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Items: 30


Flap Endonuclease 1 Mutations A159V and E160D Cause Genomic Instability by Slowing Reaction on Double-Flap Substrates.

Algasaier SI, Finger LD, Bennet IA, Grasby JA.

Biochemistry. 2018 Dec 18;57(50):6838-6847. doi: 10.1021/acs.biochem.8b00891. Epub 2018 Dec 5.


Regional conformational flexibility couples substrate specificity and scissile phosphate diester selectivity in human flap endonuclease 1.

Bennet IA, Finger LD, Baxter NJ, Ambrose B, Hounslow AM, Thompson MJ, Exell JC, Shahari NNBM, Craggs TD, Waltho JP, Grasby JA.

Nucleic Acids Res. 2018 Jun 20;46(11):5618-5633. doi: 10.1093/nar/gky293.


Corrigendum: Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.

Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA.

Nat Commun. 2017 Aug 7;8:16145. doi: 10.1038/ncomms16145. eCollection 2017.


Human Exonuclease 1 Threads 5'-Flap Substrates through Its Helical Arch.

Shaw SJ, Finger LD, Grasby JA.

Biochemistry. 2017 Jul 25;56(29):3704-3707. doi: 10.1021/acs.biochem.7b00507. Epub 2017 Jul 11.


Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.

Tsutakawa SE, Thompson MJ, Arvai AS, Neil AJ, Shaw SJ, Algasaier SI, Kim JC, Finger LD, Jardine E, Gotham VJB, Sarker AH, Her MZ, Rashid F, Hamdan SM, Mirkin SM, Grasby JA, Tainer JA.

Nat Commun. 2017 Jun 27;8:15855. doi: 10.1038/ncomms15855. Erratum in: Nat Commun. 2017 Aug 07;8:16145.


Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.

Exell JC, Thompson MJ, Finger LD, Shaw SJ, Debreczeni J, Ward TA, McWhirter C, Siöberg CL, Martinez Molina D, Abbott WM, Jones CD, Nissink JW, Durant ST, Grasby JA.

Nat Chem Biol. 2016 Oct;12(10):815-21. doi: 10.1038/nchembio.2148. Epub 2016 Aug 15.


DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction.

Algasaier SI, Exell JC, Bennet IA, Thompson MJ, Gotham VJ, Shaw SJ, Craggs TD, Finger LD, Grasby JA.

J Biol Chem. 2016 Apr 8;291(15):8258-68. doi: 10.1074/jbc.M115.698993. Epub 2016 Feb 16.


Proline scanning mutagenesis reveals a role for the flap endonuclease-1 helical cap in substrate unpairing.

Patel N, Exell JC, Jardine E, Ombler B, Finger LD, Ciani B, Grasby JA.

J Biol Chem. 2013 Nov 22;288(47):34239-48. doi: 10.1074/jbc.M113.509489. Epub 2013 Oct 14.


Observation of unpaired substrate DNA in the flap endonuclease-1 active site.

Finger LD, Patel N, Beddows A, Ma L, Exell JC, Jardine E, Jones AC, Grasby JA.

Nucleic Acids Res. 2013 Nov;41(21):9839-47. doi: 10.1093/nar/gkt737. Epub 2013 Aug 23.


The wonders of flap endonucleases: structure, function, mechanism and regulation.

Finger LD, Atack JM, Tsutakawa S, Classen S, Tainer J, Grasby J, Shen B.

Subcell Biochem. 2012;62:301-26. doi: 10.1007/978-94-007-4572-8_16. Review.


Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases.

Beddows A, Patel N, Finger LD, Atack JM, Williams DM, Grasby JA.

Chem Commun (Camb). 2012 Sep 14;48(71):8895-7. doi: 10.1039/c2cc33400c. Epub 2012 Jul 31.


Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.

Patel N, Atack JM, Finger LD, Exell JC, Thompson P, Tsutakawa S, Tainer JA, Williams DM, Grasby JA.

Nucleic Acids Res. 2012 May;40(10):4507-19. doi: 10.1093/nar/gks051. Epub 2012 Feb 8.


Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases.

Grasby JA, Finger LD, Tsutakawa SE, Atack JM, Tainer JA.

Trends Biochem Sci. 2012 Feb;37(2):74-84. doi: 10.1016/j.tibs.2011.10.003. Epub 2011 Nov 24. Review.


