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Diminished inhibition and facilitated activation of RyR2-mediated Ca2+ release is a common defect of arrhythmogenic calmodulin mutations.

Søndergaard MT, Liu Y, Brohus M, Guo W, Nani A, Carvajal C, Fill M, Overgaard MT, Chen SRW.

FEBS J. 2019 Nov;286(22):4554-4578. doi: 10.1111/febs.14969. Epub 2019 Jul 12.


Multistate analysis of prospective Legionnaires' disease cluster detection using SaTScan, 2011-2015.

Edens C, Alden NB, Danila RN, Fill MA, Gacek P, Muse A, Parker E, Poissant T, Ryan PA, Smelser C, Tobin-D'Angelo M, Schrag SJ.

PLoS One. 2019 May 30;14(5):e0217632. doi: 10.1371/journal.pone.0217632. eCollection 2019.


Ryanodine Receptor Open Times Are Determined in the Closed State.

Fill M, Gillespie D.

Biophys J. 2018 Oct 2;115(7):1160-1165. doi: 10.1016/j.bpj.2018.08.025. Epub 2018 Sep 13.


Educational Disabilities Among Children Born With Neonatal Abstinence Syndrome.

Fill MA, Miller AM, Wilkinson RH, Warren MD, Dunn JR, Schaffner W, Jones TF.

Pediatrics. 2018 Sep;142(3). pii: e20180562. doi: 10.1542/peds.2018-0562.


Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease.

Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA.

Neurobiol Learn Mem. 2018 Oct;154:141-157. doi: 10.1016/j.nlm.2018.06.004. Epub 2018 Jun 12.


Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia.

Yan J, Thomson JK, Zhao W, Gao X, Huang F, Chen B, Liang Q, Song LS, Fill M, Ai X.

J Am Coll Cardiol. 2018 Apr 3;71(13):1459-1470. doi: 10.1016/j.jacc.2018.01.060. Erratum in: J Am Coll Cardiol. 2018 May 29;71(21):2495.


Predictors of Intravenous Immunoglobulin Nonresponse and Racial Disparities in Kawasaki Disease.

Clark DE, Denby KJ, Kaufman LM, Fill MA, Piya B, Krishnaswami S, Fonnesbeck C, Halasa N.

Pediatr Infect Dis J. 2018 Dec;37(12):1227-1234. doi: 10.1097/INF.0000000000002019.


Epidemiology and risk factors for hepatitis C virus infection in a high-prevalence population.

Fill MA, Sizemore LA, Rickles M, Cooper KC, Buecker CM, Mullins HL, Hofmeister MG, Abara WE, Foster MA, Asher AK, Schaffner W, Dunn JR, Jones TF, Wester C.

Epidemiol Infect. 2018 Mar;146(4):508-514. doi: 10.1017/S0950268818000080. Epub 2018 Feb 12.


Sarcoplasmic Reticulum Ca2+ Release Uses a Cascading Network of Intra-SR and Channel Countercurrents.

Zsolnay V, Fill M, Gillespie D.

Biophys J. 2018 Jan 23;114(2):462-473. doi: 10.1016/j.bpj.2017.11.3775.


Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.

Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X.

Cardiovasc Res. 2018 Apr 1;114(5):737-746. doi: 10.1093/cvr/cvy011.


Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.

Yan J, Zhao W, Thomson JK, Gao X, DeMarco DM, Carrillo E, Chen B, Wu X, Ginsburg KS, Bakhos M, Bers DM, Anderson ME, Song LS, Fill M, Ai X.

Circ Res. 2018 Mar 16;122(6):821-835. doi: 10.1161/CIRCRESAHA.117.312536. Epub 2018 Jan 19.


Notes from the Field: Legionellosis Outbreak Associated with a Hotel Aquatics Facility - Tennessee, 2017.

Yackley JK, Sweat D, Fill MA, Garman K, Dunn JR.

MMWR Morb Mortal Wkly Rep. 2018 Jan 19;67(2):77-78. doi: 10.15585/mmwr.mm6702a5. No abstract available.


Cryptosporidiosis Outbreak Associated With a Single Hotel.

Fill MA, Lloyd J, Chakraverty T, Sweat D, Manners J, Garman K, Hlavsa MC, Roellig DM, Dunn JR, Schaffner W, Jones TF.

J Environ Health. 2017 May;79(9):16-22.


Notes from the Field: Multiple Cases of Seoul Virus Infection in a Household with Infected Pet Rats - Tennessee, December 2016-April 2017.

