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Items: 1 to 50 of 102

1.

Tracking amyloid oligomerization with monomer resolution using a 13-amino acid peptide with a backbone-fixed spin label.

Zurlo E, Gorroño Bikandi I, Meeuwenoord NJ, Filippov DV, Huber M.

Phys Chem Chem Phys. 2019 Nov 7. doi: 10.1039/c9cp01060b. [Epub ahead of print]

PMID:
31696167
2.

Systematic Dual Targeting of Dendritic Cell C-Type Lectin Receptor DC-SIGN and TLR7 Using a Trifunctional Mannosylated Antigen.

Li RE, Hogervorst TP, Achilli S, Bruijns SC, Arnoldus T, Vivès C, Wong CC, Thépaut M, Meeuwenoord NJ, van den Elst H, Overkleeft HS, van der Marel GA, Filippov DV, van Vliet SJ, Fieschi F, Codée JDC, van Kooyk Y.

Front Chem. 2019 Oct 4;7:650. doi: 10.3389/fchem.2019.00650. eCollection 2019.

3.

Two-Step Bioorthogonal Activity-Based Protein Profiling of Individual Human Proteasome Catalytic Sites.

Xin BT, Espinal C, de Bruin G, Filippov DV, van der Marel GA, Florea BI, Overkleeft HS.

Chembiochem. 2019 Oct 9. doi: 10.1002/cbic.201900551. [Epub ahead of print]

PMID:
31597011
4.

Computational and NMR Studies on the Complexation of Lithium Ion to 8-Crown-4.

van der Ham A, Hansen T, Lodder G, Codée JDC, Hamlin TA, Filippov DV.

Chemphyschem. 2019 Aug 16;20(16):2103-2109. doi: 10.1002/cphc.201900496. Epub 2019 Jul 26.

5.

Defining the SN1 Side of Glycosylation Reactions: Stereoselectivity of Glycopyranosyl Cations.

Hansen T, Lebedel L, Remmerswaal WA, van der Vorm S, Wander DPA, Somers M, Overkleeft HS, Filippov DV, Désiré J, Mingot A, Bleriot Y, van der Marel GA, Thibaudeau S, Codée JDC.

ACS Cent Sci. 2019 May 22;5(5):781-788. doi: 10.1021/acscentsci.9b00042. Epub 2019 Apr 18.

6.

Chemical ADP-ribosylation: mono-ADPr-peptides and oligo-ADP-ribose.

Liu Q, van der Marel GA, Filippov DV.

Org Biomol Chem. 2019 Jun 5;17(22):5460-5474. doi: 10.1039/c9ob00501c. Review.

PMID:
31112180
7.

Peptides conjugated to 2-alkoxy-8-oxo-adenine as potential synthetic vaccines triggering TLR7.

Gential GPP, Hogervorst TP, Tondini E, van de Graaff MJ, Overkleeft HS, Codée JDC, van der Marel GA, Ossendorp F, Filippov DV.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1340-1344. doi: 10.1016/j.bmcl.2019.03.048. Epub 2019 Mar 30.

8.

Furanosyl Oxocarbenium Ion Conformational Energy Landscape Maps as a Tool to Study the Glycosylation Stereoselectivity of 2-Azidofuranoses, 2-Fluorofuranoses and Methyl Furanosyl Uronates.

van der Vorm S, Hansen T, van Rijssel ER, Dekkers R, Madern JM, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC.

Chemistry. 2019 May 23;25(29):7149-7157. doi: 10.1002/chem.201900651. Epub 2019 Apr 17.

9.

Dual Synthetic Peptide Conjugate Vaccine Simultaneously Triggers TLR2 and NOD2 and Activates Human Dendritic Cells.

Zom GG, Willems MMJHP, Meeuwenoord NJ, Reintjens NRM, Tondini E, Khan S, Overkleeft HS, van der Marel GA, Codee JDC, Ossendorp F, Filippov DV.

Bioconjug Chem. 2019 Apr 17;30(4):1150-1161. doi: 10.1021/acs.bioconjchem.9b00087. Epub 2019 Mar 26.

