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Efficient RNP-Directed Human Gene Targeting Reveals SPDEF is Required for IL-13-Induced Mucostasis.

Koh KD, Siddiqui S, Cheng D, Bonser LR, Sun DI, Zlock LT, Finkbeiner WE, Woodruff PG, Erle DJ.

Am J Respir Cell Mol Biol. 2019 Oct 9. doi: 10.1165/rcmb.2019-0266OC. [Epub ahead of print]


Na+/H+ Exchangers Are Required for the Development and Function of Vertebrate Mucociliary Epithelia.

Sun DI, Tasca A, Haas M, Baltazar G, Harland RM, Finkbeiner WE, Walentek P.

Cells Tissues Organs. 2018;205(5-6):279-292. doi: 10.1159/000492973. Epub 2018 Oct 9.


Combination potentiator ('co-potentiator') therapy for CF caused by CFTR mutants, including N1303K, that are poorly responsive to single potentiators.

Phuan PW, Son JH, Tan JA, Li C, Musante I, Zlock L, Nielson DW, Finkbeiner WE, Kurth MJ, Galietta LJ, Haggie PM, Verkman AS.

J Cyst Fibros. 2018 Sep;17(5):595-606. doi: 10.1016/j.jcf.2018.05.010. Epub 2018 Jun 12.


ΔF508-CFTR Modulator Screen Based on Cell Surface Targeting of a Chimeric Nucleotide Binding Domain 1 Reporter.

Phuan PW, Veit G, Tan JA, Roldan A, Finkbeiner WE, Haggie PM, Lukacs GL, Verkman AS.

SLAS Discov. 2018 Sep;23(8):823-831. doi: 10.1177/2472555218763310. Epub 2018 Mar 13.


Corticosteroid and long-acting ß-agonist therapy reduces epithelial goblet cell metaplasia.

Lachowicz-Scroggins ME, Finkbeiner WE, Gordon ED, Yuan S, Zlock L, Bhakta NR, Woodruff PG, Fahy JV, Boushey HA.

Clin Exp Allergy. 2017 Dec;47(12):1534-1545. doi: 10.1111/cea.13015. Epub 2017 Sep 26.


In vivo and in vitro ivacaftor response in cystic fibrosis patients with residual CFTR function: N-of-1 studies.

McGarry ME, Illek B, Ly NP, Zlock L, Olshansky S, Moreno C, Finkbeiner WE, Nielson DW.

Pediatr Pulmonol. 2017 Apr;52(4):472-479. doi: 10.1002/ppul.23659. Epub 2017 Jan 9.


Correctors and Potentiators Rescue Function of the Truncated W1282X-Cystic Fibrosis Transmembrane Regulator (CFTR) Translation Product.

Haggie PM, Phuan PW, Tan JA, Xu H, Avramescu RG, Perdomo D, Zlock L, Nielson DW, Finkbeiner WE, Lukacs GL, Verkman AS.

J Biol Chem. 2017 Jan 20;292(3):771-785. doi: 10.1074/jbc.M116.764720. Epub 2016 Nov 28.


Cigarette Smoke Mediates Nuclear to Cytoplasmic Trafficking of Transcriptional Inhibitor Kaiso through MUC1 and P120-Catenin.

Zhang L, Gallup M, Zlock L, Feeling Chen YT, Finkbeiner WE, McNamara NA.

Am J Pathol. 2016 Dec;186(12):3146-3159. doi: 10.1016/j.ajpath.2016.08.011. Epub 2016 Oct 17.


Correlation of Prenatal Diagnosis and Pathology Findings Following Dilation and Evacuation for Fetal Anomalies.

Boecking CA, Drey EA, Kerns JL, Finkbeiner WE.

Arch Pathol Lab Med. 2017 Feb;141(2):267-273. doi: 10.5858/arpa.2016-0029-OA. Epub 2016 Oct 20.


Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis.

Haggie PM, Phuan PW, Tan JA, Zlock L, Finkbeiner WE, Verkman AS.

FASEB J. 2016 Jun;30(6):2187-97. doi: 10.1096/fj.201600223R. Epub 2016 Mar 1.


Potentiators of Defective ΔF508-CFTR Gating that Do Not Interfere with Corrector Action.

