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Items: 41


CTCF Expression is Essential for Somatic Cell Viability and Protection Against Cancer.

Bailey CG, Metierre C, Feng Y, Baidya K, Filippova GN, Loukinov DI, Lobanenkov VV, Semaan C, Rasko JE.

Int J Mol Sci. 2018 Nov 30;19(12). pii: E3832. doi: 10.3390/ijms19123832.


A Single-Cell Atlas of In Vivo Mammalian Chromatin Accessibility.

Cusanovich DA, Hill AJ, Aghamirzaie D, Daza RM, Pliner HA, Berletch JB, Filippova GN, Huang X, Christiansen L, DeWitt WS, Lee C, Regalado SG, Read DF, Steemers FJ, Disteche CM, Trapnell C, Shendure J.

Cell. 2018 Aug 23;174(5):1309-1324.e18. doi: 10.1016/j.cell.2018.06.052. Epub 2018 Aug 2.


Small noncoding RNAs in FSHD2 muscle cells reveal both DUX4- and SMCHD1-specific signatures.

Lim JW, Wong CJ, Yao Z, Tawil R, van der Maarel SM, Miller DG, Tapscott SJ, Filippova GN.

Hum Mol Genet. 2018 Aug 1;27(15):2644-2657. doi: 10.1093/hmg/ddy173.


Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome.

Bonora G, Deng X, Fang H, Ramani V, Qiu R, Berletch JB, Filippova GN, Duan Z, Shendure J, Noble WS, Disteche CM.

Nat Commun. 2018 Apr 13;9(1):1445. doi: 10.1038/s41467-018-03694-y.


SMCHD1 regulates a limited set of gene clusters on autosomal chromosomes.

Mason AG, Slieker RC, Balog J, Lemmers RJLF, Wong CJ, Yao Z, Lim JW, Filippova GN, Ne E, Tawil R, Heijmans BT, Tapscott SJ, van der Maarel SM.

Skelet Muscle. 2017 Jun 6;7(1):12. doi: 10.1186/s13395-017-0129-7.


DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD.

Lim JW, Snider L, Yao Z, Tawil R, Van Der Maarel SM, Rigo F, Bennett CF, Filippova GN, Tapscott SJ.

Hum Mol Genet. 2015 Sep 1;24(17):4817-28. doi: 10.1093/hmg/ddv206. Epub 2015 Jun 3.


The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation.

Yang F, Deng X, Ma W, Berletch JB, Rabaia N, Wei G, Moore JM, Filippova GN, Xu J, Liu Y, Noble WS, Shendure J, Disteche CM.

Genome Biol. 2015 Mar 12;16:52. doi: 10.1186/s13059-015-0618-0.


CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

Kemp CJ, Moore JM, Moser R, Bernard B, Teater M, Smith LE, Rabaia NA, Gurley KE, Guinney J, Busch SE, Shaknovich R, Lobanenkov VV, Liggitt D, Shmulevich I, Melnick A, Filippova GN.

Cell Rep. 2014 May 22;7(4):1020-9. doi: 10.1016/j.celrep.2014.04.004. Epub 2014 May 1.


Digenic inheritance of an SMCHD1 mutation and an FSHD-permissive D4Z4 allele causes facioscapulohumeral muscular dystrophy type 2.

Lemmers RJ, Tawil R, Petek LM, Balog J, Block GJ, Santen GW, Amell AM, van der Vliet PJ, Almomani R, Straasheijm KR, Krom YD, Klooster R, Sun Y, den Dunnen JT, Helmer Q, Donlin-Smith CM, Padberg GW, van Engelen BG, de Greef JC, Aartsma-Rus AM, Frants RR, de Visser M, Desnuelle C, Sacconi S, Filippova GN, Bakker B, Bamshad MJ, Tapscott SJ, Miller DG, van der Maarel SM.

Nat Genet. 2012 Dec;44(12):1370-4. doi: 10.1038/ng.2454. Epub 2012 Nov 11.


Facioscapulohumeral muscular dystrophy: consequences of chromatin relaxation.

van der Maarel SM, Miller DG, Tawil R, Filippova GN, Tapscott SJ.

Curr Opin Neurol. 2012 Oct;25(5):614-20. doi: 10.1097/WCO.0b013e328357f22d. Review.


Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUX4 production.

Block GJ, Petek LM, Narayanan D, Amell AM, Moore JM, Rabaia NA, Tyler A, van der Maarel SM, Tawil R, Filippova GN, Miller DG.