PMID:
30865430
10.

ELTA: Enzymatic Labeling of Terminal ADP-Ribose.

Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL.

Mol Cell. 2019 Feb 21;73(4):845-856.e5. doi: 10.1016/j.molcel.2018.12.022. Epub 2019 Jan 31.

PMID:
30712989
11.

Synthesis, Reactivity, and Stereoselectivity of 4-Thiofuranosides.

Madern JM, Hansen T, van Rijssel ER, Kistemaker HAV, van der Vorm S, Overkleeft HS, van der Marel GA, Filippov DV, Codée JDC.

J Org Chem. 2019 Feb 1;84(3):1218-1227. doi: 10.1021/acs.joc.8b02536. Epub 2019 Jan 14.

12.

Novel TLR2-binding adjuvant induces enhanced T cell responses and tumor eradication.

Zom GG, Willems MMJHP, Khan S, van der Sluis TC, Kleinovink JW, Camps MGM, van der Marel GA, Filippov DV, Melief CJM, Ossendorp F.

J Immunother Cancer. 2018 Dec 12;6(1):146. doi: 10.1186/s40425-018-0455-2.

13.

Fast and pH-Independent Elimination of trans-Cyclooctene by Using Aminoethyl-Functionalized Tetrazines.

Sarris AJC, Hansen T, de Geus MAR, Maurits E, Doelman W, Overkleeft HS, Codée JDC, Filippov DV, van Kasteren SI.

Chemistry. 2018 Dec 5;24(68):18075-18081. doi: 10.1002/chem.201803839. Epub 2018 Nov 8.

PMID:
30184286
14.

ADPr-Peptide Synthesis.

Kistemaker HAV, Voorneveld J, Filippov DV.

Methods Mol Biol. 2018;1813:345-369. doi: 10.1007/978-1-4939-8588-3_24.

PMID:
30097880
15.

Synthetic α- and β-Ser-ADP-ribosylated Peptides Reveal α-Ser-ADPr as the Native Epimer.

Voorneveld J, Rack JGM, Ahel I, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2018 Jul 6;20(13):4140-4143. doi: 10.1021/acs.orglett.8b01742. Epub 2018 Jun 27.

16.

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes.

van der Gracht AMF, de Geus MAR, Camps MGM, Ruckwardt TJ, Sarris AJC, Bremmers J, Maurits E, Pawlak JB, Posthoorn MM, Bonger KM, Filippov DV, Overkleeft HS, Robillard MS, Ossendorp F, van Kasteren SI.

ACS Chem Biol. 2018 Jun 15;13(6):1569-1576. doi: 10.1021/acschembio.8b00155. Epub 2018 May 11.

17.

Streamlined Synthesis and Evaluation of Teichoic Acid Fragments.

van der Es D, Berni F, Hogendorf WFJ, Meeuwenoord N, Laverde D, van Diepen A, Overkleeft HS, Filippov DV, Hokke CH, Huebner J, van der Marel GA, Codée JDC.

Chemistry. 2018 Mar 15;24(16):4014-4018. doi: 10.1002/chem.201800153. Epub 2018 Feb 19.

18.

Proteomic analyses identify ARH3 as a serine mono-ADP-ribosylhydrolase.

Abplanalp J, Leutert M, Frugier E, Nowak K, Feurer R, Kato J, Kistemaker HVA, Filippov DV, Moss J, Caflisch A, Hottiger MO.

Nat Commun. 2017 Dec 12;8(1):2055. doi: 10.1038/s41467-017-02253-1.

19.

A Poly-ADP-Ribose Trigger Releases the Auto-Inhibition of a Chromatin Remodeling Oncogene.

Singh HR, Nardozza AP, Möller IR, Knobloch G, Kistemaker HAV, Hassler M, Harrer N, Blessing C, Eustermann S, Kotthoff C, Huet S, Mueller-Planitz F, Filippov DV, Timinszky G, Rand KD, Ladurner AG.

Mol Cell. 2017 Dec 7;68(5):860-871.e7. doi: 10.1016/j.molcel.2017.11.019.

20.

