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Items: 28


Dynamin-Related Protein 1-Dependent Mitochondrial Fission Changes in the Dorsal Vagal Complex Regulate Insulin Action.

Filippi BM, Abraham MA, Silva PN, Rasti M, LaPierre MP, Bauer PV, Rocheleau JV, Lam TKT.

Cell Rep. 2017 Mar 7;18(10):2301-2309. doi: 10.1016/j.celrep.2017.02.035.


Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.

Yue JT, Abraham MA, Bauer PV, LaPierre MP, Wang P, Duca FA, Filippi BM, Chan O, Lam TK.

Nat Commun. 2016 Nov 22;7:13501. doi: 10.1038/ncomms13501.


Activation of Short and Long Chain Fatty Acid Sensing Machinery in the Ileum Lowers Glucose Production in Vivo.

Zadeh-Tahmasebi M, Duca FA, Rasmussen BA, Bauer PV, Côté CD, Filippi BM, Lam TK.

J Biol Chem. 2016 Apr 15;291(16):8816-24. doi: 10.1074/jbc.M116.718460. Epub 2016 Feb 19.


Corrigendum: Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

Duca FA, Côté CD, Rasmussen BA, Zadeh-Tahmasebi M, Rutter GA, Filippi BM, Lam TK.

Nat Med. 2016 Feb;22(2):217. doi: 10.1038/nm0216-217b. No abstract available.


Glucagon signalling in the dorsal vagal complex is sufficient and necessary for high-protein feeding to regulate glucose homeostasis in vivo.

LaPierre MP, Abraham MA, Yue JT, Filippi BM, Lam TK.

EMBO Rep. 2015 Oct;16(10):1299-307. doi: 10.15252/embr.201540492. Epub 2015 Aug 19.


Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

Duca FA, Côté CD, Rasmussen BA, Zadeh-Tahmasebi M, Rutter GA, Filippi BM, Lam TK.

Nat Med. 2015 May;21(5):506-11. doi: 10.1038/nm.3787. Epub 2015 Apr 6. Erratum in: Nat Med. 2016 Feb;22(2):217.


Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network.

Côté CD, Rasmussen BA, Duca FA, Zadeh-Tahmasebi M, Baur JA, Daljeet M, Breen DM, Filippi BM, Lam TK.

Nat Med. 2015 May;21(5):498-505. doi: 10.1038/nm.3821. Epub 2015 Apr 6.


A fatty acid-dependent hypothalamic-DVC neurocircuitry that regulates hepatic secretion of triglyceride-rich lipoproteins.

Yue JT, Abraham MA, LaPierre MP, Mighiu PI, Light PE, Filippi BM, Lam TK.

Nat Commun. 2015 Jan 12;6:5970. doi: 10.1038/ncomms6970.


Insulin action in the hypothalamus and dorsal vagal complex.

Abraham MA, Filippi BM, Kang GM, Kim MS, Lam TK.

Exp Physiol. 2014 Sep;99(9):1104-9. doi: 10.1113/expphysiol.2014.079962. Epub 2014 Jun 27. Review.


Glucagon and lipid signaling in the hypothalamus.

LaPierre MP, Abraham MA, Filippi BM, Yue JT, Lam TK.

Mamm Genome. 2014 Oct;25(9-10):434-41. doi: 10.1007/s00335-014-9510-6. Epub 2014 Apr 10. Review.


Hypothalamic glucagon signals through the KATP channels to regulate glucose production.

Abraham MA, Yue JT, LaPierre MP, Rutter GA, Light PE, Filippi BM, Lam TK.

Mol Metab. 2013 Nov 28;3(2):202-8. doi: 10.1016/j.molmet.2013.11.007. eCollection 2014 Apr.


Leptin and aging.

Filippi BM, Lam TK.

Aging (Albany NY). 2014 Feb;6(2):82-3. No abstract available.

Free PMC Article

Jejunal leptin-PI3K signaling lowers glucose production.

Rasmussen BA, Breen DM, Duca FA, Côté CD, Zadeh-Tahmasebi M, Filippi BM, Lam TK.

Cell Metab. 2014 Jan 7;19(1):155-61. doi: 10.1016/j.cmet.2013.11.014. Epub 2013 Dec 19. Erratum in: Cell Metab. 2014 Mar 4;19(3):548.