Phuan PW, Veit G, Tan JA, Finkbeiner WE, Lukacs GL, Verkman AS.

Mol Pharmacol. 2015 Oct;88(4):791-9. doi: 10.1124/mol.115.099689. Epub 2015 Aug 5.


Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.

Veit G, Avramescu RG, Perdomo D, Phuan PW, Bagdany M, Apaja PM, Borot F, Szollosi D, Wu YS, Finkbeiner WE, Hegedus T, Verkman AS, Lukacs GL.

Sci Transl Med. 2014 Jul 23;6(246):246ra97. doi: 10.1126/scitranslmed.3008889.


Growth of alveoli during postnatal development in humans based on stereological estimation.

Herring MJ, Putney LF, Wyatt G, Finkbeiner WE, Hyde DM.

Am J Physiol Lung Cell Mol Physiol. 2014 Aug 15;307(4):L338-44. doi: 10.1152/ajplung.00094.2014. Epub 2014 Jun 6.


Pivotal role of MUC1 glycosylation by cigarette smoke in modulating disruption of airway adherens junctions in vitro.

Zhang L, Gallup M, Zlock L, Chen YT, Finkbeiner WE, McNamara NA.

J Pathol. 2014 Sep;234(1):60-73. doi: 10.1002/path.4375. Epub 2014 Jul 9.


Synergy-based small-molecule screen using a human lung epithelial cell line yields ΔF508-CFTR correctors that augment VX-809 maximal efficacy.

Phuan PW, Veit G, Tan J, Roldan A, Finkbeiner WE, Lukacs GL, Verkman AS.

Mol Pharmacol. 2014 Jul;86(1):42-51. doi: 10.1124/mol.114.092478. Epub 2014 Apr 15.


Intelectin-1 is a prominent protein constituent of pathologic mucus associated with eosinophilic airway inflammation in asthma.

Kerr SC, Carrington SD, Oscarson S, Gallagher ME, Solon M, Yuan S, Ahn JN, Dougherty RH, Finkbeiner WE, Peters MC, Fahy JV.

Am J Respir Crit Care Med. 2014 Apr 15;189(8):1005-7. doi: 10.1164/rccm.201312-2220LE. No abstract available.


Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia.

Blanchard E, Zlock L, Lao A, Mika D, Namkung W, Xie M, Scheitrum C, Gruenert DC, Verkman AS, Finkbeiner WE, Conti M, Richter W.

FASEB J. 2014 Feb;28(2):791-801. doi: 10.1096/fj.13-240861. Epub 2013 Nov 7.


Distribution and size of mucous glands in the ferret tracheobronchial tree.

Hajighasemi-Ossareh M, Borthwell RM, Lachowicz-Scroggins M, Stevens JE, Finkbeiner WE, Widdicombe JH.

Anat Rec (Hoboken). 2013 Nov;296(11):1768-74. doi: 10.1002/ar.22783. Epub 2013 Sep 17. Erratum in: Anat Rec (Hoboken). 2014 Jun;297(6):1163. Lachowicz-Scroggins, Marrah [added].


Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways.

Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara NA.

Am J Pathol. 2013 Jun;182(6):1986-95. doi: 10.1016/j.ajpath.2013.02.008. Epub 2013 Apr 2.


Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction.

Huang F, Zhang H, Wu M, Yang H, Kudo M, Peters CJ, Woodruff PG, Solberg OD, Donne ML, Huang X, Sheppard D, Fahy JV, Wolters PJ, Hogan BL, Finkbeiner WE, Li M, Jan YN, Jan LY, Rock JR.

Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16354-9. doi: 10.1073/pnas.1214596109. Epub 2012 Sep 17.


Airway epithelial miRNA expression is altered in asthma.

Solberg OD, Ostrin EJ, Love MI, Peng JC, Bhakta NR, Hou L, Nguyen C, Solon M, Nguyen C, Barczak AJ, Zlock LT, Blagev DP, Finkbeiner WE, Ansel KM, Arron JR, Erle DJ, Woodruff PG.

Am J Respir Crit Care Med. 2012 Nov 15;186(10):965-74. doi: 10.1164/rccm.201201-0027OC. Epub 2012 Sep 6.


Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1.

Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA.