A General Approach Towards Triazole-Linked Adenosine Diphosphate Ribosylated Peptides and Proteins.

Liu Q, Kistemaker HAV, Bhogaraju S, Dikic I, Overkleeft HS, van der Marel GA, Ovaa H, van der Heden van Noort GJ, Filippov DV.

Angew Chem Int Ed Engl. 2018 Feb 5;57(6):1659-1662. doi: 10.1002/anie.201710527. Epub 2018 Jan 8.

PMID:
29215186
21.

Intertwined Precursor Supply during Biosynthesis of the Catecholate-Hydroxamate Siderophores Qinichelins in Streptomyces sp. MBT76.

Gubbens J, Wu C, Zhu H, Filippov DV, Florea BI, Rigali S, Overkleeft HS, van Wezel GP.

ACS Chem Biol. 2017 Nov 17;12(11):2756-2766. doi: 10.1021/acschembio.7b00597. Epub 2017 Oct 2.

22.

Synthesis of ribosyl-ribosyl-adenosine-5',5'',5'''(triphosphate)-the naturally occurring branched fragment of poly(ADP ribose).

Liu Q, Kistemaker HAV, Overkleeft HS, van der Marel GA, Filippov DV.

Chem Commun (Camb). 2017 Sep 14;53(74):10255-10258. doi: 10.1039/c7cc05755e.

PMID:
28868552
23.

Chemical synthesis of guanosine diphosphate mannuronic acid (GDP-ManA) and its C-4-O-methyl and C-4-deoxy congeners.

Zhang Q, Howell PL, Overkleeft HS, Filippov DV, van der Marel GA, Codée JDC.

Carbohydr Res. 2017 Oct 10;450:12-18. doi: 10.1016/j.carres.2017.08.005. Epub 2017 Aug 11.

PMID:
28822279
24.

Piperidine and octahydropyrano[3,4-c] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory.

Narhe BD, Breman AC, Padwal J, Vandenput DAL, Scheidt JM, Benningshof JCJ, van der Marel GA, Overkleeft HS, van der Stelt M, Filippov DV.

Bioorg Med Chem. 2017 Oct 1;25(19):5160-5170. doi: 10.1016/j.bmc.2017.07.016. Epub 2017 Jul 10.

25.

ADP-Ribosylation Goes Normal: Serine as the Major Site of the Modification.

Liu Q, Florea BI, Filippov DV.

Cell Chem Biol. 2017 Apr 20;24(4):431-432. doi: 10.1016/j.chembiol.2017.04.003.

26.

New Quantitative Mass Spectrometry Approaches Reveal Different ADP-ribosylation Phases Dependent On the Levels of Oxidative Stress.

Bilan V, Selevsek N, Kistemaker HAV, Abplanalp J, Feurer R, Filippov DV, Hottiger MO.

Mol Cell Proteomics. 2017 May;16(5):949-958. doi: 10.1074/mcp.O116.065623. Epub 2017 Mar 21.

27.

Combined Phosphoramidite-Phosphodiester Reagents for the Synthesis of Methylene Bisphosphonates.

Engelsma SB, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV.

Angew Chem Int Ed Engl. 2017 Mar 6;56(11):2955-2959. doi: 10.1002/anie.201611878. Epub 2017 Feb 7.

PMID:
28170152
28.

ADP-ribosylhydrolase activity of Chikungunya virus macrodomain is critical for virus replication and virulence.

McPherson RL, Abraham R, Sreekumar E, Ong SE, Cheng SJ, Baxter VK, Kistemaker HA, Filippov DV, Griffin DE, Leung AK.

Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):1666-1671. doi: 10.1073/pnas.1621485114. Epub 2017 Jan 31.

29.

The Optimization of Bioorthogonal Epitope Ligation within MHC-I Complexes.

Pawlak JB, Hos BJ, van de Graaff MJ, Megantari OA, Meeuwenoord N, Overkleeft HS, Filippov DV, Ossendorp F, van Kasteren SI.

ACS Chem Biol. 2016 Nov 18;11(11):3172-3178. Epub 2016 Oct 10.

