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Cryo-EM reveals the structural basis of long-range electron transport in a cytochrome-based bacterial nanowire.

Filman DJ, Marino SF, Ward JE, Yang L, Mester Z, Bullitt E, Lovley DR, Strauss M.

Commun Biol. 2019 Jun 19;2:219. doi: 10.1038/s42003-019-0448-9. eCollection 2019.


A Small Covalent Allosteric Inhibitor of Human Cytomegalovirus DNA Polymerase Subunit Interactions.

Chen H, Coseno M, Ficarro SB, Mansueto MS, Komazin-Meredith G, Boissel S, Filman DJ, Marto JA, Hogle JM, Coen DM.

ACS Infect Dis. 2017 Feb 10;3(2):112-118. doi: 10.1021/acsinfecdis.6b00079. Epub 2016 Dec 6.


Getting to and through the inner nuclear membrane during herpesvirus nuclear egress.

Lye MF, Wilkie AR, Filman DJ, Hogle JM, Coen DM.

Curr Opin Cell Biol. 2017 Jun;46:9-16. doi: 10.1016/ Epub 2017 Jan 10. Review.


Cryo-electron Microscopy Structures of Expanded Poliovirus with VHHs Sample the Conformational Repertoire of the Expanded State.

Strauss M, Schotte L, Karunatilaka KS, Filman DJ, Hogle JM.

J Virol. 2017 Jan 18;91(3). pii: e01443-16. doi: 10.1128/JVI.01443-16. Print 2017 Feb 1.


Five of Five VHHs Neutralizing Poliovirus Bind the Receptor-Binding Site.

Strauss M, Schotte L, Thys B, Filman DJ, Hogle JM.

J Virol. 2016 Jan 13;90(7):3496-505. doi: 10.1128/JVI.03017-15.


Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex.

Lye MF, Sharma M, El Omari K, Filman DJ, Schuermann JP, Hogle JM, Coen DM.

EMBO J. 2015 Dec 2;34(23):2937-52. doi: 10.15252/embj.201592651. Epub 2015 Oct 28.


Structure of a herpesvirus nuclear egress complex subunit reveals an interaction groove that is essential for viral replication.

Leigh KE, Sharma M, Mansueto MS, Boeszoermenyi A, Filman DJ, Hogle JM, Wagner G, Coen DM, Arthanari H.

Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):9010-5. doi: 10.1073/pnas.1511140112. Epub 2015 Jul 6.


Characterization of Poliovirus Neutralization Escape Mutants of Single-Domain Antibody Fragments (VHHs).

Schotte L, Thys B, Strauss M, Filman DJ, Rombaut B, Hogle JM.

Antimicrob Agents Chemother. 2015 Aug;59(8):4695-706. doi: 10.1128/AAC.00878-15. Epub 2015 May 26.


Nectin-like interactions between poliovirus and its receptor trigger conformational changes associated with cell entry.

Strauss M, Filman DJ, Belnap DM, Cheng N, Noel RT, Hogle JM.

J Virol. 2015 Apr;89(8):4143-57. doi: 10.1128/JVI.03101-14. Epub 2015 Jan 28.


Structural dynamics as a contributor to error-prone replication by an RNA-dependent RNA polymerase.

Moustafa IM, Korboukh VK, Arnold JJ, Smidansky ED, Marcotte LL, Gohara DW, Yang X, Sánchez-Farrán MA, Filman D, Maranas JK, Boehr DD, Hogle JM, Colina CM, Cameron CE.

J Biol Chem. 2014 Dec 26;289(52):36229-48. doi: 10.1074/jbc.M114.616193. Epub 2014 Nov 6.


Mechanism of action and capsid-stabilizing properties of VHHs with an in vitro antipolioviral activity.

Schotte L, Strauss M, Thys B, Halewyck H, Filman DJ, Bostina M, Hogle JM, Rombaut B.

J Virol. 2014 Apr;88(8):4403-13. doi: 10.1128/JVI.03402-13. Epub 2014 Feb 5.


Cryo-electron microscopy reconstruction shows poliovirus 135S particles poised for membrane interaction and RNA release.

Butan C, Filman DJ, Hogle JM.

J Virol. 2014 Feb;88(3):1758-70. doi: 10.1128/JVI.01949-13. Epub 2013 Nov 20.


RNA transfer from poliovirus 135S particles across membranes is mediated by long umbilical connectors.

Strauss M, Levy HC, Bostina M, Filman DJ, Hogle JM.