PLoS One. 2012;7(4):e35532. doi: 10.1371/journal.pone.0035532. Epub 2012 Apr 20.


Loss of maternal CTCF is associated with peri-implantation lethality of Ctcf null embryos.

Moore JM, Rabaia NA, Smith LE, Fagerlie S, Gurley K, Loukinov D, Disteche CM, Collins SJ, Kemp CJ, Lobanenkov VV, Filippova GN.

PLoS One. 2012;7(4):e34915. doi: 10.1371/journal.pone.0034915. Epub 2012 Apr 20.


CTCF regulates ataxin-7 expression through promotion of a convergently transcribed, antisense noncoding RNA.

Sopher BL, Ladd PD, Pineda VV, Libby RT, Sunkin SM, Hurley JB, Thienes CP, Gaasterland T, Filippova GN, La Spada AR.

Neuron. 2011 Jun 23;70(6):1071-84. doi: 10.1016/j.neuron.2011.05.027.


Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.

Snider L, Geng LN, Lemmers RJ, Kyba M, Ware CB, Nelson AM, Tawil R, Filippova GN, van der Maarel SM, Tapscott SJ, Miller DG.

PLoS Genet. 2010 Oct 28;6(10):e1001181. doi: 10.1371/journal.pgen.1001181.


RNA transcripts, miRNA-sized fragments and proteins produced from D4Z4 units: new candidates for the pathophysiology of facioscapulohumeral dystrophy.

Snider L, Asawachaicharn A, Tyler AE, Geng LN, Petek LM, Maves L, Miller DG, Lemmers RJ, Winokur ST, Tawil R, van der Maarel SM, Filippova GN, Tapscott SJ.

Hum Mol Genet. 2009 Jul 1;18(13):2414-30. doi: 10.1093/hmg/ddp180. Epub 2009 Apr 9.


CTCF cis-regulates trinucleotide repeat instability in an epigenetic manner: a novel basis for mutational hot spot determination.

Libby RT, Hagerman KA, Pineda VV, Lau R, Cho DH, Baccam SL, Axford MM, Cleary JD, Moore JM, Sopher BL, Tapscott SJ, Filippova GN, Pearson CE, La Spada AR.

PLoS Genet. 2008 Nov;4(11):e1000257. doi: 10.1371/journal.pgen.1000257. Epub 2008 Nov 14.


CTCF physically links cohesin to chromatin.

Rubio ED, Reiss DJ, Welcsh PL, Disteche CM, Filippova GN, Baliga NS, Aebersold R, Ranish JA, Krumm A.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8309-14. doi: 10.1073/pnas.0801273105. Epub 2008 Jun 11.


Genetics and epigenetics of the multifunctional protein CTCF.

Filippova GN.

Curr Top Dev Biol. 2008;80:337-60. Review.


An antisense transcript spanning the CGG repeat region of FMR1 is upregulated in premutation carriers but silenced in full mutation individuals.

Ladd PD, Smith LE, Rabaia NA, Moore JM, Georges SA, Hansen RS, Hagerman RJ, Tassone F, Tapscott SJ, Filippova GN.

Hum Mol Genet. 2007 Dec 15;16(24):3174-87. Epub 2007 Oct 6.


Antisense transcription and heterochromatin at the DM1 CTG repeats are constrained by CTCF.

Cho DH, Thienes CP, Mahoney SE, Analau E, Filippova GN, Tapscott SJ.

Mol Cell. 2005 Nov 11;20(3):483-9.


Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development.

Filippova GN, Cheng MK, Moore JM, Truong JP, Hu YJ, Nguyen DK, Tsuchiya KD, Disteche CM.

Dev Cell. 2005 Jan;8(1):31-42.


Escape from X inactivation.

Disteche CM, Filippova GN, Tsuchiya KD.

Cytogenet Genome Res. 2002;99(1-4):36-43. Review.


Thyroid hormone-regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor.

Lutz M, Burke LJ, LeFevre P, Myers FA, Thorne AW, Crane-Robinson C, Bonifer C, Filippova GN, Lobanenkov V, Renkawitz R.

EMBO J. 2003 Apr 1;22(7):1579-87.


Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.

Filippova GN, Qi CF, Ulmer JE, Moore JM, Ward MD, Hu YJ, Loukinov DI, Pugacheva EM, Klenova EM, Grundy PE, Feinberg AP, Cleton-Jansen AM, Moerland EW, Cornelisse CJ, Suzuki H, Komiya A, Lindblom A, Dorion-Bonnet F, Neiman PE, Morse HC 3rd, Collins SJ, Lobanenkov VV.