J Pathol. 2013 Jan;229(1):74-86. doi: 10.1002/path.4070. Epub 2012 Sep 28.


Chloride secretion by cultures of pig tracheal gland cells.

Widdicombe JH, Borthwell RM, Hajighasemi-Ossareh M, Lachowicz-Scroggins ME, Finkbeiner WE, Stevens JE, Modlin S.

Am J Physiol Lung Cell Mol Physiol. 2012 May 15;302(10):L1098-106. doi: 10.1152/ajplung.00253.2011. Epub 2012 Feb 24.


Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction.

Namkung W, Yao Z, Finkbeiner WE, Verkman AS.

FASEB J. 2011 Nov;25(11):4048-62. doi: 10.1096/fj.11-191627. Epub 2011 Aug 11.


Cystic fibrosis and the relationship between mucin and chloride secretion by cultures of human airway gland mucous cells.

Finkbeiner WE, Zlock LT, Morikawa M, Lao AY, Dasari V, Widdicombe JH.

Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L402-14. doi: 10.1152/ajplung.00210.2010. Epub 2011 Jul 1.


Hyperviscous airway periciliary and mucous liquid layers in cystic fibrosis measured by confocal fluorescence photobleaching.

Derichs N, Jin BJ, Song Y, Finkbeiner WE, Verkman AS.

FASEB J. 2011 Jul;25(7):2325-32. doi: 10.1096/fj.10-179549. Epub 2011 Mar 22.


CFTR and calcium-activated chloride channels in primary cultures of human airway gland cells of serous or mucous phenotype.

Fischer H, Illek B, Sachs L, Finkbeiner WE, Widdicombe JH.

Am J Physiol Lung Cell Mol Physiol. 2010 Oct;299(4):L585-94. doi: 10.1152/ajplung.00421.2009. Epub 2010 Jul 30.


CFTR-adenylyl cyclase I association responsible for UTP activation of CFTR in well-differentiated primary human bronchial cell cultures.

Namkung W, Finkbeiner WE, Verkman AS.

Mol Biol Cell. 2010 Aug 1;21(15):2639-48. doi: 10.1091/mbc.E09-12-1004. Epub 2010 Jun 16.


Interleukin-13-induced mucous metaplasia increases susceptibility of human airway epithelium to rhinovirus infection.

Lachowicz-Scroggins ME, Boushey HA, Finkbeiner WE, Widdicombe JH.

Am J Respir Cell Mol Biol. 2010 Dec;43(6):652-61. doi: 10.1165/rcmb.2009-0244OC. Epub 2010 Jan 15.


Cultures of human tracheal gland cells of mucous or serous phenotype.

Finkbeiner WE, Zlock LT, Mehdi I, Widdicombe JH.

In Vitro Cell Dev Biol Anim. 2010 May;46(5):450-6. doi: 10.1007/s11626-009-9262-x. Epub 2009 Dec 9.


Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function.

Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS.

Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1131-40. doi: 10.1152/ajplung.00085.2009. Epub 2009 Oct 9.


In vitro susceptibility to rhinovirus infection is greater for bronchial than for nasal airway epithelial cells in human subjects.

Lopez-Souza N, Favoreto S, Wong H, Ward T, Yagi S, Schnurr D, Finkbeiner WE, Dolganov GM, Widdicombe JH, Boushey HA, Avila PC.

J Allergy Clin Immunol. 2009 Jun;123(6):1384-90.e2. doi: 10.1016/j.jaci.2009.03.010. Epub 2009 May 9.


In situ measurement of airway surface liquid [K+] using a ratioable K+-sensitive fluorescent dye.

Namkung W, Song Y, Mills AD, Padmawar P, Finkbeiner WE, Verkman AS.

J Biol Chem. 2009 Jun 5;284(23):15916-26. doi: 10.1074/jbc.M808021200. Epub 2009 Apr 13.


Basolateral Cl channels in primary airway epithelial cultures.

Fischer H, Illek B, Finkbeiner WE, Widdicombe JH.

Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1432-43. Epub 2007 Feb 23.


Differentiated structure and function of primary cultures of monkey oviductal epithelium.

Rajagopal M, Tollner TL, Finkbeiner WE, Cherr GN, Widdicombe JH.

