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Items: 21

1.

High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.

Anderhub SJ, Mak GW, Gurden MD, Faisal A, Drosopoulos K, Walsh K, Woodward HL, Innocenti P, Westwood IM, Naud S, Hayes A, Theofani E, Filosto S, Saville H, Burke R, van Montfort RLM, Raynaud FI, Blagg J, Hoelder S, Eccles SA, Linardopoulos S.

Mol Cancer Ther. 2019 Oct;18(10):1696-1707. doi: 10.1158/1535-7163.MCT-18-1203.

PMID:
31575759
2.

Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.

Bratt JM, Chang KY, Rabowsky M, Franzi LM, Ott SP, Filosto S, Goldkorn T, Arif M, Last JA, Kenyon NJ, Zeki AA.

J Immunol. 2018 Jun 1;200(11):3840-3856. doi: 10.4049/jimmunol.1601317. Epub 2018 Apr 27.

3.

Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MCU, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788b. No abstract available.

PMID:
28586336
4.

Erratum: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN.

Nat Med. 2017 Apr 7;23(4):526. doi: 10.1038/nm0417-526c. No abstract available.

PMID:
28388604
5.

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.

Brasó-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, Plumb DA, Zakka L, Gazinska P, Liccardi G, Meier P, Gris-Oliver A, Cheang MC, Perdrix-Rosell A, Shafat M, Noël E, Patel N, McEachern K, Scaltriti M, Castel P, Noor F, Buus R, Mathew S, Watkins J, Serra V, Marra P, Grigoriadis A, Tutt AN.

Nat Med. 2016 Nov;22(11):1303-1313. doi: 10.1038/nm.4198. Epub 2016 Oct 24. Erratum in: Nat Med. 2017 Apr 7;23 (4):526. Nat Med. 2017 Jun 6;23 (6):788.

6.

Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium.

Chung S, Vu S, Filosto S, Goldkorn T.

Am J Respir Cell Mol Biol. 2015 Jun;52(6):738-48. doi: 10.1165/rcmb.2014-0122OC.

7.
8.

Src mediates cigarette smoke-induced resistance to tyrosine kinase inhibitors in NSCLC cells.

Filosto S, Baston DS, Chung S, Becker CR, Goldkorn T.

Mol Cancer Ther. 2013 Aug;12(8):1579-90. doi: 10.1158/1535-7163.MCT-12-1029. Epub 2013 May 17.

9.

Lung cancer and lung injury: the dual role of ceramide.

Goldkorn T, Chung S, Filosto S.

Handb Exp Pharmacol. 2013;(216):93-113. doi: 10.1007/978-3-7091-1511-4_5. Review.

10.

Simvastatin inhibits smoke-induced airway epithelial injury: implications for COPD therapy.

Davis BB, Zeki AA, Bratt JM, Wang L, Filosto S, Walby WF, Kenyon NJ, Goldkorn T, Schelegle ES, Pinkerton KE.

Eur Respir J. 2013 Aug;42(2):350-61. doi: 10.1183/09031936.00042512. Epub 2012 Nov 22.

11.

Cigarette smoke induces aberrant EGF receptor activation that mediates lung cancer development and resistance to tyrosine kinase inhibitors.

Filosto S, Becker CR, Goldkorn T.

Mol Cancer Ther. 2012 Apr;11(4):795-804. doi: 10.1158/1535-7163.MCT-11-0698. Epub 2012 Feb 1.

12.

Neutral sphingomyelinase 2 activity and protein stability are modulated by phosphorylation of five conserved serines.

Filosto S, Ashfaq M, Chung S, Fry W, Goldkorn T.

J Biol Chem. 2012 Jan 2;287(1):514-22. doi: 10.1074/jbc.M111.315481. Epub 2011 Nov 10.

13.

EGF receptor exposed to oxidative stress acquires abnormal phosphorylation and aberrant activated conformation that impairs canonical dimerization.

Filosto S, Khan EM, Tognon E, Becker C, Ashfaq M, Ravid T, Goldkorn T.

PLoS One. 2011;6(8):e23240. doi: 10.1371/journal.pone.0023240. Epub 2011 Aug 10.

14.

Lung injury and cancer: Mechanistic insights into ceramide and EGFR signaling under cigarette smoke.

Goldkorn T, Filosto S.

Am J Respir Cell Mol Biol. 2010 Sep;43(3):259-68. doi: 10.1165/rcmb.2010-0220RT. Epub 2010 Jun 4. Review.

15.

Neutral sphingomyelinase 2: a novel target in cigarette smoke-induced apoptosis and lung injury.

Filosto S, Castillo S, Danielson A, Franzi L, Khan E, Kenyon N, Last J, Pinkerton K, Tuder R, Goldkorn T.

Am J Respir Cell Mol Biol. 2011 Mar;44(3):350-60. doi: 10.1165/rcmb.2009-0422OC. Epub 2010 May 6.

16.

Neutral sphingomyelinase 2 (nSMase2) is a phosphoprotein regulated by calcineurin (PP2B).

Filosto S, Fry W, Knowlton AA, Goldkorn T.

J Biol Chem. 2010 Apr 2;285(14):10213-22. doi: 10.1074/jbc.M109.069963. Epub 2010 Jan 27.

17.

New therapeutic prospects in HCV treatment.

Almasio PL, Ingrassia D, Vergara B, Filosto S.

Expert Rev Anti Infect Ther. 2008 Dec;6(6):775-9. doi: 10.1586/14787210.6.6.775. Review. No abstract available.

PMID:
19053890
18.

Environmentally relevant cadmium concentrations affect development and induce apoptosis of Paracentrotus lividus larvae cultured in vitro.

Filosto S, Roccheri MC, Bonaventura R, Matranga V.

Cell Biol Toxicol. 2008 Dec;24(6):603-10. doi: 10.1007/s10565-008-9066-x. Epub 2008 Mar 6.

PMID:
18322810
19.

Cadmium induces an apoptotic response in sea urchin embryos.

Agnello M, Filosto S, Scudiero R, Rinaldi AM, Roccheri MC.

Cell Stress Chaperones. 2007 Spring;12(1):44-50.

20.

Anaemia in cancer: pathophysiology and treatment.

Mercadante S, Gebbia V, Marrazzo A, Filosto S.

Cancer Treat Rev. 2000 Aug;26(4):303-11. Review.

PMID:
10913385
21.

Immunocytochemical determination of estrogen and progesterone receptors on 219 fine-needle aspirates of breast cancer. A prospective study.

Marrazzo A, Taormina P, Leonardi P, Lupo F, Filosto S.

Anticancer Res. 1995 Mar-Apr;15(2):521-6.

PMID:
7763033

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