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Items: 1 to 50 of 104

1.

Loss of lipin 1-mediated phosphatidic acid phosphohydrolase activity in muscle leads to skeletal myopathy in mice.

Schweitzer GG, Collier SL, Chen Z, McCommis KS, Pittman SK, Yoshino J, Matkovich SJ, Hsu FF, Chrast R, Eaton JM, Harris TE, Weihl CC, Finck BN.

FASEB J. 2018 Jul 20:fj201800361R. doi: 10.1096/fj.201800361R. [Epub ahead of print]

PMID:
30028636
2.

Hepatic tristetraprolin promotes insulin resistance through RNA destabilization of FGF21.

Sawicki KT, Chang HC, Shapiro JS, Bayeva M, De Jesus A, Finck BN, Wertheim JA, Blackshear PJ, Ardehali H.

JCI Insight. 2018 Jul 12;3(13). pii: 95948. doi: 10.1172/jci.insight.95948. [Epub ahead of print]

3.

High-fat-diet-induced remission of diabetes in a subset of KATP -GOF insulin-secretory-deficient mice.

Yan Z, Shyr ZA, Fortunato M, Welscher A, Alisio M, Martino M, Finck BN, Conway H, Remedi MS.

Diabetes Obes Metab. 2018 Jun 12. doi: 10.1111/dom.13423. [Epub ahead of print]

PMID:
29896801
4.

Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.

Liss KHH, Lutkewitte AJ, Pietka T, Finck BN, Franczyk M, Yoshino J, Klein S, Hall AM.

J Lipid Res. 2018 Sep;59(9):1630-1639. doi: 10.1194/jlr.M084947. Epub 2018 May 31.

5.

The impact of diet-induced hepatic steatosis in a murine model of hepatic ischemia/reperfusion injury.

Liss KHH, McCommis KS, Chambers KT, Pietka TA, Schweitzer GG, Park SL, Nalbantoglu I, Weinheimer CJ, Hall AM, Finck BN.

Liver Transpl. 2018 Jul;24(7):908-921. doi: 10.1002/lt.25189.

PMID:
29729104
6.

Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.

Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR.

Food Chem Toxicol. 2018 May;115:273-283. doi: 10.1016/j.fct.2018.03.014. Epub 2018 Mar 11. No abstract available.

PMID:
29534981
7.

Treating fatty liver disease by modulating mitochondrial pyruvate metabolism.

Colca JR, McDonald WG, McCommis KS, Finck BN.

Hepatol Commun. 2017 Apr 18;1(3):193-197. doi: 10.1002/hep4.1036. eCollection 2017 May.

8.

Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.

Vozenilek AE, Navratil AR, Green JM, Coleman DT, Blackburn CMR, Finney AC, Pearson BH, Chrast R, Finck BN, Klein RL, Orr AW, Woolard MD.

Arterioscler Thromb Vasc Biol. 2018 Feb;38(2):324-334. doi: 10.1161/ATVBAHA.117.310455. Epub 2017 Dec 7. Erratum in: Arterioscler Thromb Vasc Biol. 2018 May;38(5):e89.

PMID:
29217509
9.

Inhibition of the Mitochondrial Pyruvate Carrier by Tolylfluanid.

Chen Y, McCommis KS, Ferguson D, Hall AM, Harris CA, Finck BN.

Endocrinology. 2018 Feb 1;159(2):609-621. doi: 10.1210/en.2017-00695.

PMID:
29126303
10.

ChREBP refines the hepatic response to fructose to protect the liver from injury.

Hall AM, Finck BN.

J Clin Invest. 2017 Jun 30;127(7):2533-2535. doi: 10.1172/JCI95008. Epub 2017 Jun 19.

11.

The beneficial metabolic effects of insulin sensitizers are not attenuated by mitochondrial pyruvate carrier 2 hypomorphism.

Vigueira PA, McCommis KS, Hodges WT, Schweitzer GG, Cole SL, Oonthonpan L, Taylor EB, McDonald WG, Kletzien RF, Colca JR, Finck BN.

Exp Physiol. 2017 Aug 1;102(8):985-999. doi: 10.1113/EP086380. Epub 2017 Jul 10.

12.

Reply.

McCommis KS, Colca JR, Finck BN.

Hepatology. 2018 May;67(5):2055-2056. doi: 10.1002/hep.29162. Epub 2017 May 27. No abstract available.

PMID:
28317182
13.

