquinol Administration on the Parkinsonian Human A53T Transgenic Mouse.

Billings JL, Hare DJ, Nurjono M, Volitakis I, Cherny RA, Bush AI, Adlard PA, Finkelstein DI.

ACS Chem Neurosci. 2016 Mar 16;7(3):360-6. doi: 10.1021/acschemneuro.5b00305. Epub 2016 Jan 7.


A time-course analysis of changes in cerebral metal levels following a controlled cortical impact.

Portbury SD, Hare DJ, Sgambelloni C, Finkelstein DI, Adlard PA.

Metallomics. 2016 Feb;8(2):193-200. doi: 10.1039/c5mt00234f.


Correction: Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.

Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedzwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, Finkelstein DI, Hellstrom J, Hergt JM, Woodhead JD, Doble PA.

Chem Sci. 2015 Nov 1;6(11):6677. doi: 10.1039/c5sc90051d. Epub 2015 Sep 10.


Clioquinol Improves Cognitive, Motor Function, and Microanatomy of the Alpha-Synuclein hA53T Transgenic Mice.

Finkelstein DI, Hare DJ, Billings JL, Sedjahtera A, Nurjono M, Arthofer E, George S, Culvenor JG, Bush AI, Adlard PA.

ACS Chem Neurosci. 2016 Jan 20;7(1):119-29. doi: 10.1021/acschemneuro.5b00253. Epub 2015 Oct 30.


Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging.

Paul B, Hare DJ, Bishop DP, Paton C, Nguyen VT, Cole N, Niedwiecki MM, Andreozzi E, Vais A, Billings JL, Bray L, Bush AI, McColl G, Roberts BR, Adlard PA, Finkelstein DI, Hellstrom J, Hergt JM, Woodhead JD, Doble PA.

Chem Sci. 2015 Oct 1;6(10):5383-5393. doi: 10.1039/c5sc02231b. Epub 2015 Jul 27. Erratum in: Chem Sci. 2015 Nov 1;6(11):6677. Chem Sci. 2016 Oct 1;7(10):6576.


Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau.

Li X, Lei P, Tuo Q, Ayton S, Li QX, Moon S, Volitakis I, Liu R, Masters CL, Finkelstein DI, Bush AI.

Neurotherapeutics. 2015 Oct;12(4):862-73. doi: 10.1007/s13311-015-0378-2.


Zinc affects the proteolytic stability of Apolipoprotein E in an isoform-dependent way.

Xu H, Gupta VB, Martins IJ, Martins RN, Fowler CJ, Bush AI, Finkelstein DI, Adlard PA.

Neurobiol Dis. 2015 Sep;81:38-48. doi: 10.1016/j.nbd.2015.06.016. Epub 2015 Jun 25.


Is early-life iron exposure critical in neurodegeneration?

Hare DJ, Arora M, Jenkins NL, Finkelstein DI, Doble PA, Bush AI.

Nat Rev Neurol. 2015 Sep;11(9):536-44. doi: 10.1038/nrneurol.2015.100. Epub 2015 Jun 23. Review.


Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy.

Davies KM, Hare DJ, Bohic S, James SA, Billings JL, Finkelstein DI, Doble PA, Double KL.

Anal Chem. 2015 Jul 7;87(13):6639-45. doi: 10.1021/acs.analchem.5b01454. Epub 2015 Jun 9.


Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.

Rivet CJ, Zhou K, Gilbert RJ, Finkelstein DI, Forsythe JS.

Biomatter. 2015;5:e1005527. doi: 10.1080/21592535.2015.1005527.


Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse.

Lei P, Ayton S, Appukuttan AT, Volitakis I, Adlard PA, Finkelstein DI, Bush AI.

Neurobiol Dis. 2015 Sep;81:168-75. doi: 10.1016/j.nbd.2015.03.015. Epub 2015 Mar 18.


Parkinson's disease iron deposition caused by nitric oxide-induced loss of β-amyloid precursor protein.

Ayton S, Lei P, Hare DJ, Duce JA, George JL, Adlard PA, McLean C, Rogers JT, Cherny RA, Finkelstein DI, Bush AI.

J Neurosci. 2015 Feb 25;35(8):3591-7. doi: 10.1523/JNEUROSCI.3439-14.2015.


Serotonergic markers in Parkinson's disease and levodopa-induced dyskinesias.

Cheshire P, Ayton S, Bertram KL, Ling H, Li A, McLean C, Halliday GM, O'Sullivan SS, Revesz T, Finkelstein DI, Storey E, Williams DR.

Mov Disord. 2015 May;30(6):796-804. doi: 10.1002/mds.26144. Epub 2015 Feb 4.


Metal chaperones prevent zinc-mediated cognitive decline.

Adlard PA, Parncutt J, Lal V, James S, Hare D, Doble P, Finkelstein DI, Bush AI.

Neurobiol Dis. 2015 Sep;81:196-202. doi: 10.1016/j.nbd.2014.12.012. Epub 2014 Dec 27.


A review of β-amyloid neuroimaging in Alzheimer's disease.

Adlard PA, Tran BA, Finkelstein DI, Desmond PM, Johnston LA, Bush AI, Egan GF.

Front Neurosci. 2014 Oct 31;8:327. doi: 10.3389/fnins.2014.00327. eCollection 2014. Review.


GSK-3β dysregulation contributes to parkinson's-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein.

Credle JJ, George JL, Wills J, Duka V, Shah K, Lee YC, Rodriguez O, Simkins T, Winter M, Moechars D, Steckler T, Goudreau J, Finkelstein DI, Sidhu A.

Cell Death Differ. 2015 May;22(5):838-51. doi: 10.1038/cdd.2014.179. Epub 2014 Nov 14.


High order W02-reactive stable oligomers of amyloid-β are produced in vivo and in vitro via dialysis and filtration of synthetic amyloid-β monomer.

Robb E, Perez K, Hung LW, Masters CL, Barnham KJ, Cherny RA, Bush AI, Adlard PA, Finkelstein DI.

J Alzheimers Dis. 2015;44(1):69-78. doi: 10.3233/JAD-132024.


Motor and cognitive deficits in aged tau knockout mice in two background strains.

Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI, Bush AI.

Mol Neurodegener. 2014 Aug 14;9:29. doi: 10.1186/1750-1326-9-29.


Iron accumulation confers neurotoxicity to a vulnerable population of nigral neurons: implications for Parkinson's disease.

Ayton S, Lei P, Adlard PA, Volitakis I, Cherny RA, Bush AI, Finkelstein DI.

Mol Neurodegener. 2014 Jul 10;9:27. doi: 10.1186/1750-1326-9-27.

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