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Items: 28

1.

Efficacy of a Covalent ERK1/2 Inhibitor, CC-90003, in KRAS Mutant Cancer Models Reveals Novel Mechanisms of Response and Resistance.

Aronchik I, Dai Y, Labenski M, Barnes C, Jones T, QIao L, Beebe L, Malek M, Elis W, Shi T, Mavrommatis K, Bray GL, Filvaroff EH.

Mol Cancer Res. 2018 Oct 1. pii: molcanres.0554.2017. doi: 10.1158/1541-7786.MCR-17-0554. [Epub ahead of print]

PMID:
30275173
2.

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.

Thijssen R, Ter Burg J, Garrick B, van Bochove GG, Brown JR, Fernandes SM, Rodríguez MS, Michot JM, Hallek M, Eichhorst B, Reinhardt HC, Bendell J, Derks IA, van Kampen RJ, Hege K, Kersten MJ, Trowe T, Filvaroff EH, Eldering E, Kater AP.

Blood. 2016 Jul 28;128(4):574-83. doi: 10.1182/blood-2016-02-700328. Epub 2016 May 27.

3.

A technology platform to assess multiple cancer agents simultaneously within a patient's tumor.

Klinghoffer RA, Bahrami SB, Hatton BA, Frazier JP, Moreno-Gonzalez A, Strand AD, Kerwin WS, Casalini JR, Thirstrup DJ, You S, Morris SM, Watts KL, Veiseh M, Grenley MO, Tretyak I, Dey J, Carleton M, Beirne E, Pedro KD, Ditzler SH, Girard EJ, Deckwerth TL, Bertout JA, Meleo KA, Filvaroff EH, Chopra R, Press OW, Olson JM.

Sci Transl Med. 2015 Apr 22;7(284):284ra58. doi: 10.1126/scitranslmed.aaa7489.

4.

Viable tumor tissue detection in murine metastatic breast cancer by whole-body MRI and multispectral analysis.

Barck KH, Willis B, Ross J, French DM, Filvaroff EH, Carano RA.

Magn Reson Med. 2009 Dec;62(6):1423-30. doi: 10.1002/mrm.22109.

5.

Blocking neuropilin-2 function inhibits tumor cell metastasis.

Caunt M, Mak J, Liang WC, Stawicki S, Pan Q, Tong RK, Kowalski J, Ho C, Reslan HB, Ross J, Berry L, Kasman I, Zlot C, Cheng Z, Le Couter J, Filvaroff EH, Plowman G, Peale F, French D, Carano R, Koch AW, Wu Y, Watts RJ, Tessier-Lavigne M, Bagri A.

Cancer Cell. 2008 Apr;13(4):331-42. doi: 10.1016/j.ccr.2008.01.029.

6.

TGF-beta regulates the mechanical properties and composition of bone matrix.

Balooch G, Balooch M, Nalla RK, Schilling S, Filvaroff EH, Marshall GW, Marshall SJ, Ritchie RO, Derynck R, Alliston T.

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18813-8. Epub 2005 Dec 14.

7.

Loss of the serine/threonine kinase fused results in postnatal growth defects and lethality due to progressive hydrocephalus.

Merchant M, Evangelista M, Luoh SM, Frantz GD, Chalasani S, Carano RA, van Hoy M, Ramirez J, Ogasawara AK, McFarland LM, Filvaroff EH, French DM, de Sauvage FJ.

Mol Cell Biol. 2005 Aug;25(16):7054-68.

8.

Angiogenesis is required for successful bone induction during distraction osteogenesis.

Fang TD, Salim A, Xia W, Nacamuli RP, Guccione S, Song HM, Carano RA, Filvaroff EH, Bednarski MD, Giaccia AJ, Longaker MT.

J Bone Miner Res. 2005 Jul;20(7):1114-24. Epub 2005 Mar 7.

9.

VEGF and bone.

Filvaroff EH.

J Musculoskelet Neuronal Interact. 2003 Dec;3(4):304-7; discussion 320-1. No abstract available.

10.

Effect of anti-TGF-beta antibodies in syngeneic mouse models of metastasis.

Carano R, Li Y, Bao M, Li J, Berry L, Ross J, Kowalski J, French D, Dugger D, Schwall R, Wang Y, Fei D, Moseley SL, Filvaroff EH.

J Musculoskelet Neuronal Interact. 2004 Dec;4(4):377-8. No abstract available.

11.

WISP-1 is an osteoblastic regulator expressed during skeletal development and fracture repair.