Targeting the mitochondrial pyruvate carrier attenuates fibrosis in a mouse model of nonalcoholic steatohepatitis.

McCommis KS, Hodges WT, Brunt EM, Nalbantoglu I, McDonald WG, Holley C, Fujiwara H, Schaffer JE, Colca JR, Finck BN.

Hepatology. 2017 May;65(5):1543-1556. doi: 10.1002/hep.29025. Epub 2017 Mar 30.

14.

PPARs and nonalcoholic fatty liver disease.

Liss KH, Finck BN.

Biochimie. 2017 May;136:65-74. doi: 10.1016/j.biochi.2016.11.009. Epub 2016 Dec 2. Review.

15.

Myeloid Cell-Specific Lipin-1 Deficiency Stimulates Endocrine Adiponectin-FGF15 Axis and Ameliorates Ethanol-Induced Liver Injury in Mice.

Wang J, Kim C, Jogasuria A, Han Y, Hu X, Wu J, Shen H, Chrast R, Finck BN, You M.

Sci Rep. 2016 Sep 26;6:34117. doi: 10.1038/srep34117.

16.

An ancestral role for the mitochondrial pyruvate carrier in glucose-stimulated insulin secretion.

McCommis KS, Hodges WT, Bricker DK, Wisidagama DR, Compan V, Remedi MS, Thummel CS, Finck BN.

Mol Metab. 2016 Jul 7;5(8):602-614. doi: 10.1016/j.molmet.2016.06.016. eCollection 2016 Aug.

17.

Mitochondrial Pyruvate Import Promotes Long-Term Survival of Antibody-Secreting Plasma Cells.

Lam WY, Becker AM, Kennerly KM, Wong R, Curtis JD, Llufrio EM, McCommis KS, Fahrmann J, Pizzato HA, Nunley RM, Lee J, Wolfgang MJ, Patti GJ, Finck BN, Pearce EL, Bhattacharya D.

Immunity. 2016 Jul 19;45(1):60-73. doi: 10.1016/j.immuni.2016.06.011. Epub 2016 Jul 5.

18.

Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis.

DeBosch BJ, Heitmeier MR, Mayer AL, Higgins CB, Crowley JR, Kraft TE, Chi M, Newberry EP, Chen Z, Finck BN, Davidson NO, Yarasheski KE, Hruz PW, Moley KH.

Sci Signal. 2016 Feb 23;9(416):ra21. doi: 10.1126/scisignal.aac5472.

19.

Loss of Mitochondrial Pyruvate Carrier 2 in the Liver Leads to Defects in Gluconeogenesis and Compensation via Pyruvate-Alanine Cycling.

McCommis KS, Chen Z, Fu X, McDonald WG, Colca JR, Kletzien RF, Burgess SC, Finck BN.

Cell Metab. 2015 Oct 6;22(4):682-94. doi: 10.1016/j.cmet.2015.07.028. Epub 2015 Sep 3.

20.

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

Finck BN, Hall AM.

Biomed Res Int. 2015;2015:104132. doi: 10.1155/2015/104132. Epub 2015 Jul 26. Review.

21.

Rhabdomyolysis-Associated Mutations in Human LPIN1 Lead to Loss of Phosphatidic Acid Phosphohydrolase Activity.

Schweitzer GG, Collier SL, Chen Z, Eaton JM, Connolly AM, Bucelli RC, Pestronk A, Harris TE, Finck BN.

JIMD Rep. 2015;23:113-22. doi: 10.1007/8904_2015_440. Epub 2015 May 13.

22.

Mitochondrial pyruvate transport: a historical perspective and future research directions.

McCommis KS, Finck BN.

Biochem J. 2015 Mar 15;466(3):443-54. doi: 10.1042/BJ20141171. Review.

23.

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice.

Schweitzer GG, Chen Z, Gan C, McCommis KS, Soufi N, Chrast R, Mitra MS, Yang K, Gross RW, Finck BN.

J Lipid Res. 2015 Apr;56(4):848-58. doi: 10.1194/jlr.M055962. Epub 2015 Feb 26.

24.

Head over hepatocytes for FGF21.

Potthoff MJ, Finck BN.

Diabetes. 2014 Dec;63(12):4013-5. doi: 10.2337/db14-1185. No abstract available.

25.

The functional characterization of long noncoding RNA SPRY4-IT1 in human melanoma cells.