Fill MA, Mullins H, May AS, Henderson H, Brown SM, Chiang CF, Patel NR, Klena JD, de St Maurice A, Knust B, Nichol ST, Dunn JR, Schaffner W, Jones TF.

MMWR Morb Mortal Wkly Rep. 2017 Oct 13;66(40):1081-1082. doi: 10.15585/mmwr.mm6640a4. No abstract available.


Evaluation of a Spotted Fever Group Rickettsia Public Health Surveillance System in Tennessee.

Fill MA, Moncayo AC, Bloch KC, Dunn JR, Schaffner W, Jones TF.

Am J Trop Med Hyg. 2017 Sep;97(3):789-794. doi: 10.4269/ajtmh.16-0765. Epub 2017 Jul 19.


Highly Selective Volatile Organic Compounds Breath Analysis Using a Broadly-Tunable Vertical-External-Cavity Surface-Emitting Laser.

Tuzson B, Jágerská J, Looser H, Graf M, Felder F, Fill M, Tappy L, Emmenegger L.

Anal Chem. 2017 Jun 20;89(12):6377-6383. doi: 10.1021/acs.analchem.6b04511. Epub 2017 May 26.


Extensive Ca2+ leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca2+ hypersensitivity.

Uehara A, Murayama T, Yasukochi M, Fill M, Horie M, Okamoto T, Matsuura Y, Uehara K, Fujimoto T, Sakurai T, Kurebayashi N.

J Gen Physiol. 2017 Feb;149(2):199-218. doi: 10.1085/jgp.201611624. Epub 2017 Jan 12.


Health Care Provider Knowledge and Attitudes Regarding Reporting Diseases and Events to Public Health Authorities in Tennessee.

Fill MA, Murphree R, Pettit AC.

J Public Health Manag Pract. 2017 Nov/Dec;23(6):581-588. doi: 10.1097/PHH.0000000000000492.


The Arrhythmogenic Calmodulin p.Phe142Leu Mutation Impairs C-domain Ca2+ Binding but Not Calmodulin-dependent Inhibition of the Cardiac Ryanodine Receptor.

Søndergaard MT, Liu Y, Larsen KT, Nani A, Tian X, Holt C, Wang R, Wimmer R, Van Petegem F, Fill M, Chen SR, Overgaard MT.

J Biol Chem. 2017 Jan 27;292(4):1385-1395. doi: 10.1074/jbc.M116.766253. Epub 2016 Dec 7.


Novel Clinical and Pathologic Findings in a Heartland Virus-Associated Death.

Fill MA, Compton ML, McDonald EC, Moncayo AC, Dunn JR, Schaffner W, Bhatnagar J, Zaki SR, Jones TF, Shieh WJ.

Clin Infect Dis. 2017 Feb 15;64(4):510-512. doi: 10.1093/cid/ciw766.


Sarcoplasmic reticulum Ca2+, Mg2+, K+, and Cl- concentrations adjust quickly as heart rate changes.

Berti C, Zsolnay V, Shannon TR, Fill M, Gillespie D.

J Mol Cell Cardiol. 2017 Feb;103:31-39. doi: 10.1016/j.yjmcc.2016.10.018. Epub 2016 Nov 30.


Notes from the Field: Measles Outbreak of Unknown Source - Shelby County, Tennessee, April-May 2016.

Fill MM, Sweat D, Morrow H, Haushalter A, Martin JC, Zerwekh T, Chakraverty T, Kmet J, Morris K, Moore K, Kainer M, Murphree R, Dunn JR, Schaffner W, Jones TF.

MMWR Morb Mortal Wkly Rep. 2016 Sep 30;65(38):1039-40. doi: 10.15585/mmwr.mm6538a3.


Nebivolol suppresses cardiac ryanodine receptor-mediated spontaneous Ca2+ release and catecholaminergic polymorphic ventricular tachycardia.

Tan Z, Xiao Z, Wei J, Zhang J, Zhou Q, Smith CD, Nani A, Wu G, Song LS, Back TG, Fill M, Chen SR.

Biochem J. 2016 Nov 15;473(22):4159-4172. Epub 2016 Sep 13.


Notes from the Field: Intoxication and Deaths Associated with Ingestion of a Racing Fuel and Carbonated Soft Drink Mixture - Tennessee, January 2016.

Fill MM, Seger DL, Dunn JR, Schaffner W, Jones TF.