Insulin signals through the dorsal vagal complex to regulate energy balance.

Filippi BM, Bassiri A, Abraham MA, Duca FA, Yue JT, Lam TK.

Diabetes. 2014 Mar;63(3):892-9. doi: 10.2337/db13-1044. Epub 2013 Nov 22.


Insulin and glucagon signaling in the central nervous system.

Filippi BM, Abraham MA, Yue JT, Lam TK.

Rev Endocr Metab Disord. 2013 Dec;14(4):365-75. Review.


Hypothalamic glucagon signaling inhibits hepatic glucose production.

Mighiu PI, Yue JT, Filippi BM, Abraham MA, Chari M, Lam CK, Yang CS, Christian NR, Charron MJ, Lam TK.

Nat Med. 2013 Jun;19(6):766-72. doi: 10.1038/nm.3115. Epub 2013 May 19.


Insulin activates Erk1/2 signaling in the dorsal vagal complex to inhibit glucose production.

Filippi BM, Yang CS, Tang C, Lam TK.

Cell Metab. 2012 Oct 3;16(4):500-10. doi: 10.1016/j.cmet.2012.09.005.


Linking inflammation to the brain-liver axis.

Mighiu PI, Filippi BM, Lam TK.

Diabetes. 2012 Jun;61(6):1350-2. doi: 10.2337/db12-0330. No abstract available.


Is insulin action in the brain clinically relevant?

Filippi BM, Mighiu PI, Lam TK.

Diabetes. 2012 Apr;61(4):773-5. doi: 10.2337/db12-0048. No abstract available.


MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases.

Filippi BM, de los Heros P, Mehellou Y, Navratilova I, Gourlay R, Deak M, Plater L, Toth R, Zeqiraj E, Alessi DR.

EMBO J. 2011 May 4;30(9):1730-41. doi: 10.1038/emboj.2011.78. Epub 2011 Mar 18.


Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation.

Zeqiraj E, Filippi BM, Deak M, Alessi DR, van Aalten DM.

Science. 2009 Dec 18;326(5960):1707-11. doi: 10.1126/science.1178377. Epub 2009 Nov 5.


The glycerophosphoinositols: cellular metabolism and biological functions.

Corda D, Zizza P, Varone A, Filippi BM, Mariggiò S.

Cell Mol Life Sci. 2009 Nov;66(21):3449-67. doi: 10.1007/s00018-009-0113-4. Epub 2009 Aug 9. Review.


ATP and MO25alpha regulate the conformational state of the STRADalpha pseudokinase and activation of the LKB1 tumour suppressor.

Zeqiraj E, Filippi BM, Goldie S, Navratilova I, Boudeau J, Deak M, Alessi DR, van Aalten DM.

PLoS Biol. 2009 Jun 9;7(6):e1000126. doi: 10.1371/journal.pbio.1000126. Epub 2009 Jun 9.


Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters.

Filippi BM, Alessi DR.

J Cell Biol. 2008 Oct 6;183(1):7-9. doi: 10.1083/jcb.200809056.


SRC-dependent signalling regulates actin ruffle formation induced by glycerophosphoinositol 4-phosphate.

Filippi BM, Mariggiò S, Pulvirenti T, Corda D.

Biochim Biophys Acta. 2008 Dec;1783(12):2311-22. doi: 10.1016/j.bbamcr.2008.07.021. Epub 2008 Aug 3.


Cytosolic phospholipase A2 alpha regulates cell growth in RET/PTC-transformed thyroid cells.

Mariggiò S, Filippi BM, Iurisci C, Dragani LK, De Falco V, Santoro M, Corda D.

Cancer Res. 2007 Dec 15;67(24):11769-78.


A novel pathway of cell growth regulation mediated by a PLA2alpha-derived phosphoinositide metabolite.

Mariggiò S, Sebastià J, Filippi BM, Iurisci C, Volonté C, Amadio S, De Falco V, Santoro M, Corda D.

FASEB J. 2006 Dec;20(14):2567-9. Epub 2006 Oct 23.


Reorganization of actin cytoskeleton by the phosphoinositide metabolite glycerophosphoinositol 4-phosphate.

Mancini R, Piccolo E, Mariggio' S, Filippi BM, Iurisci C, Pertile P, Berrie CP, Corda D.

Mol Biol Cell. 2003 Feb;14(2):503-15.

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