The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.

Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK.

Cell Cycle. 2011 Jun 15;10(12):1998-2007. Epub 2011 Jun 15.


Human flap endonuclease structures, DNA double-base flipping, and a unified understanding of the FEN1 superfamily.

Tsutakawa SE, Classen S, Chapados BR, Arvai AS, Finger LD, Guenther G, Tomlinson CG, Thompson P, Sarker AH, Shen B, Cooper PK, Grasby JA, Tainer JA.

Cell. 2011 Apr 15;145(2):198-211. doi: 10.1016/j.cell.2011.03.004.


Functional regulation of FEN1 nuclease and its link to cancer.

Zheng L, Jia J, Finger LD, Guo Z, Zer C, Shen B.

Nucleic Acids Res. 2011 Feb;39(3):781-94. doi: 10.1093/nar/gkq884. Epub 2010 Oct 6. Review.


The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis.

Finger LD, Blanchard MS, Theimer CA, Sengerová B, Singh P, Chavez V, Liu F, Grasby JA, Shen B.

J Biol Chem. 2009 Aug 14;284(33):22184-94. doi: 10.1074/jbc.M109.015065. Epub 2009 Jun 11.


Comprehensive mapping of the C-terminus of flap endonuclease-1 reveals distinct interaction sites for five proteins that represent different DNA replication and repair pathways.

Guo Z, Chavez V, Singh P, Finger LD, Hang H, Hegde ML, Shen B.

J Mol Biol. 2008 Mar 28;377(3):679-90. doi: 10.1016/j.jmb.2007.10.074. Epub 2007 Nov 4.


The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.

Liu R, Qiu J, Finger LD, Zheng L, Shen B.

Nucleic Acids Res. 2006 Mar 31;34(6):1772-84. Print 2006.


Structure of the Tetrahymena thermophila telomerase RNA helix II template boundary element.

Richards RJ, Theimer CA, Finger LD, Feigon J.

Nucleic Acids Res. 2006 Feb 1;34(3):816-25. Print 2006.


Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

Shen B, Singh P, Liu R, Qiu J, Zheng L, Finger LD, Alas S.

Bioessays. 2005 Jul;27(7):717-29. Review.


Structure determination of protein/RNA complexes by NMR.

Wu H, Finger LD, Feigon J.

Methods Enzymol. 2005;394:525-45.


Contributions of the RNA-binding and linker domains and RNA structure to the specificity and affinity of the nucleolin RBD12/NRE interaction.

Finger LD, Johansson C, Rinaldi B, Bouvet P, Feigon J.

Biochemistry. 2004 Jun 8;43(22):6937-47.


Solution structure of the complex formed by the two N-terminal RNA-binding domains of nucleolin and a pre-rRNA target.

Johansson C, Finger LD, Trantirek L, Mueller TD, Kim S, Laird-Offringa IA, Feigon J.

J Mol Biol. 2004 Apr 2;337(4):799-816.


Solution structures of stem-loop RNAs that bind to the two N-terminal RNA-binding domains of nucleolin.

Finger LD, Trantirek L, Johansson C, Feigon J.

Nucleic Acids Res. 2003 Nov 15;31(22):6461-72.


Mutations linked to dyskeratosis congenita cause changes in the structural equilibrium in telomerase RNA.

Theimer CA, Finger LD, Trantirek L, Feigon J.

Proc Natl Acad Sci U S A. 2003 Jan 21;100(2):449-54. Epub 2003 Jan 13.


Solution nuclear magnetic resonance probing of cation binding sites on nucleic acids.

Feigon J, Butcher SE, Finger LD, Hud NV.

Methods Enzymol. 2001;338:400-20. Review. No abstract available.


Recognition of pre-formed and flexible elements of an RNA stem-loop by nucleolin.

Bouvet P, Allain FH, Finger LD, Dieckmann T, Feigon J.

J Mol Biol. 2001 Jun 8;309(3):763-75. Erratum in: J Mol Biol 2001 Aug 3;311(1):229.


Enzymatic synthesis of a quorum-sensing autoinducer through use of defined substrates.

Moré MI, Finger LD, Stryker JL, Fuqua C, Eberhard A, Winans SC.

Science. 1996 Jun 14;272(5268):1655-8.


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