In Vitro Cell Dev Biol Anim. 2006 Sep-Oct;42(8-9):248-54.


Hypertonic saline therapy in cystic fibrosis: Evidence against the proposed mechanism involving aquaporins.

Levin MH, Sullivan S, Nielson D, Yang B, Finkbeiner WE, Verkman AS.

J Biol Chem. 2006 Sep 1;281(35):25803-12. Epub 2006 Jul 7.


Expansion of cultures of human tracheal epithelium with maintenance of differentiated structure and function.

Widdicombe JH, Sachs LA, Morrow JL, Finkbeiner WE.

Biotechniques. 2005 Aug;39(2):249-55.


Submucosal gland dysfunction as a primary defect in cystic fibrosis.

Salinas D, Haggie PM, Thiagarajah JR, Song Y, Rosbe K, Finkbeiner WE, Nielson DW, Verkman AS.

FASEB J. 2005 Mar;19(3):431-3. Epub 2004 Dec 13.


Disseminated microsporidiosis in a pancreas/kidney transplant recipient.

Carlson JR, Li L, Helton CL, Munn RJ, Wasson K, Perez RV, Gallay BJ, Finkbeiner WE.

Arch Pathol Lab Med. 2004 Mar;128(3):e41-3.


Effects of media on differentiation of cultured human tracheal epithelium.

Sachs LA, Finkbeiner WE, Widdicombe JH.

In Vitro Cell Dev Biol Anim. 2003 Jan-Feb;39(1-2):56-62.


Effects of growth surface on differentiation of cultures of human tracheal epithelium.

Widdicombe JH, Sachs LA, Finkbeiner WE.

In Vitro Cell Dev Biol Anim. 2003 Jan-Feb;39(1-2):51-5.


Protease XXIV increases detection of mucin gene expression during in situ hybridization in archival tissue.

Rheinhardt JM, Finkbeiner WE.

J Histochem Cytochem. 2001 Jul;49(7):923-4.


A comparative study of mammalian tracheal mucous glands.

Choi HK, Finkbeiner WE, Widdicombe JH.

J Anat. 2000 Oct;197 Pt 3:361-72.


Physiology and pathology of tracheobronchial glands.

Finkbeiner WE.

Respir Physiol. 1999 Dec 1;118(2-3):77-83. Review.


Measurement of fibroblast proliferative activity in bronchoalveolar lavage fluid in the analysis of obliterative bronchiolitis among lung transplant recipients.

Jonosono M, Fang KC, Keith FM, Turck CW, Blanc PD, Hall TS, Fukano AK, Rifkin CJ, Gold WM, Webb WR, Edinburgh KJ, Finkbeiner WE, Golden JA.

J Heart Lung Transplant. 1999 Oct;18(10):972-85.


Restoration of cyclic adenosine monophosphate-stimulated chloride channel activity in human cystic fibrosis tracheobronchial submucosal gland cells by adenovirus-mediated and cationic lipid-mediated gene transfer.

Jiang C, Finkbeiner WE, Widdicombe JH, Fang SL, Wang KX, Nietupski JB, Hehir KM, Cheng SH.

Am J Respir Cell Mol Biol. 1999 Jun;20(6):1107-15.


Alveolar epithelial fluid transport capacity in reperfusion lung injury after lung transplantation.

Ware LB, Golden JA, Finkbeiner WE, Matthay MA.

Am J Respir Crit Care Med. 1999 Mar;159(3):980-8.


Differential regulation of centrin genes during ciliogenesis in human tracheal epithelial cells.

LeDizet M, Beck JC, Finkbeiner WE.

Am J Physiol. 1998 Dec;275(6):L1145-56. doi: 10.1152/ajplung.1998.275.6.L1145.


Fluid transport across cultures of human tracheal glands is altered in cystic fibrosis.

Jiang C, Finkbeiner WE, Widdicombe JH, Miller SS.

J Physiol. 1997 Jun 15;501 ( Pt 3):637-47.


Fetal congenital cystic adenomatoid malformations of the lung: a clinicopathologic study of eleven cases.

Cha I, Adzick NS, Harrison MR, Finkbeiner WE.

Am J Surg Pathol. 1997 May;21(5):537-44.


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