Mazar J, Zhao W, Khalil AM, Lee B, Shelley J, Govindarajan SS, Yamamoto F, Ratnam M, Aftab MN, Collins S, Finck BN, Han X, Mattick JS, Dinger ME, Perera RJ.

Oncotarget. 2014 Oct 15;5(19):8959-69.

26.

Inhibiting monoacylglycerol acyltransferase 1 ameliorates hepatic metabolic abnormalities but not inflammation and injury in mice.

Soufi N, Hall AM, Chen Z, Yoshino J, Collier SL, Mathews JC, Brunt EM, Albert CJ, Graham MJ, Ford DA, Finck BN.

J Biol Chem. 2014 Oct 24;289(43):30177-88. doi: 10.1074/jbc.M114.595850. Epub 2014 Sep 11.

27.

An animal model with a cardiomyocyte-specific deletion of estrogen receptor alpha: functional, metabolic, and differential network analysis.

Devanathan S, Whitehead T, Schweitzer GG, Fettig N, Kovacs A, Korach KS, Finck BN, Shoghi KI.

PLoS One. 2014 Jul 7;9(7):e101900. doi: 10.1371/journal.pone.0101900. eCollection 2014.

28.

Mitochondrial pyruvate carrier 2 hypomorphism in mice leads to defects in glucose-stimulated insulin secretion.

Vigueira PA, McCommis KS, Schweitzer GG, Remedi MS, Chambers KT, Fu X, McDonald WG, Cole SL, Colca JR, Kletzien RF, Burgess SC, Finck BN.

Cell Rep. 2014 Jun 26;7(6):2042-2053. doi: 10.1016/j.celrep.2014.05.017. Epub 2014 Jun 5.

29.

Lipin 2 binds phosphatidic acid by the electrostatic hydrogen bond switch mechanism independent of phosphorylation.

Eaton JM, Takkellapati S, Lawrence RT, McQueeney KE, Boroda S, Mullins GR, Sherwood SG, Finck BN, Villén J, Harris TE.

J Biol Chem. 2014 Jun 27;289(26):18055-66. doi: 10.1074/jbc.M114.547604. Epub 2014 May 8.

30.

Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.

Hall AM, Soufi N, Chambers KT, Chen Z, Schweitzer GG, McCommis KS, Erion DM, Graham MJ, Su X, Finck BN.

Diabetes. 2014 Jul;63(7):2284-96. doi: 10.2337/db13-1502. Epub 2014 Mar 4.

31.

Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.

Debosch BJ, Chen Z, Saben JL, Finck BN, Moley KH.

J Biol Chem. 2014 Apr 18;289(16):10989-98. doi: 10.1074/jbc.M113.527002. Epub 2014 Feb 11.

32.

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

Chambers KT, Chen Z, Lai L, Leone TC, Towle HC, Kralli A, Crawford PA, Finck BN.

Mol Metab. 2013 May 9;2(3):194-204. doi: 10.1016/j.molmet.2013.05.001. eCollection 2013.

33.

Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice.

DeBosch BJ, Chen Z, Finck BN, Chi M, Moley KH.

Mol Endocrinol. 2013 Nov;27(11):1887-96. doi: 10.1210/me.2013-1137. Epub 2013 Sep 12.

34.

Hepatic-specific lipin-1 deficiency exacerbates experimental alcohol-induced steatohepatitis in mice.

Hu M, Yin H, Mitra MS, Liang X, Ajmo JM, Nadra K, Chrast R, Finck BN, You M.

Hepatology. 2013 Dec;58(6):1953-63. doi: 10.1002/hep.26589. Epub 2013 Oct 17.

35.

Identification of a mitochondrial target of thiazolidinedione insulin sensitizers (mTOT)--relationship to newly identified mitochondrial pyruvate carrier proteins.

Colca JR, McDonald WG, Cavey GS, Cole SL, Holewa DD, Brightwell-Conrad AS, Wolfe CL, Wheeler JS, Coulter KR, Kilkuskie PM, Gracheva E, Korshunova Y, Trusgnich M, Karr R, Wiley SE, Divakaruni AS, Murphy AN, Vigueira PA, Finck BN, Kletzien RF.

PLoS One. 2013 May 15;8(5):e61551. doi: 10.1371/journal.pone.0061551. Print 2013.

36.

Effect of Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding on branched-chain amino acid metabolism.