MMWR Morb Mortal Wkly Rep. 2016 Jun 10;65(22):585-6. doi: 10.15585/mmwr.mm6522a4.


Approaching ryanodine receptor therapeutics from the calcin angle.

Ramos-Franco J, Fill M.

J Gen Physiol. 2016 May;147(5):369-73. doi: 10.1085/jgp.201611599. No abstract available.


Characterizing the Clamor: An In-Depth Analysis of Inpatient Paging Communication.

Kummerow Broman K, Kensinger C, Phillips C, Fesseha B, Fill MM, Borges N, Mathisen J, Allen D, Land E, Patel N.

Acad Med. 2016 Jul;91(7):1015-21. doi: 10.1097/ACM.0000000000001132.


Non-β-blocking R-carvedilol enantiomer suppresses Ca2+ waves and stress-induced ventricular tachyarrhythmia without lowering heart rate or blood pressure.

Zhang J, Zhou Q, Smith CD, Chen H, Tan Z, Chen B, Nani A, Wu G, Song LS, Fill M, Back TG, Chen SR.

Biochem J. 2015 Sep 1;470(2):233-42. doi: 10.1042/BJ20150548. Epub 2015 Jul 8.


Cytosolic Ca²⁺ buffering determines the intra-SR Ca²⁺ concentration at which cardiac Ca²⁺ sparks terminate.

Bovo E, Mazurek SR, Fill M, Zima AV.

Cell Calcium. 2015 Sep;58(3):246-53. doi: 10.1016/j.ceca.2015.06.002. Epub 2015 Jun 10.


The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice.

Zhang J, Chen B, Zhong X, Mi T, Guo A, Zhou Q, Tan Z, Wu G, Chen AW, Fill M, Song LS, Chen SR.

Biochem J. 2014 Jul 1;461(1):99-106. doi: 10.1042/BJ20140126.


The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias.

Chen W, Wang R, Chen B, Zhong X, Kong H, Bai Y, Zhou Q, Xie C, Zhang J, Guo A, Tian X, Jones PP, O'Mara ML, Liu Y, Mi T, Zhang L, Bolstad J, Semeniuk L, Cheng H, Zhang J, Chen J, Tieleman DP, Gillis AM, Duff HJ, Fill M, Song LS, Chen SR.

Nat Med. 2014 Feb;20(2):184-92. doi: 10.1038/nm.3440. Epub 2014 Jan 19.


Sarcoplasmic reticulum K(+) (TRIC) channel does not carry essential countercurrent during Ca(2+) release.

Guo T, Nani A, Shonts S, Perryman M, Chen H, Shannon T, Gillespie D, Fill M.

Biophys J. 2013 Sep 3;105(5):1151-60. doi: 10.1016/j.bpj.2013.07.042.


Potential role of cardiac calsequestrin in the lethal arrhythmic effects of cocaine.

Sanchez EJ, Hayes RP, Barr JT, Lewis KM, Webb BN, Subramanian AK, Nissen MS, Jones JP, Shelden EA, Sorg BA, Fill M, Schenk JO, Kang C.

Drug Alcohol Depend. 2013 Dec 1;133(2):344-51. doi: 10.1016/j.drugalcdep.2013.06.012. Epub 2013 Jul 19.


Mechanism of calsequestrin regulation of single cardiac ryanodine receptor in normal and pathological conditions.

Chen H, Valle G, Furlan S, Nani A, Gyorke S, Fill M, Volpe P.

J Gen Physiol. 2013 Aug;142(2):127-36. doi: 10.1085/jgp.201311022. Epub 2013 Jul 15.


Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca2+ release in a genetic model of arrhythmia.

Brunello L, Slabaugh JL, Radwanski PB, Ho HT, Belevych AE, Lou Q, Chen H, Napolitano C, Lodola F, Priori SG, Fedorov VV, Volpe P, Fill M, Janssen PM, Györke S.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):10312-7. doi: 10.1073/pnas.1300052110. Epub 2013 Jun 3.


Pernicious attrition and inter-RyR2 CICR current control in cardiac muscle.

Gillespie D, Fill M.

J Mol Cell Cardiol. 2013 May;58:53-8. doi: 10.1016/j.yjmcc.2013.01.011. Epub 2013 Jan 28. Review.


Ryanodine receptor current amplitude controls Ca2+ sparks in cardiac muscle.

Guo T, Gillespie D, Fill M.