PMID:
27704768
30.

TLR2 ligand-synthetic long peptide conjugates effectively stimulate tumor-draining lymph node T cells of cervical cancer patients.

Zom GG, Welters MJ, Loof NM, Goedemans R, Lougheed S, Valentijn RR, Zandvliet ML, Meeuwenoord NJ, Melief CJ, de Gruijl TD, Van der Marel GA, Filippov DV, Ossendorp F, Van der Burg SH.

Oncotarget. 2016 Oct 11;7(41):67087-67100. doi: 10.18632/oncotarget.11512.

31.

Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.

Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10634-8. doi: 10.1002/anie.201604058. Epub 2016 Jul 28.

PMID:
27464500
32.

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes.

Xin BT, de Bruin G, Huber EM, Besse A, Florea BI, Filippov DV, van der Marel GA, Kisselev AF, van der Stelt M, Driessen C, Groll M, Overkleeft HS.

J Med Chem. 2016 Aug 11;59(15):7177-87. doi: 10.1021/acs.jmedchem.6b00705. Epub 2016 Aug 1.

PMID:
27438186
33.

Synthesis and evaluation of fluorescent Pam3Cys peptide conjugates.

Gential GP, Ho NI, Chiodo F, Meeuwenoord N, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV.

Bioorg Med Chem Lett. 2016 Aug 1;26(15):3641-5. doi: 10.1016/j.bmcl.2016.05.094. Epub 2016 Jun 1.

PMID:
27289322
34.

Interaction of the amyloid β peptide with sodium dodecyl sulfate as a membrane-mimicking detergent.

Shabestari MH, Meeuwenoord NJ, Filippov DV, Huber M.

J Biol Phys. 2016 Jun;42(3):299-315. doi: 10.1007/s10867-016-9408-5. Epub 2016 Mar 16.

35.

Branching of poly(ADP-ribose): Synthesis of the Core Motif.

Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV.

Org Lett. 2015 Sep 4;17(17):4328-31. doi: 10.1021/acs.orglett.5b02143. Epub 2015 Aug 26.

PMID:
26307949
36.

Chemoselective Cleavage of p-Methoxybenzyl and 2-Naphthylmethyl Ethers Using a Catalytic Amount of HCl in Hexafluoro-2-propanol.

Volbeda AG, Kistemaker HA, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

J Org Chem. 2015 Sep 4;80(17):8796-806. doi: 10.1021/acs.joc.5b01030. Epub 2015 Aug 14.

PMID:
26230920
37.

Sequence specificity for uridylylation of the viral peptide linked to the genome (VPg) of enteroviruses.

Schein CH, Ye M, Paul AV, Oberste MS, Chapman N, van der Heden van Noort GJ, Filippov DV, Choi KH.

Virology. 2015 Oct;484:80-5. doi: 10.1016/j.virol.2015.05.016. Epub 2015 Jun 11.

38.

Lipophilic Muramyl Dipeptide-Antigen Conjugates as Immunostimulating Agents.

Willems MM, Zom GG, Meeuwenoord N, Khan S, Ossendorp F, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

ChemMedChem. 2016 Jan 19;11(2):190-8. doi: 10.1002/cmdc.201500196. Epub 2015 Jun 9.

PMID:
26059481
39.

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study.

Liu N, Hoogendoorn S, van de Kar B, Kaptein A, Barf T, Driessen C, Filippov DV, van der Marel GA, van der Stelt M, Overkleeft HS.

Org Biomol Chem. 2015 May 14;13(18):5147-57. doi: 10.1039/c5ob00474h.

PMID:
25849561
40.

Stereoselectivity in the Lewis acid mediated reduction of ketofuranoses.

van Rijssel ER, van Delft P, van Marle DV, Bijvoets SM, Lodder G, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

J Org Chem. 2015 May 1;80(9):4553-65. doi: 10.1021/acs.joc.5b00419. Epub 2015 Apr 13.

PMID:
25826382
41.

Bioorthogonal deprotection on the dendritic cell surface for chemical control of antigen cross-presentation.