J Virol. 2013 Apr;87(7):3903-14. doi: 10.1128/JVI.03209-12. Epub 2013 Jan 30.


Structure of the Fab-labeled "breathing" state of native poliovirus.

Lin J, Lee LY, Roivainen M, Filman DJ, Hogle JM, Belnap DM.

J Virol. 2012 May;86(10):5959-62. doi: 10.1128/JVI.05990-11. Epub 2012 Mar 7.


An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.

Lin J, Cheng N, Chow M, Filman DJ, Steven AC, Hogle JM, Belnap DM.

J Virol. 2011 Oct;85(19):9974-83. doi: 10.1128/JVI.05013-11. Epub 2011 Jul 20.


Poliovirus RNA is released from the capsid near a twofold symmetry axis.

Bostina M, Levy H, Filman DJ, Hogle JM.

J Virol. 2011 Jan;85(2):776-83. doi: 10.1128/JVI.00531-10. Epub 2010 Oct 27.


Catching a virus in the act of RNA release: a novel poliovirus uncoating intermediate characterized by cryo-electron microscopy.

Levy HC, Bostina M, Filman DJ, Hogle JM.

J Virol. 2010 May;84(9):4426-41. doi: 10.1128/JVI.02393-09. Epub 2010 Feb 24.


The crystal structure of PF-8, the DNA polymerase accessory subunit from Kaposi's sarcoma-associated herpesvirus.

Baltz JL, Filman DJ, Ciustea M, Silverman JE, Lautenschlager CL, Coen DM, Ricciardi RP, Hogle JM.

J Virol. 2009 Dec;83(23):12215-28. doi: 10.1128/JVI.01158-09. Epub 2009 Sep 16.


The human cytomegalovirus UL44 C clamp wraps around DNA.

Komazin-Meredith G, Petrella RJ, Santos WL, Filman DJ, Hogle JM, Verdine GL, Karplus M, Coen DM.

Structure. 2008 Aug 6;16(8):1214-25. doi: 10.1016/j.str.2008.05.008.


Post-imaging fiducial markers aid in the orientation determination of complexes with mixed or unknown symmetry.

Bubeck D, Filman DJ, Kuzmin M, Fuller SD, Hogle JM.

J Struct Biol. 2008 Jun;162(3):480-90. doi: 10.1016/j.jsb.2008.03.006. Epub 2008 Mar 25.


The positively charged surface of herpes simplex virus UL42 mediates DNA binding.

Komazin-Meredith G, Santos WL, Filman DJ, Hogle JM, Verdine GL, Coen DM.

J Biol Chem. 2008 Mar 7;283(10):6154-61. doi: 10.1074/jbc.M708691200. Epub 2008 Jan 4.


Single particle cryoelectron tomography characterization of the structure and structural variability of poliovirus-receptor-membrane complex at 30 A resolution.

Bostina M, Bubeck D, Schwartz C, Nicastro D, Filman DJ, Hogle JM.

J Struct Biol. 2007 Nov;160(2):200-10. Epub 2007 Aug 24.


Identification of a glycosaminoglycan binding region of the alpha C protein that mediates entry of group B Streptococci into host cells.

Baron MJ, Filman DJ, Prophete GA, Hogle JM, Madoff LC.

J Biol Chem. 2007 Apr 6;282(14):10526-36. Epub 2007 Jan 26.


Crystal structure of poliovirus 3CD protein: virally encoded protease and precursor to the RNA-dependent RNA polymerase.

Marcotte LL, Wass AB, Gohara DW, Pathak HB, Arnold JJ, Filman DJ, Cameron CE, Hogle JM.

J Virol. 2007 Apr;81(7):3583-96. Epub 2007 Jan 24.


A structural basis for allosteric control of DNA recombination by lambda integrase.

Biswas T, Aihara H, Radman-Livaja M, Filman D, Landy A, Ellenberger T.

Nature. 2005 Jun 23;435(7045):1059-66.


Cryo-electron microscopy reconstruction of a poliovirus-receptor-membrane complex.

Bubeck D, Filman DJ, Hogle JM.

Nat Struct Mol Biol. 2005 Jul;12(7):615-8. Epub 2005 Jun 19.


Crystal structure of the N-terminal domain of the group B streptococcus alpha C protein.

Aupérin TC, Bolduc GR, Baron MJ, Heroux A, Filman DJ, Madoff LC, Hogle JM.

J Biol Chem. 2005 May 6;280(18):18245-52. Epub 2005 Mar 6.