Magkos F, Bradley D, Schweitzer GG, Finck BN, Eagon JC, Ilkayeva O, Newgard CB, Klein S.

Diabetes. 2013 Aug;62(8):2757-61. doi: 10.2337/db13-0185. Epub 2013 Apr 22.

37.

Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals.

Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, Chen Z, Finck BN, Han DH, Magkos F, Conte C, Bradley D, Fraterrigo G, Eagon JC, Patterson BW, Colonna M, Klein S.

Gastroenterology. 2013 Aug;145(2):366-74.e1-3. doi: 10.1053/j.gastro.2013.04.010. Epub 2013 Apr 15.

38.

Liver-specific PGC-1beta deficiency leads to impaired mitochondrial function and lipogenic response to fasting-refeeding.

Chambers KT, Chen Z, Crawford PA, Fu X, Burgess SC, Lai L, Leone TC, Kelly DP, Finck BN.

PLoS One. 2012;7(12):e52645. doi: 10.1371/journal.pone.0052645. Epub 2012 Dec 28.

39.

Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.

Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24.

40.

Complex interplay between the lipin 1 and the hepatocyte nuclear factor 4 α (HNF4α) pathways to regulate liver lipid metabolism.

Chen Z, Gropler MC, Mitra MS, Finck BN.

PLoS One. 2012;7(12):e51320. doi: 10.1371/journal.pone.0051320. Epub 2012 Dec 7.

41.

IRE1α-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis.

Wang S, Chen Z, Lam V, Han J, Hassler J, Finck BN, Davidson NO, Kaufman RJ.

Cell Metab. 2012 Oct 3;16(4):473-86. doi: 10.1016/j.cmet.2012.09.003.

42.

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Solingapuram Sai KK, Kil KE, Tu Z, Chu W, Finck BN, Rothfuss JM, Shoghi KI, Welch MJ, Gropler RJ, Mach RH.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6233-6. doi: 10.1016/j.bmcl.2012.08.010. Epub 2012 Aug 9.

43.

Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione.

Chen Z, Vigueira PA, Chambers KT, Hall AM, Mitra MS, Qi N, McDonald WG, Colca JR, Kletzien RF, Finck BN.

J Biol Chem. 2012 Jul 6;287(28):23537-48. doi: 10.1074/jbc.M112.363960. Epub 2012 May 23.

44.

Sexually dimorphic effect of aging on skeletal muscle protein synthesis.

Smith GI, Reeds DN, Hall AM, Chambers KT, Finck BN, Mittendorfer B.

Biol Sex Differ. 2012 May 23;3(1):11. doi: 10.1186/2042-6410-3-11.

45.

A sweet new role for ubiquitin-specific protease 2 in controlling hepatic gluconeogenesis.

Finck BN.

Diabetes. 2012 May;61(5):993-4. doi: 10.2337/db12-0198. No abstract available.

46.

Evidence for regulated monoacylglycerol acyltransferase expression and activity in human liver.

Hall AM, Kou K, Chen Z, Pietka TA, Kumar M, Korenblat KM, Lee K, Ahn K, Fabbrini E, Klein S, Goodwin B, Finck BN.

J Lipid Res. 2012 May;53(5):990-9. doi: 10.1194/jlr.P025536. Epub 2012 Mar 6.

47.

Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice.

Hu M, Wang F, Li X, Rogers CQ, Liang X, Finck BN, Mitra MS, Zhang R, Mitchell DA, You M.

Hepatology. 2012 Feb;55(2):437-46. doi: 10.1002/hep.24708. Epub 2011 Dec 29.

48.

mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway.

Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN, Sabatini DM.

Cell. 2011 Aug 5;146(3):408-20. doi: 10.1016/j.cell.2011.06.034.

49.

FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.

Potthoff MJ, Boney-Montoya J, Choi M, He T, Sunny NE, Satapati S, Suino-Powell K, Xu HE, Gerard RD, Finck BN, Burgess SC, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2011 Jun 8;13(6):729-38. doi: 10.1016/j.cmet.2011.03.019.

50.

Cardiac lipin 1 expression is regulated by the peroxisome proliferator activated receptor γ coactivator 1α/estrogen related receptor axis.

Mitra MS, Schilling JD, Wang X, Jay PY, Huss JM, Su X, Finck BN.

J Mol Cell Cardiol. 2011 Jul;51(1):120-8. doi: 10.1016/j.yjmcc.2011.04.009. Epub 2011 Apr 28.

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