Cancer Res. 2002 Jan 1;62(1):48-52.


Cell growth inhibition by the multifunctional multivalent zinc-finger factor CTCF.

Rasko JE, Klenova EM, Leon J, Filippova GN, Loukinov DI, Vatolin S, Robinson AF, Hu YJ, Ulmer J, Ward MD, Pugacheva EM, Neiman PE, Morse HC 3rd, Collins SJ, Lobanenkov VV.

Cancer Res. 2001 Aug 15;61(16):6002-7.


CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus.

Filippova GN, Thienes CP, Penn BH, Cho DH, Hu YJ, Moore JM, Klesert TR, Lobanenkov VV, Tapscott SJ.

Nat Genet. 2001 Aug;28(4):335-43.


Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF.

Klenova EM, Chernukhin IV, El-Kady A, Lee RE, Pugacheva EM, Loukinov DI, Goodwin GH, Delgado D, Filippova GN, León J, Morse HC 3rd, Neiman PE, Lobanenkov VV.

Mol Cell Biol. 2001 Mar;21(6):2221-34.


[The use of low-frequency magnetotherapy and EHF puncture in the combined treatment of arterial hypertension in vibration-induced disease].

Drobyshev VA, Filippova GN, Loseva MI, Shpagina LA, Shelepova NV, Zhelezniak MS.

Vopr Kurortol Fizioter Lech Fiz Kult. 2000 May-Jun;(3):9-11. Russian.


Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence.

Awad TA, Bigler J, Ulmer JE, Hu YJ, Moore JM, Lutz M, Neiman PE, Collins SJ, Renkawitz R, Lobanenkov VV, Filippova GN.

J Biol Chem. 1999 Sep 17;274(38):27092-8.


Characterization of the chicken CTCF genomic locus, and initial study of the cell cycle-regulated promoter of the gene.

Klenova EM, Fagerlie S, Filippova GN, Kretzner L, Goodwin GH, Loring G, Neiman PE, Lobanenkov VV.

J Biol Chem. 1998 Oct 9;273(41):26571-9.


Mechanisms of cycloheximide-induced apoptosis in liver cells.

Alessenko AV, Boikov PYa, Filippova GN, Khrenov AV, Loginov AS, Makarieva ED.

FEBS Lett. 1997 Oct 13;416(1):113-6.


Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF.

Burcin M, Arnold R, Lutz M, Kaiser B, Runge D, Lottspeich F, Filippova GN, Lobanenkov VV, Renkawitz R.

Mol Cell Biol. 1997 Mar;17(3):1281-8.


An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes.

Filippova GN, Fagerlie S, Klenova EM, Myers C, Dehner Y, Goodwin G, Neiman PE, Collins SJ, Lobanenkov VV.

Mol Cell Biol. 1996 Jun;16(6):2802-13.


[Change in the level of sphingosine in rat liver nuclei and cells during oncogene superexpression induced by cycloheximide].

Alesenko AV, Boĭkov PIa, Drobot LB, Rusakov SA, Filippova GN.

Biokhimiia. 1994 Jul;59(7):1076-87. Russian.


[The effect of tumor necrosis factor on the free sphingosine level and sphingomyelinase in murine liver cells and nuclei].

Rusakov SA, Filippova GN, Pushkareva MIu, Korobko VG, Alesenko AV.

Biokhimiia. 1993 May;58(5):724-32. Russian.


[Change in the level of endogenous sphingosine in cell nuclei from regenerating rat liver].

Alesenko AV, Pantaz EA, Pushkareva MIu, Rusakov SA, Filippova GN.

Biokhimiia. 1993 Mar;58(3):461-70. Russian.


[Comparison of lipid metabolism in rat liver cells and nuclei during cycloheximide-induced superinduction of nuclear oncogenes].

Filippova GN, Borovkova OV, Alesenko AV.

Biokhimiia. 1991 May;56(5):892-902. Russian.


[Turbidimetric method of determination of glycogen synthase activity in rabbit skeletal muscles].

Solov'eva GA, Sundukov SIu, Filippova GN.

Vopr Med Khim. 1990 May-Jun;36(3):88-91. Russian.


[Expression of oncogenes in the rat liver under conditions of template biosynthesis uncoupling by sublethal doses of cycloheximide].

Filippova GN, Spitkovskiĭ DD, Boĭkov PIa, Alesenko AV.

Mol Biol (Mosk). 1989 May-Jun;23(3):843-50. Russian.


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