French DM, Kaul RJ, D'Souza AL, Crowley CW, Bao M, Frantz GD, Filvaroff EH, Desnoyers L.

Am J Pathol. 2004 Sep;165(3):855-67.

12.

Creation and characterization of a mouse model of mandibular distraction osteogenesis.

Fang TD, Nacamuli RP, Song HM, Fong KD, Warren SM, Salim A, Carano RA, Filvaroff EH, Longaker MT.

Bone. 2004 Jun;34(6):1004-12.

PMID:
15193546
13.

Angiogenesis and bone repair.

Carano RA, Filvaroff EH.

Drug Discov Today. 2003 Nov 1;8(21):980-9. Review.

PMID:
14643161
14.

A slow release formulation of insulin as a treatment for osteoarthritis.

Cai L, Okumu FW, Cleland JL, Beresini M, Hogue D, Lin Z, Filvaroff EH.

Osteoarthritis Cartilage. 2002 Sep;10(9):692-706.

15.

Stanniocalcin 1 alters muscle and bone structure and function in transgenic mice.

Filvaroff EH, Guillet S, Zlot C, Bao M, Ingle G, Steinmetz H, Hoeffel J, Bunting S, Ross J, Carano RA, Powell-Braxton L, Wagner GF, Eckert R, Gerritsen ME, French DM.

Endocrinology. 2002 Sep;143(9):3681-90.

PMID:
12193584
16.

Interleukin 17 induced nitric oxide suppresses matrix synthesis and protects cartilage from matrix breakdown.

Cai L, Suboc P, Hogue DA, Fei DT, Filvaroff EH.

J Rheumatol. 2002 Aug;29(8):1725-36.

PMID:
12180737
17.

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover.

Street J, Bao M, deGuzman L, Bunting S, Peale FV Jr, Ferrara N, Steinmetz H, Hoeffel J, Cleland JL, Daugherty A, van Bruggen N, Redmond HP, Carano RA, Filvaroff EH.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9656-61. Epub 2002 Jul 12.

18.

Pathways by which interleukin 17 induces articular cartilage breakdown in vitro and in vivo.

Cai L, Yin JP, Starovasnik MA, Hogue DA, Hillan KJ, Mort JS, Filvaroff EH.

Cytokine. 2001 Oct 7;16(1):10-21.

PMID:
11669582
19.

IL-17s adopt a cystine knot fold: structure and activity of a novel cytokine, IL-17F, and implications for receptor binding.

Hymowitz SG, Filvaroff EH, Yin JP, Lee J, Cai L, Risser P, Maruoka M, Mao W, Foster J, Kelley RF, Pan G, Gurney AL, de Vos AM, Starovasnik MA.

EMBO J. 2001 Oct 1;20(19):5332-41.

20.

Functional inactivation of the IGF-I receptor delays differentiation of skeletal muscle cells.

Cheng ZQ, Adi S, Wu NY, Hsiao D, Woo EJ, Filvaroff EH, Gustafson TA, Rosenthal SM.

J Endocrinol. 2000 Oct;167(1):175-82.

PMID:
11018765
21.

Osteoblastic responses to TGF-beta during bone remodeling.

Erlebacher A, Filvaroff EH, Ye JQ, Derynck R.

Mol Biol Cell. 1998 Jul;9(7):1903-18.

22.

Expression of a truncated, kinase-defective TGF-beta type II receptor in mouse skeletal tissue promotes terminal chondrocyte differentiation and osteoarthritis.

Serra R, Johnson M, Filvaroff EH, LaBorde J, Sheehan DM, Derynck R, Moses HL.

J Cell Biol. 1997 Oct 20;139(2):541-52.

23.
25.

Vgr-1/BMP-6 induces osteoblastic differentiation of pluripotential mesenchymal cells.

Gitelman SE, Kirk M, Ye JQ, Filvaroff EH, Kahn AJ, Derynck R.

Cell Growth Differ. 1995 Jul;6(7):827-36.

26.

Toward a molecular understanding of skeletal development.

Erlebacher A, Filvaroff EH, Gitelman SE, Derynck R.

Cell. 1995 Feb 10;80(3):371-8. Review. No abstract available.

27.
28.

An emerging complexity of receptors for transforming growth factor-beta.

Derynck R, Chen RH, Ebner R, Filvaroff EH, Lawler S.

Princess Takamatsu Symp. 1994;24:264-75. Review.

PMID:
8983081

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