Cofolding organizes alfalfa mosaic virus RNA and coat protein for replication.

Guogas LM, Filman DJ, Hogle JM, Gehrke L.

Science. 2004 Dec 17;306(5704):2108-11.


Ligand-induced conformational changes in poliovirus-antiviral drug complexes.

Hiremath CN, Filman DJ, Grant RA, Hogle JM.

Acta Crystallogr D Biol Crystallogr. 1997 Sep 1;53(Pt 5):558-70.


The cytomegalovirus DNA polymerase subunit UL44 forms a C clamp-shaped dimer.

Appleton BA, Loregian A, Filman DJ, Coen DM, Hogle JM.

Mol Cell. 2004 Jul 23;15(2):233-44.


Structure of the coiled-coil dimerization motif of Sir4 and its interaction with Sir3.

Chang JF, Hall BE, Tanny JC, Moazed D, Filman D, Ellenberger T.

Structure. 2003 Jun;11(6):637-49. Erratum in: Structure (Camb). 2004 Aug;12(8):1547.


Use of MCSS to design small targeted libraries: application to picornavirus ligands.

Joseph-McCarthy D, Tsang SK, Filman DJ, Hogle JM, Karplus M.

J Am Chem Soc. 2001 Dec 26;123(51):12758-69.


The structure and oligomerization of the yeast arginine methyltransferase, Hmt1.

Weiss VH, McBride AE, Soriano MA, Filman DJ, Silver PA, Hogle JM.

Nat Struct Biol. 2000 Dec;7(12):1165-71.


Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus.

Belnap DM, Filman DJ, Trus BL, Cheng N, Booy FP, Conway JF, Curry S, Hiremath CN, Tsang SK, Steven AC, Hogle JM.

J Virol. 2000 Feb;74(3):1342-54.


Three-dimensional structure of poliovirus receptor bound to poliovirus.

Belnap DM, McDermott BM Jr, Filman DJ, Cheng N, Trus BL, Zuccola HJ, Racaniello VR, Hogle JM, Steven AC.

Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):73-8.


Crystal structure of a brominated RNA helix with four mismatched base pairs: An investigation into RNA conformational variability.

Anderson AC, O'Neil RH, Filman DJ, Frederick CA.

Biochemistry. 1999 Sep 28;38(39):12577-85.


Structure determination of echovirus 1.

Filman DJ, Wien MW, Cunningham JA, Bergelson JM, Hogle JM.

Acta Crystallogr D Biol Crystallogr. 1998 Nov 1;54(Pt 6 Pt 2):1261-72.


Crystal structure of a 14 bp RNA duplex with non-symmetrical tandem GxU wobble base pairs.

Trikha J, Filman DJ, Hogle JM.

Nucleic Acids Res. 1999 Apr 1;27(7):1728-39.


The crystal structure of Dps, a ferritin homolog that binds and protects DNA.

Grant RA, Filman DJ, Finkel SE, Kolter R, Hogle JM.

Nat Struct Biol. 1998 Apr;5(4):294-303.


Structural studies of poliovirus mutants that overcome receptor defects.

Wien MW, Curry S, Filman DJ, Hogle JM.

Nat Struct Biol. 1997 Aug;4(8):666-74.


A pseudo-cell based approach to efficient crystallographic refinement of viruses.

Jacobson DH, Hogle JM, Filman DJ.

Acta Crystallogr D Biol Crystallogr. 1996 Jul 1;52(Pt 4):693-711.


A genetic algorithm for the ab initio phasing of icosahedral viruses.

Miller ST, Hogle JM, Filman DJ.

Acta Crystallogr D Biol Crystallogr. 1996 Mar 1;52(Pt 2):235-51.


An enzyme-substrate complex involved in bacterial cell wall biosynthesis.

Benson TE, Filman DJ, Walsh CT, Hogle JM.

Nat Struct Biol. 1995 Aug;2(8):644-53.


Binding of the antiviral drug WIN51711 to the sabin strain of type 3 poliovirus: structural comparison with drug binding in rhinovirus 14.

Hiremath CN, Grant RA, Filman DJ, Hogle JM.

Acta Crystallogr D Biol Crystallogr. 1995 Jul 1;51(Pt 4):473-89.


Structure of the complex between the Fab fragment of a neutralizing antibody for type 1 poliovirus and its viral epitope.

Wien MW, Filman DJ, Stura EA, Guillot S, Delpeyroux F, Crainic R, Hogle JM.

Nat Struct Biol. 1995 Mar;2(3):232-43.


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