Circ Res. 2012 Jun 22;111(1):28-36. doi: 10.1161/CIRCRESAHA.112.265652. Epub 2012 May 24.


Is ryanodine receptor a calcium or magnesium channel? Roles of K+ and Mg2+ during Ca2+ release.

Gillespie D, Chen H, Fill M.

Cell Calcium. 2012 Jun;51(6):427-33. doi: 10.1016/j.ceca.2012.02.001. Epub 2012 Mar 3.


Abnormal termination of Ca2+ release is a common defect of RyR2 mutations associated with cardiomyopathies.

Tang Y, Tian X, Wang R, Fill M, Chen SR.

Circ Res. 2012 Mar 30;110(7):968-77. doi: 10.1161/CIRCRESAHA.111.256560. Epub 2012 Feb 28.


Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release.

Zhou Q, Xiao J, Jiang D, Wang R, Vembaiyan K, Wang A, Smith CD, Xie C, Chen W, Zhang J, Tian X, Jones PP, Zhong X, Guo A, Chen H, Zhang L, Zhu W, Yang D, Li X, Chen J, Gillis AM, Duff HJ, Cheng H, Feldman AM, Song LS, Fill M, Back TG, Chen SR.

Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.


Single ryanodine receptor channel basis of caffeine's action on Ca2+ sparks.

Porta M, Zima AV, Nani A, Diaz-Sylvester PL, Copello JA, Ramos-Franco J, Blatter LA, Fill M.

Biophys J. 2011 Feb 16;100(4):931-8. doi: 10.1016/j.bpj.2011.01.017.


Ryanodol action on calcium sparks in ventricular myocytes.

Ramos-Franco J, Gomez AM, Nani A, Liu Y, Copello JA, Fill M.

Pflugers Arch. 2010 Sep;460(4):767-76. doi: 10.1007/s00424-010-0839-8. Epub 2010 Apr 24.


Flux regulation of cardiac ryanodine receptor channels.

Liu Y, Porta M, Qin J, Ramos J, Nani A, Shannon TR, Fill M.

J Gen Physiol. 2010 Jan;135(1):15-27. doi: 10.1085/jgp.200910273. Epub 2009 Dec 14.


Reinterpreting the anomalous mole fraction effect: the ryanodine receptor case study.

Gillespie D, Giri J, Fill M.

Biophys J. 2009 Oct 21;97(8):2212-21. doi: 10.1016/j.bpj.2009.08.009.


Ryanodine receptor luminal Ca2+ regulation: swapping calsequestrin and channel isoforms.

Qin J, Valle G, Nani A, Chen H, Ramos-Franco J, Nori A, Volpe P, Fill M.

Biophys J. 2009 Oct 7;97(7):1961-70. doi: 10.1016/j.bpj.2009.07.030.


Trifluoperazine: a rynodine receptor agonist.

Qin J, Zima AV, Porta M, Blatter LA, Fill M.

Pflugers Arch. 2009 Aug;458(4):643-51. doi: 10.1007/s00424-009-0658-y. Epub 2009 Mar 11.


Optically pumped 5 microm IV-VI VECSEL with Al-heat spreader.

Rahim M, Felder F, Fill M, Zogg H.

Opt Lett. 2008 Dec 15;33(24):3010-2.


Tricyclic antidepressant amitriptyline alters sarcoplasmic reticulum calcium handling in ventricular myocytes.

Zima AV, Qin J, Fill M, Blatter LA.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2008-16. doi: 10.1152/ajpheart.00523.2008. Epub 2008 Sep 12.


Intracellular calcium release channels mediate their own countercurrent: the ryanodine receptor case study.

Gillespie D, Fill M.

Biophys J. 2008 Oct;95(8):3706-14. doi: 10.1529/biophysj.108.131987. Epub 2008 Jul 11.


Luminal Ca2+ regulation of single cardiac ryanodine receptors: insights provided by calsequestrin and its mutants.

Qin J, Valle G, Nani A, Nori A, Rizzi N, Priori SG, Volpe P, Fill M.

J Gen Physiol. 2008 Apr;131(4):325-34. doi: 10.1085/jgp.200709907. Epub 2008 Mar 17.


Ca2+ entry-independent effects of L-type Ca2+ channel modulators on Ca2+ sparks in ventricular myocytes.

Copello JA, Zima AV, Diaz-Sylvester PL, Fill M, Blatter LA.

Am J Physiol Cell Physiol. 2007 Jun;292(6):C2129-40. Epub 2007 Feb 21.

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