Pawlak JB, Gential GP, Ruckwardt TJ, Bremmers JS, Meeuwenoord NJ, Ossendorp FA, Overkleeft HS, Filippov DV, van Kasteren SI.

Angew Chem Int Ed Engl. 2015 May 4;54(19):5628-31. doi: 10.1002/anie.201500301. Epub 2015 Mar 17.

PMID:
25784151
42.

A mutasynthesis approach with a Penicillium chrysogenum ΔroqA strain yields new roquefortine D analogues.

Ouchaou K, Maire F, Salo O, Ali H, Hankemeier T, van der Marel GA, Filippov DV, Bovenberg RA, Vreeken RJ, Driessen AJ, Overkleeft HS.

Chembiochem. 2015 Apr 13;16(6):915-23. doi: 10.1002/cbic.201402686. Epub 2015 Mar 12.

PMID:
25766600
43.

Synthesis of well-defined adenosine diphosphate ribose oligomers.

Kistemaker HA, Lameijer LN, Meeuwenoord NJ, Overkleeft HS, van der Marel GA, Filippov DV.

Angew Chem Int Ed Engl. 2015 Apr 13;54(16):4915-8. doi: 10.1002/anie.201412283. Epub 2015 Feb 20.

PMID:
25704172
44.

Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery.

Padwal JD, Filippov DV, Narhe BD, Aertssen S, Beuving RJ, Benningshof JC, van der Marel GA, Overkleeft HS, van der Stelt M.

Bioorg Med Chem. 2015 Jun 1;23(11):2650-5. doi: 10.1016/j.bmc.2015.01.040. Epub 2015 Jan 31.

PMID:
25691210
45.

Two in one: improving synthetic long peptide vaccines by combining antigen and adjuvant in one molecule.

Zom GG, Filippov DV, van der Marel GA, Overkleeft HS, Melief CJ, Ossendorp F.

Oncoimmunology. 2014 Jul 3;3(7):e947892. eCollection 2014.

46.

Furanosyl oxocarbenium ion stability and stereoselectivity.

van Rijssel ER, van Delft P, Lodder G, Overkleeft HS, van der Marel GA, Filippov DV, Codée JD.

Angew Chem Int Ed Engl. 2014 Sep 22;53(39):10381-5. doi: 10.1002/anie.201405477. Epub 2014 Jul 31.

PMID:
25081839
47.

N-tetradecylcarbamyl lipopeptides as novel agonists for Toll-like receptor 2.

Willems MM, Zom GG, Khan S, Meeuwenoord N, Melief CJ, van der Stelt M, Overkleeft HS, Codée JD, van der Marel GA, Ossendorp F, Filippov DV.

J Med Chem. 2014 Aug 14;57(15):6873-8. doi: 10.1021/jm500722p. Epub 2014 Jul 23.

PMID:
25019313
48.

Design, automated synthesis and immunological evaluation of NOD2-ligand-antigen conjugates.

Willems MM, Zom GG, Meeuwenoord N, Ossendorp FA, Overkleeft HS, van der Marel GA, Codée JD, Filippov DV.

Beilstein J Org Chem. 2014 Jun 26;10:1445-53. doi: 10.3762/bjoc.10.148. eCollection 2014.

49.

Exploring dual electrophiles in peptide-based proteasome inhibitors: carbonyls and epoxides.

Xin BT, de Bruin G, Verdoes M, Filippov DV, van der Marel GA, Overkleeft HS.

Org Biomol Chem. 2014 Aug 14;12(30):5710-8. doi: 10.1039/c4ob00893f. Epub 2014 Jun 26.

PMID:
24968066
50.

Efficient induction of antitumor immunity by synthetic toll-like receptor ligand-peptide conjugates.

Zom GG, Khan S, Britten CM, Sommandas V, Camps MG, Loof NM, Budden CF, Meeuwenoord NJ, Filippov DV, van der Marel GA, Overkleeft HS, Melief CJ, Ossendorp F.

Cancer Immunol Res. 2014 Aug;2(8):756-64. doi: 10.1158/2326-6066.CIR-13-0223. Epub 2014 Apr 21.

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